list of recently approved new drugs and combinations in india during 1999 july 2006

Báo cáo y học: "A hidden reservoir of integrative elements is the major source of recently acquired foreign genes and ORFans in archaeal and bacterial genomes" pdf

Ngày tải lên : 14/08/2014, 21:20

... of ORFans in CAGs: ORFans in CAGs of viral origin (red); ORFans in CAGs of plasmid origin (green); ORFans in CAGs of viral/plasmid origin (yellow); ORFans in CAGs of cellular origin (blue); and ... of likely virus origin 875 (25.1% of all ORFans inside CAGs) Number of ORFans in CAGs of likely plasmid origin 680 (19.5% of all ORFans inside CAGs) Number of ORFans in CAGs of likely virus and ... proportion of identified CAGs of viral origin (red); proportion of newly identified CAGs of viral/plasmid origin (yellow); proportion of newly identified CAGs of cellular origin (blue); proportion of newly...

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Báo cáo y học: " Recently published papers: New evidence for old debates, new drugs and some timely reminders" pps

Ngày tải lên : 12/08/2014, 19:21

... subject of troponin, it is encouraging to find a little light being shed on the difficulties of its meaningful interpretation It has been observed that troponin levels are elevated in the presence of ... of outcome, a composite of death and myocardial infarction within 30 days, in a large cohort of patients (n = 7033) with suspected acute coronary syndrome and both normal and reduced creatinine ... sequelae of all the commonly used doperminergic drugs On a final cardiac note, the encouraging results of a trial of ibutilide as second-line therapy in the treatment of atrial fibrillation in the...

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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 17)

Ngày tải lên : 18/10/2013, 00:15

... sampling until injection to GC, and from the standard solution to a test specimen) In principle, the sampling, extraction and GC analysis should be made at low temperature, in a gastight state and ... measurements of inorganic nitrite in blood seem useless for assessment of toxicity of alkyl nitrites The most useful indicator of alkyl nitrite poisoning is methemogloblin concentrations in blood; ... kept airtightly in a refrigerator A 5-µL volume of the above solution is placed using a microsyringe in a glass vial containing mL of dimethyl sulfoxide (DMSO), capped airtightly and mixed well...

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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 67)

Ngày tải lên : 18/10/2013, 00:15

... form of VX The absorption of VX through the eye mucosa and the skin results in its poisoning In the murder terrorism with VX taking place in Osaka, Japan, 1994, VX was sprayed on the back of the ... procedures including various documents clarifying the purpose of its use are required VX and its decomposition products d) Upon the use of t-BDMS derivatization of EMPA, the final solution containing ... containing a large amount of the derivatization reagent has to be injected into GC/MS, resulting in the marked contamination of the ion source of an MS instrument The lighting-up time for the filament...

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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 20)

Ngày tải lên : 24/10/2013, 19:15

... Cannabinoids and their metabolites GC analysis of cannabinoids in plant specimensa Reagents and their preparation • • • Extraction and purification of cannabinoids [3]: Cannabis sativa L is being ... spectra of the methyl ester plus TMS and TMS derivatives of ∆9-THC-11-oic acid The Substance Abuse and Mental Service Administration (SAMSA) in USA set the cutoff value of ∆9-THC-11-oic acid in urine ... 194 Cannabinoids and their metabolites References 1) Wall ME, Sadler BM, Brine D et al (1983) Metabolism, disposition, and kinetics of delta-9-tetrahydrocannabinol in men and women Clin Pharmacol...

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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 21)

Ngày tải lên : 24/10/2013, 19:15

... Main metabolic pathways of morphine, heroin and codeine The thick and thin arrows show the main and minor metabolic pathways, respectively ⊡ Figure 3.1 196 Morphine and its analogues GC and ... food containing poppy seeds [9] It should be noted that an amount of codeine comparable to that of morphine are also included in the poppy seed- containing foods [10] The half-life of heroin disappearance ... specimen cannot be a proof of the intake of the drug The level of morphine in urine of healthy subjects determined by GC/MS was reported to be about ng/mL [8] The poppy seeds are being used for various...

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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 70)

Ngày tải lên : 24/10/2013, 19:15

... In > Table 5.1, clinical symptoms according to the concentrations of methemoglobin are presented ⊡ Table 5.1 Clinical symptoms appearing according to methemoglobin concentrations Methemoglobin ... Cyanosis in infants caused by nitrates in well water JAMA 257:2788–2792 12) Fan AM, Steinberg VE (1996) Health implications of nitrate and nitrite in drinking water: an update on methemoglobinemia ... hemoglobin into methemoglobin; for such conversion, nitrate should be reduced to nitrite in a human body In the present case, the victim had ingested a preparation including a large amount of nitrate,...

