list of food that is bad for your skin
Báo cáo khoa học: Replacement of two invariant serine residues in chorismate synthase provides evidence that a proton relay system is essential for intermediate formation and catalytic activity docx
Ngày tải lên :
07/03/2014, 05:20
... structure of the enzyme, we propose that Ser16 and Ser127
form part of a proton relay system among the isoalloxazine ring of FMN,
histidine 106 and the phosphate group of EPSP that is essential for ... product dissociation, this internal proton relay
system can be reloaded, leading to protonation of
His106, such that the enzyme is ready for the next sub-
strate turnover.
In this mechanism, His106 ... active site of the enzyme. Based on
this structural information we performed our first
mutagenesis study where we investigated the role of
two conserved histidine residues (His17 and His106),
revealing...
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The Six Driving Forces That Affect Your Business Plan _ And How to Focus on the Best One for Your Company’s Needs
Ngày tải lên :
24/10/2013, 09:20
... people for taking
care of the properties. Disney World is famous for the cleanliness
of its properties. The structure is highly disciplined in the care and
feeding of the physical plant. Disney ... need for a single focus is very consistent with the intent of this
book—to help you describe your story in congruent, authentic, and
believable form. The internal integrity of your story is destroyed
when ... or Motel 6? Don’t for-
get Blockbuster Video or that string of rental companies just down
the street that can rent you everything from art for your offices to
mattresses for your beds at home....
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Tài liệu Báo cáo khoa học: Myristoylation of the dual-specificity phosphatase c-JUN N-terminal kinase (JNK) stimulatory phosphatase 1 is necessary for its activation of JNK signaling and apoptosis pdf
Ngày tải lên :
16/02/2014, 14:20
... phosphorylation of the p46 isoform of JNK,
whereas sorbitol treatment induced phosphorylation of
both the p46 and p55 isoforms. To confirm functional
activation of the JNK signaling pathway, we per-
formed ... system, as the presence of the SV40 large
T antigen in these cells enhances their resistance to
apoptosis.
Apoptosis is a tightly regulated mechanism for the
disposal of damaged cells and to ... suggest that JSP1
induces apoptosis when overexpressed in cells, and fur-
ther demonstrate the importance of myristoylation for
this functional activity of JSP1.
It is reasonable to suggest that...
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Tài liệu Báo cáo khoa học: Mitogen-activated protein kinase phosphatase-1 modulated JNK activation is critical for apoptosis induced by inhibitor of epidermal growth factor receptor-tyrosine kinase pdf
Ngày tải lên :
18/02/2014, 13:20
... treatment,
indicating that the expression of MKP-1, but not that
of MKP-2, is controlled by signals via EGFRs.
Brondello et al. reported that activation of the ERK
cascade is sufficient to promote the expression of
MKP-1 ... FasL system may be one of the mechanisms
responsible for drug-induced apoptosis in a variety of
cancer cells of different histotype [51]. Chang et al.
recently reported that an increase in Fas ... inhibitors. Here, we demon-
strate that JNK-phosphatase MKP-1 expression is con-
trolled by a signal downstream of EGFR and that if
this signal is abolished by an inhibitor of EGFR tyro-
sine kinase,...
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Tài liệu Managed Investment Funds Product Disclosure Statement - A range of funds that allows you to create an investment portfolio that suits your individual needs ppt
Ngày tải lên :
19/02/2014, 09:20
... 24.
All of the funds in this PDS are subject to some or
all of these risks which can also vary from time to
time. You should consult your financial adviser before
making a decision to invest. Your ... options.
Role of your financial adviser
Your financial adviser may play a large role in implementing
your financial plan and can assist you to meet your financial
needs. We have therefore designed ... situation. Distribution dates should be checked prior to
transacting on your account.
Receiving income
Any income that you receive from your investment will be in the form of distributions.
Your distribution...
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Tài liệu Báo cáo khoa học: AcmA of Lactococcus lactis is an N-acetylglucosaminidase with an optimal number of LysM domains for proper functioning ppt
Ngày tải lên :
19/02/2014, 18:20
... specificity.
