markers of cartilage metabolism
Báo cáo y học: "Hormone replacement therapy, calcium and vitamin D3 versus calcium and vitamin D3 alone decreases markers of cartilage and bone metabolism in rheumatoid arthritis: a randomized controlled trial [ISRCTN46523456]" ppsx
... effects of hormone replacement therapy (HRT) on serum markers of bone and cartilage metabolism (a) Effect of HRT on serum (S) levels of metabolism type I collagen C-telopeptide (CTX-I) (b) Effect of ... available for analysis of biochemical markers The number of samples available for each analysis is presented in Table The impact of HRT on biochemical markers of bone and cartilage turnover As ... structuremodifying therapeutic effect of HRT in RA We found that HRT reduced markers of both bone and cartilage metabolism and that the decrease in markers of bone turnover was associated with...
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practical markers of the transition from aerobic to anaerobic metabolism during exercise
... exhaustion Of particular interest was the behavior of these markers in relation to the VT, which was used as an index of the transition from aerobic to anaerobic metabolism The main finding was that, of ... poster-size version of the scales that was placed in front of them whenever responses were required Metabolic analysis and heart rate data were kept out of the field of vision of the participant ... point of reference compared to general percentages of maximal capacity (e.g., Refs [2,26,22,39]) This argument is based on evidence that this level of intensity offers both an adequate rate of accumulation...
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Báo cáo y học: "The response to oestrogen deprivation of the cartilage collagen degradation marker, CTX-II, is unique compared with other markers of collagen turnove" doc
... levels of ovariectomy-rats were back to the control levels of sham-operated rats The present study aims to investigate the relevance of CTX-II to cartilage collagen metabolism in situations of oestrogen ... of markers to oestrogen reflect measurements of activities at different sites in the cartilage [33] Our CTX-II immunostaining frequency analysis indeed indicates that specific areas of knee cartilage ... our present study extends body fluid measurements of CTX-II to immunostainings of CTX-II in knee cartilage of ovariectomised rats, by analysing cartilage sections from ovariectomised rats at early...
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Báo cáo y học: "The response to oestrogen deprivation of the cartilage collagen degradation marker, CTX-II, is unique compared with other markers of collagen turnover" doc
... levels of ovariectomy-rats were back to the control levels of sham-operated rats The present study aims to investigate the relevance of CTX-II to cartilage collagen metabolism in situations of oestrogen ... of markers to oestrogen reflect measurements of activities at different sites in the cartilage [33] Our CTX-II immunostaining frequency analysis indeed indicates that specific areas of knee cartilage ... our present study extends body fluid measurements of CTX-II to immunostainings of CTX-II in knee cartilage of ovariectomised rats, by analysing cartilage sections from ovariectomised rats at early...
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Báo cáo y học: "Regional characterization of energy metabolism in the brain of normal and MPTP-intoxicated mice using new markers of glucose and phosphate transport" doc
... step-size of μm with a specimen magnification of 100× Deconvolution was performed through Huygens professional software (Scientific Volume Imaging, Hilversum, The Netherlands) with 0% background offset ... [21,22] Here, we took advantage of these transporter ligands as new metabolic markers, to monitor the distribution of GLUT1, PiT1 and PiT2 in several regions of normal and MPTP-intoxicated mice ... cross-react with GLUT3 or other GLUT isoforms [16,15] However, we cannot formerly exclude that a lack of labeling may not be due to the absence of cell surface expression of the transporter but merely...
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Báo cáo y học: "iagnostic Markers based on a Computational Model of Lipoprotein Metabolism" ppsx
... VLDL metabolism affect VLDL performance General dyslipidemia In order to obtain an indication of the clinical relevance of our new markers for VLDL metabolism, we applied the Particle Profiler ... first indication of clinical usefulness of lipoprotein metabolism ratios based on Particle Profiler Future development We plan to conduct a further clinical validation of Particle Profiler-based ... the Particle Profiler model, owned by TNO quality of life and the University of Leiden DBvS and AAdG - 23 - are named inventors on a patent application for Particle Profiler-derived markers for...
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Báo cáo y học: "Cytokine profile of autologous conditioned serum for treatment of osteoarthritis, in vitro effects on cartilage metabolism and intra-articular levels after injection" potx
... Effect of conditioned serum on proteoglycan metabolism To measure the effects of conditioned serum on proteoglycan metabolism, 48 full thickness osteoarthritic cartilage explants were taken of the ... be enhancement of cartilage integrity through the inhibition of inflammatory activity, in particular with respect to Il-1 signalling In fact, the direct effect of the entire blend of known and ... administration of this product may result in reduction of OA symptoms is not yet fully understood [14,16,17] Although the primary goal of ACS treatment is alleviation of OA symptoms, one of the mechanisms...
