... Neurological TumorsLocalTreatmentof Head and Neck TumorsLocalTreatmentof Lung TumorsLocalTreatmentofBladderTumors Intraarterial IFN Therapy 108 ... LocalTreatmentof Malignant Melanoma LocalTreatmentof Breast Cancer LocalTreatmentof Cancer of the Uterine Cervix LocalTreatmentof Neurological Tumors ... XVI Systemic Treatmentof Brain Tumors XVII Systemic Treatmentof Neuroblastoma XVIII Systemic Treatmentof Prostate Carcinoma XIX Systemic Treatmentof Carcinoma of the Uterine...
... evidence III Studies with level of evidence IV DS, diagnostic studies Levels of evidence for studies of the accuracy of diagnostic tests Levels of evidence Ia Type of evidence • Ib II • • III • ... professionals and patients is essential It should be supported by the provision of evidence-based information, offered in a form that is tailored to the needs of the individual patient The treatment, ... radiotherapy should be offered sequential chemoradiotherapy A 1.8 Treatmentof small-cell lung cancer 1.8.1 Patients with SCLC should be offered an assessment that includes evaluation of the major prognostic...
... (Table 5) Crude incidence of acute GU toxicity was similar in both groups among patients with rectal cancer (Table 6) Discussion Use of IMRT in the treatmentof pelvic tumors has been increasing ... conventional RT versus IMRT in the treatmentof cervical cancer Results of these two trials will contribute to assess the benefits and risks of IMRT in patients with gynecologic tumors The most important ... considerable advantage for IMRT Because use of CT is now well established for treatmentof some pelvic tumors sites, such as the rectum, cervix, anal canal and bladder, IMRT can be very useful to reduce...
... fossa Parasellar Orbit Petroclival Goal of CyberKnife treatment Primary treatment for local disease (%) Secondary treatment (%) Previous treatment Previous craniofacial surgery Previous external beam ... responsibility for all aspects of the treatment planning and procedure, determined the minimal tumor margin dose of the target vol- ume, the treatment isodose and the number oftreatment sessions into ... challenging tumors In this retrospective study, we evaluated the efficacy and safety of staged stereotactic radiosurgery for treatmentof malignant skull base tumors, either as a primary treatment...
... side of the equation is the rate of increase of φ while the second term on the left is the net rate of flow of φ out of fluid element The first term on the right side is the rate of change of φ ... tumors (organ tumors) and liquid tumors (blood cancers) This work focuses on treatments for solid tumors The global burden of cancer continues to increase because of the growth of the world population ... Development of the ice front and the boundary of the complete ablation 77 Figure 5.16 Classification of profiles and equivalent ellipsoid: (a) classification of profile in terms of border...
... Moreover, the laparoscopic technique, one of the best examples of modern surgery, is now more widely used for the diagnosis and treatmentof pancreatic tumors including laparoscopic distal pancreatomy ... attempted because of locally unresectable disease [29] In an analysis by Shimada et al of 88 patients with extended DP, which Page of 10 (page number not for citation purposes) World Journal of Surgical ... first proposed en-bloc resection of the celiac trunk with distal pancreatectomy and total gastrectomy for the treatmentof locally advanced gastric cancer, resection of the celiac axis was proven...
... (range, 0.9 – 3.5 cm) Treatment characteristics Three equal fractions of 15 to 20 Gy were delivered in an average of days (Table 3) Treatment plans were composed of hundreds of pencil beams shaped ... Despite treatment one patient died of progressive metastatic disease at months A second single lung metastasis patient died of a myocardial infarction at 11 months without evidence oflocal or ... the shape of the tumors [22] Twenty-four patients have been treated in 24 months without notable discomfort during the treatment procedure With a median follow-up of 12 months the crude local control...
... limit of pore size in the BBTB of the microvasculature of early, less mature and smaller malignant brain tumor colonies is to nanometers lower than that of the BBTB of the microvasculature of late, ... randomized trial of surgery in the treatmentof single metastases to the brain New England Journal of Medicine 1990, 322:494 Jellinger K, Volc D, Grisold W: Multimodality treatmentof malignant gliomas ... Delivery of herpesvirus and adenovirus to nude rat intracerebral tumors after osmotic blood-brain barrier disruption Proceedings of the National Academy of Sciences of the United States of America...
... T3/T4 and/or N1/N2 tumors [1,2] The strategy of performing preoperative instead of postoperative treatment, has the proven advantages of lower acute toxicity [3-6], lower total dose of radiation needed ... subject of controversy One of the most important controversies is whether the degree of downstaging warrants this type of surgery [1] Results of the German (CAO/ARO/AIO 94) randomized trial of preoperative ... Results Neadjuvant treatmentOf the 101 patients treated, (6.9%) did not complete the prescribed dose of preoperative RT because of persistent neutropenia and/or diarrhea Of these, two died due...
... single measure of how well the treatment dose distribution of a specific radiation treatment plan conforms to the size and shape of the target volume In general, the conformity index of a given radiosurgical ... simultaneous irradiation of multiple lesions The lack of a requirement for the use of a head-frame allows for staged treatment Since the planning system has access to a large number of potential non-isocentric ... appropriate treatment option for many patients [5] However, single-fraction radiosurgical treatment may be difficult because of the potentially large size and irregular shapes of these tumors Their...
