matrix cytokines and cell matrix adhesion
Molecular mechanisms of mechanosensing at cell cell and cell matrix adhesion 2
... at cell- adhesions As cell adhesions play a pivotal role in the proper function of cells, misregulation of cell adhesions often leads to severe pathological consequences Altered cell- cell and cell -matrix ... conformation changes At subcellular level, vinculin plays important roles in regulating cell -matrix and cell- cell adhesions Cells lacking vinculin develop less stable focal adhesions and migrate faster ... between adhesion proteins [44] Mechanical force is a critical factor that couples tightly with the formation and dynamics of cell -matrix adhesions Most cell -matrix adhesions, such as focal complex and...
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Báo cáo y học: "Human T-cell leukemia virus type I infects human lung epithelial cells and induces gene expression of cytokines, chemokines and cell adhesion molecules" ppt
... of expression of cytokines, chemokines and cell adhesion molecule in A549 cells cocultured with MT2 cells A549 cells were cocultured with MMC-treated MT-2 or CCRF-CEM cells At and days after cocultivation, ... IL-8 and CCL20 and Induction of cell surface ICAM-1 expression in A549 cells cocultured with MT-2 cells Secretion of IL-8 and CCL20 and Induction of cell surface ICAM-1 expression in A549 cells ... of NF-κB and AP1 A549 cells cocultured with MT-2 cells exhibited high transcriptional activity of NF-κB and AP-1, compared with control A549 cells and A549 cells cocultured with CCRFCEM cells (Figure...
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Báo cáo khoa học: Activation of p21-activated kinase 1 is required for lysophosphatidic acid-induced focal adhesion kinase phosphorylation and cell motility in human melanoma A2058 cells potx
... activity, and thereby stimulate cell spreading and motility in neuroblastoma cells [34] It is possible that different small G proteins are involved in LPA-induced cell motility in different cell types ... Trends Cell Biol 8, 151–157 17 Gilmore, A.P & Romer, L.H (1996) Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreased cell motility and proliferation Mol Biol Cell 7, ... actin stress fibers and focal adhesion [31] LPA1 and LPA2 receptors couple to MAPK/ ERK, PLC and RhoA-dependent signaling cascade, while LPA3 receptors activate only MAPK/ERK and PLC pathways [32]...
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Báo cáo y học: " Inflammatory cytokines, goblet cell hyperplasia and altered lung mechanics in Lgl1+/- mice" pptx
... http://respiratory-research.com/content/10/1/83 roles in cell differentiation, motility and migration [5,7]; cell adhesion and matrix deposition [8,9]; and hostdefense and innate immunity [4,10,11] The results ... mouse LR and IM characterized Lgl1 mRNA and protein, elastin and tropoelastin mRNA, and goblet cells and mucin mRNA in Lgl1+/- heterozygotes and wild type controls TB participated in H and E histochemistry ... proteins, has been implicated in directional cell migration and differentiation [5,7], extracellular matrix deposition [5,8], cell adhesion [9] and innate host-defense mechanisms [4,10,11] While Lgl1...
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Báo cáo y học: " The predictive role of serum and bronchoalveolar lavage cytokines and adhesion molecules for acute respiratory distress syndrome development and outcome" pptx
... lung adenocarcinoma cell line, NCI-H441, and human fetal lung explants H441 cells resemble bronchiolar epithelial Clara cells in phenotype and produce both SP-A and SP-B mRNA and protein [14] The ... vehicle or insulin (2.5 µg/ml) for an additional 1, 4, and 24 hours The cells were then rinsed and trypsinized, and nuclei from control and treated cells were harvested The transcription elongation ... MAPK and p70 S6 kinase in cells incubated in the presence of insulin (2.5 µg/ml), PD98059 (10 µM) and/ or rapamycin (50 nM) Cells were harvested and immunoblotted for phosphorylated p44/42 MAPK and...
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Báo cáo y học: " The predictive role of serum and bronchoalveolar lavage cytokines and adhesion molecules for acute respiratory distress syndrome development and outcome" doc
... response to IL-1b and TNF-α, microvascular epithelium is activated and expresses intercellular adhesion molecule-1 (ICAM-1), vascular adhesion molecule-1 (VCAM-1) and selectins [12,13] The adhesion molecules ... serumintercellular adhesion molecule-1; sVCAM = serum vascular adhesion molecule Table Median (range) bronchoalveolar lavage fluid (BALF) and serum levels (pg/ml) of the measured cytokines and adhesion ... serumintercellular adhesion molecule-1; sVCAM = serum vascular adhesion molecule Table Median (range) bronchoalveolar lavage fluid (BALF) and serum levels (pg/ml) of the measured cytokines and adhesion...
