kit stem cell factor —receptor in oncogenesis
Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer ppt
... receptor tyrosine kinase All ERBB proteins have four functional domains: an extracellular ligand-binding domain; a transmembrane domain; an intracellular tyrosine kinase domain; and a C-terminal regulatory ... regulatory domain are relatively low, being 33, 24 and 28%, respectively regulin and epigen); (b) those that bind to EGFR and ERBB4 (including betacellulin, heparin-binding EGF and epiregulin); and ... resulting in the overexpression of EGFR lacking amino acids 30–297, corresponding to domains I and II In this case, the EGFR tyrosine kinase is activated constitutively without ligand binding, as in...
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Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy doc
... continued cancer cell survival, even in the presence of upstream EGFR inhibition [7,8] EGFR mutations and sensitivity to EGFR-tyrosine kinase inhibitor therapy in non–small cell lung cancer Imatinib ... compete with ATP for binding to the tyrosine kinase pocket of the receptor, thereby inhibiting receptor tyrosine kinase activity and EGFR signaling pathways (Fig 1) Early clinical studies showed ... results in EGFR signaling pathways being turned off and the cancer cells undergoing apoptosis Moreover, EGFR mutations result in repositioning of critical residues surrounding the ATP-binding cleft...
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Asymmetric cell division in the regulation of neural stem cell self renewel in drosophila melanogaster
... cell and its surrounding cap cells (in ovary) or hub cells (in testes) is a good example of how stem cells utilizing this mechanism establishes polarity and maintains its stem cell state (Li and ... function in promoting and inhibiting stem cell self-renewal, loss of Pins function causes a reduction in neuroblast numbers in the larval brain due to occurrence of GMC/GMC siblings and in turn ... 2001) This results in two Introduction daughter cells that are distinct at birth The neural stem cells in the developing central nervous system (CNS) of Drosophila adopt this intrinsic regulation...
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báo cáo khoa học: "Hepatocyte growth factor incorporated chitosan nanoparticles augment the differentiation of stem cell into hepatocytes for the recovery of liver cirrhosis in mice" pptx
... multi-lineage engraftment by a single bone marrow derivedstem cells Cell 2001, 105:369-377 Afonso FA, Siapati EK, Bonnet D: In vivo contribution of murine mesenchymal stem cells into multiple cell- types ... stem cells regenerate the respective parenchymal cells, heading to repair of the organs in vivo is yet to be completely understood Cell fusion, in which stem cells fuse with the somatic cell in ... protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo Int J Pharmacol 2002, 249:139-147 Neuman RE, Logan MA: The determination of collagen and elastin...
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Dual roles of transcription factor zic3 in regulating embryonic stem cell pluripotency and differentiation
... greater detail in the following sections 1.2.2 Extrinsic signalling pathways maintaining ES cell pluripotency Embryonic stem cells are maintained by a network of extrinsic and intrinsic signals ... Introduction 1.1 Derivation of embryonic stem cells 1.2 Regulation of embryonic stem cells 1.2.1 The key properties of ES cells 1.2.2 Extrinsic signalling pathways maintaining ES cell ... reprogramming factors Viral infection of fibroblast cells Establishment of clonal cell lines Clonal Zic3 knockdown lines Clonal Zic3-inducible ES cells ES cell differentiation protocols Retinoic...
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Tài liệu Review of Chronic Graft- Versus-Host Disease in Children After Allogeneic Stem Cell Transplantation: Nursing Perspective pptx
... GVHD is initiated, T-cells produce additional proinflammatory cytokines, including tumor necrosis fac tor (TNF)-α, interferon (IFN)-γ, and interleukin (IL)-2, which in turn attract more T-cells ... (Th2) cells can initiate a response against autoantigens leading to B -cell hyperre activity and production of autoantibodies, causing targetorgan damage, including skin, mucosa, eyes, joints, ... Consensus recom mends a system for scoring chronic GVHD manifestations in organs and sites, including the skin, mouth, eyes, gastro intestinal tract, liver, lungs, joints and fascia, genital...
