k atpase on signal transduction
Tài liệu Báo cáo khoa học: Effects of sequestration on signal transduction cascades docx
... Journal compilation ª 2006 FEBS N Bluthgen et al ¨ Effects of sequestration MAPKKKK P MAPKKK MAPKKK MAPKK MAPKK P P MAPKK P P MAPK MAPK P MAPK P Fig Sketch of the MAPK cascade A MAPKKKK stimulates ... the upstream kinases of MAPK and MAPKK are only slightly activated and can sequester only limited fractions of MAPK and MAPKK Discussion The function of the signal transduction network is to sense ... compilation ª 2006 FEBS N Bluthgen et al ¨ Effects of sequestration activated MAPK (nM) A B 50 300 200 25 100 0 MAPKKKK (nM) 0 MAPKKKK (nM) C no sustained oscillations Phophatase concentrations Fig...
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Báo cáo y học: " Effects of Liver × receptor agonist treatment on signal transduction pathways in acute lung inflammation" potx
... regulation of acute inflammation J Leukoc Biol 2006, 79(5):999-1010 Page 15 of 15 42 Choe SS, Choi AH, Lee JW, Kim KH, Chung JJ, Park J, Lee KM, Park KG, Lee IK, Kim JB: Chronic activation of liver ... Hardaker E, Wong S, Willson TM, McCluskie K, Leonard T, Farrow SN, Collins JL, Haj-Yahia S, Belvisi MG: Novel role for the liver × nuclear receptor in the suppression of lung inflammatory responses ... with SuperSignal West Pico Chemioluminescent (PIERCE) The relative expression of the protein bands of IB-a (~37 kDa), NF-kB p65 (~65 kDa), Bax (~23 kDa), Bcl-2 (~29 kDa) iNOS (~130 kDa), was...
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Báo cáo khoa học: No evidence for a role in signal-transduction of Na+/K+-ATPase interaction with putative endogenous ouabain potx
... a theme at the 10th International Conference on Na ,K- ATPase and Related Cation Pumps in Elsinore, Denmark, in August 2002 The meeting of 250 specialists on Na+ /K+ -ATPase and related topics didn’t ... demonstration of signal- transduction as ouabain-sensitive a-isoforms of Na+ /K+ -ATPase, possibly confined to membrane structures near cytosolic microdomains, would be totally blocked at ouabain concentrations ... Endogenous ouabain in normal signal- transduction? (Eur J Biochem 270) 1919 Conclusions Giving ouabain a novel physiological role in signal- transduction appears erroneous unless putative endogenous...
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Báo cáo khoa học: Action of palytoxin on apical H+/K+-ATPase in rat colon pdf
... targets not only the sodium pump but also the colonic H+ /K+ -ATPase Apparently, as with the Na+/ K+ -ATPase, the toxin converts the H+ /K+ -ATPase into an ion channel that allows cations to pass ... toxin converts the Na+ /K+ -pump into a cation channel, the cytosolic Na+ concentration will increase and finally reach the extracellular concentration, whereas the cytosolic K+ concentration will ... inhibitory action on (Na ,K) -ATPase J Biol Chem 258, 7900–7902 Habermann, E (1989) Palytoxin acts through Na+ /K+ -ATPase Toxicon 27, 1171–1187 Kodama, A.M., Hokama, Y., Yasumoto, T., Fukui, M., Manea,...
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Báo cáo khoa học: Salicylic acid and the hypersensitive response initiate distinct signal transduction pathways in tobacco that converge on the as-1-like element of the PR-1a promoter pot
... enlarged local lesions after TMV infection Once formed, lesions kept on expanding for several weeks and typically reached diameters of up to 22 mm weeks after virus inoculation on progeny plants ... gene expression by differential interaction of the mutated promoter region with different transcription complexes To seek for support for our model of distinct signal transduction pathways leading ... from lesions on control plants (B) The same leaf as depicted in A is shown The photograph was taken at 14 days postinfection (C) Close-up demonstrating discontinuous enlargement of lesions in nahG...
