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localization and transport of charge by nonlinearity and spatial discreteness in biomolecules and semiconductor nanorings aharonov bohm effect for neutral excitons

Báo cáo khoa học: Transport of taurocholate by mutants of negatively charged amino acids, cysteines, and threonines of the rat liver sodium-dependent taurocholate cotransporting polypeptide Ntcp docx

Báo cáo khoa học: Transport of taurocholate by mutants of negatively charged amino acids, cysteines, and threonines of the rat liver sodium-dependent taurocholate cotransporting polypeptide Ntcp docx

Báo cáo khoa học

... domains model), is involved in taurocholate transport of the human isoform [21] We therefore looked for the role of each of the eight cysteines of the rat Ntcp for taurocholate transport Finally, ... determined in a liquid scintillation counter (Wallac 1407, Wallac Inc., Turku, Finland) Results Search for conserved negatively charged amino acids, cysteines and C-terminal threonines by sequence ... domains into the membrane, forming P-loops [40] P-loops allow the introduction of charged molecules into inner parts of the cell membrane from where these can be overtaken by further binding...
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Báo cáo khoa học: Regulation of DNp63a by tumor necrosis factor-a in epithelial homeostasis docx

Báo cáo khoa học: Regulation of DNp63a by tumor necrosis factor-a in epithelial homeostasis docx

Báo cáo khoa học

... degradation of DNp63a by TNF-a was attenuated by inhibition of NF-jB, suggesting that activation of NF-jB may be involved in the regulation of the degradation of DNp63a Interestingly, knockdown of DNp63a ... Regulation of DNp63a by TNF-a H.-o Lee et al dominant negative towards p53 and TA (transactivating) isoforms of p63 and p73 (TAp63 and TAp73) [4–7] In addition to its p53-dominant negative ... is determined by ubiquitin–proteasomal degradation The levels of DNp63a are critical for controlling epithelial cell fate Therefore, understanding the mechanism for DNp63a turnover is of great...
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Automatic spike sorting and robust power line interference cancellation for neural signal processing

Automatic spike sorting and robust power line interference cancellation for neural signal processing

Thạc sĩ - Cao học

... frequency bands of 80–500 Hz in [7], 40–180 Hz in [9], 76–150 Hz in [10], 0–200 Hz in [15], and 30–200 Hz in [13] have been shown useful for studying cognitive and motor processing In this case, in addition ... Imaginary part of z T Function for a test of unimodality φk Phase of k th harmonic φi,k Phase of the k th harmonic in channel i ˆ φk Estimate of φk ψk Initial phase shift of uk and uk µk Center of ... cognition and study the brain’s mechanisms of information processing Extracellular recording using micro-electrode arrays provides high fidelity signals of both single- and multi-unit activities and...
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Tài liệu Báo cáo khoa học: Properties of ecdysteroid receptors from diverse insect species in a heterologous cell culture system – a basis for screening novel insecticidal candidates docx

Tài liệu Báo cáo khoa học: Properties of ecdysteroid receptors from diverse insect species in a heterologous cell culture system – a basis for screening novel insecticidal candidates docx

Báo cáo khoa học

... control of MHR3 promoter activity by isoforms of the ecdysone receptor and inhibitory effects of E75A and MHR3 Dev Biol 272, 510–21 Azotei A & Spindler-Barth M (2009) DNA affects ligand binding of ... Steroids and nonsteroidal agonists bind exclusively to the EcR ligand-binding domain (LBD), although the presence of USP increases ligand-binding affinity [12–15] The diversity of ligand-responsive ... activity induced by (A) MurA and (B) RH2485 of DmEcRB2–VP16-DmUSP and analogous LdEcR–VP16-LdUSP complexes Parentheses in (A) indicate a potentiation effect, and arrows in (B) indicate an absence of...
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Báo cáo y học:

Báo cáo y học: "Sequential gene profiling of basal cell carcinomas treated with imiquimod in a placebo-controlled study defines the requirements for tissue rejection" pps

