its role in multiple sclerosis
Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
Ngày tải lên :
14/02/2014, 19:20
... deletion of RasGEF; KIND1, KIND1 domain; KIND2, KIND2 domain (B) KIND2 domain anchors v-KIND to dendrites Flag-tagged v-KIND, DKIND1, DKIND2, DKIND1 + 2, DRasN, DGEF, KIND1 or KIND2 together with ... very-KIND-MAP2 interaction A 37–217 456–620 KIND1 KIND2 v-KIND ΔKIND1 ΔKIND2 ΔKIND1+2 ΔRasN ΔGEF KIND1 KIND2 ΔKIND1-Flag RasN ΔKIND2-Flag 1461–1734 1742 GEF ΔKIND1+2-Flag dendrite axon ΔGEF-Flag KIND1-Flag ... functional determinants of the protein–protein interaction between v-KIND and MAP2 (i.e the MAP2-binding core module in v-KIND and the v-KIND-binding core module in MAP2) across a range of amino acid...
- 11
- 658
- 0
Tài liệu Báo cáo khoa học: A novel splice variant of occludin deleted in exon 9 and its role in cell apoptosis and invasion docx
Ngày tải lên :
18/02/2014, 18:20
... occludin in apoptosis and invasion A C B D E F Fig Identification of a human occludin splice variant in liver cell lines (A) Occludin protein expression was examined with an antibody to the N-terminus ... cells In Chang cells, stained occludin was observed in the cytoplasmic region Additionally, in OccWT-overexpressing Hep3B and Huh7 cells, regions stained with antibody to hemagglutinin (HA), indicating ... To determine the function of occludin, we reduced occludin expression in Huh7 cells by using occludin short hairpin RNA (shRNA) After determining the reduced expression level of occludin with...
- 12
- 613
- 0
Tài liệu Báo cáo khoa học: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation docx
Ngày tải lên :
19/02/2014, 06:20
... folding of the mutant The lower intensity may arise from partitioning of the protein into an aggregated state The effect of copper binding on the secondary structure was determined using CD in ... C-terminus (box in Fig 1) at sites: 92, 75, 66 and 58 As histidine residues are central to copper binding in many proteins they probably form part of the copper binding sites in this protein Although ... remains to be seen by more in vivo studies Stefin B as a copper binding protein We have demonstrated that human stefin B is a high affinity copper binding protein It exerts two high affinity biding...
- 14
- 586
- 0
Tài liệu Báo cáo khoa học: Biochemical characterization of human 3-methylglutaconyl-CoA hydratase and its role in leucine metabolism docx
Ngày tải lên :
19/02/2014, 07:20
... in the AUH gene This indicated that AUH, in addition to its RNA binding function, must play an important role in leucine catabolism AUH was overproduced in E coli and characterized by measuring ... suggesting that this enzyme had another function in cellular metabolism Indeed, AUH had enoyl-CoA hydratase activity, which was described as an additional intrinsic function of the protein Its role ... localisation of AUH, an AU-specific RNA-binding enoyl-CoA hydratase Gene 228, 85–91 Nakagawa J & Moroni C (1997) A 20-amino-acid autonomous RNA-binding domain contained in an enoyl-CoA hydratase Eur J...
- 11
- 625
- 0
Tài liệu Báo cáo khoa học: Inorganic pyrophosphatase in the roundworm Ascaris and its role in the development and molting process of the larval stage parasites doc
Ngày tải lên :
20/02/2014, 11:20
... Vmax (maximum velocity) values were determined by incubating the diluted recombinant proteins in the standard reaction mixture in the presence of increasing concentrations of PPi (0.05–0.5 mM) ... the cDNAs were determined by the Sanger dideoxy chain termination method using a PRISMTM Ready Dye Terminator Cycle Sequencing Kit (PerkinElmer) DNA samples were analyzed using an automated sequencer ... provide information concerning the kinetics and properties of the enzyme More strikingly, we show a novel role of the PPase enzyme in the development and molting process of A suum larvae in vitro...
