malignant benign and normal non malignant tissue
Chapter 091. Benign and Malignant Diseases of the Prostate (Part 1) pps
Ngày tải lên :
07/07/2014, 02:20
... cells Both prostate epithelial cells and stromal cells express androgen receptors and depend on androgens for growth Testosterone, the major circulating androgen, is converted by the enzyme 5αreductase ... 5αreductase to dihydrotestosterone in the gland The periurethral portion of the gland increases in size during puberty and after the age of 55 due to the growth of nonmalignant cells in the transition ... tubuloalveolar glands arranged in lobules and surrounded by a stroma The acinal unit includes an epithelial compartment made up of epithelial, basal, and neuroendocrine cells and a stromal compartment...
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Chapter 091. Benign and Malignant Diseases of the Prostate (Part 2) pot
Ngày tải lên :
07/07/2014, 02:20
... prostate size and consistency and abnormalities within or beyond the gland Many cancers occur in the peripheral zone and can be palpated on DRE Carcinomas are characteristically hard, nodular, and irregular, ... produced by both nonmalignant and malignant epithelial cells PSA is prostate-specific, not prostate cancer–specific, and serum PSA increases may occur from prostatitis, BPH, and prostate cancer ... cancers and cancer control, in which the tempo of the illness is altered and symptoms controlled until the patient dies of other causes These can be equivalent therapeutically from a patient standpoint...
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Chapter 091. Benign and Malignant Diseases of the Prostate (Part 3) docx
Ngày tải lên :
07/07/2014, 02:20
... based on the DRE and PSA findings is illustrated in Fig 91-2 In general, a biopsy is recommended if the DRE or PSA is abnormal Twenty-five percent of men with a PSA >4 ng/mL and an abnormal DRE have ... 40% are not palpable, and of these, 70% are pathologically organ-confined The downside of widespread PSA screening is the detection and treatment of cancers with such a low malignant potential ... complexed to total, and free to complexed PSA have also been used In one series, specificity improved by 20% by defining normal ranges as free/total >0.15, complexed/total
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Chapter 091. Benign and Malignant Diseases of the Prostate (Part 4) potx
Ngày tải lên :
07/07/2014, 02:20
... solely on the basis of an abnormal PSA (T1c), those that are palpable but clinically confined to the gland (T2), and those that have extended outside the gland (T3 and T4) (Table 91-1) DRE alone ... and the Whitmore-Jewett Staging System TNM Stage Description WhitmoreJewett Stage Description T1a Nonpalpable, A1 Well with 5% or less of differentiated tumor on resected few chips from one tissue ... resected few chips from one tissue with cancer T1b lobe Nonpalpable, A2 with >5% of resected Involvement more diffuse tissue with cancer T1c Nonpalpable, detected due to elevated serum PSA T2a Palpable,...
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Chapter 091. Benign and Malignant Diseases of the Prostate (Part 5) pot
Ngày tải lên :
07/07/2014, 02:20
... relatively nonspecific because areas of increased uptake are not always related to metastatic disease Healing fractures, arthritis, Paget's disease, and other conditions will also cause abnormal ... during his lifetime and thus require treatment, and the probability that the tumor can be cured by single-modality therapy directed at the prostate or requires both local and systemic therapy ... radiation therapy, in contrast, PSA does not become undetectable because the remaining nonmalignant elements of the gland continue to produce PSA even if all cancer cells have been eliminated Similarly,...
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Chapter 091. Benign and Malignant Diseases of the Prostate (Part 6) docx
Ngày tải lên :
07/07/2014, 02:20
... the gland improves based on different biopsy algorithms and with imaging The result is better case selection and better surgical planning, which in turn have led to more rapid recovery and higher ... at multiple centers showed that at 3, 12, and 24 months following surgery, 58, 35, and 42% (respectively) wore pads in their underwear, and 24, 11, and 15% reported "a lot" of urine leakage Factors ... to decrease the size of the prostate and, consequently, to reduce the exposure of normal tissues to full-dose radiation, to increase local control rates, and to decrease the rate of systemic...
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Chapter 091. Benign and Malignant Diseases of the Prostate (Part 7) potx
Ngày tải lên :
07/07/2014, 02:20
... of 0–4, 4–10, and >10 ng/mL were 98, 90, and 89%, respectively In a separate report of 201 patients who underwent posttreatment biopsies, 80% were negative, 17% were indeterminate, and 3% were ... prostatectomy, 74% for external beam radiation, and 84% for deferred treatment Arguing against active surveillance are the results of a Swedish randomized trial of radical prostatectomy vs active ... relative to active surveillance patients (4.6% vs 8.9%) and a lower risk of metastatic progression (hazard ratio 0.63) Case selection is critical, and the criteria to select men who can safely choose...
