last but not least my family is really the biggest motivation for me my parents and my brother always encourage me when i have stress and difficulty i would like to send them great love and gratefulness
Báo cáo khoa học: H2O2, but not menadione, provokes a decrease in the ATP and an increase in the inosine levels in Saccharomyces cerevisiae An experimental and theoretical approach pot
... characteristics, the maximum velocities in the direct (V8d, synthesis of ATP) and in the reverse (V8r, synthesis of ADP) directions were mathematically adjusted, using the MATHEMATICA-3.0 program (to ... situation in which V8d ẳ V8r ẳ Together, the graphs depicted in Fig 6BF show that the inhibition in the rate of synthesis of ATP from ADP is accompanied by an increase in the rate of synthesis of Ino, ... enzymes participate in vivo), these results would indicate that H2O2 diminishes the rate of synthesis of ATP, probably through inhibition of glycolysis It is worth noting that H2O2 has no appreciable...
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Báo cáo khoa học: "Last but Definitely not Least: On the Role of the Last Sentence in Automatic Polarity-Classification" pdf
... position which best benefits such processing is text initial; it facilitates processing of oncoming propositions (with respect to the DT) relative to when the DT is placed in text final position ... while number indicates that the reviewer was unsatisfied with the product and did not recommend it.” In the second experiment, in addition to the psychological experiment, the latencies following ... of the distribution of differences between the authors’ and the readers’ ratings of the texts are presented in Figure 1: The distribution of differences for whole reviews is (unsurprisingly) the...
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Báo cáo y học: "Genetic polymorphism of p53, but not GSTP1, is association with susceptibility to esophageal cancer risk – A Meta-Analysis"
... study, the OR is plotted on a logarithmic scale against the precision (the reciprocal of the SE) Discussion The GSTP1 gene, which encodes the GST π isoenzyme, is the most important form in the esophagus.[35] ... it is reasonable to hypothesize that the GSTP1 Ile105Val polymorphism may be at best a modifier for esophageal cancer by interactive with some lifestyle and dietary habits, but is not a significant ... stratification analysis by ethnicity The χ2-based Q statistic test was used for the assessment of heterogeneity, and it was considered significant for P < 0.05 We used the fixed-effects model and...
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Tài liệu Báo cáo khoa học: Activated Rac1, but not the tumorigenic variant Rac1b, is ubiquitinated on Lys 147 through a JNK-regulated process docx
... as indicated with proteasome inhibitor MG132 (Sigma, St Louis, MO, USA), the protein synthesis inhibitor cycloheximide (Sigma), and the JNKspecific inhibitor SP600125 (Sigma) Cells were transiently ... position 75–76 induces significant changes in the GTP-binding and 390 effector-binding regions, i. e an open switch I conformation and a highly mobile switch II, but does not interfere with the ... association with guanine nucleotide dissociation inhibitors, and a GTPbound form localized on various membranes and mediating interaction with specific effectors to activate downstream signaling pathways...
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Báo cáo Y học: Ruk is ubiquitinated but not degraded by the proteasome ppt
... ubiquitin Ubiquitination of all three isoforms of Ruk indicates that ubiquitin conjugation occurs at the C-terminal region, which is common between them It is well established that ubiquitin is ... are in complex with Cbl and are ubiquitinated, Cbl is a potential E3 ligase responsible for ubiquitination of Ruk isoforms This hypothesis is currently under investigation The discovery of Ruk isoform ... a coiled-coil domain Numerous studies have implicated coiled-coil domains in mediating protein–protein interaction via homodimerizations and heterodimerizations [21] Taking this into account,...
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Báo cáo khoa học: Insulin is a kinetic but not a thermodynamic inhibitor of amylin aggregation pot
... lower light scattering intensity, indicating the inhibitory effect of insulin on amylin aggregation in this time period This inhibitory effect is also shown in Fig 3A We also employed a thioflavin ... Incubation time before addition of inuslin (h) Fig Insulin facilitates amylin aggregation by interacting with amylin monomers or oligomers rather than preformed fibrils The concentration of amylin ... normally in T2D patients, the inhibitory ability of insulin exists for only a limited time period, and the promotional effect of insulin on amylin aggregation may begin to appear This promotional...
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Báo cáo khoa học: Novel isoenzyme of 2-oxoglutarate dehydrogenase is identified in brain, but not in heart potx
... activity yield is the ratio of the total activity of OGDHC in the eluate to the total activity of the OGDHC applied to the column ND, not determined Dissociation of E1o from OGDHC Dissociation ... isoform and its implication in brain metabolism Distinguishing proteins with highly similar primary structures, such as the products of alternative splicing or of different genes (isoforms or isoenzymes), ... conditions when the overall activity remained membrane bound, the component activity was solubilized This indicates that the mitochondrial disruption detected by the component activity is not...