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Báo cáo Y học: High pressure-induced changes of biological membrane Study on the membrane-bound Na+/K+-ATPase as a model system pdf
... tritium incorporation into Na+ /K+ -ATPase are shown in Fig Tritium incor- Fig Eect of pressure on tritium incorporation into membrane-bound Na+ /K+ -ATPase Membrane-bound Na+ /K+ -ATPase was mixed ... denaturation of chymotrypsinogen and conclusions regarding the accuracy of the two-state approximation Biochemistry 9, 2294± 2301 30 Kunugi, S., Yanagi, Y., Kitayaki, M., Tanaka, N & UeharaKunugi, ... Na+ ,K+ pump Protein structure and conformations of the pure (Na+ +K+ ) -ATPase Biochim Biophys Acta 694, 27±68 11 Jùrgensen, P.L & Anderson, J.P (1988) Structural basis for E1±E2 conformational...
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Báo cáo Y học: Na+/K+-ATPase as a signal transducer Zijian Xie and Amir Askari docx
... Oguchi, A., Okada, K. , Ishikawa, S.-e., Saito, T., Kawakami, K. , Hara, Y & Shimada, K (1993) Regulation of Na ,K- adenosine triphosphatase gene expression by sodium ions in cultured neonatal rat ... sufficient for the activation of Ras/Raf/MEK/MAPK cascade Ouabaininduced activation of protein kinase C (PKC) is also required for MAPK activation [31], most likely due to PKC activation of Raf whose recruitment ... PATHWAYS L I N K E D T O C A R D I A C N A +/ K + - A T P A S E THROUGH PROTEIN–PROTEIN INTERACTIONS To date, most of the work on signal transduction by Na+ /K+ -ATPase has been carried out on cardiac...
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Báo cáo y học: " Low concentration of ethanol induce apoptosis in HepG2 cells: role of various signal transduction pathways"
... inhibition of JNK and NFκB signaling in association with a slight activation of the cell death receptor signaling In addition, ethanol also phosphorylated protein kinases belonging to signal transduction ... AR, Shukla SD MAP kinase signaling in diverse effects of ethanol Life Sciences 2004;74:2339-64 20 Shen K, Novak RF Fas-signaling and effects on receptor tyrosine kinase signal transduction in ... that was intensified by a slight inhibition of the JNK and the NFκB signaling pathway as demonstrated by a reduced phosphorylation of MEK4, IKKα, JNK and MEK6; with values of -36%, -33%, -27% and...
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Tài liệu Báo cáo khoa học: 1. Signal Transduction 1.1 Integration of Metabolism and Survival pdf
... will be presented: Kallikrein (KLK4), six transmembrane protein of prostate (STAMP1), and STAMP2 KLK4 belongs to the KLK family, which includes Prostate Specific Antigen (PSA, or KLK3), a secreted ... the auto-inhibition control Once resuming an open conformation, Syk can recruit other signalling molecules thus facilitating their phosphorylation and the propagation of the BCR signal These studies, ... m.frame@beatson.gla.ac.uk FAK expression is elevated, often at the level of gene dosage/ amplification, in epithelial cancer cells We reported the first skin-specific conditional knockout of FAK using Cre-lox...
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Tài liệu Báo cáo khoa học: The phosphatase activity of the isolated H4-H5 loop of Na+/K+ ATPase resides outside its ATP binding site docx
... Albers, R.W (2000) Contribution of quarternary protein interactions to the mechanism of energy transduction in Na+ /K+ -ATPase In Na /K- ATPase and Related ATPases (Taniguchi, K & Kaya, S., eds), pp ... Taniguchi, K. , Kaya, S., Abe, K & Mardh, S (2001) The oligomeric nature of Na+ /K+ -transport ATPase J Biochem (Tokyo) 129, 335342 13 Karlish, S.J.D (1980) Characterization of conformational changes ... Lingrel, J.B & Kuntzweiler, T (1994) Na+ ,K+ -ATPase J Biol Chem 269, 1965919662 Jorgensen, P.L., Hakansson, K. O & Karlish, S.J.D (2003) Structure and mechanism of Na ,K- ATPase: Functional Sites and...