Báo cáo khoa học

... according to GEO (series # GSE5121) [71] interactions 12 refereed research After confirming the presence of epidermis, dermis and tumor using hematoxylin and eosin, IHC was performed by staining ... ΔCD8 = Figure for CD56 and CD8 in BCC from (a) P40 (imiquimod treated) and (b) P8 (vehicle-control) IHC staining IHC staining for CD56 and CD8 in BCC from (a) P40 (imiquimod treated) and (b) P8 ... predominantly innate immune effector functions (Figure 3a) CXCR3, a ligand for IP-10 and monokine induced by IFN-γ (MIG/CXCL9) was the earliest upregulated cytokine receptor, suggesting its early involvement...
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Tài liệu Báo cáo khoa học: Oocyte membrane localization of vitellogenin receptor coincides with queen flying age, and receptor silencing by RNAi disrupts egg formation in fire ant virgin queens ppt

Tài liệu Báo cáo khoa học: Oocyte membrane localization of vitellogenin receptor coincides with queen flying age, and receptor silencing by RNAi disrupts egg formation in fire ant virgin queens ppt

Báo cáo khoa học

... serially for 10 min, each in 100%, 95% and 70% ethanol and in water for 30 at room temperature After rinsing twice for with PBST (NaCl ⁄ Pi containing 0.05% Triton X-100), slides were incubated in ... readiness of alate queens for a mating flight and upon mating, de-alation, the sudden increase in vitellogenesis and concomitant ovarian development, and the onset of egg-laying behavior To begin ... maturation of virgin queens for flying and mating should include regulation of VgR expression Here, we investigate the temporal ovarian expression and subcellular localization of the VgR in fire ant...
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Báo cáo khoa học: Regulated expression by PPARa and unique localization of 17b-hydroxysteroid dehydrogenase type 11 protein in mouse intestine and liver pdf

Báo cáo khoa học: Regulated expression by PPARa and unique localization of 17b-hydroxysteroid dehydrogenase type 11 protein in mouse intestine and liver pdf

Báo cáo khoa học

... 17b-HSD11 was greatly induced in the intestine and liver of mice by administration of a PPARa agonist, Wy-14 643 [5], the changes in protein levels were examined by western blotting For this purpose, ... PAGE and analyzed by western blotting using the specific antibodies against 17b-HSD11, calnexin and L-FABP 17b-HSD11 gene in the intestine may be of help in understanding the physiologic role of ... Liver + + Intestine + + 17β-HSD11 CBB-stain Fig Expression of 17b-HSD11 protein in the gastrointestinal tract (A) The gastrointestinal tract of mice [29] fed a diet containing Wy-14 643 for days...
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Báo cáo khoa học: The stop transfer sequence of the human UDPglucuronosyltransferase 1A determines localization to the endoplasmic reticulum by both static retention and retrieval mechanisms docx

Báo cáo khoa học: The stop transfer sequence of the human UDPglucuronosyltransferase 1A determines localization to the endoplasmic reticulum by both static retention and retrieval mechanisms docx

Báo cáo khoa học

... consisting of 16 exons The isoforms are generated by alternative splicing of exon to the four common exons 2–5 resulting in isoforms with an identical C-terminal half of the protein [15] and a unique ... to contain important information for localization in the ER [19] We found that the TMD of UGT1A proteins appended to the C-terminus of the ectodomain of CD4 plasma membrane glycoprotein was able ... proteins contain a stop transfer sequence at the C-terminus consisting of a TMD of 17 residues followed by a short CT of 25 residues containing a KXKXX ER retrieval signal In this study, we investigated...
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Báo cáo khoa học: Epoxidation of benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1 in reconstituted membranes Effects of charge and nonbilayer phase propensity of the membrane pot

Báo cáo khoa học: Epoxidation of benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1 in reconstituted membranes Effects of charge and nonbilayer phase propensity of the membrane pot

Báo cáo khoa học

... stoichiometry of 0.9, and molar lipid/protein ratio of 1200 The intra- and interday degree of variation in relative P450, reductase, and lipid content did not exceed 10% in any of the vesicular ... temperature in Ela2PtdEtn (about 65 °C) than in Ole2PtdEtn (about 10 °C) and has been used to investigate the impact of the hexagonal phase forming tendency by Yang and Hwang [31] Data in Fig 1A and in ... phospholipid charge and the type of lipid used For instance, Vmax for (–)-7,8-diol oxidation to DE2 was about 33 pmolÆmin)1Æpmol)1 in vesicles containing PtdSer This rate is very high for a CYP1A1-catalyzed...
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Báo cáo khóa học: Membrane transport of fatty acylcarnitine and free L-carnitine by rat liver microsomes pot