- 13
- 691
- 0
Báo cáo khoa học: Molecular and functional characterization of a novel splice variant of ANKHD1 that lacks the KH domain and its role in cell survival and apoptosis docx
Ngày tải lên :
07/03/2014, 21:20
... Cancer Institute, Shanghai, China Smith RK, Carroll PM, Allard JD & Simon MA (2000) MASK, a large ankyrin repeat and KH domain-containing protein involved in Drosophila receptor tyrosine kinase ... cultured in RPMI containing 10% FBS, 1% penicillin– streptomycin and interleukin-2 growth factor Monocytes were isolated using CD14 beads and differentiated into macrophages and dendritic cells using ... containing multiple ankyrin repeat motif domains and a single KH domain similar to the MASK gene found in Drosophila Drosophila MASK (dMASK) has been implicated in cell survival and may play a role...
- 12
- 561
- 0
Báo cáo Y học: Functional expression of human liver cytosolic b-glucosidase in Pichia pastoris Insights into its role in the metabolism of dietary glucosides ppt
Ngày tải lên :
08/03/2014, 16:20
... mLámin)1 The following gradients were used: incubations containing arbutin or salicin as substrate; 100% C initial, increasing D to 20% (10 min), 50% (15 min), 100% (5 min), held at 100% (5 min); ... (genistin) Daidzein-7-Glc (daidzin) Daidzein-7-MalGlc Flavonols Quercetin-4¢-Glc (spiraeoside) Quercetin-7-Glc Quercetin-3,4¢-diGlc Flavones Apigenin-7-Glc (apigetrin) Luteolin-4¢-Glc Luteolin-7-Glc ... Naringenin-7-GlcRha (naringin) Hesperetin-7-GlcRha (hesperidin) Phloretin-7-Glc (phlorizin) Oleuropein Cyanidin-3-Glc (kuromanin) Cyanidin-3,5-diGlc Flavanones Dihydrochalcones Secoiridoids Anthocyanidins Ó FEBS...
- 10
- 775
- 0
Solar and Space Physics and Its Role in Space Exploration doc
Ngày tải lên :
14/03/2014, 10:20
... Engineering in providing services to the government, the public, and the scientific and engineering communities The Council is administered jointly by both Academies and the Institute of Medicine ... PHYSICS AND ITS ROLE IN SPACE EXPLORATION EXPLORERS Status Ongoing line of scientifically focused principal-investigator-led missions Mission The Explorer program has, since the beginning of the ... Printing Office, Washington, D.C., 2004 SOLAR AND SPACE PHYSICS AND ITS ROLE IN SPACE EXPLORATION the fundamental role of solar and space physics research both in scientific exploration and in...
- 74
- 369
- 0
Interest Rate Policy in Egypt - Its Role in Stabilization and Adjustment pdf
Ngày tải lên :
15/03/2014, 14:20
... deficit IV THE ROLE OF INTERI T RATES IN THE ADJUSTHKUT PROG*MM Among the multitude of reasons arguing for interest rate reform in Egypt it is its role in facilitatingthe country's ongoing process ... discounted A Interest Rate and Business Investment The first step in examining how higher interestrates may influence business investmentdecisions and performances is the understandingof firms' ... publicat largeremainvery dim In that case, of banks will continueto operateas the dominantfinancial intermediary the in Egyptian financial system Figure 1, Deposit Banking Institutions: Total...
- 39
- 368
- 0
Nursing Practice In Multiple Sclerosis: A Core Curriculum doc
Ngày tải lên :
15/03/2014, 19:20
... Background Information for Nursing Practice in Multiple Sclerosis The History of Multiple Sclerosis Care Domains of Multiple Sclerosis Nursing Practice Change Theory and Its Application in Multiple Sclerosis ... Chain in Multiple Sclerosis 51 iii iv CONTENTS 12 The Multiple Sclerosis Care Team 13 Bladder Dysfunction 65 69 14 Bowel Elimination and Continence 75 15 The Nurse’s Role in Advanced Multiple Sclerosis ... attacks in the brain, including many that did not manifest symptoms In 1993, FDA approved Betaseron® (IFN-beta 1b) for relapsing remitting MS (R-R MS) 4 NURSING PRACTICE IN MULTIPLE SCLEROSIS: ...
