malignant spindle cell tumors primary or metastatic

báo cáo khoa học: "Diagnostic challenge for ovarian malignant melanoma in premenopausal women: Primary or metastatic?" pptx

Ngày tải lên : 09/08/2014, 02:20

... tumor is clearly defined Diagnostic difficulties also arise histologically as the tumors not have a consistent appearance and they can be mistaken for germ cell and sex cord stromal tumors or ... a primary ovarian malignant melanoma from a metastatic tumor must be made Some authors [2,3] have restricted the diagnosis of primary ovarian malignant melanoma to those cases with no history ... antisense inhibitor of Bcl-2, and ‘Sorafenib’, an orally active small molecule inhibitor of wild type and mutant BRAF or PLX4032 a potent inhibitor of BRAF with the V600E mutation are at the forefront...

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Báo cáo hóa học: " Herpes simplex virus type-1(HSV-1) oncolytic and highly fusogenic mutants carrying the NV1020 genomic deletion effectively inhibit primary and metastatic tumors in mice" pptx

Ngày tải lên : 20/06/2014, 01:20

... mice in the PBS group had metastatic nodes in liver, spleen, or kidneys Some of the mice had tumors in all three organs (Fig 5) Importantly, there were no metastatic tumors observed in the kidneys ... intervals prior and after treatment (x axis) Tumors were injected with either OncSyn, OncdSyn viruses, or PBS when tumors reached approximately 80–90 mm3 in volume Tumor volumes were measured prior to ... virotherapy to reduce metastatic tumors in internal organs, a second experiment was performed in a similar fashion to the previous one with the exception that in the new experiment tumors were allowed...

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báo cáo khoa học: "Selective intraarterial radionuclide therapy with Yttrium-90 (Y-90) microspheres for unresectable primary and metastatic liver tumors" potx

Ngày tải lên : 09/08/2014, 02:20

... patient group Keywords: Selective intraarterial radionuclide therapy (SIRT), liver tumors, survival times Background Primary or metastatic tumors of the liver generally have poor prognosis and ... had received chemotherapy for the treatment of primary tumors Furthermore, all of them had taken chemotherapy for liver metastases and they had been accepted as refractory to chemotherapy Partial ... mainly HCC, colorectal cancer and neuroendocrine tumors; SIRT has been used for the treatment of liver metastasis of several tumors and primary hepatocellular cancer There have been different results...

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báo cáo khoa học: "Correction: Selective intraarterial radionuclide therapy with Yttrium-90 (Y-90) microspheres for unresectable primary and metastatic liver tumors." pptx

Ngày tải lên : 09/08/2014, 02:21

... Correction: Selective intraarterial radionuclide therapy with Yttrium-90 (Y-90) microspheres for unresectable primary and metastatic liver tumors N Ozlem Kucuk¹, Cigdem ... intraarterial radionuclide therapy with Yttrium-90 (Y-90) microspheres for unresectable primary and metastatic liver tumors World J Surg Oncol 2011 Aug 6;9:86 ... Medical School, Department of Radiology, Ankara, Turkey *Corresponding author: csoydal@yahoo.com Correction After the publication of this work [1], we became aware of the fact that there was date...

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Báo cáo khoa học: "Malignant mixed Mullerian tumors of the uterus: histopathological evaluation of cell cycle and apoptotic regulatory proteins" ppt

Ngày tải lên : 09/08/2014, 03:21

... Uncontrolled tumor cell proliferation is frequent in tumor cells with the progression of a normal cell to a transformed tumor cell involving many genetic events that include the checkpoints of the cell ... vital importance to malignant neoplasms in prolonging cell survival Despite the understanding that cell cycle regulatory protein dysregulation may be involved in numerous malignant tumors [2], ... A combined immunoreactivity score was calculated by multiplying the score for the percentage x the score of intensity, resulting in a combined score that ranged from to 12 Scores and above were...

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Báo cáo y học: "Spindle Cell Lipoma of the Hypopharynx"

Ngày tải lên : 25/10/2012, 10:51

... spindle cells are dominant Spindle cells appear as uniform cells with single elongated nucleus, and narrow bipolar cytoplasm in SCL Nucleolus is not prominent Mitosis is rare Spindle cells form ... yellowish, sessile or pedicled masses They contain histologically mature, uniform adipose cells Spindle cell lipomas contain collagen fibers and small, cylindiric spindle cells and mixed mature ... lipoma at vocal cords have been reported Hypopharyngeal lipomas originating from pyriform sinus have similar symptoms and pathological features with laryngeal lipogenic tumors Laryngeal or hypopharyngeal...