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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 71 and End)

Ngày tải lên : 24/10/2013, 19:15

... determination of methemoglobin in blood Clin Chim Acta 30:679–682 5) Katsumata Y, Aoki M, Oya M et al (1980) Simultaneous determination of carboxyhemoglobin and methemoglobin in victims of carbon ... blood samples at the ratio of 1:1 References 1) Evelyn KA, Malloy HAT (1938) Microdetermination of oxyhemoglobin, methemoglobin and sulfhemoglobin in a single sample of blood J Biol Chem 126:655–662 ... meperidine 241 mephenytoin 351 mepindolol 373 mepivacaine 383, 387 mesaconine 461 mesaconitine 455, 459 Met-Hb 91, 655 metabolism of drugs 17 metal-plating 113 metallurgy 113 methamphetamine 171,...

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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 22)

Ngày tải lên : 29/10/2013, 01:15

... the discrepancies of results among testing institutions and to secure the accuracy of each analysis The cutoff values [9] of BE in urine for cocaine abuse being established in U.S.A are 300 ng/mL ... cocaine inhalation; the ratio was 10.6 on average for urine sampled 0–8 h after the inhalation The ratios increased according to the increase in time interval between the inhalation and samplings ... In the present case, the ratio counted 6.3, suggesting a relatively short period between the times of his ingestion and death In addition, the ratios of cocaine to BE in blood and in the brain,...

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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 23)

Ngày tải lên : 29/10/2013, 02:15

... Pentazocine Pentazocine In two autopsy cases of pentazocine poisoning, its concentrations were 9.2 and 3.3 µg/mL in blood, 43 and 34 µg/g in the liver, and not detectable and 4.5 µg/mL in urine, ... 214 (IS) and at m/z 285 plus 217 (pentazocine) were used at the retention times of 3–7 and 7–8 min, respectively The amount of pentazocine and IS spiked into mL of blank whole blood or urine was ... detection and quantitation of both therapeutic and toxic levels of pentazocine in blood The recovery of pentazocine using the Sep-Pak C18 cartridge was close to 100 % for both whole blood and urine...

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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 24)

Ngày tải lên : 08/11/2013, 01:15

... ng/mL in blood and 0.2–7.7 ng/mL in urine [4] References 1) Tu AT (1999) Principle of Toxicology – Science of Poisons – Jiho Inc., Tokyo, pp 108–109 (in Japanese) 2) The Pharmaceutical Society of ... (1992) Standard Methods of Chemical Analysis in Poisoning – With Commentary – Nanzando, Tokyo, p 43 and p 151 (in Japanese) 3) Cody JT (2000) Hallucinogens In: Bogusz MJ (ed) Handbook of Analytical ... blood and urine, because its amount to be ingested is as small as about 10 µg and LSD is rapidly metabolized in human bodies As metabolites of LSD, 2-oxo-LSD, 3-, 13- and 14-hydroxy-LSDs and an...

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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 25)

Ngày tải lên : 08/11/2013, 01:15

... catecholamine (including serotonin) release and blockade of reuptake resulting in cardiac and central nervous system effects [15] The effects of MDMA vary depending on its doses, frequency and duration ... determination of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxymethamphetamine, and 3,4-methylenedioxyethylamphetamine in urine by solid-phase extraction and GC-MS: ... rings, HMMA and HMA, were detected in the urine sample (HHMA not monitored) The mass spectra of TFA derivatives of MDMA and its three metabolites obtained from the urine specimen are shown in...

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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 26)

Ngày tải lên : 08/11/2013, 01:15

... If the remaining volume of dichloromethane containing cyclized GHB is more than 100 µL in the vial, the proportion of dichloromethane gas, being contained in the headspace vapor to be injected ... production of GHB is slower in cerebrospinal fluid, vitreous humor and urine than in blood Villain et al [21] and Elliott [31] have tentatively set positive cutoff limits of GHB at 50 and 30 µg/mL ... in antemortem urine and blood Forensic Sci Int 128:120–122 25) LeBeau MC, Christenson RH, Levine B et al (2002) Intra- and interindividual variations in urinary concentrations of endogenous gamma-hydroxybutyrate...

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