- 130
- 333
- 0
Báo cáo khoa học: Characterization of Trypanosoma brucei PEX14 and its role in the import of glycosomal matrix proteins pptx
Ngày tải lên :
23/03/2014, 17:21
... production of a fusion protein bearing an N-terminal extension of 20 residues including a His6-tag At a later stage, a point mutation was introduced in the vector pET28a-TbPEX14-N in order to fuse the ... several copies in the N-terminal domain of all PEX5s [22,32,38] In this paper, in vitro experiments showed that also in T brucei the N-terminal part of TbPEX14 (amino acids 1–146) interacts specifically ... various molar ratios Protein concentrations were determined by the Bradford method using bovine serum albumin as standard [28] This method was also used in experiments involving subcellular fractionation...
- 9
- 549
- 0
Báo cáo sinh học: " Neopterin production and tryptophan degradation during 24-months therapy with interferon beta-1a in multiple sclerosis patients" docx
Ngày tải lên :
18/06/2014, 19:20
... activity Initially, IFNb-1a administration may result in a sharp increase in the neopterin levels owing to the acute, proinflammatory actions of IFNb-1a [35,36] However, in the long term its repeated ... W, Coats ME, Goodkin DE, Weinstock-Guttman B, Herndon RM, et al: Incidence and significance of neutralizing antibodies to interferon beta-1a in multiple sclerosis Multiple Sclerosis Collaborative ... neopterin as marker of disease activity in multiple sclerosis Acta Neurol Scand 1987, 75:352-355 Ott M, Demisch L, Engelhardt W, Fischer PA: Interleukin-2, soluble interleukin-2-receptor, neopterin,...
- 9
- 389
- 0
báo cáo hóa học: " Fatigue characteristics in multiple sclerosis: the North American Research Committee on Multiple Sclerosis (NARCOMS) survey" pot
Ngày tải lên :
18/06/2014, 19:20
... fatigue in multiple sclerosis In Multiple sclerosis clinical practice guideline Washington, DC: Paralyzed Veterans Association; 1998 Freal JE, Kraft GH, Coryell JK: Symptomatic fatigue in multiple sclerosis ... Psychosocial correlates of fatigue in multiple sclerosis Arch Phys Med Rehabil 1996, 77:165-170 Krupp LB, Elkins LE: Fatigue and declines in cognitive functioning in multiple sclerosis Neurology 2000, ... IFN Change in IMA B Percent (%) 50 40 30 20 10 1.0-3.0 4.0 5.0-6.0 Fatigue Score Figure Changes 2in fatigue rating following a change in IMA Changes in fatigue rating following a change in IMA NARCOMS...
- 11
- 387
- 0
Báo cáo hóa học: "Adaptive robot training for the treatment of incoordination in Multiple Sclerosis" doc
Ngày tải lên :
19/06/2014, 08:20
... (d = 3): Figure Training protocol and study design Top: Phases of the training protocol: Baseline (B1), Robot Training, Baseline (B2), Subject Training, Wash-out The phases in which the robot ... regards changes within one session, to distinguish between the changes in performance occurring during the Robot Training phase from those occurring during the Subject Training phase, we directly ... changes in movement kinematics We found no significant effects of Robot Training (baseline vs baseline 2) As regards the effect of Subject Training (baseline vs wash-out), we found a decrease in the...
- 11
- 596
- 0
Báo cáo hóa học: " The Armeo Spring as training tool to improve upper limb functionality in multiple sclerosis: a pilot study" ppt
Ngày tải lên :
19/06/2014, 08:20
... time of the unilateral activities (i.e grasping and moving a jar, pouring water from a jug into a cup, inserting coins in a slot, pinching and moving small objects) was registered The maximal ... Sanguineti V: Adaptive robot training for the treatment of incoordination in Multiple Sclerosis J Neuroeng Rehabil 2010, 7:37 McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, ... that completed the training program (n = 9) are presented in Table Each of them concluded all 24 training sessions within maximal weeks Effects of the Armeo Spring training program on upper limb...
