... Fig 52-3) andto formulate a differential diagnosis (Table 52-4) For instance, the finding of scaling papules (present in patients with psoriasis or atopic dermatitis) places thepatientin a different ... of erythema and scaling, he or she may incorrectly assume that the erosion is the primary lesion andthe redness and scale are secondary, while the correct interpretation would be that thepatient ... with a color different from the surrounding skin This differs from a macule only in size Papule: A small, solid lesion,
... from coalescing rings or incomplete rings Pruritus: A sensation that elicits the desire to scratch Pruritus is often the predominant symptom of inflammatory skin diseases (e.g., atopic dermatitis, ... Scar: A change inthe skin secondary to trauma or inflammation Sites may be erythematous, hypopigmented, or hyperpigmented depending on their age or character Sites on hair-bearing areas may be ... associated with xerosis and aged skin Systemic conditions that can be associated with pruritus include chronic renal disease, cholestasis, pregnancy, malignancy, thyroid disease, polycythemia vera, and...
... on the lower legs are seen in this patientwith cutaneous small vessel vasculitis (Courtesy of Robert Swerlick, MD; with permission.)[newpage] APPROACHTOTHE PATIENT: SKIN DISORDER In examining ... examining the skin it is usually advisable to assess thepatient before taking an extensive history This way, the entire cutaneous surface is sure to be evaluated, and objective findings can be integrated ... lesions, the shape of individual lesions, andthe arrangement of the lesions An ideal skin examination includes evaluation of the skin, hair, and nails as well as the mucous membranes of the mouth,...
... The distribution of some common dermatologic diseases and lesions Figure 52-7 Psoriasis This papulosquamous skin disease is characterized by small and large erythematous papules and plaques with ... papulosquamous skin disease is characterized by small and large erythematous papules and plaques with overlying adherent silvery scale Figure 52-8 ...
... dermatitis In contrast, lesions with a generalized arrangement are common and suggest a systemic etiology Figure 52-9 Erythema multiforme This eruption is characterized by multiple erythematous plaques ... erythematous plaques with a target or iris morphology It usually represents a hypersensitivity reaction to drugs (e.g., sulfonylamides) or infections (e.g., HSV) (Courtesy of the Yale Resident's ... (e.g., sulfonylamides) or infections (e.g., HSV) (Courtesy of the Yale Resident's Slide Collection; with permission.) Figure 52-10 ...
... selected areas of the body In this procedure, a small area of skin is anesthetized with 1% lidocaine with or without epinephrine The skin lesion in question can be excised or saucerized with a scalpel ... dermatophyte infections, pseudohyphae and budding yeast in Candida infections (see Fig 196-1), and "spaghetti and meatballs" yeast forms in tinea versicolor The same sampling technique can be used to obtain ... biopsy Inthe latter technique, a punch is pressed against the surface of the skin and rotated with downward pressure until it penetrates tothe subcutaneous tissue The circular biopsy is then...
... allergens is applied tothepatient' s back under occlusive dressings and allowed to remain in contact withthe skin for 48 h The dressings are removed, andthe area is examined for evidence of ... lamp, and previously unsuspected areas of involvement often become apparent A Wood's lamp may also aid inthe demonstration of tinea versicolor andin recognition of ash leaf spots in patients with ... designed to assess whether a skin lesion will blanch with pressure as, for example, in determining whether a red lesion is hemorrhagic or simply blood-filled Urticaria (Fig 52-11) will blanch with...
... For the interval between birth and age 39, in 72 men andin 51 women will develop cancer; for the interval between ages 40 and 59, in 12 men andin 11 women will develop cancer; and for the interval ... behind heart disease Deaths from heart disease have declined 45% inthe United States since 1950 and continue to decline Cancer has overtaken heart disease as the number one cause of death in ... period of increases, cancer deaths began to decline in 1997 (Fig 77-2) The five leading causes of cancer deaths are shown for various populations in Table 77-2 Along withthe decrease in incidence...
... obtained from every portion of the routine history and physical examination The duration of symptoms may reveal the chronicity of diseaseThe past medical history may alert the physician tothe ... that may influence the course of diseaseand its treatment The family history may suggest an underlying familial cancer predisposition and point out the need to begin surveillance or other preventive ... on invasive tissue biopsy and should never be made without obtaining tissue; no noninvasive diagnostic test is sufficient to define a disease process as cancer Although in rare clinical settings...