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Báo cáo khoa học: The activation of gelsolin by low pH The calcium latch is sensitive to calcium but not pH docx
... the possibility of a pH sensitivity in the interaction of the G4–6 domains with the G2 domain by two independent methods In ELISA experiments, G4–6 domains were coated onto plastic and the binding ... similar but distinct set of ionpair exchanges, presumably initiated at histidine residues, that also disrupts interdomain bonds but not those formed through the G2–6 interface Methods Proteins ... Pope, B., Maciver, S & Weeds, A.G (1995) Localization of the calcium-sensitive actin monomer binding site in gelsolin to segment and identification of calcium-binding sites Biochemistry 34, 1583–1588...
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Báo cáo Y học: The C-terminal region of ammodytoxins is important but not sufficient for neurotoxicity pot
... ligated into pUC19 The BamHI/BstBI fragment (coding for N1–F106 of AtnI2) was excised from this cloning vector and inserted, together with the BstBI/HindIII fragment (coding for Arg107–Cys133 of the ... critically involved in binding to R180, as the binding affinities of AtnI2 and both chimeras for this M-type sPLA2 receptor were similar This is also in line with the proposed structural elements ... [21–23] The same region is also involved in the high-affinity binding of these toxins to R25 and CaM In contrast to AtnI2, both AtnI2/ AtxA(K108N) chimeric proteins were able to bind to these AtxA-binding...
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báo cáo hóa học:" Reduced renal function is associated with progression to AIDS but not with overall mortality in HIV-infected kenyan adults not initially requiring combination antiretroviral therapy" potx
... but this availability is not yet sufficient to treat all patients who would otherwise meet current treatment initiation criteria used in resource-rich settings Thus, identifying even a relatively ... cART initiation criteria over the first year is similar to a previous Ugandan study [27] investigating the natural progression of HIV infection to WHO stage disease (26%) for those who had either ... shorter times to meeting cART initiation criteria Having an eGFR < 60 mL/min/1.73 m2 (Table 3, Model 1) was significantly associated with shorter times to meeting cART initiation criteria (HR,...
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Báo cáo y học: "Coaggregation of Fc RI with Fc RIIB Inhibits Degranulation but Not Induction of Bcl-2 Family Members A1 and Bim in Mast Cells" ppsx
... activation (ie, Fc⑀RI aggregation) is negatively regulated by coaggregation of Fc⑀RI with Fc␥RIIB.9,12 The release of mediators and cytokines is inhibited in a process in which Fc⑀RI contributes ... which SHIP mediates its Fc␥RIIB inhibitory function have also suggested p62dok as a possible mediator of Fc␥RIIB inhibition of Fc⑀RI signalling downstream of SHIP in mast cells.16 Fc⑀RI-mediated ... leading to Fc⑀RI signal abrogation.11,13,14 The receptors interact with the Factin skeleton that enables Fc␥RIIB to recruit SHIP1, which is provided by filamin-1 Fc␥RIIB is believed to negatively...
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Báo cáo y học: "Suppression of inflammation by low-dose methotrexate is mediated by adenosine A2A receptor but not A3 receptor activation in thioglycollate-induced peritonitis" pps
... played similar roles in regulating inflammation in the peritoneum We examined the pharmacologic mechanism by which methotrexate diminishes inflammation in the thioglycollate-induced peritoneal inflammation ... knockout mice, this increase did not achieve statistical significance Due to the high variability in the IL-10 levels we found in our experiments, it would Page of (page number not for citation purposes) ... metabolites, in addition to inhibiting folate metabolism, directly inhibit 5-aminoimidazole-4carboxamide ribonucleotide transformylase, resulting in an intracellular accumulation of 5-aminoimidazole-4-carboxamide...
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Báo cáo y học: " High sensitivity C-reactive protein is associated with lower tibial cartilage volume but not lower patella cartilage volume in healthy women at mid-life" pdf
... Development of criteria for the classification and reporting of osteoarthritis Classification of osteoarthritis of the knee Diagnostic and Therapeutic Criteria Committee of the American Rheumatism ... alcohol to this model did not significantly increase the proportion of variation in total tibial cartilage volume explained, however we retained these variables in the analysis to form our standard ... precedes clinical OA merits specific investigation If activation of inflammation is found to have a pathogenic role in OA development this could have implications as a target for preventative therapy...
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Báo cáo y học: "Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity" pdf
... further support our hypothesis that cartilage loss is reversible if the catabolic stimulation is short Similarly, the potential for reversing cartilage degradation diminishes if cytokine treatment ... factor, IGF) and without stimulation (vehicle) IGF -I significantly induced collagen type II formation at low and intermediate catabolic insult, but not at maximal insult *P < 0.05 PIINP, N-terminal ... induction The collagen type II synthesis in the identical 14-day periods with or without IGF stimulation following the three different periods of catabolic stimulation was measured by the PIINP ELISA...
