legal and ethical issues
Veterinary Medical Specialization: Bridging Science and Medicine Volume 39 doc
Ngày tải lên :
29/03/2014, 15:20
... Issues Raised by Veterinary Specialization JERROLD TANNENBAUM I Veterinary Specialization and the Law 11 Ethical Issues Raised by Veterinary Specialization 111 Some Legal and Ethical Issues ... research, teaching, and testing Also, society has demanded improved veterinary patient care, and more attention has been paid to ethical and legal considerations in veterinary and comparative medicine ... immunological and infectious challenge (Shoenfeld and Cohen, 1987; Tomer and Davies, 1993), but also to better understand the earlier and current increases in adverse reactions to vaccines in both human and...
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Autoimmune Diseases – Contributing Factors, Specific Cases of Autoimmune Diseases, and Stem Cell and Other Therapies pdf
Ngày tải lên :
16/03/2014, 21:20
... and Stem Cell and Other Therapies disease initiation method, with a single and defined myelin peptide allows for the observation and measurement of changing T cell specificities over time (Vanderlugt ... Diseases, and Stem Cell and Other Therapies Vetsika, E K and Callan, M (2004) Infectious mononucleosis and Epstein-Barr virus Expert Rev Mol Med 6, 1-16 Vukusic, S., Van Bockstael, V., Gosselin, S and ... Diseases, and Stem Cell and Other Therapies thereby lowering the pH of the blood The combination of hyperglycemia and acidosis is called diabetic ketoacidosis and leads to hyperventilation and to...
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Báo cáo y học: "Autoantibody profiling for the study and treatment of autoimmune disease" docx
Ngày tải lên :
09/08/2014, 06:22
... against Ro52 (upper center box) and doublestranded DNA (dsDNA, lower right box) Antibodies against Candida skin test antigens (lower center box) are also detected, and serve as a positive control ... autoimmune-target tissues Once candidate autoantigens are identified, proteomics technologies can rigorously characterize the sensitivity and specificity of autoantibodies directed against candidate antigens ... disadvantage using alternative surface chemistries, and linkers to orient and to serve as spacers between antigens and the surface, particle, or tag Bead and tag systems are currently limited by the...
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Báo cáo y học: "Amplification of autoimmune disease by infection" potx
Ngày tải lên :
09/08/2014, 06:22
... T, Tanioka H, Fujita S: Detection of human herpesvirus and human herpesvirus in the submandibular gland, parotid gland, and lip salivary gland by PCR J Clin Microbiol 1996, 34:2320-2321 Lautenschlager ... Luca D, Mirandola P, Ravaioli T, Dolcetti R, Frigatti A, Bovenzi P, Sighinolfi L, Monini P, Cassai E: Human herpesviruses and in salivary glands and shedding in saliva of healthy and human immunodeficiency ... Brytting M, Bjerregaard L, Julander I, Linde A: Shedding of cytomegalovirus and herpesviruses 6, 7, and in saliva of human immunodeficiency virus type 1-infected patients and healthy controls Clin...
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Báo cáo y học: "Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination" pot
Ngày tải lên :
09/08/2014, 13:22
... inflamed tissues, may expand and effectively boost ACPA responses that may contribute to more severe and chronic disease in CIA and perhaps EAE Further investigation is needed to better understand ... encephalomyelitis (EAE) using myelin and myelin and synovial antigen arrays (a, b) Synovial and (d, e) myelin arrays were produced by printing synovial and myelin peptides and proteins in ordered arrays ... in human RA, and to determine if the evolution and/ or expansion of ACPA responses is associated with the persistence and severity of RA Citrullination exists in a variety of tissues and circumstances...
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Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx
Ngày tải lên :
16/02/2014, 09:20
... leading to hemorrhage and perivascular microgliosis and astrocytosis The Dutch and Iowa mutations both reduce the negative charge of Ab and stimulate the formation of amyloid fibrils and attachment to ... cerebrospinal fluid (CSF) and plasma of young transgenic mice and healthy human Measures in PDAPP refer to Ab 1–x, in Tg2576, APP23 and humans to the sum of Ab1–40 and Ab1–42, and in tgArcSwe they ... that metal ions like Zn2+ and Cu2+ play a role in Ab biology, and possibly in AD pathogenesis Both ions bind APP and Ab with high affinity, and stimulate Ab aggregation and oxidizing effects of...
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báo cáo hóa học: " Gait dynamics in mouse models of Parkinson''''s disease and Huntington''''s disease" doc
Ngày tải lên :
19/06/2014, 10:20
... pharmacology and physiology, data interpretation, and manuscript review TGH designed the study, and participated in the collection and analyses of data, data interpretation, and manuscript preparation and ... between the major axes of the left and right paw images during peak stance Gait data were collected and pooled from both the left and right forelimbs, and the left and right hind limbs Measures of ... light: 12-hour dark schedule with ad libitum access to food and water Handling and care of mice were consistent with federal guidelines and approved institutional protocols Experimental groups MPTP...