... analysis of the number of attached cells in rabbits Full-thickness osteochondral defects (5 mm × mm wide, mm deep) were created in the trochlear groove of the femurs of adult rabbits The distal end of ... small portion of the cells adhered to the cartilage defect Injection of more cells would increase the number of cells that adhered to the defect; however, the injection of a large number of cells ... sections of the repaired tissue were analyzed using a grading system consisting of five categories (cell mor- 15 aTotal smooth area of the reparative cartilage compared with the entire area of the...
... cause of death and different treatment groups Our analysis reveals 27 of 60 patients with no attempt at local control, died of myeloma This ratio of progression to myeloma was similar in other treatment ... the impact oflocaltreatment on disease progression in patients with skeletal plasmacytoma Specifically, the study sought to establish the incidence of development of myeloma and the treatment ... for cases of myeloma as plasma- Figure Survival stratified by LocalTreatment Overall Overall Survival stratified by LocalTreatment cytoma In order to overcome this problem, the use of MRI in...
... from the date of completion oftreatment to the last date of follow-up or the date of death Actuarial local control and overall survival were calculated using the Kaplan-Meier method Treatment Delivery ... high dose Figure Kaplan-Meier plot oflocal control per fraction Furthermore, within months oftreatment there was no evidence oflocal tumor progression and the local control rate at year was 63% ... the response to treatment in solid tumors European Organization for Research and Treatmentof Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada J Natl...
... tight dose fall-off in the area of vertebral body invasion Figure demonstrates the sharp fall-off from the treatment dose of 74 Gy (red) to the approximate spinal cord tolerance dose of 50 Gy (purple) ... accuracy of fiducial markers with the use of other forms of IGRT Watchman et al [10] compared KV X-ray imaging and fiducial marker matching for the set-up of 18 treatment fractions of stereotactic ... weeks after treatment was completed A CT scan of the chest and abdomen obtained 10 months after radiation treatment showed stable soft-tissue asymmetry in the mediastinum, with no evidence of recurrent...
... Function efficacy of small molecules on stiffness of ASM at the level of a single living cell Figure S2: Modulation of pCofilin-14-3-3 protein interactions A potential mechanism of action of small molecules ... Phosphorylated cofilin is bound to 14-3-3 proteins [20-22] and, in human ASM, PKA-activated phosphorylation of HSP20 is associated with dephosphorylation of cofilin and subsequent loss of actin stress ... analogs of HSP20 (pHSP20) co-precipitate with a class of 143-3 proteins and, moreover, competitively inhibit the binding of phosphorylated cofilin to 14-3-3 proteins Using SPR-based evaluation of...
... control of physiological variables as well as therapeutic modalities is of the outmost importance [9] The use oftreatment bundles’ could be a further necessary step in the direction of optimal ... phases of ALI, how can it be assessed in order to initiate heparin administration as rapidly as necessary? How can dosage of the drug be titrated to achieve maximal local effects without the risk of ... Critical Care Vol 12 No Suter The translation of a potentially beneficial effect of inhaled heparin in experimental models of ALI to clinical practice has not yet been achieved; important...
... I is Professor of Clinical Psychology in the Department of Psychology at the University of Montreal Fearing Others The Nature and Treatmentof Social Phobia Ariel Stravynski University of Montreal ... disruptive social anxiety are features of the lives of many thousands of people But exactly what is social phobia? What causes it? What is its nature and what kinds of treatments can improve it? Using ... and ways of testing them 81 5.3 Reliability: agreeing about the entity of social phobia 86 5.4 Predictors of response to treatment 95 5.5 Social phobia in the family 99 5.6 Association of social...
... by insufficient treatmentof AF or, on the contrary, is caused by adverse effects of the treatment, however, is too realistic to be ignored All we have stated about the treatmentof AF in MICU ... 80% of patients with AF convert to SR within 24 hours The use of β-blockers before the start of AF and the absence of diabetes and left ventricular hypertrophy were independent predictors of conversion ... disease and other nosocomial complications Can treatmentof atrial fibrillation improve survival? There are few data on the effect oftreatmentof AF on mortality in ICU patients A meta-analysis...
... Antipsychotics [29] Initiation ofTreatment First Year ofTreatment Duration ofTreatment • Baseline fasting glucose level • Fasting glucose level every 3–4 months • Observe for signs of hyperglycemia • ... of our patients develop renal disease, psychiatrists must be aware of the effects of psychotropics on the kidneys, as well the effects of decreased renal functioning on the pharmacokinetics of ... bioavailability of free, active highly protein-bound drugs Accumulation of active hydroxylated metabolites of carbamazepine may lead to symptoms of drug toxicity despite therapeutic drug levels [70] Of all...
... mind, in the presence of adherent scars, after having infiltrated the whole area with a solution of Lidocaine 0.5% and Epinephrine 1:200,000 very close to one of the two edges of the scar, a small ... that brings great improvement to the treatmentof depressed scars AUTHORS' CONTRIBUTIONS FI: participated in the surgical treatment and in the follow-up of this patient MT: drafted the manuscript ... literature FMA: participated in the surgical treatment and in the follow-up of this patient MM: participated in the design of this case study and in the follow-up of this patient ADI: revised the literature...