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Báo cáo y học: "Response to: Cytokine profile of autologous conditioned serum for treatment of osteoarthritis, in vitro effects on cartilage metabolism and intra-articular levels after injection – authors’ reply" ppt
... 2010 References Moser C: Response to: Cytokine profile of autologous conditioned serum for treatment of osteoarthritis, in vitro effects on cartilage metabolism and intra-articular levels after injection ... Saris DBF, Dhert WJA, Creemers LB: Cytokine profile of autologous conditioned serum for treatment of osteoarthritis, in vitro effects on cartilage metabolism and intra-articular levels after injection ... Department of Orthopaedics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands 2Faculty of Veterinary Sciences, Utrecht University, Yalelaan 1, De Uithof, 3584...
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Báo cáo y học: "Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insig" ppt
... telopeptide of type I collagen; SE, standard error of the mean; s, serum; u, urine knee pain irrespective of grade The presence of pain did not influence the ratio of sC2C/sCPII nor that of uCTXII/sCPII ... phenotyping of other joints, the contribution of other joints to the systemic levels of biomarkers cannot be addressed Conclusions In spite of these reservations, our results reveal that changes in cartilage ... Sokoloff L, Wolfe F: Development of criteria for the classification and reporting of osteoarthritis Classification of osteoarthritis of the knee Diagnostic and Therapeutic Criteria Committee of...
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Báo cáo y học: "Relationships between free radical levels during carotid endarterectomy and markers of arteriosclerotic disease"
... concentration of OXANO in the blank sample was subtracted from that of the corresponding test sample Around ten per cent of the signal was diminished as a result of the inhibitors 2.2.5 Measurement of MCP-1, ... withdrawn for an analysis of markers of arteriosclerosis together with OXANO samples 1, and 9, i.e before clamping, just before declamping and 15 minutes after start of reperfusion The blood samples ... containing a conformational epitope in the apoB-100 moiety of LDL that is generated as a consequence of substitution of lysine residues of apoB-100 with malondialdehyde The specificity for the...
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Molecular Biology of Secondary Metabolism - Case Study for Glycyrrhiza Plants
... shows the contribution of this strategy to the development of plants with biofarming potential in the frame of a high demand of natural and ecologically accepted sources of renewable compounds ... export of the excess of reducing power via the malate valve, and productive consumption of the surplus of NADPH by the Calvin cycle Finally, as is the case with iron deficiency, the extent of protection ... the evolution of vascular plants The case of Fld and Cyt c6 shows that reintroduction of these genes in the proper subcellular compartment of model and crop plants restored some of the selective...
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Regulating Phytonutrient Levels in Plants – Toward Modification of Plant Metabolism for Human Health
... availability of precursors for an introduced pathway, the choice of the right gene to engineer in the case of multigene families, understanding of related competing pathways, prediction of spillover ... specificity of the pathway, availability of tissue-specific promoters, knowledge of the inter- and intra-cellular transport mechanisms for intermediates and end-products of the pathway, and knowledge of ... pigmentation of fruits of these mutants is due to significantly elevated levels of chlorophylls at most of their 314 I Levin pre-mature developmental stages The mature ripe-red fruits of these mutants...
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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
... treatment of the chick face with RA, and this is accompanied by an increase in apoptosis [73] The authors of this study ascribe the regulation of outgrowth of limb buds and patterning of the digits ... involvement of transcription factors (henatoxylin and eosin-stained section of an embryonic cartilaginous limb) of the development of neural crest derivates, including embryonic cartilage and ... encoding Sox9 leads to severe cartilage abnormalities called campomelic dysplasia [51,52] The effect of a complete loss of Sox9 during chondrogenesis was analyzed using a model of mice chimeras injected...
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Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Potential role of ceramide metabolism in Lewy body disease pptx
... that some of the genes involved in the genetics of Lewy body disease, have in common the fact that they impinge on ceramide metabolism One shortfall of the present theory is the lack of neuropathological ... loss -of- function mutations in the predominantly neuronal P-type ATPase gene ATP13A2 are the cause of Kufor–Rakeb syndrome [33] The clinical features of Kufor–Rakeb syndrome are similar to those of ... ceramide metabolism Levels of cellular ceramide are regulated by the de novo pathway and the recycling pathway The former relates to the synthesis of ceramide through the condensation of palmitate...