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báo cáo hóa học: " Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer''''s disease" potx
Ngày tải lên :
19/06/2014, 22:20
... data and constructed dendrograms AQ aided in ELISA and Bio-plex assays and collected mouse brain tissues FC oversees management of the mouse colonies MM aided in manuscript preparation and gave ... 15 fold more Aβ1–40, and 20 fold more 1– 42) but there was considerable slice-to-slice variation in soluble and insoluble Aβ levels within and between genotypes The TgAPPsw and PS1/APPsw mice express ... patient brain and show an increased production of inflammatory markers such as COX-2, PGE2 and also increased levels of the pro-inflammatory cytokines IFN-γ and IL-12, TNF-α, IL-1α, IL-1β and IL-6...
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Báo cáo y học: "The retinoic acid binding protein CRABP2 is increased in murine models of degenerative joint disease" pot
Ngày tải lên :
09/08/2014, 01:22
... dedifferentiation and DJD [21] More recently, antagonists of the retinoic acid receptors have been tested in a rheumatoid arthritis model in mice and rats and found to improve histological scores, and this ... that PMX and MTX surgeries lead to a slowly progressing arthrosis in mice and that Crabp2 represents an early and sustained marker of DJD Crabp2 expression is regulated by retinoic acid and its ... retinoic acid receptor activity by sequestering ligands and also as a vehicle to deliver ligands to the retinoic acid receptors, thereby enhancing ligand-mediated retinoic acid receptor transcriptional...
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Báo cáo y học: " Multiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune disease" pot
Ngày tải lên :
09/08/2014, 01:23
... seems to act as a negative regulator of CTLA-4 function and dissociates from CTLA-4 upon ligand binding The ligands are the dimeric CD80 and the monomeric CD86 Binding of CD80 to the divalent ... CD28 and CTLA-4 CD28 and CTLA-4 have distinct functions during T cell activation Triggering of CD28 enhances raft accumulation and the accumulation of transcription factors, such as AP-1 and nuclear ... rheumatoid arthritis (RA) and other autoimmune diseases 50 The human CD28 and CTLA-4 genes map to chromosome 2q33 and are separated by about 60 kilobases The homologies between CD28 and CTLA-4 strongly...
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Báo cáo y học: "Role of RUNX in autoimmune diseases linking rheumatoid arthritis, psoriasis and lupus" pptx
Ngày tải lên :
09/08/2014, 01:23
... involved in skeletal development [27] and has been found expressed in the skin and other epithelial tissues [27] Mice made deficient for RUNX3 develop gastric cancer, and these studies have also shown ... during embryogenesis and later found to have functions in sex determination and neurogenesis [12] A second member, named lozenge, is required for cell patterning in the eye and for hematopoiesis ... bone malformation and boneless mice; RUNX2 is therefore of Available online http://arthritis-research.com/content/6/4/169 major importance in skeletal development and in osteoblast and chondrocyte...
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Báo cáo y học: "The current status of targeting BAFF/BLyS for autoimmune diseases" pps
Ngày tải lên :
09/08/2014, 01:24
... transmembrane activator and calcium modulator ligand interactor; TWE-PRIL, a fusion protein of TWEAK (TNFSF12) and APRIL proliferative response to lipopolysaccharide or anti-CD40L stimulation and an increase ... BAFF and APRIL levels are increased in patients with systemic lupus erythematosus (SLE) [17] and correlate with titers of autoantibodies [31] and disease activity scores [32] Both BAFF and APRIL ... onset and death by 4–5 months when given before the emergence of nephritis in NZB/W F1 mice, and the combination of TACIIg and CTLA4Ig can even reverse established nephritis in this model ([26] and...
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báo cáo khoa học: " Multi-locus models of genetic risk of disease" pptx
Ngày tải lên :
11/08/2014, 12:20
... + cov(X,R)/K with cov(X,R) the genetic covariance between the proband, X , and a relative, R For individuals X and R we Wray and Goddard Genome Medicine 2010, 2:10 http://genomemedicine.com/content/2/2/10 ... locus is biallelic and is in Hardy-Weinberg equilibrium so that the frequency of wild type, carrier and homozygous risk genotypes in the population are (1 – p)2, 2p(1 – p) and p2 and x is distributed ... generations, we calculate λMZ, λSib, λOP and the recurrence risk of disease in grandchildren of affected grandparents, λOG From these we calculate H 01 (using equation 1) and H 01 ≈ 4(λOG – 1)K/(1 – K),...
