last but not least
Báo cáo khoa học: "Last but Definitely not Least: On the Role of the Last Sentence in Automatic Polarity-Classification" pdf
... http://www.amazon.com 333 tribution of differences for last sentences (Figure 1b) is somewhat wider than (but still quite similar to) the distribution of differences for whole reviews The distribution of differences ... computational linguists should focus on the last sentences for efficient and accurate automatic polarity-classification Indeed, last but definitely not least! We are currently running experiments ... the difference between latency times is not significant, as a paired t-test could not reject the null hypothesis that those distributions have equal means, but might show some tendency We also used...
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Báo cáo y học: "Genetic polymorphism of p53, but not GSTP1, is association with susceptibility to esophageal cancer risk – A Meta-Analysis"
... Pro/Arg+Pro/Pro genotypes, compared with the Arg/Arg genotype Figure ORs (log scale) of esophageal cancer associated with GSTP1 Ile106Val for the Ile/Val+Val/Val genotypes, compared with the Ile/Ile genotype ... polymorphism and esophageal cancer, but this conclusion was consistent with Hiyama T et al’ s review.[40] These findings suggest that the GSTP1 Ile105Val genotype alone does not show any association with ... in this study & data from the same source, so selected by the latest sample size # NA: Not available & Genotypic odds ratios for homozygotes and heterozygotes Power was calculated by the DSTPLAN4.2...
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Báo cáo y học: "TPO, but not soluble-IL-6 receptor, levels increase after anagrelide treatment of thrombocythemia in chronic myeloproliferative disorders"
... with PR+F (not shown) Reliable methods for the measurement of anagrelide metabolites were not available at the time of study Effects on TPO and sIL-6R levels TPO PV and ET patients did not differ ... at start did not indicate whether a patient would obtain CR or not Likewise, there was no statistically significant difference at months between those achieving CR and those who did not (95.3±103 ... the most pronounced rise of TPO Future studies of TPO interactions with its receptor, not only on platelets but also on megakaryocytes, might yield a better understanding [9] One may ask if the...
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Five stories that are almost true, but not quite
... am not overambitious I am happy with my work I am not famous but I have independence I cannot create some of the more daring clothes that I would perhaps have been able to create in Europe but ... mistress He even wanted to buy me jewelry but I did not accept That's why I am not wearing any.” “They would add nothing to your appearance Nobody would notice them,” I said “That's sweet Don't ... himself weak and a woman cannot swallow that Had he been strong and ignored his mother and proposed on his own the next day, I would not have accepted his proposal, but at least we would have stayed...
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Tài liệu Báo cáo khoa học:Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau ppt
... able to interact, but to differing extents, with Fyn-SH3 This suggests that the results shown here are not artefactual, owing to incorrect folding of the tau mutants, at least not in the regions ... a major role in mediating interactions between tau and Fyn-SH2 However, a contribution from other tyrosines cannot be excluded, as a greater proportion of Y18F than of YallF mutant tau cosedimented ... phosphorylation of Tyr394 did not appear to influence the binding of tau to Fyn-SH2, as there was no significant difference in the amount of Y394F 2930 Fig Tau interactions with Fyn-SH3 are not influenced by...
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Tài liệu Báo cáo khoa học: Dual P2Y12 receptor signaling in thrombin-stimulated platelets – involvement of phosphoinositide 3-kinase b but not c isoform in Ca2+ mobilization and procoagulant activity pdf
... additional effects (not shown) In marked contrast, post-addition of MRS2179 did not affect the thrombin-induced Ca2+ response (Fig 1) To determine whether the P2Y12 contribution to the thrombin-evoked ... not shown) As a comparison, the general PI3-K inhibitor wortmannin was given after thrombin + ADP; wortmannin had a slower, but similar type of effect as AR-C (Fig 2B) To quantify the contribution ... either case, AR-C (but not MRS2179) suppressed the Ca2+ integral to a similar degree; 38 ± 1% and 37 ± 1% (n = 3) Thus, the P2Y12-dependent part of the Ca2+ signal with thrombin does not rely on PAR4...