... and/ or tissue adjacent tothe tumor, and inspection and biopsy of organs commonly involved indisease spread Pathologic staging includes histologic examination of all tissues removed during the ... examination, radiographs, isotopic scans, CT scans, and other imaging procedures; pathologic staging takes into account information obtained during a surgical procedure, which might include intraoperative ... genes, and genes involved in metastasis are being found to influence response to therapy and prognosis The presence of selected cytogenetic abnormalities may influence survival Tumors with higher...
... is important to remember the comfort that is provided by holding thepatient' s hand, continuing regular examinations, and taking time to talk 2 The National Cancer Institute maintains a database ... possible to gain access electronically to standard treatment protocols andto every approved clinical research study in North America through a personal computer interface withthe Internet.2 The ... physician also has much to offer thepatient for whom curative therapy is no longer an option Often a combination of guilt and frustration over the inability to cure thepatientandthe pressure of a...
... and then annually At each visit, a battery of laboratoryand radiographic and imaging tests were obtained on the assumption that it is best to detect recurrent disease before it becomes symptomatic ... consequence of thediseaseand some as a consequence of the treatment An understanding of these disease- and treatment-related problems may help in their detection and management Despite these concerns, ... persists, the multidisciplinary team discusses a new salvage treatment plan If thepatient has been rendered disease- free by the original treatment, thepatient is followed regularly for disease...
... participate inthe process, including dopamine, serotonin, histamine, opioid, and acetylcholine receptors The serotonin receptor antagonists ondansetron and granisetron are the most effective drugs against ... to indicate the severity of the pain The clinical condition is often dynamic, making it necessary to reassess thepatient frequently Pain therapy should not be withheld while the cause of pain ... chemotherapy delivery Acute emesis is the best understood form Stimuli that activate signals inthe chemoreceptor trigger zone inthe medulla, the cerebral cortex, and peripherally inthe intestinal tract...
... bleomycin or g of doxycycline is infused into the chest tube in 50 mL of 5% dextrose in water; the tube is clamped; thepatient is rotated on four sides, spending 15 in each position; and, after ... after 1– h, the tube is again attached to suction for another 24 h The tube is then disconnected from suction and allowed to drain by gravity If
... of an incurable disease, andthe goal of palliative therapy is embraced inthe hope of being able to live with disease; finally, at the disclosure of imminent death, another adjustment in outlook ... affected by the diagnosis and is coping with it is an important goal of patient management It is best to speak frankly withthepatientandthe family regarding the likely course of disease These discussions ... acceptance, and hope Of course, patients not all progress through all the stages or proceed through them inthe same order or at the same rate Nevertheless, developing an understanding of how the patient...
... speakers of all the language communities) to understand the environment, to act on the others in it, and also to interpret the relevance of the first two purposes interims of the topics under discussion ... page 80, showing the problems of theme selection (including kinds of predicator theme, adjunct theme, subject theme, non - wh theme, wh theme, etc); theme more clearly expressed inthe use of mood ... schema and instance (making up hierarchies and polysemy network); the uses of S and I in phonology, in symbolic units; the different aspects of meaning including profile, base and domain and also...
... involved withthe clinical aspects of the study All authors were involved in drafting and revising the final manuscript Key messages • Percutaneous dilational tracheostomy in patients withliverdisease ... compared with previous investigations lies inthe stringent a priori definition of refractory coagulopathy andthe sole inclusion of patients with liver- related disease processes Only patients with ... 88% in- hospital mortality in patients with cirrhosis admitted to a medical ICU The average SOFA score of the patients in this study was 13, and a third of the patients had chronic liver disease...
... drain into mucosal venules, which in turn drain into collecting venules which join to form main venules and finally drain into the portal vein except the distal rectum, which drains into the internal ... paracrine mediators Catecholamines (except liverand muscle) Catecholamines (only liverand muscle) Angiotensin II, vasopressin Cholecystokinin, secretin, gastrin Serotonin Histamine, bradykinin Platelet-activating ... small intestine and yields a value of 0.5–1.0 mmHg for Pt (in the mucosa of the rat small intestine) that increases during intestinal absorption and decreases during cholera toxin-induced intestinal...