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Báo cáo y học: " Coxiella burnetii as a possible cause of autoimmune liver disease: a case report" pps
Ngày tải lên :
11/08/2014, 14:20
... clinical signs and symptoms, but with persistently elevated liver enzymes Blood cultures remained sterile, and serology was negative for leptospirosis, rickettsiosis, HIV and hepatitis A, B and C Q-fever ... first draft of the manuscript All authors contributed to patient care and all corrected and improved the manuscript, and read and approved the final manuscript References 10 11 Chazouilleres O, ... cytomegalovirus and Epstein-Barr virus as disease triggers [9] Several features suggest a causal relationship between PBC and infection, such as case clustering within well-demarcated geographical areas and...
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Báo cáo y học: "B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin" pdf
Ngày tải lên :
12/08/2014, 12:20
... (BAFF) -and a proliferation-inducing ligand (APRIL) are members of the tumor necrosis factor (TNF) family and are important regulators of B-cell maturation, survival, and function [1,2] The TNF ligands ... analyses and correlation studies for the BLyS, APRIL, and heterotrimer serum levels in patients with SLE and RA, and co-wrote the manuscript JLE helped design the heterotrimer assay and assisted ... for BLyS/ APRIL heterotrimers, and endogenous levels of heterotrimers in the sera of healthy donors and patients with SLE or RA were measured and compared with BLyS and APRIL homotrimer levels in...
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Báo cáo y học: "Spleen tyrosine kinase inhibition in the treatment of autoimmune, allergic and autoinflammatory diseases'''' pps
Ngày tải lên :
12/08/2014, 15:22
... protein Syk includes two tandem SH2 domains and a tyrosine kinase domain Interdomain A is between the two SH2 domains, and interdomain B is between the tyrosine kinase domain and C-terminal SH2 domain ... rheumatoid arthritis (RA), FLSs expand in numbers, acquire immune cell features, produce proinflammatory cytokines and enzymes, and contribute to the inflammatory process and the eventual destruction ... 57%), and ACR70 (33, 40%) responses Also, significant reductions in serum IL-6 and MMP-3 levels were noted within the first week of treatment Diarrhea and other gastrointestinal adverse Pamuk and...
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Báo cáo y học: " Models of chronic obstructive pulmonary disease" pps
Ngày tải lên :
12/08/2014, 18:21
... enlargement and an enhanced compliance and mucus cell metaplasia [75] with activation of MMP-2, -9, -12, -13, and -14 and cathepsins B, S, L, H, and K in this model Parallel to protease-based and extracellular ... subepithelial fibrosis and mucus metaplasia combined with an eosinophil-, lymphocyte-, and macrophage-rich inflammation and increased hyperresponsiveness [73] Since asthma and COPD pathogenesis ... to guinea pigs, rabbits, and dogs, and also rats and mice have been used Guinea pigs have been reported to be a very susceptible species They develop COPD-like lesions and emphysema-like airspace...
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Báo cáo y học: "Animal models of copper-associated liver disease" doc
Ngày tải lên :
13/08/2014, 13:20
... lamp current 17 mA Standards used are 3, and 12 ppm prepared from 1000 ppm stock standard in 0.2 M HNO3 Peak area is read with a read delay of s, and a read time of s Standard reference materials ... transport, and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin Physiol Rev 1985, 65:238-309 DiDonato M and Sarkar B Copper transport and its alterations ... and the second case had centrilobular degeneration and necrosis In both ferrets, liver copper concentration was markedly elevated and special staining revealed copper pigment in hepatocytes and...
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Báo cáo y học: " A mechanistic model of infection: why duration and intensity of contacts should be included in models of disease spread" ppt
Ngày tải lên :
13/08/2014, 16:20
... period of one day and basic reproduction numbers R0 = 1.5, 3.0, 4.5, and 6.0 With these assumptions, the contact intensity and the shedding rate can be Table 2: Time categories and translation ... differing contact situations: Alexandersen et al [16] and Sørensen et al [17], for example, show that basing large scale simulation models on quantities, such as intensity and duration of an exposure ... the ingested dose and the infection risk as derived in Haas et al [18] and used in several other publications [22-24] Details describing how the following assumptions 1, 3, and translate into...
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Báo cáo y học: "Relationships between free radical levels during carotid endarterectomy and markers of arteriosclerotic disease"
Ngày tải lên :
26/10/2012, 10:03
... production and concentrations of MCP-1, ICAM-1, MMP-9 and oxLDL, mean values for all the OXANO concentrations measured during clamping and reperfusion and for the markers sampled before, during and ... [6] and is elevated in diabetic patients [7] Monocyte chemoattractant protein-1 (MCP-I) originates from endothelial, epithelial, and glial cells and mediates recruitment of monocytes into tissues ... regression coefficients All PCA and PLS models, as well as graphics and standard error estimates, were generated using the Simca-P 8.0 Software (Umetrics, Inc.) Anova and paired T-test were used...
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