m staging of gastric cancer by eus
báo cáo hóa học:" Serum high mobility group box-1 (HMGB1) is closely associated with the clinical and pathologic features of gastric cancer" pptx
... Expression of high-mobility group1 mRNA in human gastrointestinal adenocarcinoma and corresponding non-cancerous mucosa Int J Cancer 1997, 74:1-6 Terry MB, Gaudet MM, Gammon MD: The epidemiology of gastric ... GmbH, Mannheim, Germany), a modular immunoassay analyzer HMGB1 was measured by the commercially available HMGB1 ELISA Kit II (SHINO-TEST Corporations, Kanagawa, Japan) Briefly, 100 μl of sample ... activity of HMGB1 and the progression of GC Although the measurement of HMGB1 activity in tissues is clinically important, this method of biomarker analysis is somewhat limited because the measurement...
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Báo cáo hóa học: " Co-evolution of cancer microenvironment reveals distinctive patterns of gastric cancer invasion: laboratory evidence and clinical significance" pptx
... simply degradation of ECM during tumor invasion and metastasis The proteolysis of ECM by MMPs may reveal cryptic matrix binding sites, MMPs can act as tumor suppressor by revealing cryptic matrix ... tumor dissemination as a result of the co-evolution of cancer microencironment and cancer cells and promoted by those components MMPs are major proteolytic enzymes to breakdown ECM during cancer ... useful for new prognostic models and novel treatment strategies List of abbreviations GC: Gastric Cancer; MVD: Microvessel density; BM: Basement Membrane; MMP: Matrix Metalloproteinases; OS: Overall...
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Báo cáo sinh học: " Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy improves survival of gastric cancer with peritoneal carcinomatosis: evidence from an " pdf
... nude mouse model of gastric cancer PC constructed by implanting human gastric cancer cells [25-28]; mouse colon cancer PC model constructed by injecting colon cancer cells into the abdominal ... rats were randomized into groups of animals each, control, HIPEC (mitomycin C 15 mg /m2 at 40.5 - 41.5°C for 90 min), and normathermic intraperitoneal chemotherapy (mitomycin C 10 mg /m i.p.) Although ... peritoneum, the omentum, stomach, liver, spleen, small intestine, colon, bladder and other pelvic tissues Thereafter, maximal CRS was performed including a routine omentectomy, and optimal removal of...
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Báo cáo sinh học: "Combination immunotherapy and active-specific tumor cell vaccination augments anti-cancer immunity in a mouse model of gastric cancer" pdf
... antitumor immunity in a subcutaneous mouse model of gastric cancer by (i) combining a low immunogenic whole tumor cell vaccine (prepared from the established gastric cell lines) with granulocyte macrophage ... Moskalenko M, Du T, Creson J, VanRoey MJ, Jooss K: GM-CSF-secreting cancer immunotherapies: preclinical analysis of the mechanism of action Cancer Immunol Immunother 2007, 56:1653-1665 Emens LA, ... al.: Combination immunotherapy and active-specific tumor cell vaccination augments anti -cancer immunity in a mouse model of gastric cancer Journal of Translational Medicine 2011 9:140 Submit your...
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báo cáo hóa học:" Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy improves survival of gastric cancer with peritoneal carcinomatosis: evidence from an experimental study" doc
... nude mouse model of gastric cancer PC constructed by implanting human gastric cancer cells [25-28]; mouse colon cancer PC model constructed by injecting colon cancer cells into the abdominal ... rats were randomized into groups of animals each, control, HIPEC (mitomycin C 15 mg /m2 at 40.5 - 41.5°C for 90 min), and normathermic intraperitoneal chemotherapy (mitomycin C 10 mg /m i.p.) Although ... peritoneum, the omentum, stomach, liver, spleen, small intestine, colon, bladder and other pelvic tissues Thereafter, maximal CRS was performed including a routine omentectomy, and optimal removal of...
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MANAGEMENT OF GASTRIC CANCER potx
... also perigastric lymph node involvement in the gastric carcinoma MRI is useful for staging of T staging of gastric cancer, whereas MRI has shown some limitations in N staging MRI can not completely ... intermediate SI on T2-weighted images The sizes were measured as being from 0.35 cm to 3.5 cm on MR imaging (Figure 9, 10) The accuracy of N staging by MRI was 47% 32 Management of Gastric Cancer ... reserved to a rare type of gastric carcinoma. Nabil Ismaili, MD Department of Medical Oncology Regional Cancer Center Agadir, Morocco Part Gastric Cancer Staging The Role of Computed Tomography in the Imaging...
