local treatment of malignant melanoma
advances in cancer research
... Therapy Local Treatment of Malignant Melanoma Local Treatment of Breast Cancer Local Treatment of Cancer of the Uterine Cervix Local Treatment of Neurological Tumors ... Systemic Treatment of Malignant Melanoma IX Systemic Treatment of Renal Cell Carcinoma X Systemic Treatment of Lung Cancer XI Systemic Treatment of Gastric Cancer XI1 Systemic Treatment ... of Neurological Tumors Local Treatment of Head and Neck Tumors Local Treatment of Lung Tumors Local Treatment of Bladder Tumors Intraarterial IFN Therapy ...
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Báo cáo khoa học: Arthropod nuclear receptors and their role in molting pptx
... the OH group of the tyrosine amino acid residue are observed in three EcRs (Tyr408 of HvEcR, Tyr296 of BtEcR and Tyr427 of TcEcR), illustrating conservation of binding characteristics of the molting ... interaction of USP with EcR is isoform-dependent [145] The phosphorylation of USP inhibits ecdysteroid biosynthesis in M sexta [146] and is required for normal induction of expression of the 20E ... of DmEcR-A [139] and to that of the EcR-A of M sexta (MsEcRA) [156], and the amino-terminus of AmEcR-A3 is similar in size to that of DmEcR-B2 [139] The DBD and LBD of AmEcRs share 86% and 64%...
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Báo cáo khoa học: Cloning of a rat gene encoding the histo-blood group A enzyme Tissue expression of the gene and of the A and B antigens potx
... group enzyme Examination of the tissue distribution of the corresponding mRNA and of the A and B antigens in the BDIX strain of rat was performed, allowing some aspects of the ABO genetics in this ... sequences Of note, the presence of a conserved potential N-glycosylation site at the beginning of the catalytic domain Previous studies of the human ABO transferases underscored the major importance of ... presence of the acceptor Values of the specific activities are given in pmolÆh)1Æmg protein)1 of either [14C]galactose or [14C]N-acetylgalactosamine transferred tion of cDNA and lack of contamination...
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nuclear envelope dynamics in embryos and somatic cells
... another isoform of HP1, HP1γ, localizes to the chromosome arms.78 These transient spatial distinctions are important because emerin co-localizes with BAF at the ‘core’,105 and LBR co-localizes ... main structures (Fig 1), each of which are reviewed in more detail in other Chapters of this volume The first of these, the nuclear lamina consists of lamins, proteins of the intermediate filament ... both localized to the nuclear face of the NPC were found to associate only transiently with the NPC.34,39 Using markers of the NPC core, the mobility of the whole NPC itself in the plane of the...
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báo cáo hóa học: " All-trans retinoic acid induces COX-2 and prostaglandin E2 synthesis in SH-SY5Y human neuroblastoma cells: involvement of retinoic acid receptors and extracellular-regulated kinase 1/2" potx
... medium supplemented with 0.5% FBS ATRA treatment did not induce morphological features of differentiation Page of (page number not for citation purposes) Journal of Neuroinflammation 2007, 4:1 Transient ... co-amplification of 18 S RNA, respectively Normalized density ratio of COX-2 over either α-actin or 18 S RNA is indicated for each band Page of (page number not for citation purposes) Journal of Neuroinflammation ... target of ATRA would, in turn, be responsible for the activation of a signalling pathway leading to the activation of the COX-2 promoter Previous studies have found contradictory Page of (page...
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Báo cáo hóa học: " Trichloroethylene exposure and somatic mutations of the VHL gene in patients with Renal Cell Carcinoma" potx
... with 15 mM of MgCl2, 0.8 mM of dNTP mix, 0.3 µM of each forward and reverse primers and 0.5 U of HotStarTaq® DNA Polymerase (Qia- Page of (page number not for citation purposes) Journal of Occupational ... (12 of 17) of the formalin-fixed samples, and 38% (10 of 26) of the Bouin's fixed tissues Thus, the VHL gene was entirely sequenced (ie 100% of the coding sequence analysed) for a total of 26 ... compare exposed and non exposed cases of clear cell RCC in terms of prevalence of mutations in both groups Page of (page number not for citation purposes) Journal of Occupational Medicine and Toxicology...