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Chapter 091. Benign and Malignant Diseases of the Prostate (Part 8) docx
Ngày tải lên :
07/07/2014, 02:20
... are 12 months or less Metastatic Disease: Noncastrate Metastatic disease noncastrate refers to patients with metastases visible on an imaging study and noncastrate levels of testosterone The patient ... adrenal gland Surgical orchiectomy is the "gold standard" approach but is least acceptable to patients Medical therapies can be divided into agents that lower testosterone levels and antiandrogens ... compromise (myelophthisis), coagulopathy, or spinal cord compression Standard treatment for noncastrate metastatic disease is to deplete androgens by medical or surgical means Over 90% of male hormones...
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Chapter 091. Benign and Malignant Diseases of the Prostate (Part 9) pdf
Ngày tải lên :
07/07/2014, 02:20
... quality of life Combined androgen blockade—the administration of an antiandrogen plus a GnRH analogue or surgical orchiectomy—was designed to inhibit both testicular and adrenal androgens at the outset ... of randomized comparisons involving thousands of patients showed no advantage for combining an antiandrogen with surgical orchiectomy, while separate analyses of trials combining an antiandrogen ... the cells that survive androgen depletion will induce a normal differentiation pathway In this way, the surviving cells that are allowed to proliferate in the presence of androgen will retain sensitivity...
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Chapter 091. Benign and Malignant Diseases of the Prostate (Part 11) pdf
Ngày tải lên :
07/07/2014, 02:20
... 148:1549, 1992 Used with permission Diagnostic Procedures and Treatment Asymptomatic patients not require treatment regardless of the size of the gland, while those with an inability to urinate, gross ... surgery In patients with symptoms, uroflowmetry can identify those with normal flow rates who are unlikely to benefit from surgery and those with high postvoid residuals who may need other interventions ... tract problems Medical therapies for BPH include 5α-reductase inhibitors and α-adrenergic blockers Finasteride (10 mg/d PO) and other 5α-reductase inhibitors that block the conversion of testosterone...
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Tài liệu Báo cáo khoa học: Comparison of membrane fraction proteomic profiles of normal and cancerous human colorectal tissues with gel-assisted digestion and iTRAQ labeling mass spectrometry pptx
Ngày tải lên :
16/02/2014, 15:20
... from paired tumoral and adjacent normal tissue of CRC patients A total of eight tumor tissues and eight matched normal tissues were collected from eight CRC patients (Table S1) and protein expression ... proteins from tumoral and adjacent normal tissues After surgery, paired tumoral and adjacent normal tissues were obtained from the same CRC patient and stored at )80 °C Frozen tissues were unfrozen ... marker for CRC and to further understand its role in the survival and ⁄ or invasion in CRC cancer cells SLC25A4 was also significantly increased in CRC tissues compared with matched normal tissues The...
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Báo cáo y học: "Differential expression of the angiogenic Tie receptor family in arthritic and normal synovial tissue" doc
Ngày tải lên :
09/08/2014, 03:24
... (8%) and normal synovial tissues (6%) The inflammatory and vascularity scores were higher in RA synovial tissue in comparison to OA and normal In accordance with the staining data, RA synovial tissue ... from subjects with osteoarthritis (OA) and normal tissues Materials and methods The patient population details and the methods used for microscopic analysis and statistical analysis are described ... staining, and minimal staining on macrophages and fibroblasts Tie1 mRNA expression was significantly higher in RA synovial tissue compared to OA synovial tissue (threefold), normal synovial tissue...
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Báo cáo y học: " Histology of adipose tissue inflammation in Dercum’s disease, obesity and normal weight controls: a case control study" doc
Ngày tải lên :
11/08/2014, 03:20
... of patients, and compare them with healthy, obese, body mass index (BMI)-matched controls and controls with normal BMI Patients and Methods Patients A total of 53 women with adipose tissue pain ... abdomen and the knee region In 28 cases, a control adipose tissue biopsy was taken from a location where the patient did not experience any pain, 21 from non- painful abdomen and from non- painful ... patients and the obese controls as regards age (p = 0.37), weight (0.52) or BMI (p = 0.44) There was a difference between the DD patients and the normal weight controls as regards weight (p = 0.01) and...