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Senescence and Cell Cycle Control
... suppression and cell mortality Cell 85:27–37 Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW (1997) Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a Cell ... human fibroblasts by p16 and the polycomb protein Bmi-1 Mol Cell Biol 23:389–401 Itahana K, Campisi J, Dimri GP (2004) Mechanisms of cellular senescence in human and mouse cells Biogerontology 5:1–10 ... in cultured mouse cells p19ARF is predominantly upregulated during senescence by oncogene activation and/ or oxidative stress Senescence and Cell Cycle Control 265 In human cells undergoing replicative...
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Tài liệu Báo cáo khoa học: The plasminogen activator inhibitor 2 transcript is destabilized via a multi-component 3¢ UTR localized adenylate and uridylate-rich instability element in an analogous manner to cytokines and oncogenes pdf
... SJS133 and SJS134 as the external primers and the constructs pTETGLOPAI)2 and pTETGLOARE II-MUT as the templates Mutation of the ARE I-AUUUA and ARE III-AUUUA sequences used primers SJS172 and SJS173, ... SJS173, and SJS174 and SJS175, respectively Mutation of the atypical AU-rich sequence used primers SJS259 and SJS260, and the creation of the ARE II ⁄ ARE IV double mutant used primers SJS261 and ... the contribution and mechanism of this ARE, and the individual ARE domains, to PAI-2 mRNA stabilization and, subsequently, PAI-2 gene expression Experimental procedures Plasmids and mutant construction...
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Tài liệu Báo cáo khoa học: Inhibition of pneumococcal choline-binding proteins and cell growth by esters of bicyclic amines pptx
... the daughter cells at the end of cell division and in cellular autolysis [9], where it mediates the release of toxins that damage the host tissues and allows the entry of pneumococcal cells into ... analysis of ligand binding to C-LytA (A) Conformational changes induced by ligands on C-LytA monitored by near-UV CD with no ligand added (—) and upon addition of ligands: s, d, 2.5 and 20 mM choline; ... analogs on cell growth and viability Fig Effect of choline and analogs on the activity of cell wall lytic enzymes Data are shown as percentage of activity with respect to nonligated enzyme, and are...
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Báo cáo khoa học: The dipeptidyl peptidase IV family in cancer and cell biology pot
... literature that DPIVand FAP-exerted effects on cell behaviour are cell- type dependent For example, while FAP overexpression in 293T cells was associated with decreased cell adhesion and cell migration, ... recruitment of CD26 and CD45 to these rafts [80] and induces T -cell activation DPIV family in cancer and cell biology Fig Features of the effects of DP upon T -cell activation ⁄ function Cell- surface ... in the HEK293T epithelial cell line have revealed roles for DP9 in cell adhesion, in in vitro wound healing, in cell migration, and in proliferation and apoptosis, and roles for DP8 have been...
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Understanding the participatory news consumer - How internet and cell phone users have turned news into a social experience pdf
... incomes, and broadband and wireless users—report more frequent chance encounters with news as well as more frequent hunting and gathering experiences The youngest adults (those under age 30) and cell ... groups: women, African-Americans, and older Americans (those 65 and older) By comparison, those who are internet users and those who have a cell phone but no landline are less likely to get local ... the cell- only population (those who have dropped their landline and rely exclusively on their cell phone) get radio news on a typical day, compared with 39% of those who rely exclusively on landlines...
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Báo cáo khoa học: Linking pseudouridine synthases to growth, development and cell competition potx
... from defects in cell adhesion and ⁄ or cell communication mfl silencing triggers apoptosis and sorting out of D cells towards the V compartment To assess the specific effects on cell apoptosis, ... were chosen, and their total wing area, anterior (A) and P compartments area and cell density were measured (see Experimental procedures) Cell size was then estimated as the inverse of cell density ... cells expressing different levels of Mfl or still unexplained cell nonautonomous effects, such as defects in cell communication and ⁄ or cell affinity In order to evaluate the growth of mfl 05 cells...
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Báo cáo khoa học: Bridging the gap between in silico and cell-based analysis of the nuclear factor-jB signaling pathway by in vitro studies of IKK2 ppt
... l-glutamine and 5% fetal bovine serum) and maintained at 37 C and 5% CO2 For translocation experiments, cells were removed with 0.05% trypsin EDTA, and plated with cell solution of ã 106 cellsặmL)1 ... prepared for cell assay and was added following the same procedure described for the time course cell assay The cells were washed with NaCl Pi and xed after 400 min, and the standard immunocytochemical ... regulators of immune and inammatory responses and also genes involved in apoptosis and cell proliferation [36] In this paper, we report the results of cell- based, in vitro and in silico experiments...