- 8
- 678
- 0
Báo cáo hóa học: " Objective assessment of motor fatigue in multiple sclerosis using kinematic gait analysis: a pilot study" docx
Ngày tải lên :
19/06/2014, 08:20
... fatigue in multiple sclerosis Multiple Sclerosis Council for Clinical Practice Guidelines; 1998 35 Iyengar V, Santos MJ, Ko M, Aruin AS: Grip force control in individuals with multiple sclerosis Neurorehabilitation ... evaluate fatigue in multiple sclerosis Multiple Sclerosis 1999, 5(1):10-16 28 Kos D, Nagels G, D’Hooghe MB, Duportail M, Kerckhofs E: A rapid screening tool for fatigue impact in multiple sclerosis ... assess multiple sclerosis- related fatigue Multiple Sclerosis 2009, 15(12):1509-1517 34 Guidelines MSCfCP: Fatigue and Multiple Sclerosis: evidence based management strategies for fatigue in multiple...
- 13
- 434
- 0
báo cáo hóa học: " Production of IL-16 correlates with CD4+ Th1 inflammation and phosphorylation of axonal cytoskeleton in multiple sclerosis lesions" pptx
Ngày tải lên :
19/06/2014, 22:20
... nostaining was found in normal-appearing white matter of brain and spinal cord IL-16 immunoreactivity was readily observed in CD3+ T cells in perivenular infiltrates (Fig 6A) Within the pool of infiltrating ... was undetectable in control brain (Fig 1A), and was very low in control spinal cord white matter (Fig 1B), but was abundantly present in MS lesions in brain and spinal cord In brain, levels of proIL-16 ... not detected in control brain (A) or spinal cord (B) In MS lesions, relatively high levels T-bet were measured in acute lesions (AL) and chronic lesions (CL) in brain, and in AL in spinal cord Compared...
- 13
- 425
- 0
báo cáo hóa học: " Interferon-β1a reduces plasma CD31+ endothelial microparticles (CD31+EMP) in multiple sclerosis" pptx
Ngày tải lên :
19/06/2014, 22:20
... initial role in cell adhesion, i.e slowing and initiating cell rolling, they have been shown to have a dominant role in allowing non-specifically activated cells to gain access to the CNS [5], independent ... to inward trafficking of various molecules and cells in the intravascular compartment.2 Inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) induce opening ... contrast-enhancing MRI lesion frequency as a primary outcome measure Neurology 1997, 49:862-869 Sheremata WA, Minagar A, Alexander JS, Vollmer T: The role of alpha-4 integrin in the aetiology of multiple sclerosis: ...
- 5
- 172
- 0
báo cáo hóa học: " Saliva soluble HLA as a potential marker of response to interferon-β1a in multiple sclerosis: A preliminary study" pdf
Ngày tải lên :
19/06/2014, 22:20
... Danish Multiple Sclerosis Study Group: Clinical importance of neutralizing antibodies against interferon beta in relapsing-remitting multiple sclerosis Lancet 2003, 362:1184-1191 Chadha K, Winstock-Guttman ... Beneficial effect of interferon-beta1b treatment in patients with relapsingremitting multiple sclerosis is associated with an increase in serum levels of soluble HLA-I molecules during the first months ... I, Minagar A, Gonzales-Toledo E, Featherston L, Kelley R: Soluble HLA measurement in saliva and cerebrospinal fluid in Caucasian patients with multiple sclerosis: a preliminary study J Neuroinflammation...
- 6
- 424
- 0
báo cáo hóa học: " Serum lipid profiles are associated with disability and MRI outcomes in multiple sclerosis" pptx
Ngày tải lên :
19/06/2014, 22:20
... cholesterol was associated with increases in the number of contrast-enhancing lesions on brain MRI in clinically isolated syndrome patients following a first clinical demyelinating event [21] MS patients ... Cholesterol is a major component of myelin and statins may hinder remyelination by inhibiting cholesterol synthesis in the brain [36,37] The studies of statin treatment in MS have likewise also yielded ... enlarging T2-hyperintense lesions over years [40] The STAYCIS trial to assess statin treatment in slowing the conversion of CIS did not meet its primary endpoint [41] The SIMCOMBIN trial indicated...
- 7
- 612
- 0