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Tài liệu INNOVATIONS IN STEM CELL TRANSPLANTATION doc
... blood cell or a brain cell During this last decade, the number of published articles or books investigating the role of stem cells in cell transplantation or regenerative medicine increased remarkably ... the recent developments in the field of basic and clinical aspects of stem cells and cell transplantation Although we are close to finding pathways for stem cell therapies in many medical conditions, ... transplanted stem cells in the host In conclusion, Cell Transplantation is bridging cell transplantation research in a multitude of disease models as methods and technology continue to be refined The...
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Tài liệu Báo cáo khoa học: Liver X receptor agonists inhibit tissue factor expression in macrophages docx
... well) as internal control using OptiMEM medium and LipofectaminePlus reagent (Invitrogen, Carlsbad, CA, USA) After transfection, cells were incubated in medium containing 10% LPDS and the indicated ... elements The TF promoter contains binding sites for AP-1, NFjB, Egr-1 and Sp1 [14] These binding sites are highly conserved in human, porcine and mouse TF genes Then, we examined the possibility 1548 ... constructs contained the region )228 ⁄ )188, which contains AP-1-binding sites (Fig 4B) Deletion of the region )188 ⁄ )181, which contains the NFjB-binding site, decreased T0901317mediated inhibition...
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Tài liệu New Advances in Stem Cell Transplantation Edited by Taner Demirer ppt
... RNA binding protein and stem cell marker Inhibitor of microRNA processing in embryonic stem (ES) and carcinoma (EC) cells Table Combinations of the genes that have been used to obtain the induced ... transcription factors into somatic cells By using these viral delivery systems, 12 New Advances in Stem Cell Transplantation Fig Methods for producing induced pluripotent stem cells (iPSCs) by non-integrating ... associated factor 1/PD2 maintains self-renewal by its interaction with Oct3/4 in mouse embryonic stem cells Stem Cells 27, 30013011 22 New Advances in Stem Cell Transplantation Rai, K., Huggins, I.J.,...
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Báo cáo Y học: GPI-microdomains (membrane rafts) and signaling of the multi-chain interleukin-2 receptor in human lymphoma/leukemia T cell lines doc
... microdomains contain, among others, a potential regulatory protein of T cell growth, CD48 A pivotal role of cholesterol in maintaining such transient protein assemblies, including also HLA glycoproteins, ... (containing CD48) may have several functional consequences in T cells First, rafts may concentrate the a chains (CD25) in the vicinity of signaling IL-2R b and cc chains, forming a common signaling ... glycoproteins in T leukemia and lymphoma cell lines (A) Representative FRET efficiency (E, %) histograms measured on T lymphoma/leukemia cell lines, on cell- by -cell basis, using flow cytometry The cell- independent...
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Báo cáo Y học: A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor pot
... 1.5 mM KH2PO4 Cell culture BaF3-cells, a murine pro-B lymphocyte line, were cultured in RPMI 1640 containing 10% fetal bovine serum, 100 mgÆL)1 streptomycin, 60 mgÆL)1 penicillin and 5% conditioned ... high affinity binding of the ligand is abrogated in this chimera, indicating that the reason for the missing signal transduction is not an incorrect spacing between the ligand binding epitopes ... possibility is an intramolecular bond between the remaining cysteines C466 and C491 of gp130 This could result in a conformational change within the receptor chain enabling the activating interaction...
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Báo cáo khoa học: The gp130⁄STAT3 signaling pathway mediates b-adrenergic receptor-induced atrial natriuretic factor expression in cardiomyocytes ppt
... minutes [10], ISO-induced STAT3 tyrosine phosphorylation was relatively delayed (it was apparent after 60 min; Fig 1A), indicating that b-AR may induce STAT3 activation in an indirect manner In ... cytokines in a wide variety of cells [21–23] The gp130 ⁄ STAT3 signaling pathway mediated b-AR-induced ANF expression b-AR-induced cardiac remodeling is closely linked to ANF expression To determine ... serine ⁄ threonine kinase, its effect on STAT3 activation, particularly the tyrosine phosphorylation, is probably an indirect action gp130 family cytokines were involved in b-AR-induced STAT3...
