matrix metalloproteinases and proteolytic opening of the blood brain barrier in neuroinflammation
Báo cáo y học: "Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis" ppt
Ngày tải lên :
13/08/2014, 15:21
... surrounding brain cells, relaying into the brain inflammatory response and jeopardising the functional integrity of the BBB [55-57] In the present study, we found that, during experimental sepsis, the ... tightly regulating the passage of molecules into and out of the brain to protect the brain from microorganisms and neurotoxic substances During sepsis, however, blood- borne proinflammatory mediators ... consequence of inflammation-mediated dysfunction of the blood- brain barrier (BBB), thus allowing neurotoxic mediators to extravasate from the peripheral circulation into the subarachnoid space or into the...
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báo cáo hóa học: " Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF" potx
Ngày tải lên :
19/06/2014, 22:20
... blood- brain barrier to various sized molecules Am J Physiology 1985, 248:H712-H718 Chou S, Dix RD: Viral infections and the blood- brain barrier In Implications of the Blood- Brain Barrier and Its ... microliters (µL) of radioactive tracer diffusing from the luminal to abluminal (influx) chamber and was calculated from the initial level of radioactivity in the loading chamber and final level of radioactivity ... microliter of collecting chamber (in cpm/µL), and VC is the volume of collecting chamber (in µL) During a 90-min period of the experiment, the clearance volume increased linearly with time The volume...
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Nanoparticles of biodegradable polymers for delivery of therapeutic agents and diagnostic sensitizers to cross the blood brain barrier (BBB) for chemotherapy and MRI of the brain
Ngày tải lên :
26/11/2015, 22:48
... History and Anatomy of the Blood Brain Barrier 1.1.2 Functions of the Blood Brain Barrier 1.1.3 Clinical Significance of the Blood Brain Barrier 1.2 METHODS TO OVERCOME THE BLOOD BRAIN BARRIER 1.3 NANOPARTICLES ... Functions of the Blood Brain Barrier The main function of the blood brain barrier is to protect the brain The BBB serves as an impermeable wall to prevent the entry of agents from outside of the brain ... 2.2 BRAIN CANCER AND OTHER BRAIN DISEASES A brain tumor is a mass of unnecessary cells growing in the brain [94] There are two basic kinds of brain tumors: primary brain tumors and metastatic brain...
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A contrastive analysis of semantic and pragmatic features of the words denoting birds in english and vietnamese
Ngày tải lên :
26/11/2013, 13:30
... study of the WDBs contributes to the interesting phenomenon in language In daily communication, people present recognition of the field And the findings of semantic aspects often borrow the WDBs ... implications An investigation into semantic and fields as well as pragmatic features of the WDBs The finding of the pragmatic features of the WDBs leads both teachers and learners of study may be in one ... a study of the semantic and pragmatic the same image or meaning of these words If we both have different features of the WDBs in English and Vietnamese However, there are meanings in mind for...
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Báo cáo khoa học: Contributions to catalysis and potential interactions of the three catalytic domains in a contiguous trimeric creatine kinase doc
Ngày tải lên :
16/03/2014, 06:20
... substrate binding are shown in blue, and the N-terminal ‘hinge’ proline is shown in pink The highly conserved reactive cysteine residues that were the mutagenic target of this study are shown in green ... whereby the closing of one active site exerts pressure through a suite of atomic interactions to inhibit the binding and closing of any other active sites that are in communication with the closed ... constraints imposed upon it by both domains and Domains and 3, on the other hand, only experience the constraints from domain 2, which explains two results seen in analysis of kcat values: the lower...
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Báo cáo khoa học: Regulation of the expression and subcellular localization of the taurine transporter TauT in mouse NIH3T3 fibroblasts doc
Ngày tải lên :
30/03/2014, 15:20
... taurine uptake in NIH3T3 mouse fibroblasts is linear within the initial 20 following the addition of 14C-labelled taurine Using taurine uptake within the initial 20 in NaCl medium containing extracellular ... time point was estimated as the negative slope of the graph between the time point and the proceeding time point The taurine efflux at a given time point can be estimated as the product of the rate ... experimental medium from the time of the initiation of the in ux experiment The in ux was estimated from the slope of the uptake curves and in each case given relative to the in ux in control cells ± SEM...