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báo cáo hóa học:" Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone" pptx

Ngày tải lên : 20/06/2014, 04:20

... VEGF receptors in giant cell tumors (GCTs) of bone Surgical specimens were fixed in formalin and serially sectioned (a) VEGF was expressed in stromal cells (arrows), monocyte-like cells (arrowheads) ... Kawano M, Sudo A, Uchida A, Ito Y: Spindle- shaped cells derived from giant -cell tumor of bone support differentiation of blood monocytes to osteoclast-like cells J Orthop Res 2000, 18:647-654 Goldring ... Papadimitriou JM: Gene expression of transforming growth factor-beta and its type II receptor in giant cell tumors of bone Possible involvement in osteoclast-like cell migration Am J Pathol 1994, 145:1095-1104...

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báo cáo hóa học:" Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone" potx

Ngày tải lên : 20/06/2014, 07:20

... VEGF receptors in giant cell tumors (GCTs) of bone Surgical specimens were fixed in formalin and serially sectioned (a) VEGF was expressed in stromal cells (arrows), monocyte-like cells (arrowheads) ... Kawano M, Sudo A, Uchida A, Ito Y: Spindle- shaped cells derived from giant -cell tumor of bone support differentiation of blood monocytes to osteoclast-like cells J Orthop Res 2000, 18:647-654 Goldring ... Papadimitriou JM: Gene expression of transforming growth factor-beta and its type II receptor in giant cell tumors of bone Possible involvement in osteoclast-like cell migration Am J Pathol 1994, 145:1095-1104...

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Báo cáo khoa học: "Comparative immunohistochemical characterization of canine seminomas and Sertoli cell tumors" ppt

Ngày tải lên : 07/08/2014, 23:22

... 5% normal goat serum (Vector Laboratories, USA) for 30 All primary antibodies were incubated with sections o overnight at C To “visualize” immunolabeling, a Table Primary antibodies used for immunohistochemical ... markers in canine Sertoli cell tumors (A) Cells within the tumor resemble Sertoli cells that normally populate the seminiferous tubules and are arranged into sheets or tubules separated by fibrous ... tumor resembled Sertoli cells that normally populate the seminiferous tubules, and were arranged into sheets or tubules separated by fibrous connective tissue The tumor cells had small, round or...

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Báo cáo khoa học: "Delayed malignant melanoma recurrence simulating primary ovarian cancer: Case report" docx

Ngày tải lên : 09/08/2014, 07:22

... from neighboring organs or via the peritoneal route Most common primary tumors include gynecologic and gastrointestinal cancers [1,5] Other malignancies, such as breast cancer and malignant melanoma ... number not for citation purposes) World Journal of Surgical Oncology 2008, 6:124 smear with a single cell population of large pleomorphic round undifferentiated pigmented malignant cells with ... Survival was poor despite aggressive surgical debulking with or without adjuvant therapy A more favorable subset of patients with metastatic ovarian involvement included gynecologic [5] or colonic...

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Báo cáo khoa học: " SemiIntensity modulated radiotherapy (IMRT) in benign giant cell tumors – a single institution case series and a short review of the literatur" docx

Ngày tải lên : 09/08/2014, 08:22

... in of 25 (8%) patients after surgery The appearance of malignant giant cell tumors of bone or malignant foci inside benign giant cell tumors has been described also in a small number of patients ... giant cell tumors of the bone is complete surgical excision Especially in patients with extremity tumors, this treatment results in high local control rates of more than 85% [3] without major complications ... giant cell tumor in the sphenoid sinus suffered from large tumors in the sacral region Three tumors were judged primarily irresectable, and one patient had undergone a subtotal resection prior to...

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Báo cáo khoa học: "High-dose rate brachytherapy (HDRB) for primary or recurrent cancer in the vagina" docx

Ngày tải lên : 09/08/2014, 09:22

... was intracavitary brachytherapy for superficially invasive tumors (less than mm of invasion), while interstitial brachytherapy was used for more deeply invasive tumors greater than mm Five patients ... ratio was taken to be 10 Gy for tumor effects and Gy for late effects The median EQ2 for the tumor was 66.48 Gy (31.25 – 75.4 Gy) for the entire group The median EQ2 for the late effects on vaginal ... without any prior radiation and 4/6 (67%) for group with recurrence and any prior radiation therapy No grade or worse early toxicity was observed Two patients had late grade or morbidity One patient...

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Báo cáo y học: "Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer" pdf

Ngày tải lên : 09/08/2014, 23:20

... specific for the molecular environment of either the primary tumor or the metastasis The distinct genetic mutation patterns in primary and metastatic tumors, illustrate the need for much more comprehensive ... in advanced colorectal tumors, suggesting a role in metastasis formation [35] Therefore, the distinct genetic changes in metastastic samples compared to corresponding primary tumors, likely contribute ... rearrangements have head-head or tail-tail orientation (c) Lesion-specific presence of rearrangements in primary and metastatic tumors as based on PCR genotyping of samples for primary tumor, metastasis and...

