leveraging structural information for the discovery of new drugs computational methods
Tài liệu Developing Culturally and Linguistically Competent Health Education Materials: A Guide for the State of New Jersey ppt
... prescriptions for improving the quality of life The differences are between perspectives: the individual and the societal; the negative and the positive; the curative and the preventive; the reductivist ... tremendous implications for material development 23.9% of the foreign-born population of New Jersey lives in linguistic isolation (About 19.5% of the population of New Jersey is foreign-born) A linguistically ... which the client/family is at the center and controls the flow of information The educator asks questions and listens thereby allowing the client/family to lead the discussion based on their...
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Tài liệu Báo cáo khoa học: "Incorporating Context Information for the Extraction of Terms" pdf
... ) otherwise (2) where a is the examined string, lal the length of a in terms of number of words, f(a) the frequency of a in the corpus, Ta the set of candidate terms that contain a, P(T~) the ... presents the higher density on terms among any other part of the list This top of the list, or else, the 'first' of these ranked candidate terms will give the weights to the context We take the top ... the number of these candidate terms At this point the incorporation of the context information will take place Step 3: Since C-value is a measure for extracting terms, the top of the previously...
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The importance of project management in small- and medium-sized enterprises (SMEs) for the development of new products through E-collaboration docx
... to h The participants were given an explanation regarding the purpose of the feedback, the purpose of the conceptual model, some background of the research that lead to the development of the ... concept (either for the company or for the customer) It includes all activities from the development of an idea or a concept for a product, to the realization of the product during the production ... collaboration, led by the project manager, the information for production of a new product will be integrated, and the project will be finished in real time Furthermore, the cost for production will...
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Báo cáo khoa học: Structural basis for the recognition of complex-type biantennary oligosaccharides by Pterocarpus angolensis lectin ppt
... second conformation of the side chain of Glu221, which also adopts two conformations but not correlated with the anomeric form of the bound mannose is shown in dark green site for subunit B The crystal ... arm in the monosaccharide binding site [34] The conformation of the GlcNAcb(1–2)Man entity occupying the )1 and M subsites of LOL roughly resembles the conformation seen in the NA2F complex of PAL ... consequence of the correlation of fitting parameters often observed for weak binding events Evidence for this stems from the reproducibility of this result as well as from the c-value used in the titration...
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Báo cáo y học: "Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies" ppsx
... reactivated in 60% of the patients tested (25 out of 42 patients) [302] These results constitute a proof -of- concept for the co-administration of (at least) two different categories of therapeutically ... Nucleotide (nt1) is the start of U3 in the 5'LTR The transcription start site corresponds to the junction of U3 and R (C) Schematic representation of the nucleosomal organization of the HIV-1 genome ... In the next parts of this review, we draw the current portrait of the epigenetic control of HIV-1 transcription and we underline the potential of some new pharmacological agents to address the...
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Novel chiral stationary phase for the enantioseparation of racemic drugs 1
... The rate at which the associated complex is formed is determined in large part by the accessibility of the guest molecule to the CD cavity and the magnitude of the net thermodynamic driving force ... community towards restricting the use of chiral drugs in their racemic form, the Food & Drug Administration of the U.S (FDA) began to regulate the marketing of racemates in new drug submissions.24, ... to these solvents increases the polarity of the mobile phase, which increases the retention of the solutes Other solvents such as tetrahydrofuran (THF), dichloromethane (CH2Cl2) and chloroform...
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Novel chiral stationary phase for the enantioseparation of racemic drugs 2
... that the enantioseparations of the CD CSPs are partially attributed to the spacer which kept the cavity of the chiral molecules away from the support surface.12 The length of the attachment of the ... is the gas constant, T is the absolute temperature, and ∆G° is the difference in the free energy of the solute in the two phases, ∆H ° and ∆S ° are the enthalpy and entropy of the transfer of ... αexp is the surface concentration, %C is the percentage of carbon of the βCD CSP (from elemental analysis), MW is the relative molecular mass of the chiral ligand unit and Nc is the number of carbon...
