loss oxidative damage and apoptosis
báo cáo hóa học: " Neuronal oxidative damage and dendritic degeneration following activation of CD14-dependent innate immune response in vivo" doc
... ICV LPS-induced neuronal oxidative damage Finally, mice lacking prostaglandin E2 receptor subtype (EP2), one of four prostaglandin E2 (PGE2) receptors expressed in brain and one of the two PGE2 ... mouse hippocampus and adjacent structures 24 hr after ipsilateral ICV LPS injection Note normal density and distribution of neurons without a cellular infiltrate Neuronal oxidative damage Numerous ... detectable neuronal oxidative damage is delayed several hours following ICV LPS, others have shown that altered gene transcription and increased cytokine secretion occur rapidly and peak within a...
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Báo cáo y học: "Ethanol extract of Scutellaria baicalensis Georgi prevents oxidative damage and neuroinflammation and memorial impairments in artificial senescense mice" ppt
... model was caused by oxidative damage and apoptosis by chronic injection of D-galactose and sodium nitrate, we evaluated the antioxidative effects of superoxide dismutase, catalase and malodialdehyde ... baicalein and baicalin were recorded at 315 nm and 272 nm respectively HPLC (Shimadzu, Japan) analysis content of baicalin and baicalein was 4.1522% and 3.3075%, respectively in SBG Baicalin and baicalein ... significantly inhibited both Cox-2 and iNOS expression in both low and high doses of SBG (Figure 4B) Macrophage-derived NO and PGE2 are an important host defense and microbial and tumor cell killing agent,...
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Oxidative damage and immunological responses in ageing hybrid mice with resveratrol intervention
... 1.1 Background and significance of the research 1.2 Theories of ageing and biomarkers of ageing 1.3 Oxidative damage and ageing 1.4 Immunological changes during ageing 1.5 Research and applications ... evaluate the effects of ageing and long-term RSV treatment in drinking water for or 12 months on biomarkers of oxidative damage and immunological responses The oxidative damage biomarkers examined ... consistently attenuated oxidative damage in tissues where age-related oxidative damage accumulation was prominent and was able to modulate specific immune cell responses and cytokine expression...
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Báo cáo khoa học: Cysteine residues exposed on protein surfaces are the dominant intramitochondrial thiol and may protect against oxidative damage docx
... Total and exposed protein thiols and GSH in liver and heart tissue homogenates and mitochondria (A, B) Total and exposed protein thiols in sequential supernatants from 3000 g, 10 000 g and 100 ... oxidative damage These findings suggest that more attention should be paid to the role of thiols exposed on the surface of proteins in the defence of cells and mitochondria against oxidative damage ... centrifuged and exposed protein thiols were measured (H) GSH content of rat liver and heart mitochondria Mitochondria (5 mgÆmL)1 protein) were incubated in KCl buffer for 10 at 30 °C and the GSH and...
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Báo cáo khoa học: Expression of CYP2E1 increases oxidative stress and induces apoptosis of cardiomyocytes in transgenic mice pdf
... dilation and contractile dysfunction, as well as myocyte disarray, interstitial fibrosis, ultrastructural degeneration with myofibrillar disorganization and mitochondria damage) (Figs and and Table ... cardiac oxidative stress, myocyte apoptosis and the DCM phenotype Materials and methods * Animals WT CYP2E1 cTnTR141W Fig Determination of the levels of cytochrome c release, cleaved caspases and ... CYP2E1-mediated oxidative stress and myocyte apoptosis are also evident in cTnTR141W transgenic mice These results support a possible correlation between CYP2E1 expression and apoptosis in this...
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Báo cáo khoa học: "Combined low initial DNA damage and high radiation-induced apoptosis confers clinical resistance to long-term toxicity in breast cancer patients treated with high-dose radiotherapy" pdf
... predictor assays taking into account the initial DNA damage and radiation-induced apoptosis levels, and introduces new data which may help to understand and define the complex mechanisms behind the normal ... Abbreviations: DSB/Gy/DNA unit = double-strand breaks induced per Gy and per 200 Mbp; RIA = radiation-induced apoptosis at 1, and Gy after 24 hours a and b are the constants that define the model ... severity of the DNA damage and the cell type involved, cells may undergo apoptosis instead of attempting to repair the damage [46] Lymphocytes are particularly sensitive to apoptosis, partly because...
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Tài liệu OXIDATIVE STRESS AND DISEASES pptx
... OXIDATIVE STRESS AND DISEASES Edited by Volodymyr Lushchak and Dmytro V Gospodaryov Oxidative Stress and Diseases Edited by Volodymyr Lushchak and Dmytro V Gospodaryov ... current understanding and advise them quite novel and non-standard approaches to find and decipher mechanisms of diseases Finally, we would like to thank all authors for their contributions and hard ... pathologies and oxidative modification of proteins Most antioxidant and related enzymes are targets for oxidative modification Hence, if oxidative stress was primary event, possible oxidative modifications...