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Báo cáo khoa học: "Effects of propranolol in combination with radiation on apoptosis and survival of gastric cancer cells in vitro" ppsx
... Journal of Immunological Methods 1995, 17:39-51 11 Ahmed KM, Li JJ: ATM-NF-kappaB connection as a target for tumor radiosensitization Curr Cancer Drug Targets 2007, 7:335-342 12 Tamatani T, Azuma M, ... antagonist) might be a useful irradiation sensitizer in gastric cancer therapy Guidelines of the NCCN on gastric cancer Figure Quantification of mRNA expression of different genes Analysis of mRNA expression ... The epidemiology of gastric cancer Gastric Cancer 2002, 5:5-11 Macdonald JS, Smalley SR, Benedeth J, Estes N, Haller DG, Ajani JA, Gunderson LL, Jessup M, Martenson JA: Postoperative combined radiation...
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báo cáo khoa học: " The function and mechanism of COX-2 in angiogenesis of gastric cancer cells" pdf
... Journal of Experimental & Clinical Cancer Research 2011, 30:13 http://www.jeccr.com/content/30/1/13 medium (ATCC) with mM Lglutamine, 1.5 g/l sodium bicarbonate, 0.1 mg/ml heparin, 0.03 mg/ml endothelial ... quantified by Bradford method [7] A measure of 80 ug of lysates were electrophoresed in 12% SDS-PAGE and blotted on a nitrocellulose membrane (Immoblin-P, Millipore, Bedford, MA, USA) Membranes ... in nude mice Female athymic nu/nu mice, 5-6 weeks of age, were obtained from FMMU Experimental Animal Co (Shaanxi, China) and housed in a pathogen-free facility for all of the experiments The...
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báo cáo khoa học: " Down-regulation of miR-27a might inhibit proliferation and drug resistance of gastric cancer cells" docx
... showed, MKN45 cells were transfected with either the antagomirs of miR-27a or control RNA The antagomirs of miR-27a could significantly inhibit the expression of miR-27a by almost 67% as compared ... using MTT assay C, colony numbers of the cells were detected in soft agar D, tumorigenicity of the cells in BALB/c nu/nu mice was detected The volumes of tumors were monitored at the indicated time ... compared, we transfected MKN45 cells with the antagomirs of miR-27a or control RNA The Table IC50 values (μg/mL) of drugs for gastric cancer cells VCR MKN45 MKN45-control MKN45-antagomir ADR 5-Flu CDDP...
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báo cáo khoa học: "Recombinant immunotoxin anti-c-Met/PE38KDEL inhibits proliferation and promotes apoptosis of gastric cancer cells" docx
... Shinomura Y, Matsuzawa Y: PPARgamma inhibits the expression of c-MET in human gastric cancer cells through the suppression of Ets Biochem Biophys Res Commun 1999, 265:453-456 12 Kaji M, Yonemura ... level of c-Met than MKN-45 cells Normal gastric mucosa cells GES-1 expressed a minimum level of c-Met Studies have shown that c-Met overexpression in carcinoma cells is associated with liver metastasis ... pharmacological treatment of gastro-oesophageal cancer Drugs Aging 2009, 26:627-646 Asaoka Y, Tada M, Ikenoue T, Seto M, Imai M, Miyabayashi K, Yamamoto K, Yamamoto S, Kudo Y, Mohri D, Isomura Y, Ijichi...
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báo cáo khoa học: "BRCAA1 monoclonal antibody conjugated fluorescent magnetic nanoparticles for in vivo targeted magnetofluorescent imaging of gastric cancer" ppsx
... gastric cancer tissues with mm in diameter in nude mice model Compared with previous reports, bigger size of tumor tissues (>5 mm ) could be easily imaged by using fluorescent imaging and MRI imaging, ... distribution for FMNPs-BRCAA1 nanoparticles in MGC803 human gastric tumor-bearing athymic nude mice A, In vivo fluorescence images of athymic nude mice bearing MGC803 human gastric tumor was obtained ... images of in vivo gastric cancer tissues with mm in diameter in nude mice model Using the strong magnetic signals of asprepared nanoprobes, we also successfully obtained MR images of in vivo gastric...
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Molecular signatures of gastric cancer an integrated approach to molecular cytogenetics, whole genome copy number and transcriptome profiles
... of IM95 by chromosomal CGH Figure 9-18 100K SNP mapping array copy number analysis of Chromosome and in IM95 xvi List of Figures Chapter 10 Figure 10-1 Global summary of whole genome copy number ... Antibody MALT Mucosa-Associated Lymphoid Tissue mar Marker Mb Megabase M- FISH Multi-color FISH miRNA microRNA NHEJ Non-Homologous End Joining NOD-SCID Non Combine Diabetic-Severe Combine Immune Deficiency ... incidence and mortality Adenocarcinomas account for close to 95% of all malignant gastric tumors, the remaining being stromal cell tumors, lymphomas, leiomyosarcomas, other rare sarcomas and carcinoids...
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Genomic and transcriptomic analysis of gastric cancer systematic studies on transcriptional bias in aneuploidy and gene coexpression meta network
... http://www.oncomine.com from University of Michigan, comprising of ~10k expression profiles from 31 different cancers (Dec 2005) 10 Perou CM et al Molecular portraits of human breast tumours Nature ... aim expression profiling of gastric cancers was conducted at our lab titled: A Combined Comparative Genomic Hybridization and Expression Microarray Analysis of Gastric Cancer Reveals Novel Molecular ... vi Summary Whole-genome sequencing projects have imparted much of the initial momentum for genome-wide studies, but it is microarrays and their application to cancer that has proved instrumental...