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Tài liệu Báo cáo khoa học: Elementary modes analysis of photosynthate metabolism in the chloroplast stroma ppt
... of these, and consider the likely outcomes of changing the topology of stromal metabolism in the dark Thus it is that the goals of this investigation are threefold By applying the technique of ... subsets of reactions, so-called elementary modes, within a system These may be defined in terms of modes thus: a mode of a system is a set of reactions whose net stoichiometry (i.e in terms of external ... general property of the model or to some inauspicious choice of parameter values: the large number of parameters in any realistic model obviates the possibility of a systematic search of the space...
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Báo cáo Y học: Molecular interaction of neutral trehalase with other enzymes of trehalose metabolism in the fission yeast Schizosaccharomyces pombe pdf
... behavior of trehalase depending on the nature of the activation stress (Fig 5B) This shift might argue against the participation of a unique set of interactions involving association of Ntp1p ... the regulation of Ntp1p activity under stress relies on the existence of some kind of interaction between Ntp1p and Tps1p, or other elements, that may be lost under the conditions of the in vitro ... particular strain For sporulation of diploids, MEL medium was employed [19] Solid media were made by the addition of 2% (w/v) bacto-agar (Difco Laboratories) Transformation of S pombe strains was performed...
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Báo cáo khoa học: Enzymes of mannitol metabolism in the human pathogenic fungusAspergillus fumigatus– kinetic properties of mannitol-1-phosphate 5-dehydrogenase and mannitol 2-dehydrogenase, and their physiological implications pot
... that, in terms of Km, AfM1PDH binds Man-ol1P two orders of magnitude more tightly than AfM2DH binds Man-ol Enzymes of mannitol metabolism in A fumigatus of $ 800 lm, AMP binds one order of magnitude ... Af M2DH Interpretation of the kinetic properties of an enzyme in the context of its role in cellular metabolism relies on knowledge of the physiological concentrations of substrates, products, ... intracellular concentration of Fru is about two orders of magnitude below the apparent Km of 40 mm A physiological role of AfM2DH in the utilization of intracellular Man-ol via reversal of path in Scheme...
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Báo cáo khoa học: A comparative study of methylglyoxal metabolism in trypanosomatids potx
... excess of 20 lm Methylglyoxal metabolism in trypanosomatids Products of trypanosomatid metabolism of methylglyoxal In all studies to date, the principal product of thioldependent metabolism of methylglyoxal ... Methylglyoxal metabolism in trypanosomatids N Greig et al Fig Metabolism of methylglyoxal In T cruzi and L major, the principal end-product of methylglyoxal metabolism is D-lactate In the absence of GLO1, ... methylglyoxal despite the absence of a complete glyoxalase pathway 20 40 Time (min) 60 Fig Metabolism of methylglyoxal in the Tritryp trypanosomatids The metabolism of methylglyoxal (1.5 mM) by mid-log...
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Báo cáo khoa học: P NMR studies of energy metabolism in xanthosine5¢-monophosphate overproducing Corynebacterium ammoniagenes pot
... temperature of the whole system was kept at 30 °C using a circulating water bath, and acidification was corrected by automated additions of 10% NH4OH NMR operation Using cells at high density (> g of DCWÆL)1), ... XMP/Hyp ratio, being dependent on the increased level of glu/glc ratio up to 0.46, which mainly resulted from the extension of the length of phase I Additionally, a noticeable reduction in either ... onset of hypoxanthine production (Fig 1D) Cumulatively, it can be concluded that glu availability determines the efficiency of energy production or TCA cycle fluxes, which may specify Table Effect of...
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Báo cáo khoa học: Thiamin diphosphate in biological chemistry: new aspects of thiamin metabolism, especially triphosphate derivatives acting other than as cofactors pdf
... precursor of ThMP, ThTP and AThTP This ‘rapid’ pool plays a pivotal role in the metabolism of phosphorylated thiamin derivatives in eukaryotic cells The bound ThDP represents the low turnover cofactor ... final step of thiamin biosynthesis, but ThMP also exists in animal cells unable to carry out de novo synthesis of thiamin In animal tissues, ThMP is a product of the enzymatic hydrolysis of ThDP ... mainly beriberi and Wernicke– Korsakoff syndrome, are the consequence of decreased ThDP levels, resulting in reduced activity 2918 of key enzymes for oxidative metabolism such as 2-oxoglutarate...
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