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báo cáo khoa học: "SMI of Bcl-2 TW-37 is active across a spectrum of B-cell tumors irrespective of their proliferative and differentiation status" pptx

Ngày tải lên : 10/08/2014, 22:20

... to each sample prior to analysis by fluorescent microscope Using fluorescence microscope, cells seen in orange or light orange were counted as apoptotic whereas cells in green or light green were ... apoptosis-resistance and is believed to be a major reason for treatment failure in lymphoid tumors [15-19] In this report, we show that exposure of a variety of B -cell tumor cells to TW-37 is sufficient to inhibit ... medium These cells were subjected to phenotypic analysis for comparison with the established tumor cell line to insure the human origin and its stability After formation of SC tumors, serial propagation...

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Báo cáo y học: "Treatment of stasis dermatitis using aminaphtone: Spindle cell oncocytoma of the adenohypophysis in a woman: a case report and review of the literature" pdf

Ngày tải lên : 11/08/2014, 00:22

... and immunoprofile of spindle cell oncocytoma Spindle cell neoplasm with interlacing fascicles of spindled to epithelioid cells with eosinophilic and oncocytic cytoplasm (original magnification, ... cytokeratin or with anterior pituitary hormones, including somatotropin, corticotropin, thyrotropin, FSH, LH and prolactin (Figure 2D) Tumour cells expressed the thyroid transcription factor (TTF-1) ... folliculostellate cells Very little is known about the functioning of the folliculostellate cells Some authors have reported that these cells are implicated in long-distance communication in the anterior pituitary...

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báo cáo khoa học: "Eosinophilic and neutrophilic leukemoid reaction in a woman with spindle cell sarcoma: a case report" doc

Ngày tải lên : 11/08/2014, 02:21

... from necrosis of the tumor causing an eosinophilotactic response, the release of chemotactic factors for eosinophils from tumor cells, the seeding of metastatic tumor cells to the bone marrow ... stimulation of bone marrow cells to produce eosinophils by eosinophilotactic factors produced by the tumor cells [13] It is not know if eosinophilia is a good or poor prognostic sign, as eosinophilia ... our knowledge, it has never been reported in the literature with a spindle cell sarcoma A number of hypotheses have been put forward regarding the etiology for eosinophilia associated with malignancy...

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Báo cáo y học: "Rapid construction of a dendritic cell vaccine through physical perturbation and apoptotic malignant T cell loading" pot

Ngày tải lên : 11/08/2014, 10:23

... cell response to column-activated malignant T cell loaded DC CD8 T cell response to column-activated malignant T cell loaded DC Fig 10A: CD8 T cells were magnetic-bead enriched (≥96% CD8+ T cells) ... Immunophenotyping In order to monitor DC differentiation, the cells were stained by two-color immunofluorescence with a panel of antibodies to monocytes, DC and apoptotic cells Cells (1 × 106) were ... CTCL cells may be lysed in the presence of CD8 T cells stimulated with DC that have ingested apoptotic malignant T cells Finally, further support for the contention that functional CD8 T cells...

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Báo cáo y học: " Low-grade pelvic masses with spindle cell and fibroblastic proliferation: a case report." pptx

Ngày tải lên : 11/08/2014, 10:23

... propensity for metastases [1] Fibromyxoid tumors demonstrating a proliferation of spindle fibroblastic cells are uncommonly identified in The case was referred to Stanford Pathology for an independent ... low-grade spindle cell proliferation with fibroblastic features were very rare The negative immunologic findings exclude more specific markers for smooth muscle, fat tumors, solitary fibrous tumor, ... dedifferentiated portion was indicative of an atypical lipomatous tumor (Figures &2) Conclusion We report the rare status of a patient with low-grade abdominal pelvic tumors exhibiting spindle cell and...

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Báo cáo y học: "Tenosynovial giant cell tumors as accidental findings after episodes of distortion of the ankle: two case reports" ppsx

Ngày tải lên : 11/08/2014, 14:21

... giant cell tumor anterior toankleankle Sagittal T1-weighted spin-echo MRI of the right ankle showing a well delineated giant cell tumor anterior to the ankle (arrow) Microscopically, the tumor was ... a number of other tumors into account, including lipoma, ganglia or fibromas Prior to an operation, it is usually very difficult to distinguish whether the tumor is benign or malignant In the ... composed of round to polygonal cells Some were spindle cells and some were multinucleated giant cells (Figure 2B) The diagnosis of localized tenosynovial giant cell tumor of the tendon sheath was...

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báo cáo khoa học: " A spindle cell carcinoma presenting with osseous metaplasia in the gingiva: a case report with immunohistochemical analysis" ppsx

Ngày tải lên : 11/08/2014, 20:20

... the oral cavity and oropharynx: Factors affecting outcome J Chin Med Assoc 2006, 69:478-483 Banes L, Eveson JW, Reichart P, Sidransky D, Eds: World Health Organization Classification of Tumors ... squamous cell carcinoma In some areas, spindle shape cells were transitional to the epithelial cancer nest-like structure The stromal cells were intermingled with the spindle shape cells, showing ... The cells around the materials were vimentin-positive low activity cells, and cancer cells did not show positive reaction for neither BMP-2 nor BMP-4, which indicates these materials were formed...

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