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Báo cáo hóa học: " Epidermal growth factor receptor gene copy number in 101 advanced colorectal cancer patients treated with chemotherapy plus cetuximab" doc
... both as single agent or in combination: a 2-hour intravenous infusion at 400 mg/m2 followed by weekly 1hour infusion of 250 mg/m2 In the GOIM study Cetuximab was administrated in combination with ... Figure PFS in four group of patients For corresponding lines see the key in figure Group A: +GCN/1st line; Group B: -GCN/1st line; Group C: +GCN/more lines; Group D: - GCN/more lines; (+: increased; ... containing only mix was run for every PCR reaction The PCR products were purified using Nucleospin Extract II Purification kit (M-Medical) Cycle sequencing was performed using BigDye Terminator...
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Báo cáo hóa học: " Modulation of the major histocompatibility complex by neural stem cell-derived neurotrophic factors used for regenerative therapy in a rat model of stroke" ppt
... neural stem cells and Schwann Cells results in functional recovery in a rat spinal cord contusion injury model Biomed Environ Sci 2007, 20:242-249 Lindvall O, Kokaia Z, Martinez-Serrano A: Stem cell ... S, Weidner N, Winkler J: Adult stem cell therapy in stroke Curr Opin Neurol 2005, 18:59-64 Li M, Decherchi P, Raisman G: Transplantation of Olfactory Ensheathing Cells into Spinal Cord Lesions ... until staining Immunohistochemistry staining Immunohistochemical staining of nestin and BrdU were performed to assess the property of NSC in cultures and track the migration and homing of allogeneic...
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Báo cáo sinh học: " Risk factors in the development of stem cell therapy" pdf
... stem cells that originate from the inner cell mass of a blastocyst stage embryo The embryonal carcinoma cells replicate and grow in cell culture conditions In 1981, embryonic stem cells (ES cells) ... by cell sorting to minimise the number of pluri/ multipotent stem cells in the cell preparation [86], or to separate tumourigenic stem cells from non-tumourigenic stem cells (by e.g cell sorting ... cultured cells, including stem cells These risk factors are not unique to stem cells and apply to all cell based medicinal products Donor history is of particular importance for stem cell lines which...
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báo cáo hóa học:" MUC4 stabilizes HER2 expression and maintains the cancer stem cell population in ovarian cancer cells" ppt
... protein in MUC4transfected ovarian cancer cells The exogenous MUC4 expression in ovarian cancer cells showed an increase in HER2 expression and colocalization, suggesting that MUC4 is involved in ... population of stem/ progenitor cells in the breast cancer (MCF7) cell line [11] The fact that the vast majority of MCF7 stem cell enriched SP cells express MUC1 suggests that epithelial cancer stem cells ... overexpressed cells behave like cancer stem cells which are capable of maintaining the self-renewal property (Figure 5) Figure Colony formation in MUC4-trasfected cells SKOV3-Vector and SKOV3-MUC4 cells...
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báo cáo hóa học: " Function, Adjustment, Quality of Life and Symptoms (FAQS) in Allogeneic Hematopoietic Stem Cell " potx
... enriched by the inclusion of subgroups that have been understudied in prior stem cell transplant survivorship research, including Spanish speakers, and individuals undergoing reduced intensity transplantation ... survey instruments and for resource management including the budget and workload management among study team members At the time of study initiation, we determined that enrolling Spanish-speaking ... physical functioning, physical role functioning, emotional role functioning, social functioning, bodily pain, mental health, vitality, and general health In addition to the individual subscale...
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