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báo cáo hóa học: " Immunological characterization and transcription profiling of peripheral blood (PB) monocytes in children with autism spectrum disorders (ASD) and specific polysaccharide antibody deficiency (SPAD): Case study" pot
Ngày tải lên :
19/06/2014, 22:20
... geneticist and currently is an Assistant Professor at the Institute of Genomic Medicine, UMDNJ-NJMS He has been involved in clinical studies of CGH, transcription profiling, and microRNA profiling in ... transcription profiling and analysis of the data of transcription profiling as well as manuscript preparation associated with transcription profiling All the authors read and approved the final manuscript ... pathogenesis and the need for careful evaluation of the use of IVIG in ASD children, other than for antibody deficiency syndrome The limitation of this study is the lack of transcription profiling data in...
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Báo cáo lâm nghiệp: "A change in structural diversity and regeneration processes of the spruce virgin forest in Nefcerka NNR (TANAP) in relation to altitude" docx
Ngày tải lên :
07/08/2014, 10:22
... spruce natural forest in the whole height profile of the virgin forest The testing of the influence of the altitude revealed its great influence in the growth stage In the optimum and breakdown stages ... difference in the index was confirmed in the spruce virgin forest in the altitudinal range of 1,300–1,400 m The analysis of the structure of the spruce virgin forest in Nefcerka NNR assessed according ... wood is increasing with the ascending altitude, the most of them being in the initial phase of the growth stage Conditions of spruce natural forests in NNR in Slovakia are highly variable The phenomenon...
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Báo cáo y học: "The biological and clinical importance of the ‘new generation’ cytokines in rheumatic diseases" pot
Ngày tải lên :
09/08/2014, 14:20
... activation in joint inflammation Indeed, the administration of sST2 decreased the production of inflammatory cytokines and the severity of collagen-induced arthritis (CIA) [27] Mice deficient in ST2 ... receptor chain with high affinity (1011/M) and slow off-rate, rendering it a useful and specific inhibitor in biologic systems Common γ-chain signalling cytokines – interleukin-15 and interleukin-21 ... belonging to both the innate and adaptative immunity Pro-inflammatory effects of interleukin-17 Several in vitro and in vivo data indicate that IL-17 plays a critical role in acute and chronic inflammatory...
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báo cáo khoa học: " Expression profiling and integrative analysis of the CESA/CSL superfamily in rice" doc
Ngày tải lên :
11/08/2014, 11:21
... expressed in the tissues we examined, confirming their major roles in the biosynthesis of cellulose, the main component of plant cell walls The co-expression profiling of the CESA genes can somehow indicate ... BW and XC participated in the growing of the rice and in data interpretation LP supervised the project and finalized the paper All authors have read and approved the final manuscript Received: ... indicate the preferential expression, while the minus sign indicates lower expression; The asterisks indicate the genes expressed throughout the tissues examined; The numbers in parentheses indicate...
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Báo cáo sinh học: " Genetic and morphological characterisation of the Ankole Longhorn cattle in the African Great Lakes region" pptx
Ngày tải lên :
14/08/2014, 13:21
... (i.e centre of gravity of the landmarks) and each of the configured landmarks Then, the centroids of all the landmark configurations are superimposed and translated to the origin The landmark configurations ... highland, the Ntuuku cattle from the Lake Albert region of the Albertine Rift Valley in Uganda, the Watusi and Inkuku cattle from Rwanda, the Inyaruguru and Inyambu cattle from Burundi, the Enyambu ... transformations, maintaining the characteristics of shape while reducing the number of dimensions The resulting 2n – relative warp scores (n being the number of landmarks) are the dependent variables in conventional...
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Báo cáo y học: "Characterization and comparative profiling of the small RNA transcriptomes in two phases of locust" docx
Ngày tải lên :
14/08/2014, 21:20
... information to understanding the function and evolution of small RNAs in insects The analysis of the characteristics and expression of small RNAs in the locust enhances the knowledge of gene expression ... miR-281, and miR-307; Table S2 in Additional data file 3) in the locust library, indicating conservation of these miRNAs* between the locust and the fruit fly To test whether the locust miRNA* and their ... regulate the expression of protein coding genes in the two phases must be involved in the process of phase changes It is possible that we could provide insight into the phase changes and find new...
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Application of biologically active micelles in drug delivery across the blood brain barrier
Ngày tải lên :
11/09/2015, 09:10
... predominantly affects the meninges surrounding the brain and the spinal cord is called meningitis The infection of the brain tissue is called encephalitis If both brain and meninges are affected, the ... 12% of all drugs are active in the CNS, only 8% of them are active in the brain for the treatment of diseases or disorders (Lipinski, 2000) The BBB lies between the blood flow and the brain parenchyma ... parenchyma The blood brain barrier (BBB) lies between the blood flow and the brain parenchyma The BBB prohibits most foreign molecules entering from the blood to brain, including CNS drugs The limited...