Báo cáo khóa học: Membrane transport of fatty acylcarnitine and free L-carnitine by rat liver microsomes pot

Báo cáo khoa học

... of unlabelled carnitine, lCi [3H]carnitine and lCi [14C]inulin At each time-point, two 50 lL samples were removed quickly and transferred to tubes containing mL of ice-cold HS buffer containing ... which must rely on an internal, luminal pool of CoASH Transport of L-carnitine into sealed microsomal vesicles Transport of L-[3H]carnitine was studied by measurement of uptake into microsomal vesicles ... evidenced by an overt AEAT activity of only 972 ± 88 pmolÆmin)1Æmg)1 (indicating 95% latency of AEAT) and had complete inactivation of CPT1, as evidenced by the lack of any ethanol-independent...
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Báo cáo khoa học: Transport of the phosphonodipeptide alafosfalin by the H+/peptide cotransporters PEPT1 and PEPT2 in intestinal and renal epithelial cells doc

Báo cáo khoa học: Transport of the phosphonodipeptide alafosfalin by the H+/peptide cotransporters PEPT1 and PEPT2 in intestinal and renal epithelial cells doc

Báo cáo khoa học

... cells, 20 and 50 lM for SKPT cells) in the presence of increasing amounts of alafosfalin The linear, nonmediated transport components, i.e simple diffusion plus tracer binding, of 19.2% and 5.1% ... For alafosfalin, Ki values of 140 lM for PEPT1 and 73 lM for PEPT2 were calculated from the point of intersection In a third series of experiments, the effects of alafosfalin on the kinetic parameters, ... values of 194 ± 13 lM for PEPT1 and 74 ± 10 lM for PEPT2 were obtained For comparison, the inhibition constants (Ki) of Ala-Ala are 80 ± 10 lM for PEPT1 and 6.3 ± 0.3 lM for PEPT2 and those of Ala-Lys...
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báo cáo hóa học:

báo cáo hóa học: " Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF" potx

Toán học

... IL-6 and GM-CSF into both the luminal and abluminal chambers [34] To determine whether IL-6 and GM-CSF secreted by BMECs into the abluminal chamber are also involved in the LPS-induced increase in ... microliter of loading chamber (in cpm/µL), [C]C is the radioactivity in a microliter of collecting chamber (in cpm/µL), and VC is the volume of collecting chamber (in µL) During a 90-min period of the ... design in an interactive and synergistic fashion Experiments were performed by SD and MAF-D Writing was a joint effort with WAB overseeing and editing final draft All authors have read and validated...
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Regulation of subcellular localization and functions of RGK proteins by 14 3 3 and calmodulin

Regulation of subcellular localization and functions of RGK proteins by 14 3 3 and calmodulin

Cao đẳng - Đại học

... called G domains namely G1, G2, G3, G4 and G5 These domains play specific roles in phosphate binding, guanine binding and effector binding Key amino acids and motifs in the various domains of the core ... localization of RGK proteins by CaM 63 3.5 Modulation of localization of RGK proteins by 14-3-3 in the absence of CaM binding 65 Chapter 4: Roles of 14-3-3 and CaM in cell shape remodeling and down ... composed of a Nterminal dimerization region and a target binding region The target binding region involves amino acids from both the N- and C-termini of the protein 14-3-3 proteins function by binding...
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An analysis of errors made by vietnamese secondary school students in using english modal auxiliary verbs can, could, may, must and semi   auxiliary verb have to

An analysis of errors made by vietnamese secondary school students in using english modal auxiliary verbs can, could, may, must and semi auxiliary verb have to

Khoa học xã hội

... process are inevitable Making error is a part of learning and finding error is a part of teaching, this helps the process of learning quicker and effective, given the fact that description and analysis ... given individuals tend to transfer the form, meanings, and the distribution of forms and meanings of their native language and culture to the foreign language and culture (Lado 1957: 2) and interference ... transfer the forms and the meanings, the distribution of forms and meanings of their native language and to the foreign language and culture To sum up, Interlingual errors or errors caused by the first...
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The victorious laugh of love, frienship, justice and commonsence in the merchant of venice by shakespeare

The victorious laugh of love, frienship, justice and commonsence in the merchant of venice by shakespeare