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Tài liệu Báo cáo khoa học: Separation of a cholesterol-enriched microdomain involved in T-cell signal transduction doc
... Schuck S, Honsho M, Ekroos K, Shevchenko A & Simons K (2003) Resistance of cell membranes to different detergents Proc Natl Acad Sci USA 100, 5795–5800 25 Renkonen O, Gahmberg CG, Simons K & Kaariainen ... subpopulation after anti-CD3 stimulation X-100 concentration on the partitioning of signalling molecules into BCh-bound membranes Total raft fractions prepared with 0.2% (v ⁄ v) Triton X-100 contained ... fractions prepared at lower Triton X-100 concentration, these molecules were found exclusively in the BCh-unbound membrane fraction regardless of Triton X-100 concentration (Fig 4) Thus, the Triton...
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Báo cáo khoa học: Organizing signal transduction through A-kinase anchoring proteins (AKAPs) docx
... transcription [28] Thus, mAKAP participates in response to oxygen tension by facilitating the proteasomal degradation or stabilization of the transcription factor HIF-1a AKAP signaling AKAP-Lbc signaling ... mAKAP–PKA–PDE configuration forms a classic enzyme feedback loop because anchored PKA activity eventually leads to the termination of cAMP signals Interestingly, the same AKAP A B C D Fig mAKAP signaling ... disrupt AKAP ⁄ PKA interactions inside cells [9,10] This minireview focuses on some of the recent work elucidating the functions of selected AKAPs Three anchoring proteins (AKAP150, mAKAP and AKAP-Lbc)...
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Báo cáo khoa học: Control of transforming growth factor b signal transduction by small GTPases pot
... accumulation and signaling Cell 87, 1215–1224 Nakao A, Imamura T, Souchelnytskyi S, Kawabata M, Ishisaki A, Oeda E, Tamaki K, Hanai J, Heldin C-H, Miyazono K et al (1997) TGF-b receptor-mediated signalling ... 19008–19018 Tsuchida K, Nakatani M, Matsuzaki T, Yamakawa N, Liu Z, Bao Y, Arai KY, Murakami T, Takehara Y, Kurisaki A et al (2004) Novel factors in regulation of activin signaling Mol Cell Endocrinol ... and LIM-kinase Science 285, 895–898 131 Ohashi K, Nagata K, Maekawa M, Ishizaki T, Narumiya S & Mizuno K (2000) Rho-associated kinase ROCK activates LIM-kinase by phosphorylation at threonine 508...
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Báo cáo khoa học: The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B1 and B2 bradykinin receptors potx
... characterization of a human bradykinin (BK-2) receptor Biochem Biophys Res Commun 184, 260–268 10 Menke JG, Borkowski JA, Bierillo KK, MacNeil T, Derrick AW, Schneck KA, Ransom RW, Strader CD, Linemeyer ... play a key role in B2wt sequestration The following results from our gain-of-function approach, however, led us to conclude that additional motifs in the more B V V C KB B /V KB B 2 /S C KQ KB B ... ice for additional 30 As a baseline control one tray was left on ice with LiCl incubation buffer without agonist The EC50 was determined by adding escalating concentrations of agonist (10)12 to...
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Báo cáo khoa học: Stimulation of p-nitrophenylphosphatase activity of Na+ ⁄ K+-ATPase by NaCl with oligomycin or ATP docx
... inactivated ATPase On the other hand, omission of NaCl completely inactivated ATPase (Fig 9B) 677 Stimulation of pNPPase activity of Na+ ⁄ K+ -ATPase Fig Na+-dependent activation curves for Na+ ⁄ K+ -ATPase ... dimerization of Ca2+ -ATPase large cytoplasmic portion expressed in bacteria Biochim Biophys Acta 1467, 73–84 33 Abe K, Kaya S, Hayashi Y, Imagawa T, Kikumoto M, Oiwa K, Katoh T, Yazawa M & Taniguchi K ... combination decreased the K0 .5 for K+ from to 0.2 mm, which was one-fifth of the K0 .5, mm, under the usual conditions Competition between oligomycin and ATP Figure shows the competition between...