AcmA is the major autolysin of the Gram-positive
bacterium Lactococcus lactis ssp. cremoris MG1363.
AcmA is required for cell separation and is responsible
for lysis in the stationary ... part of the putative active center
of this peptidoglycan hydrolase that is essential for flag-
ellar rod formation [10]. In the sequence of the genome
of L. lactis IL1403 genes putatively encoding ... concomitant lysis of the cell.
A minimum of three repeats is needed for this to
occur: derivative A2, containing two LysM domains
is not able to lyse cells in trans , whereras derivative
A4 is. Lysis does...
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Tài liệu Báo cáo khoa học: Nop53p, an essential nucleolar protein that interacts with Nop17p and Nip7p, is required for pre-rRNA processing in Saccharomyces cerevisiae pdf
Ngày tải lên :
20/02/2014, 01:20
... responsible for the formation of
the mature 5.8S rRNA, indicates that this novel pro-
tein is important for proper exosome function.
During the final preparation of this article a study
was published ... used for image acquisition and the
confocal software used for image analysis.
Acknowledgements
We would like to thank the following people for their
support during the development of this work: ... Ana-
lysis of rRNA processing showed that depletion of
Nop53p leads to an accumulation of the 27S and 7S
pre-rRNAs, confirming a role for Nop53p on late steps
of processing. Accumulation of unprocessed...
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Tài liệu Báo cáo Y học: The insert within the catalytic domain of tripeptidyl-peptidase II is important for the formation of the active complex potx
Ngày tải lên :
21/02/2014, 15:20
... surrounding
Arg252 is of importance for the formation of the oligomeric
enzyme complex, which is a prerequisite for obtaining a
fully active enzyme [8,15]. Upon removal of this entire
region (amino ... is
demonstrated that the fo rmation of the active complex is
profoundly influenced by a single amino acid difference, i.e.
G252R, in a region within the catalytic domain. This is the
first evidence that this ... the exact mechanism for
complex formation and activation of the enzyme remains
to be determined, it can be concluded that the insert
within the catalytic domain is of importance for oligome-
rization.
ACKNOWLEDGEMENTS
This...
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Tài liệu Báo cáo Y học: Phosphorylation of initiation factor-2a is required for activation of internal translation initiation during cell differentiation ppt
Ngày tải lên :
22/02/2014, 07:20
... initiation.
Translation of eukaryotic gene expression is controlled both
by global mechanisms that affect the overall rate of protein
synthesis and by selective control mechanisms that affect the
translation of subsets ... we showed that utilization of the weak
IRES of platelet-derived growth factor (PDGF2) is activated
during megakaryocytic differentiation. The establishment of
permissive conditions for IRES-mediated ... whether
phosphorylation of eIF2a is involved in IRES activation.
In this study we show that: (a) not only are differentiation
conditions permissive for the recruitment of the PDGF2
IRES, but also for the vascular...
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Báo cáo khoa học: N-Glycosylation is important for the correct intracellular localization of HFE and its ability to decrease cell surface transferrin binding pptx
Ngày tải lên :
06/03/2014, 22:21
... the accumulation of forms of
the mutant proteins that were of lower apparent
molecular mass and of similar size to the unglycosy-
lated form of the wild-type protein (see Fig. 2B for
single mutants ... N-glycosylation is important for HFE regula-
tion of transferrin uptake. To this end, transfected
HuTu80 cells expressing HA-tagged forms of wild-type
or mutant HFEs were analysed for their ability ... endoglycosi-
dase H-resistant HFE isoforms can be detected by
30 min post translation [10,13,18,23]. Although these
studies demonstrate that HFE is glycosylated, the
specific role, if any, that glycosylation...
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- tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam
- điều tra đối với đối tượng giảng viên và đối tượng quản lí
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- nội dung cụ thể cho từng kĩ năng ở từng cấp độ
- xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct
- phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ
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