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Histology of adipose tissue inflammation in Dercum’s disease, obesity and normal weight controls: a case control study pdf
Ngày tải lên :
11/08/2014, 06:23
... of patients, and compare them with healthy, obese, body mass index (BMI)-matched controls and controls with normal BMI Patients and Methods Patients A total of 53 women with adipose tissue pain ... abdomen and the knee region In 28 cases, a control adipose tissue biopsy was taken from a location where the patient did not experience any pain, 21 from non- painful abdomen and from non- painful ... patients and the obese controls as regards age (p = 0.37), weight (0.52) or BMI (p = 0.44) There was a difference between the DD patients and the normal weight controls as regards weight (p = 0.01) and...
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BuMP and norMal MaPPIng
Ngày tải lên :
27/08/2012, 14:32
... colors around the mouth and eyes and in the recesses of the neck and ears (for both male and female and across races) Warmer colors appear on the nose, cheeks, and forehead, and some yellows are ... texture and displacement maps is easy and error free Master it╇╉ Map UV texture coordinates on a giraffe’s leg; then try a complete figure ╇╉ Create bump and normal maps╇╉ Bump and normal ... interface | Bump and Normal Mapping â•… 603 Expand the Source Meshes rollout, right-click the HIRES layer, and choose Select Objects Click the Add Selected button to add it to the list Expand the Output...
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Báo cáo y học: "Comparative study of serum Na+ and K+ levels in senile cataract patients and normal individuals"
Ngày tải lên :
03/11/2012, 09:49
... senile cataract (79 female, 76 male) and the control one consisted of 155 of cases’ close relatives (79 female, 76 male) Mean age and standard deviation of patients and control group were 61.96±14.5, ... range of patients and controls were 44-85 year and 43-86 year respectively Table shows serum Na+, K+ of case and control groups, with a significant difference in serum + Na of case and control ones ... hypertension and any other systemic disease Then positive ones of both groups were excluded from the study Case and control groups were both examined by an expert ophthalmologist and routine ophthalmic...
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iec 60079-27 fieldbus intrinsically safe concept (fisco) and fieldbus non-incendive concept (fnico)
Ngày tải lên :
25/12/2013, 10:43
... report on ONE STANDARD and ONE STANDARD ONLY Enter the exact number of the standard: (e.g 60601-1-1) Q6 standard is out of date standard is incomplete standard is too academic standard is too superficial ... constructional and installation requirements of FISCO and FNICO apparatus and systems are determined by IEC 60079-11, IEC 60079-14, IEC 60079-15 and IEC 60079-25, except as modified by this standard ... measurement and control Fieldbus for use in industrial control systems - Part 2: Physical layer specification and service definition Terms and definitions For the purposes of this document, the terms and...
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Tài liệu Báo cáo khoa học: Domain IV of mouse laminin b1 and b2 chains Structure, glycosaminoglycan modi®cation and immunochemical analysis of tissue contents pptx
Ngày tải lên :
21/02/2014, 03:20
... Contents [pmolá(g wet tissue) )1] of laminin c1, b1 and b2 chains in tissue extracts from normal adult and mutant (b2 +/±; b2 ±/±) mice as determined by radioimmuno-inhibition assays Tissues were extracted ... tissues Kidney (A and B) and skeletal muscle (C and D) from 3-week-old Lamb2 +/+ and ±/± littermates were stained with anti-b2 serum In the control, basement membranes throughout the kidney and ... adult mouse tissues were then extracted with EDTA and detergent only and examined by these three assays (Table 1) A variable content of laminin b1 chain [17±422 pmolá(g wet tissue) )1] and lower...
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Prevalence of Celiac disease in Turkish children with type 1 Diabetes Mellitus and their non-diabetic first-degree relatives pptx
Ngày tải lên :
05/03/2014, 12:20
... analyzed the prevalence of CD in Turkish children with T1DM and their non- diabetic first-degree relatives MATERIALS AND METHODS Patients and Control Subjects A total of 48 children with T1DM (18 ... control group and healthy Turkish children In children with T1DM, increased prevalence of CD is well documented (2) The association of CD and T1DM can be explained by common HLA and non- HLA genes, ... found as 1.4 (1/69) in relatives of diabetic children None of the healthy children was positive for IgA- tTG, and serum total IgA level was normal in all of them (Table 1) The prevalence of seropositivity...
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