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Báo cáo hóa học: " Expression of HIV receptors, alternate receptors and co-receptors on tonsillar epithelium: implications for HIV binding and primary oral infection" doc
... into the design of the experiments, the interpretation of the data and the overall organization of the text PJS was responsible for the broad design of the study, processing of the tonsil tissue ... immunocytochemistry and completion of the submitted version of the text All of the authors made meaningful contributions to the process of revising draft versions of the text 10 11 12 13 14 15 Acknowledgements ... These invading cells were a mix of approximately 25% CD4+ and 75% CD8+ T cells, with some of these T cells expressing either CXCR4 or CCR5 A series of double label immunofluorescence experiments were...
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Báo cáo y học: " Eph Receptors and Ephrin Signaling" pps
... coupling of bone resorption and bone formation is critical during the normal process of bone remodeling, and the dysregulation of this coupling results in the development of a range of pathological ... morphology[17] The mechanisms of reverse signaling of ephrinA ligands are less understood, but Int J Med Sci 2008, are thought to be the result of ephrinA clustering and recruitment of regulatory proteins ... complex mechanism of Eph/ephrin interactions is suggested, with two distinct types of interactions identified, one of which blocks interactions which use the ligand-binding domain of the Eph receptor,...
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Báo cáo y học: "Phobic memory and somatic vulnerabilities in anorexia nervosa: a necessary unity" ppsx
... activation of K+ channels may be among other regulators of pacemaker activity of interneurons that govern the quasi-periodic repetition of group activities and EEG synchronization The excitability of ... distribution of SK channels and the fundamental role of K+ currents in controlling membrane excitability of diverse organ systems pose a question of their role in regulation and dysregulation of the ... studies of EEG in behavioral disorders of childhood, eating disorders were not even mentioned [102] However, the absence of clear indices of epileptiform abnormalities is not a critical violation of...
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Báo cáo y học: "The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus" potx
... encountered a vast range of antigens, including many environmental antigens, over a prolonged period of time, whereas germinal centres (GCs) in the spleen or lymph nodes provide a profile of B cells that ... [7,8] demonstrated the presence of autoantibody-producing B cells in the spleen of an SLE patient by analysis of hybridomas generated from splenic B cells The aims of the present study were to identify ... independently rearranged groups of genes used the VH5-51 gene R117 Arthritis Research & Therapy Vol No Fraser et al Figure 10 Number of sequences GCA GCB C D No of mutations (% of length) Figure 40 35...
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Báo cáo khoa học: "Probing the link between oestrogen receptors and oesophageal cancer" ppt
... Page of 10 Rashid et al World Journal of Surgical Oncology 2010, 8:9 http://www.wjso.com/content/8/1/9 Page of 10 Figure Pathways of oestrogen action The ERa/ERb is a simplified schematic of the ... [48] The effects of various doses of E on in vitro growth of these cell lines has established that one of the cell lines (ES-25C) showed significant inhibition at concentrations of 10 -10 and 10 ... Table Studies assessing the risk of oesophageal cancer in relation to oestrogen receptors No of patients M:F PR ER-a ER-b Histological subtypes of OC Source & affinity of ER AB Significance/Dedifferentiation...
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Báo cáo y học: "Toll-like receptors and innate immune responses in systemic lupus" docx
... models of autoimmunity The importance of TLR activation has been studied in several animal models of lupus In the MRL/lpr mouse, deletion of the fas gene leads spontaneously to the development of ... lupus erythematosus The parallel discoveries of the role of TLRs in stimulating type I IFNs, of pDCs as the primary source of this cytokine, and of the IFN-signature in lupus patients by microarray ... by microarray analyses of gene expression of leukocytes from lupus patients [37,38] Leukocytes from lupus patients exhibit highly increased expression of a wide variety of genes that are known...
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Báo cáo y học: "Myeloid dendritic cells display downregulation of C-type lectin receptors and aberrant lectin uptake in systemic lupus erythematosus" pdf
... downregulation of an additional CTLR, DCSIGN, indicating a more global defect in expression of members of this family Interestingly, we detected no decrease in surface expression of CR3 or any of the ... lymphocytes Uptake of pathogenic antigens in the presence of other stimulatory signals induces DC maturation, manifested by downregulation of phagocytic receptors and upregulation of antigen-presentation ... in an inactive, highly phagocytic state at sites of potential antigen exposure Uptake of harmless environmental or self-antigens (often products of normal cellular senescence, apoptosis or necrosis)...