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Liquid phase microextraction for the determination of acidic drugs and beta blockers in water samples
... for their help during the course of this project Special thanks to Xiaofeng for her insight to the project; Junie for proofreading this thesis; Elaine and Debbie for their friendship during the ... orders of magnitude in the concentration range, 0.2-200 ppb, with r2 values >0.992 for most of the analytes The RSD for these compounds were between 7.4-11.8% The LODs for these drugs were in the ... low viscosity of chloroform impeded the stability of the organic phase immobilized in the hollow fiber pores due to dissolution of chloroform in the midst of extraction n-Octanol was the only solvent...
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Báo cáo hóa học: " Research Article New Structured Illumination Technique for the Inspection of High-Reflective Surfaces: Application for the Detection of Structural Defects" doc
... See, for example, the inner parts of the “3D abrasion” image and the “2D rough” image of Figures 6(d2), 6(c1) The direct consequence is that, if all the variations of the surface normal of a structural ... difj,max ferent methods: the center -of- mass and the Blais-and-Rioux operators The first uses the distribution of the grey level to retrieve the positions of the maxima, whereas the second applies ... of a widely used real-time industrial application The core component of the algorithm is the selection and the extraction of the features best describing the image contents The first step of the...
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Báo cáo y học: "Endoscopic Facet Debridement for the treatment of facet arthritic pain – a novel new technique
... 100% relief of their pain in 86% of the patients with a median relief period of months The range of relief varied from zero days to up to 13 months for the facet injection group None of the lumbar ... median period of pain relief being months The range of relief for the radiofrequency group was from zero days to 16 months for all 26 patients who underwent the radiofrequency procedure Of the 14 patients ... that the direct visualization of the joint allows better de-innervation of the joint and removal of the entire end-plate receptors that adhere to the bone and capsular tissue Limitations of the...
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Tài liệu Response statistics for ''''New Legislative Framework for the marketing of products: proposal to align 10 product harmonisation directives to Decision 768/2008.'''' pdf
... (2.6%) B11 How you evaluate the impact of the four elements of Action recalled below on the level of compliance, safety of products and functioning of the internal market for the product categories ... 95/16/EC of 29 June 1995 on the approximation of the laws of the Member States relating to lifts Pressure Equipment Directive: Directive 97/23/EC of the 25 European Parliament and of the Council on the ... Alignment of modules: The existing text of the modules in the directives is aligned to the standard modules set out in Annex II of Decision 768/2008 D33.1 Are you notified for more than one of the...
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Tài liệu Báo cáo khoa học: "An Information-Theory-Based Feature Type Analysis for the Modelling of Statistical Parsing" docx
... and the physical position information have respectively to the predictive information quantities of the feature types z Data: Table-4 gives the evidence for the claim Table-4: the predictive information ... the influence of the structural relation and structural distance between the current node and the node that the given feature type related to has to the predictive information quantities of these ... predictive information quantity, predictive information gain, predictive information redundancy and predictive information summation The other 10% of the corpus (133,814 words) is taken as the held-out...
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Tài liệu Báo cáo Y học: Interallelic recombination is probably responsible for the occurrence of a new as1-casein variant found in the goat species potx
... indicate the position of the introns The boxes indicate amino-acid substitutions skipping of three successive exons during the course of the processing of the primary transcripts [9] At the peptide ... wonder whether the donor allele of the 5¢ part is the F allele or another allele belonging to the same B allelic lineage (excluding B1 and C), as they share the same simplified haplotype formula, ... expected for the F variant This result is the first evidence for the heterozygous status (M/F) of the individual goat milk analysed In addition to this, the HPLC profile confirms that the M variant...