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Báo cáo khoa học: Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells pot
... control and mutant DNAzyme-treated cells (Fig 5) Inhibition of Saos-2 cell invasion by Dz720 The plasminogen activator system can promote the breakdown of ECM and facilitate cell invasion and metastasis ... controls (P < 0.01) (Fig 6) Saos-2 cells treated with the active Dz720 had 42% and 17% fewer cells on the lower side of the filter compared with untreated control cells and cells treated with Dz720 mutant, ... integrated into the colon cancer cell line HCT116 led to the suppression of the Erk-MAP kinase pathway and reductions in uPA secretion, cell adhesion, and plasminogen-dependent matrix degradation Importantly,...
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Anatomy, Histology, and Cell Biology PreTestTM Self-Assessment and Review pptx
... The TH cell secretes cytokines (small protein or peptide intercellular communication molecules) that activate TC cells, B cells, and macrophages Release of cytokines by TH cells induces TC cells ... with glands in the fundus and body that produce mucus (surface and neck cells), pepsinogen (chief cells), and acid and intrinsic factor (parietal cells) Intrinsic factor binds to vitamin B12 and ... infection and release histaminases to counteract basophils and mast cells; and basophils, which contain histamine and heparin and assist mast cell function Bone marrow is the site of blood cell development...
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Targeting New Pathways and Cell Death in Breast Cancer Edited by Rebecca L. Aft docx
... glutamine, cysteine, and glycine It is the most abundant intracellular small molecule thiol present in mammalian cells and it serves as a potent intracellular antioxidant protecting cells from toxins ... tumor suppressors p53 and PTEN, and cell cycle inhibitors p21 Cip1/WAF1 and p27Kip1 (Park et al, 2008) Whereas the molecular machinery utilized by HER2 to promote cell migration and invasion remains ... molecules involve extracellular cytokines or ligands representing death stimuli, e.g FasL, tumor necrosis factor-α (TNF-α) or the TNF-related apoptosis-inducing ligand (TRAIL), and cellular mediators...
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Báo cáo khoa học: ERK and cell death: Mechanisms of ERK-induced cell death – apoptosis, autophagy and senescence doc
... Daniels MA (2009) ERK and cell death: ERK location and T cell selection FEBS J Martin P & Pognonec P (2009) ERK and cell death: cadmium toxicity, sustained ERK activation and cell death FEBS J Taylor ... ⁄ and MEK5 in those cells FEBS Journal 277 (2010) 2–21 ª 2009 The Authors Journal compilation ª 2009 FEBS 13 ERK and cell death S Cagnol and J.-C Chambard Fig The hallmarks of ERK-mediated cell ... of cell death that correlated with extensive cell rounding and the formation of cytoplasmic macrovacuoles, which pushed the nucleus and the cytoplasm to the side of the dying cell Although cell...
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Báo cáo khoa học: ERK and cell death: ERK1⁄2 in neuronal death Srinivasa Subramaniam1 and Klaus Unsicker2 pptx
... membrane damage and independently of caspase-3 J Cell Biol 165, 357–369 35 Mebratu Y & Tesfaigzi Y (2009) How ERK1 ⁄ activation controls cell proliferation and cell death: is subcellular localization ... hand, in non-neuronal cells, cytoplasmic retention of ERK1 ⁄ is required for death-associated protein kinase-mediated cell death [35] Thus, ERK1 ⁄ might promote cell death depending upon the cell ... multiple activators and targets, it is possible that activation and its cell death-promoting function may involve multiple partners and regulations [5] ERK1 ⁄ in neurodegeneration and ischemia ERK1...
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Báo cáo khoa học: ERK and cell death: ERK location and T cell selection pdf
... problem Interestingly, JNK activity and subcellular location are the same regardless of the ligand strength, ERK location and T cell selection whereas ERK activity and location change depending of ... a cell It was recently shown, that in thymocytes, positive and negative selecting ligands induce the localization of the components of the Ras ⁄ ERK cascade and active ERK into distinct subcellular ... negative selecting ligand Note the separate location of pJNK and pERK, and Ras-GRP1 ⁄ Grb2 ⁄ SOS ⁄ Ras ⁄ Raf at the plasma membrane lead to such distinct cell fates as survival and death Much is...
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