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Tài liệu Báo cáo khoa học: Activated Rac1, but not the tumorigenic variant Rac1b, is ubiquitinated on Lys 147 through a JNK-regulated process docx
... not involved in contacts with any of the interacting proteins described so far, and is not affected by the 19-residue insertion in Rac1b Therefore, the impairment of Rac1b ubiquitination is not ... increase in Rac1b ubiquitination (see white bars in Fig 3A below for quantitative analysis), but did not sensitize it significantly to proteasome-mediated degradation in HEK293 cells (Fig 1D, right ... requirements for Rac1 ubiquitination, which may not be fulfilled by Rac1b pull-down C Lys147 The main target site for Rac1 ubiquitination is Lys147, a surface residue not hampered in Rac1b We first reasoned...
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Cytoskeleton reorganization mediates alpha beta integrin-associated actions of laminin on proliferation and survival, but not on steroidogenesis of ovine granulosa cells pdf
... These observations indicate that ECM components contribute to the microenvironment of GC, but their specific roles in follicular development have not yet been established LN is one of the most abundant ... ratios of LN and RGD peptides that specifically recognize the α5/ α8/ αv/ αIIb but not the α6 integrin subfamilies [35] Lastly, the consequences of inhibiting the ERK1/2 (Extracellular signal-Related ... index and pyknotic index GC proliferation and survival were assessed by measuring the thymidine labeling index (percentage of labeled cells) and the pyknotic index (percentage of pyknotic cells)...
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Blackwell Science, Ltd Group breeding dramatically increases reproductive success of yearling but not older female scrubwrens: a model for cooperatively breeding birds? ppt
... pairs for at least one comparison in ‘good’ circumstances and another (the splendid fairy-wren, Malurus splendens, Quoy & Gaimard), revealed an effect so small (1·1 increase) it was not statistically ... conditions may be even lower It is therefore not surprising that many studies have not detected group-size effects A greater ratio of effect in poor conditions does not necessarily mean that there is a ... distributions for the two classes of female were directly comparable Some females were represented in both the ‘yearling’ and ‘older’ class, which enabled pairwise comparisons (Results), but many...
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Dangerous But Not Omnipotent pptx
... East As a result of these perceived attributes, the Iranian leadership has shown a marked tendency not only to push for a greater role in regional affairs but also to exaggerate Iran’s strategic ... international s ystem but not because of its revolutionary foundations Iranian leaders no longer seek to radically reshape the regional order as they did after the revolution, but rather to raise ... Division, Center for Strategic Research, Expediency Council, 2006 14 Dangerous But Not Omnipotent In recent years, these attributes have informed a policy outlook that attaches inflated geopolitical...
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Báo cáo khoa học: Protein crystallography for non-crystallographers, or how to get the best (but not more) from published macromolecular structures potx
... symmetryequivalent contributors) is not the most useful indicator, because it does not take into account the multiplicity of measurements More elaborate versions of Rmerge have been proposed [32,33], but they ... definitive resolution, but typically it is at least an order of magnitude worse than in X-ray crystallography NMRderived models not possess any resolution and their quality cannot be assessed by ... model, but it would not be easy to convincingly build this part of the model into such a map The map quality is poor because the phases used to construct it were rather inaccurate, and does not...
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Báo cáo khoa học: H2O2, but not menadione, provokes a decrease in the ATP and an increase in the inosine levels in Saccharomyces cerevisiae An experimental and theoretical approach pot
... different concentrations of menadione (10, 30, 83, 90 and 110 mM) on cell viability (results not shown) and noticed that 83 mM menadione produced a viability similar to that evoked by 1.5 mM H2O2 ... and results not shown) Although its UV spectrum coincides with that of adenosine, both compounds are different because (a) they elute in a slightly different chromatographic position (not shown) ... 2, and mM H2O2 A concentration of H2O2 as high as mM did not change the HPLC nucleotide prole obtained with untreated cells (results not shown) In a different experiment, yeast cells were grown...
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Báo cáo Y học: Ruk is ubiquitinated but not degraded by the proteasome ppt
... 2002 Ruk is ubiquitinated but not degraded by the proteasome (Eur J Biochem 269) 3407 proteins Many ubiquitinated proteins are targeted for degradation by 26S proteasomes, but some undergo endocytosis, ... human and yeast proteins Therefore, Ub is not an optimal antigen and anti-Ub Ig rarely possess good affinity Taking this into account and that anti-Ruk Ig are not very efficient in immunoprecipitation ... [21] Taking this into account, we speculated that association of Ruk M and Ruk S with Cbl is not direct, but could be mediated via heterodimerization with the longest isoform, Ruk L In order to test...