Khoa học xã hội

... leading manufacture in England Landowners drove thousands of peasants out of their lands , turning these lands into pastures , or "enclosures " for sheep There was no work for the peasants and ... His insatiable greed for gold and silver exceeds the feeling between father and daughter When Jessica elopes and brings his jewels and money with her, he is paintful and insane and wanders in ... say in choosing a husband She wants to have freedom in choosing a marriage partner She has progressive thoughts of choosing her husband Standing in front of Bassanio, she feels wonderful things...
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Expansion and its realization in the short story “the law of life” by jack london

Expansion and its realization in the short story “the law of life” by jack london

Khoa học xã hội

... exchange: giving and demanding He goes on to analyze the nature of the commodity being exchange into (a) goods and service and (b) information This analysis can be illustrated in the following table: ... between clauses in a clause complex in which one clause expands on another by one of three ways: by elaborating, by extending, or by enhancing In this way expansion can be divided into three categories: ... those of reading and writing, which involve a good understanding of logical and semantic relation between elements in a clause complex, and more broadly, in a text Third, the awareness of the...
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Tài liệu Báo cáo khoa học: Degradation of tropoelastin by matrix metalloproteinases – cleavage site specificities and release of matrikines pptx

Tài liệu Báo cáo khoa học: Degradation of tropoelastin by matrix metalloproteinases – cleavage site specificities and release of matrikines pptx

Báo cáo khoa học

... mm; Dionex) and elution using a linear binary gradient: 5–65% ACN in 0.1% formic acid in 35 min, maintenance at 65% ACN for 10 min, and 65–5% ACN in 10 The typical operating conditions for the mass ... gradient of 50–100% solvent B in min, maintenance at 100% solvent B for min, and linear gradient of 100–5% solvent B in The column was maintained at 30 °C and the flow rate was 300 nLÆ min)1 Detection ... primary transcript of tropoelastin undergoes substantial alternative splicing, resulting in the production of multiple isoforms in nature [80] In this work, tropoelastin isoform (also known as...
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Tài liệu Anomalies and Curiosities of Medicine, by George M. Gould and Walter Lytle Pyle doc

Tài liệu Anomalies and Curiosities of Medicine, by George M. Gould and Walter Lytle Pyle doc

Sức khỏe giới tính

... were those of the brain, give testimony of the state of mind that led to and dominated the practice of dissection In the literature of the past centuries the predominance of the interest in the curious ... out into the light the evidences of her clumsiness, and proofs of her lapses of skill,— evidences and proofs, moreover, that tell us much of the methods and means used by the vital artisan of ... encyclopedic collection of rare and extraordinary cases, and of the most striking instances of abnormality in all branches of medicine and surgery, derived from an exhaustive research of medical literature...
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Tài liệu Báo cáo khoa học: Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates pdf

Tài liệu Báo cáo khoa học: Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates pdf

Báo cáo khoa học

... given in A NADP+-binding pocket and restricts the binding depth of cofactor in a similar fashion to that observed for OaPDH [12] In TbPDH, the alanine in this motif is replaced by glycine suggesting ... according to the domain in which they occur; blue for domain I, yellow for domain II and red for domain III Aligned sequences of OaPDH and TbPDH are also shown Most of the amino acids conserved in ... domain alteration involves a rotation ofand translation of ˚ 0.7 A Five segments of polypeptide within the cofactorbinding domain (Fig 2) constitute the bending or hinge regions These involve...
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Tài liệu Báo cáo khóa học: Non-specific depolymerization of chitosan by pronase and characterization of the resultant products pptx

Tài liệu Báo cáo khóa học: Non-specific depolymerization of chitosan by pronase and characterization of the resultant products pptx

Báo cáo khoa học

... cm)1 in the spectra of both chitosan and LMWC indicated the absence of free -OH groups and the involvement of both -OH…3 and -CH2OH…6 in intra- and intermolecular hydrogen bonding (Fig 2) [31] Line ... the effect of molecular mass and DA on lipase loaded chitosan bead characteristics, in which increases in molecular mass and DA resulted in efficient loading and minimization of the release of ... decrease in the DA (Table 1) of LMWC, which results in lower degree of hydration of the molecule affecting the crystallinity index and thus the orderliness This was further confirmed by a decrease in...
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