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Tài liệu Báo cáo khoa học: Myristoylation of the dual-specificity phosphatase c-JUN N-terminal kinase (JNK) stimulatory phosphatase 1 is necessary for its activation of JNK signaling and apoptosis pdf
... resistance to apoptosis Apoptosis is a tightly regulated mechanism for the disposal of damaged cells and to remove cells during normal growth and development [27,40] Cells that undergo apoptosis ... with endosomal and Golgi structures using specific markers (EEA1, TfnR for endosomes and GM130, TGN46 for Golgi) and found that JSP1-wt partially colocalized with the Golgi apparatus and showed minimal ... dish and undergo apoptosis Interestingly, the cells could tolerate high levels of the myristoylationdeficient mutant and remain attached, whereas similar levels of the wild-type protein induced apoptosis...
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Tài liệu Báo cáo khoa học: Functional hierarchy of plasminogen kringles 1 and 4 in fibrinolysis and plasmin-induced cell detachment and apoptosis docx
... lane 6, Glu-Pg- and mAb 34D3-treated cells Bands in lanes and correspond to forms I and II of plasmin(ogen) High molecular weight bands in lanes and correspond to mAb A10.2- and mAb 34D3-plasminogen ... Lys-plasmin(ogen) binding and activation These structural–functional transitions are determinant in the initiation and development of both fibrinolysis and cell detachment-induced apoptosis and may therefore ... their respective contribution to Gluand Lys-Pg binding and activation onto fibrin and cells, as well as their effects on fibrinolysis and on plasmin-induced cell apoptosis The LBS specificity of these...
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Tài liệu Báo cáo khoa học: Enhancement of oxidative stress-induced apoptosis by Hsp105a in mouse embryonal F9 cells pptx
... JNK and p38 pathways are activated by cellular stresses and inflammatory cytokines, resulting in growth arrest and apoptosis, and have been implicated as key regulators of stress-induced apoptosis ... Hsp105 enhances oxidative stress-induced apoptosis (Eur J Biochem 269) 4147 Fig Enhancement of oxidative stress-induced apoptosis by over-expression of Hsp105a (A) F9, V1, S3 and S23 cells were ... for induction of apoptosis by hydrogen peroxide, and Hsp105a is suggested to enhance the oxida- Fig Effects of Hsp105a on activation of JNK and p38 by oxidative stress F9, V1, S3 and S23 cells were...
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Ambient particulate air pollution induces oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues ppt
... oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues Particle and Fibre Toxicology 2011 8:20 Submit your next manuscript to BioMed Central and ... (eWAT, rWAT, and iWAT, left), and brown adipose depots (iBAT, and mBAT, right) by real-time PCR n = *P < 0.05 vs FA Xu et al Particle and Fibre Toxicology 2011, 8:20 http://www.particleandfibretoxicology.com/content/8/1/20 ... ES017412, and ES018900 to Dr Sun, ES015146 and ES017290, and EPA grant R834797-01 to Dr Rajagopalan, an NPACT Initiative grant from the Health Effects Institute to Drs Lippmann and Chen, and laboratory...
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Báo cáo khoa học: Molecular and functional characterization of a novel splice variant of ANKHD1 that lacks the KH domain and its role in cell survival and apoptosis docx
... 2B that VBARP-L and VBARP-S are coded by these specific exons VBARP-L and VBARP-S code for precursor proteins of 627 and 435 amino acids and with calculated peptide masses of 69 and 49 kDa, respectively ... were constructed and used to further confirm the Vpr and VBARP interaction using in vitro and in vivo interaction studies Ten microliters of 35S-labeled in vitro translated VBARP and Vpr or Nef ... were mixed and immunoprecipitated with VBARP-, Vpr- or Nef-specific antibody and analyzed by autoradiography (Fig 1A) Results indicate that both Vpr and VBARP were able to form a complex and the...
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Báo cáo khoa học: ATP-binding domain of heat shock protein 70 is essential for its effects on the inhibition of the release of the second mitochondria-derived activator of caspase and apoptosis in C2C12 cells potx
... activation of caspases-9 and -3 and apoptosis (A) The effects of HSP70 and its deletion mutant proteins on the activation of caspases-9 and -3 were analyzed Cells over-expressing HSP70 and its deletion ... demonstrated that HSP70 inhibited Smac release and the activation of caspases-9 and -3, thereby preventing DNA fragmentation and apoptosis in cells under H2O2-induced oxidative stress This is similar to ... of the release of Smac and apoptosis GAPDH Ratio of HSP70 to GAPDH 14 # 12 # 10 * The role of the ATP-binding domain of HSP70 in the prevention of the release of Smac and apoptosis after exposure...