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Báo cáo khoa học: Amyloid structure – one but not the same: the many levels of fibrillar polymorphism potx
... conditions, is a general property of the polypeptide chain [10,11] This ability not only has pathological consequences, but can be turned into good use as functional amyloid, serving as structural ... three different types of amyloid according to solid-state NMR [39] that differ from one another in subtle but distinct ways, such as variations in the mobility of the aromatic Tyr ring There is ... [33], b2-microglobulin [34], Ab [35] and glucagon [27] fibrils demonstrated that strain behavior was not limited to proteins with a prion-like sequence Recently it has been demonstrated that even small...
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Báo cáo khoa học: Insulin is a kinetic but not a thermodynamic inhibitor of amylin aggregation pot
... long-term incubation These results indicate that insulin may be not only a natural inhibitor of amylin aggregation, but also a contributor to the amyloid formation and pathogenesis of T2D We also ... caseins during their fibrillation Altogether, these results indicate that insulin is a kinetic but not a thermodynamic inhibitor of amylin aggregation, and insulin can eventually promote fibril ... formation However, our study demonstrates that insulin itself does not act simply as a natural inhibitor of amylin aggregation but has opposite influences on amylin aggregation during different...
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Báo cáo khoa học: Novel isoenzyme of 2-oxoglutarate dehydrogenase is identified in brain, but not in heart potx
... signal transduction Regulated by thioredoxin, OGDHC is at the intercept of not only energy production and glutamate turnover, but also mitochondrial production ⁄ scavenging of reactive oxygen species ... et al the distribution of OGDHC activity between the supernatant and the detergent extract of the broken mitochondria pellet Mitochondrial disruption with the probe sonicator did not reproducibly ... E3 level, under standard assay conditions we did not observe any activation of brain OGDHC in the presence of or following preincubation with at least a 10-fold protein excess of E3 (commercial...
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Báo cáo khoa học: The activation of gelsolin by low pH The calcium latch is sensitive to calcium but not pH docx
... is not reduced by low pH It is possible therefore that in pH-activated gelsolin, the helical latch may be the last event to occur being triggered not by direct disruption of the interface but ... activation of gelsolin Deletion of the last 23 residues from the C-terminus of gelsolin for example, reduces the requirement for calcium in activation but does not abolish it totally [39] Also, it ... similar to those obtained at pH 7.5 It appears that the interaction between G2 and G4–6 is calcium but not pH sensitive Fig Binding of G4–6 domain with 159–193 and 197–226 fragments derived from gelsolin...
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Social capital and Health status: a protective impact among elderly or inactive but not among active ? doc
... three groups: “individuals who report having autonomy”, “individuals who report not having autonomy” and lastly not applicable question” As previously, the descriptive analysis proves some differences ... nationality and country of birth And lastly, the “second-generation migrant” group represents individuals who are not foreigner born abroad and whose at least one parent is a foreigner born abroad ... best health category This population does not combine a paid job and have fewer familial constraints so that they not have a multiple roles burden They not have to cope with many expectations and...
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Báo cáo Y học: The C-terminal region of ammodytoxins is important but not sufficient for neurotoxicity pot
... to bind to these AtxA-binding proteins, but were not toxic Our results show that F24 and the last 26 amino acid residues of potently neurotoxic AtxA are not enough to transform a nontoxic sPLA2 ... which are spatially close to the C-terminal residues contribute to this interaction Substitution of N24 by F in the second chimera did not significantly influence binding to each of the three Atxs-binding ... with the 14 residues differing from the corresponding AtnI2 region distributed mainly on the molecular surface (Fig 2), did not induce any substantial conformational changes in the protein fold...
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Báo cáo sinh học: " The E5 protein of the human papillomavirus type 16 down-regulates HLA-I surface expression in calnexin-expressing but not in calnexin-deficient c" pptx
... surface expression in calnexin-containing but not in calnexin-deficient cells HPV16 E5 decreases HLA-I surface expression in calnexin-containing but not in calnexin-deficient cells CEM-C7 (calnexin) ... M2-AU1 D M3-AU1 10 m Figure HPV16 E5, M2 and M3 mutants but not M1 mutant strongly co-localize with calnexin HPV16 E5, M2 and M3 mutants but not M1 mutant strongly co-localize with calnexin HaCaT ... showing that HPV16 E5 down-regulates cell surface expression of HLA-I in calnexin-expressing but not in calnexin-deficient cells We http://www.virologyj.com/content/4/1/116 further show that...
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