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Plant physiology - Chapter 14 Gene Expression and Signal Transduction potx
... activated Ras-GTP Ras-GDP MAPKKK (Raf) phosphorylates MAP kinase kinase (MAPKK) MAPKKK (Raf) P MAPKK MAPKK MAPKK phosphorylates MAP kinase (MAPK) MAPK P MAPK P The activated MAPK enters the nucleus and ... the activation of Raf (see Figure 14.23), also known as MAP kinase kinase kinase (MAPKKK) (1) MAPKKK phosphorylates MAP kinase kinase (MAPKK) (2) MAPKK phosphorylates MAP kinase (MAPK) (3) The ... activated Ras context as MAP kinase kinase kinase (MAPKKK) MAPKKK passes the phosphate baton to MAP kinase kinase (MAPKK), which hands it off to MAP kinase (MAPK) MAPK, the “anchor” of the relay...
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Báo cáo khoa học: Signal Transduction pot
... enhancer 138 Y Jeon1,2, J You1,3, J Park1, W Choi4, H Lee2 and J Han1 Sungkyunkwan University, Suwon, REPUBLIC OF KOREA, 2Konyang University, Daejeon, REPUBLIC OF KOREA, 3Konkuk University, Chungju, ... more conceivable 167 Abstracts C2-76 ERK activation by Bax inhibitor-1 overexpression S Cho, J Kim, E Lee, H Choi, S Kim, H Min, B Kim, G Kang and H Jeong Konkuk University, Seoul, REPUBLIC OF KOREA ... Kokura1, Y Naito1, H Ichikawa1, H Ohshima2 and T Yoshikawa1 Kyoto Prefectural University of Medicine, Kyoto, JAPAN, University of Shizuoka, Shizuoka, JAPAN J Cho, S Hong, E Kim, S Park, S Kwon,...
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Báo cáo khoa học: Bistability from double phosphorylation in signal transduction Kinetic and structural requirements potx
... Vm1 KaS1 þ KaS1 þ KbS3 Vm2 KbS2 þ KcS4 þ KbS2 v3 ¼ v4 ¼ Vm3 KbS3 þ KaS1 þ KbS3 Vm4 KcS4 ð1Þ þ KcS4 þ KbS2 where a ¼ [Wa]/WT, b ¼ [Wb]/WT and c ¼ [Wc]/WT are the dimensionless concentrations of ... rate equations we obtain: v1 ¼ v2 ¼ Vm1 KaS1 þ KaS1 þ b KS3 Vm2 KbS2 þ KcS4 þ KbS2 v3 ¼ v4 ¼ Vm3 KbS3 þ KaS1 þ KbS3 Vm4 KcS4 ðA3Þ þ KcS4 þ KbS2 Appendix B: Visualization of the bifurcation point ... range 0, Additionally, we normalize the Michaelis constants in such a way that KS1 ¼ Km1 ⁄ WT, KS2 ¼ Km2 ⁄ WT, KS3 ¼ Km3 ⁄ WT and KS4 ¼ Km4 ⁄ WT On introducing these new dimensionless variables...
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Báo cáo khoa học: Principles behind the multifarious control of signal transduction ERK phosphorylation and kinase/phosphatase control potx
... ei ;k t I ki sẳkt Z ẳ sẳ0 ki xj ki ei ; t=kt ị ẳ xj 0ị ỵ xj ei ; tị xj 0ị ki k sẳkt Z ei x ; k s :ds ẳ xei ; sị ds ki sẳ0 zẳt Z xei ; sị dz ẳ k I ei ; t ị: sẳ0 We now consider ... How kinase and phosphatase inhibition affect signal transduction In order to track down principles governing the control of signal transduction, we analyzed a kinetic Fig Schematic representation ... networks [41,42] The kinase reactions were taken to depend proportionally on the concentration of their corresponding activators (i.e the preceding phosphorylated kinase) To show that our conclusions...
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Báo cáo khoa học: The molecular chaperone a-crystallin incorporated into red cell ghosts protects membrane Na/K-ATPase against glycation and oxidative stress ppt
... present study we demonstrate the protection of the membrane enzyme Na /K- ATPase from inactivation by the heat shock protein a-crystallin Na /K- ATPase activity decreased upon incubation with fructose, ... deviation alone, indicating a selective effect of H2O2 on the Na, K pump To ensure that changes in 86Rb flux were not due to alterations in ATP concentrations or Na+ and K+ levels three control ... protection Also, the protection from modification of ghost cell Na/KATPase by a-crystallin highlights the diverse nature of molecular chaperones and suggests that protection of Na /K- ATPase is ubiquitous...
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