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A study on syntactic and semantic features of the thinking verb group in english and their vietnamese equivalents
Ngày tải lên :
24/06/2016, 21:26
... Pointing out the syntactic and semantic features of the THINKINGverbs in English and their Vietnamese equivalents Finding outthe similarities and differences of the THINKING verbs in English and ... discussed the discusses the definition of the mind and similarities and the differences between verbs of thinking and speaking Susanna Karlsson (2008), Re-thinking THINK in contrastive perspective The ... background of analyzing the syntactic and semantic features of the THINKING verbs in English Moreover, the definition of the verb and classification of verb are pointed out in details.Finally, theoretical...
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Cognitive and Physiologic Correlates of Subclinical Structural Brain Disease in Elderly Healthy Control Subjects docx
Ngày tải lên :
05/03/2014, 21:20
... the intrahemispheric coherence findings of Koyama et al70 and of Duffy et al71 using interhemispheric coherence While Geschwind and Kaplan72 and Geschwind73 advanced the idea that a process of ... )|2 Sx( f )*Sy( f ) or the square of the cross-spectrum of the channels divided by the product of the spectra of the individual channels Thatcher et al44 measured the information transmitted ... 3A]) and the projections of the visual and association cortex in the postrolandic area (Figure 3B)2; subjects with vascular dementia showed reductions in coherence in these networks In the present...
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the blood – brain barrier
Ngày tải lên :
11/04/2014, 10:34
... M E., and Brown, W J (1977) The large apparent work capability of the blood- brain barrier: A study of mitochondrial content of capillary endothelial cells in brain and other tissues of the rat ... using the index and thumb of the left hand or a pair of forceps with blunt ends and the 16-gage needle is inserted through the apex of the heart into the left ventricle Slide the needle along the ... crystals and score the marked ring on the neck of the vial with a file b Break off the tip of the vial and drop the vial into an amber colored bottle containing the required amount of distilled...
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Báo cáo y học: "Effect of magnesium sulfate administration on blood–brain barrier in a rat model of intraperitoneal sepsis: a randomized controlled experimental study" ppt
Ngày tải lên :
12/08/2014, 20:20
... the exact mechanism of brain injury in sepsis Studies have suggested that septic encephalopathy might involve a disturbance of plasma and brain neutral amino acid transport across the blood brain ... to the disturbed integrity of the BBB Our results are consistent with previous reports on the integrity of the BBB and the role of a permeability defect in the formation of cerebral edema using ... model of intra-abdominal sepsis, the cultures of brain specimens taken after the experiment were all sterile (data not shown) One of the major pitfalls in the interpretation of the data was the difficulty...
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Báo cáo y học: "The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis" pps
Ngày tải lên :
09/08/2014, 08:23
... cultures of MMP (TIMPs), and link metalloproteinases (MMPs), tisleukin (IL)-1 on the expression of matrix protein in (TNF)-α and/ or interleukin (IL)-1 on the expression of matrix metalloproteinases ... IL-1 and TNF, rather than a 'cytokine cascade' with either of these cytokines controlling the production of the other (Figure 4a) Both Enbrel and the neutralising anti-IL-1β antibody decreased the ... cytokines and/ or MMPs or indirectly due to cytokine-mediated inhibition of the production of growth factors [16] The majority of studies of the regulation of cytokines and destructive enzymes in...
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Báo cáo y học: "Glomerular matrix metalloproteinases and their regulators in the pathogenesis of lupus nephritis" pdf
Ngày tải lên :
09/08/2014, 13:22
... higher levels in patients with evidence of central nervous system involvement There are reports indicating a central role for MMPs in increasing permeability of the blood- brain barrier in inflammatory ... this review The gelatinases cleave a number of substrates, including native forms of collagens I, IV, V, VII, X and XI, elastin, laminin, fibronectin, myelin and the core protein of proteoglycans ... metalloproteinase by direct interaction between the two proteins within the nucleus [31] The concept of TIMP-1 translocating into the nucleus remains controversial [32,33], and the functions of TIMP in...
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Genetic polymorphisms of matrix metalloproteinases and their inhibitors in potentially malignant and malignant lesions of the head and neck potx
Ngày tải lên :
10/08/2014, 05:21
... 23 of them have been found in humans [21-23] The members of the MMP family have many similarities in their structure All MMPs have a zinc-binding motif in the catalytic domain In addition, they ... capable of degrading most components of the extra cellular matrix (ECM) [7-9] Degeneration of matrix is a key event in invasion and metastasis of malignant lesions of the head and neck Tissue inhibitors ... The role of genetic polymorphisms in the promoters of the matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 genes in head and neck cancer Oral Oncol 2006, 42(3):257-67 Lin...
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