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Báo cáo y học: "Rheumatoid cachexia is associated with dyslipidemia and low levels of atheroprotective natural antibodies against phosphorylcholine but not with dietary fat in patients with rheumatoid arthritis: a cross-sectional study" pdf
... Hafstrom I: Cachexia in rheumatoid arthritis is associated with inflammatory activity, physical disability, and low bioavailable insulin -like growth factor Scand J Rheumatol 2008, 37:1-8 Baylin A, ... wasting is a separate condition named sarcopenia Cachexia in chronic inflammatory diseases is suggested to be associated with increased morbidity [19] Mostly, the morbidity has been attributing the ... T, Shintani A, Raggi P, Sokka T, Pincus T, Stein CM: Prevalence of the metabolic syndrome is increased in rheumatoid arthritis and is associated with coronary atherosclerosis Atherosclerosis 2008,...
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báo cáo khoa học: " Sgt1, but not Rar1, is essential for the RB-mediated broad-spectrum resistance to potato late blight" pptx
... multiple RNAi silencing lines provide conclusive evidence that RB-mediated resistance is RAR1 independent The RAR1 protein has been proposed to be involved in forming or stabilizing the recognition ... of Mi-1-mediated potato aphid resistance, but the same plants still held the Mi-1-mediated root-knot nematode resistance These results support the hypothesis that plant R proteins differ in the ... potato This result will need to be confirmed by multiple completely silenced Sgt1 lines Requirement of the RAR1 and SGT1 proteins in disease resistance A role of the RAR1 protein in disease resistance...
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báo cáo khoa học: " Ornithine-δ-aminotransferase is essential for Arginine Catabolism but not for Proline Biosynthesis" ppsx
... However, the localisation of metabolic pathways in different compartments within the plant cell is still not satisfyingly clarified [7] Additional complications arise from the possibility of substrate ... localisation prediction of enzymes in the cytosol [3] Arg decarboxylases (ADC1 & 2), the committing enzymes for polyamine synthesis in Arabidopsis have a predicted localisation in the cytosol ... it does not seem to contribute to Pro biosynthesis Results Ornithine-δ-aminotransferase is localised in mitochondria As a first step to determine the physiological function of δOAT we determined...
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Báo cáo y học: "Suppression of the inflammatory response in experimental arthritis is mediated via estrogen receptor α but not estrogen receptor " pot
... receptor positive cells in the synovium of patients with rheumatoid arthritis and osteoarthritis: is there a link to inflammation? Ann Rheum Dis 2007, 66:53-58 Ishizuka M, Hatori M, Suzuki T, Miki Y, ... 0.05) Experimental and clinical studies have established prominent roles for TNFα, IL-6 and IL-1 inflammatory pathways in arthritis In CIA, an increase in the arthritis score of the knee joints was ... reduced inflammatory cytokine production in the synovium It remains to be established whether the data in the preclinical models can be translated to the clinical setting Discussion Our main finding...
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Báo cáo y học: " The formation of cysteine-linked dimers of BST-2/tetherin is important for inhibition of HIV-1 virus release but not for sensitivity to Vpu" potx
... cysteines in the BST-2 ectodomain can mediate BST-2 dimerization In addition to glycosylation, other predicted modifications in BST-2 arise from the ability to homo-dimerize [29] We verified this ... modification of this BST-2 mutant Glycosylation of BST-2 is not required for inhibition of virus release and sensitivity to Vpu To assess the importance of BST-2 glycosylation for the inhibition ... inhibition of virus release and for sensitivity to Vpu Glycosylation of BST-2 is not required for inhibition of virus release and for sensitivity to Vpu (A) Analysis of wt BST-2 (B) Analysis...
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Báo cáo y học: "Vpu serine 52 dependent counteraction of tetherin is required for HIV-1 replication in macrophages, but not in ex vivo human lymphoid tissue" docx
... an active CK-II for the ability of Vpu to degrade tetherin is not known Therefore, we measured Vpu-mediated tetherin degradation in the Page of 13 presence of different CK-II inhibitors (Fig 1E) ... relatively low levels of tetherin The S52A mutation in Vpu does not impair HIV-1 replication and cytopathicity in lymphoid tissue ex vivo It has been demonstrated that Vpu is critical for efficient ... replication (Fig 4A and 4B) Consistent with the results of Figure Vpu S52A is dispensable for HIV-1 replication and cytopathicity in ex vivo infected HLT Representative replication kinetics (A)...
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