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Tài liệu Một số thuốc mới chống rối loạn lipid máu (New drugs for the control of dyslipidemia) pdf
... tham khảo Tài liệu khoa học công ty dợc phẩm pfizer, MSD, Fourmier (1998 - 2004) Opie H.L: Drugs for the Heart; Edition (2001); W.B Samders Company, trang 323 350 Medline (2000 - 2004) ... ezetimibe với cholestyramin, cyclosporin Dùng riêng, rosuvastatin dễ dung nạp, kể phối hợp với fenofibrat, niacin, cholesteramin, dáng dấp an toàn tơng tự statin lu hành Chỉ định ezetimibe tăng ... "không sterol" có ích cho sức khoẻ nh dolichol, ubiliquinon (coenzym Q10) xin đọc sơ đồ Squalen synthetase xúc tác cho sinh tổng hợp cholesterol mắt xích gần cuối, chuyển farnesyl pyrophosphat sang...
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Protecting New Health Facilities from Natural Disasters: Guidelines for the Promotion of Disaster Mitigation potx
... network The Guidelines for Vulnerability Reduction in the Design of New Health Facilities • Characteristics of the health care network; 21 In the end, the selection of the site for the new health ... nearly 80 percent of the total cost of the facility is due to nonstructural components The Guidelines for Vulnerability Reduction in the Design of New Health Facilities In the course of any construction ... facilities, structural design, telecommunications, The Guidelines for Vulnerability Reduction in the Design of New Health Facilities The selection of the consultancy firms and teams of professionals for...
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Báo cáo khoa học: Identification of the structural determinant responsible for the phosphorylation of G-protein activated potassium channel 1 by cAMP-dependent protein kinase pdf
... [18] To assess the role of the S ⁄ Ts in the regulation of GIRK1 via PKA in a manner that is unbiased by the eventual contributions of the other subunits in a heterooligomer, the corresponding ... part is unique for GIRK1 among the Kir3.x isoforms Further truncations of the C-terminus revealed a 49 amino acid stretch (amino acids 362–411) that was the most prominent target for phosphorylation ... previously Plasmids for the production of recombinant protein were constructed by a PCR, where forward and reverse primers encoded the desired parts of the C- and N-termini of GIRK1 These sequences...
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Báo cáo khoa học: A novel 2D-based approach to the discovery of candidate substrates for the metalloendopeptidase meprin pot
... degrading entities [18] For example, the major role of the MMP family is the control of cellular responses critical to homeostatic regulation of the extracellular environment and the immune response ... level match-sets are the reference gels of the respective quadrants from the 2D gel sections of each condition and the four higher-level match-sets are the reference gels of the two different conditions ... selecting for cysteine-containing peptides or glycoproteins) may allow for higher resolution capacity but at the cost of information loss For example, using ICAT labelling, only pairs of intact...
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Báo cáo khoa học: NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and its antagonist Structural implications for the MHC II (I-Au)–peptide complex from docking calculations ppt
... studies of the epitope of MBP therefore we may conclude that the conformation of epitopes of the integral protein must be affected by posttranslational modifications Docking calculations of the MBP(74–85) ... was the case in water, the key characteristic of the structure of the native epitope in Me2SO is the presence of a large number of electrostatic interactions, especially in the central region of ... between the side chains of Arg78 and Glu82/Asp81 independently of the nature of the solvent (protic or nonprotic) This might come from the peptide conformation, which drives the orientation of these...
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Báo cáo khoa học: New evidence for the role of calcium in the glycosidase reaction of GH43 arabinanases pot
... that the presence of the C-terminal domain is crucial for the acquisition of the correct enzyme fold Analysis of the interactions between the two domains led us to presume that expression of the ... or in the absence of chelators (90.94 ± 7.85 UÆmg)1) These results suggest that the presence of calcium is important for the optimal activity of BsArb43B Furthermore, to determine whether the role ... to determine whether the role of the calcium is structural, thermal shift assays were performed to determine the Tm of the protein in the presence and absence of the calcium ion, using EDTA and...
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