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Báo cáo khoa học: G protein-coupled receptor-induced Akt activity in cellular proliferation and apoptosis pptx
... (TNF) receptorassociated death domain and of the TNF-related apoptosis- inducing ligand, leading to the activation of death-receptor signaling and caspase-mediated apoptosis [59] Activated Akt phosphorylates ... control growth and trigger apoptosis in human cancer cells by targeting heterotrimeric G proteins and individual GPCRs [79,80] However, experimental data obtained from transgenic and knockout mice ... SR, Kolakowski LF Jr, Lynch KR & O’Dowd BF (1999) Novel GPCRs and their endogenous ligands: expanding the boundaries of physiology and pharmacology Trends Pharmacol Sci 20, 370–375 16 Venter JC,...
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Báo cáo khoa học: Effect of oxidative stress and involvement of poly(ADP-ribose) polymerase (PARP) in Dictyostelium discoideum development doc
... were exposed to oxidative stress (2.5 mm and mm HA) with PARP inhibition and allowed to develop, the spores showed faster germination (32 h and 60 h) as compared to cells exposed to oxidative stress ... (1.0, 2.5 and 4.0 mm) for h and then allowing them to develop As can be seen from Table and Fig 3A, development was delayed in a dose-dependent manner at the loose aggregation stage by h and 12 ... 20 Oxidative stress induces PARP activation PARP activity in D discoideum was assayed at various time points (5, 10, 20 and 60 and h) after HA stress PARP activity was increased initially, and...
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Báo cáo khoa học: Extraenzymatic functions of the dipeptidyl peptidase IV-related proteins DP8 and DP9 in cell adhesion, migration and apoptosis doc
... Kable and Devanshi Seth for advice This work was supported by National Health and Medical Research Council of Australia project grant 142607 to GWM and MDG and PhD scholarships to DMTY and XMW ... biological significance of DP8 and DP9 A portfolio of cell–ECM interaction assays indicated roles for DP9 in cell adhesion, in vitro wound healing, cell migration and apoptosis, and for DP8 in wound healing, ... relatedness, DP8 and DP9 exert these differences in their cellular effects Therefore, these two proteins are likely to have different functions and ligands These data indicate that DP8 and DP9 have...
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Báo cáo khoa học: Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis pdf
... autophagy and apoptosis Fig Regulation of Bcl-2 family members between apoptosis and autophagy Depending on their specificity and preferential subcellular localization, BH3-only proteins can activate apoptosis ... mediator of apoptosis Atg5 can be cleaved following death stimuli, and appears to promote mitochondria-mediated apoptosis It cooperates with Bcl-2 and Bcl-xL to regulate both apoptosis and autophagy ... autophagy and are induced by growth factor withdrawal and stress situations, including hypoxia and oxidative stress [39–41] Recent studies have indicated that activation of Beclin and inhibition...
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Báo cáo khoa học: The silencing of adenine nucleotide translocase isoform 1 induces oxidative stress and programmed cell death in ADF human glioblastoma cells doc
... protein in Scrambleand ANT1 and ANT2 siRNA-transfected cells; the 33 kDa band corresponds to ANT proteins, the 43 kDa band corresponds to actin (E) Western blot analysis of FLAGANT1 and FLAG-ANT2 ... effects of BA, ATR and ANT1 siRNA on cell viability and glucose consumption (A,B) Cell growth curves analyzed by crystal violet assay in BA and vehicle-treated (A) and in ATR and vehicle-treated ... conductance and thus in the reduction of ROS production and oxidative stress Three previous studies [19,39,40] report that ANT1 overexpression induces apoptosis in a variety of immortalized fibroblasts and...
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Báo cáo khoa học: Oxidative stress and apoptotic events during thermal stress in the symbiotic sea anemone, Anemonia viridis potx
... to the most basal metazoan phyla as porifera and cnidaria with occurrence of apoptosis and homologues of caspases and Bcl2 proteins [28] Moreover, apoptosis has been remarkably well conserved ... antioxidant induction and on apoptotic markers (caspase-like activation and ⁄ or DNA degradation) in order to demonstrate the concomitant involvement of oxidative stress and apoptosis in a thermally ... Richier et al Apoptosis and oxidative stress in bleaching Ectodermal extracts * Relative antioxidant activity 3.0 Gastrodermal extracts suggested, such as inhibitor of apoptosis protein and heat shock...
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Báo cáo khoa học: Lysosomal enzymes promote mitochondrial oxidant production, cytochrome c release and apoptosis docx
... color digital camera and Adobe PHOTOSHOP software Materials and methods AG1518 fibroblasts, J774 and HeLa cells were seeded in 96-well plates and cultured for 24 h under standard conditions before ... cytochrome c and loss of mitochondrial transmembrane potential during apoptosis induced by oxidative stress Free Radic Biol Med 27, 1228–1237 51 Roberg, K (2001) Relocalization of cathepsin D and cytochrome ... Petri dishes and kept for 24 h before being exposed to 30 lM MSDH for h Actin staining was then performed as described in Materials and methods Ó FEBS 2003 Lysosomes, apoptosis and mitochondria-mediated...
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