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Báo cáo khoa học: "A case of virilization induced by a Krukenberg tumor from gastric cancer" docx
... increase of body hair and muscle mass of the preExtensive increase of body hair and muscle mass of the premenopausal patient Page of (page number not for citation purposes) World Journal of Surgical ... of androgenizing hormones should be performed in cases of Krukenberg tumor derived from gastric cancer Due to the possibility of rapidly developing virilization, surgical resection of symptomatic ... Krukenberg tumor of the ovaries A review of 81 records Obstet Gynecol 1968, 32:221-225 Kakushima N, Kamoshida T, Hirai S, Hotta S, Hirayama T, Yamada J, Ueda K, Sato M, Okumura M, Shimokama T, Oka...
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Overview of Trastuzumab’s Utility for Gastric Cancer pdf
... extracelluar domain (ECD) It was engineered from a cloned human IgG, with structure and antigen-binding residues of a potent murine MAb 4D5 The antibody was humanized to minimize the immunogenicity ... carcinogenesis of breast, gastric, ovarian, salivary gland, prostate and lung tumors (14) Trastuzumab is a recombinant humanized anti-HER2 MAb (rhuMAb HER2; molecular weight 145531.5 g/mol), directed ... Cetuximab • Panitumumab • Matuzumab III III I - II Cetuximab showed RR of 5% in pre-treated patients Cetuximab + 5FU and oxaliplatin or CPT-11, showed a RR of 44-65% in untreated patients Cetuximab...
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THE ANTHROPOLOGY OF ONLINE COMMUNITIES BY Samuel M.Wilson and Leighton C. Peterson doc
... phenomena of online interactions Much of the work on new media has been interdisciplinary, originating many times in communication and media studies, and often called computer-mediated communication ... whether these sorts of community are too ephemeral to investigate as communities per se, or whether the nature of the communication medium made them somehow quite different from the face-to-face ... so-called virtual communities to the face-to-face communities of the mythical opposite extreme, we miss the ways in which real communities of practice employ a whole ecology of media as they think...
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Báo cáo khoa học: Inhibition of PI3K/Akt partially leads to the inhibition of PrPC-induced drug resistance in gastric cancer cells pdf
... involved in PrPC-mediated MDR in gastric cancer To test this hypothesis, the expression of Akt and PrPC was examined by immunohistochemistry and confocal microscope in human gastric cancer cases ... PrPC-induced MDR J Liang et al Multidrug resistance (MDR) is one of the major causes of failure of chemotherapy of human malignancies Studies have shown that cellular drug resistance is mediated by various ... lysis buffer (150 mmolÆ L)1 Tris/HCl pH 8.0, 50 mmolÆL)1 NaCl, 0.2 mmolÆL)1 EDTA, 0.1 mmolÆL)1 phenylmethanesulfonyl fluoride and 10 gÆL)1 Nonidet P-40) Fifty micrograms of protein from each cell lysate...
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Pocket Guide To TNM STAGING OF HEAD AND NECK CANCER AND NECK DISSECTION CLASSIFICATION pdf
... Any N M0 M0 M0 M0 M0 M0 M0 M0 M0 M0 M0 M0 M0 M0 M0 M0 M0 M0 M1 B Thyroid Definition: The thyroid is composed of a right and left lobe, with an isthmus connecting the two lobes Primary Tumor (T) ... N1b N1b Any N N3 Any N M0 M0 M0 M0 M0 M0 M0 M0 M0 M0 M0 M0 M0 M0 M1 Medullary Carcinoma Stage I T1 Stage II T2 Stage III T3 T1 T2 T3 N0 N0 N0 N1a N1a N1a M0 M0 M0 M0 M0 M0 27 Stage IVA Stage IVB ... Stage IVC N0 N0 N0 N0 N1 N1 N1 N0 N1 N2 N2 N2 N2 Any N N3 Amy N M0 M0 M0 M0 M0 M0 M0 M0 M0 M0 M0 M0 M0 M0 M0 M1 Clinical Stage Grouping by T and N Status N0 N1 N2 N3 T1 I III IVa IVb T2 II III...
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MANAGEMENT OF OESOPHAGEAL AND GASTRIC CANCER ppt
... development of squamous cancer of the oesophagus and for gastric cancer Tobacco smoking increases the risk of squamous cancer of the oesophagus approximately nine fold compared with age and sex matched ... oesophagectomy to improve staging and local disease control B Routine extension of lymphadenectomy into the superior mediastinum or neck should not be carried out B D2 lymphadenectomy, with a minimum of ... provides a summary of the main recommendations in the SIGN guideline on the Management of oesophageal and gastric cancer Recommendations are graded A B C D to indicate the strength of the supporting...
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