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Báo cáo y học: "NOD-like receptors and inflammation" pot
... promotes formation of this inflammasome [85] The appearance of flagellin within the cytoplasm, which announces the arrival of a virulent form of bacteria, prompts the development of both an adaptive ... All of these SNPs affect the LRR region of the NOD2 protein, resulting in defective sensing of MDP [121] The inability of mutant NOD2 to detect microbial constituents translates into a lack of ... versus 31%), in cohorts of patients who were broadly matched for clinical indices of severity of disease This may represent the consequences of decreased intracellular sensing of bacterial products...
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Báo cáo y học: "Toll-like receptors and NOD-like receptors in rheumatic diseases" pdf
... al The Scientific Basis of Rheumatology: A Decade of Progress This article is part of a special collection of reviews, The Scientific Basis of Rheumatology: A Decade of Progress, published to ... T, Chan JH, Guiducci C, Coffman RL: Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms Eur ... inflammatory and regulatory roles in a murine model of lupus Immunity 2006, 25:417-428 Barrat FJ, Coffman RL: Development of TLR inhibitors for the treatment of autoimmune diseases Immunol Rev 2008, 223:...
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Báo cáo y học: "Type I interferon receptor controls B-cell expression of nucleic acid-sensing Toll-like receptors and autoantibody production in a murine model of lupus" doc
... development of proteinuria in the mice, a measure of kidney disease, was therefore assessed Over the course of 12 months, of 10 (50%) pristane-treated WT mice developed proteinuria, whereas none of 10 ... hypergammaglobulinemia characterized by the production of high levels of IgG as well as increased levels of IgM [39] Importantly, pristane induces the production of high levels of IgG2a, a pathogenic isotype that ... the development of kidney damage in the pristane model of SLE Because the development of kidney disease in the pristane model is not as severe as in other spontaneous models of SLE, such as the...
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Báo cáo y học: " Bench-to-bedside review: Toll-like receptors and their role in septic shock" pps
... ever present threat of microbial pathogens The recent discovery of the TLR family now permits a detailed evaluation of the molecular pathogenesis of sepsis The availability of human and microbial ... Postreceptor signaling of the IL-1R is well understood Binding of the ligand causes receptor dimerization and, with involvement of IL-1RAP (an accessory protein), the intracellular part of the receptor ... number of phosphorylated lipids and results in the generation of the intracellular protein kinase Akt This pathway directly activates NF-κB, independent of the phosphorylation and degradation of...
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Báo cáo y học: "A3 adenosine receptors and mitogen-activated protein kinases in lung injury following in vivo reperfusion" pps
... viii = MRS1191 pretreatment before MRS3558 (100 µg/kg) and beginning of reperfusion aTissue myeloperoxidase (MPO) activity is expressed in units of MPO/g of lung weight, each of which was defined ... lack of p38 activation with reperfusion of rat lung grafts Using type II rat pneumocytes, hours of hypoxia followed by hours of reoxygenation failed to activate p38 or JNK, whereas activation of ... of EG CW performed surgical proce- • Levels of phosphorylated JNK, p38, and ERK1/2 levels are increased following hours of ischemia and hours of reperfusion • The increase in the expression of...
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Báo cáo khoa học: " Expression of cell surface receptors and oxidative metabolism modulation in the clinical continuum of sepsis" ppt
... stained with the following isotypes: 10 μl of mIgG2a-PE and μl of mIgG2b-APC (tube 1); 10 μl of TLR2-PE and μl of CD11c-APC (tube 2) or 20 μl of TLR4-PE and μl of CD11bAPC (tube 3) Samples were incubated ... expression of cell surface receptors was performed in whole blood, drawn in EDTA tubes A total of 100 μl of whole blood from patients and controls were stained with μl of CD14-PerCP and μl of CD66-FITC ... Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study Working group on "sepsis-related problems" of the...
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Báo cáo sinh học: " Developmental temperature and somatic excision rate of mariner transposable element in three natural populations of Drosophila simulans" pps
... the number of copies and the excision rate Finally, an analysis of mariner sequence in 5’ of the initiation site showed a 14-bp sequence with 50-57% of homology with promoter sequence of several ... definition of the classe The Estimation of the somatic excision rate The somatic excision rate, in each isofemale line, was estimated after a test-cross between males of the line tested and females of ... number of Mos-1 individuals decreases at 25°C and 29°C, while the average number of Mos-2 and Mos-3 individuals increases effects Average number of copies per isofemale line The average number of...
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