... the thesis s main text The Latin terms used to describe key portions ofthe city defences are included within the English translations ofthe historical texts These, like the other non-English ... incorporated into the Crusader-era walls during their construction The inclusion of these artefacts, each possessing their own unique biographies, adds tothe functions ofthe walls But how should these ... and escape the straightjacket this PhD project seeks to answer the question: what are the military and social or symbolic functions of city walls? This thesis aims to: address the field s bias by...
... overexpress the c-secretase complex components These assays are used to test the effects of detergent concentration, solvents and metals on the c-secretase cleavage of APP substrates These studies show ... Zn Using two assay systems, these results show that zinc can inhibit in vitro c-secretase cleavage of an APP substrate Discussion The amyloid hypothesis of AD states that low molecular mass oligomers ... of c-secretase activity Lastly, zinc causes structural changes in a c-secretase substrate and acts as an inhibitor of csecretase cleavage of APP Results Design of a novel APP c-secretase substrate...
... passage Transport tothe nucleus The issue of how the papillomaviral genome transits fromthe endosome tothe nucleus has not been systematically addressed It is well established that vesicle trafficking ... Because syndecan-1 is the predominant HSPG in epithelial tissue, it was suggested to serve as the primary attachment receptor in vivo This is further supported by its high level of expression in the ... accumulates in late endosomes or lysosomes if egress fromthe endocytic compartment tothe cytosol is blocked [70] and that this requires the acidification of endosomes [61] Vesicular transport of PV...
... AND SENTENCED FOR LIFE CHARGED WITH THE £1,000,000 FORGERY ON THE BANK OF ENGLAND THIS STORY SHOWS THAT THE EVENTS OF HIS LIFE SURPASS THE IMAGINATIONS OF OUR FAMOUS NOVELISTS, ITS THRILLING SCENES, ... one to read this marvellous history of human experience Aside from its dramatic interest there are great moral lessons involved of especial value to young men and employees in positions of trust ... and Conceals a Set of Burglar 's Tools Liberated Returns and Burglarizes the Prison Boat Load of Plunder Captured Sixteen Years More in Prison Then Goes to England Gets Twenty Years Joins Me at Chatham...
... grew from a Class storm to a Class event quite possibly because ofthe warming effects of carbon released in the late 197 0s. 7 Similarly, the causes behind the weather governance S headlines ofthe ... necessary to head off the worst possibilities In the meantime, months, years, and decades slipped away Some chose to dismiss the evidence in its entirety as “doom and gloom,” but as individuals they ... including the movement of carbon from plants tothe atmosphere, oceans, soils, and living creatures All of us are vulnerable tothe remorseless workings ofthe large numbers that govern Earth systems...
... The Office ofthe Auditor The missions ofthe Office ofthe Auditor are assigned by the Hawaii State Constitution (Article VII, Section 10) The primary mission is to conduct post audits ofthe ... studies respond to requests from both houses ofthe Legislature The studies usually address specific problems for which the Legislature is seeking solutions Hawaii s laws provide the Auditor with ... benefits Such bills cannot be enacted unless they are referred tothe Office ofthe Auditor for an assessment ofthe social and financial impact ofthe proposed measure Analyses of proposed special...
... the Audit Assess whether the Hawai`i Tourism Authority adequately manages its major contracts Assess the compliance of major contractors with contract provisions and the propriety of contract ... Revenues and Appropriations, FY1999-2000 to FY2001-02 FY1999-2000 Revenues: Tourism Special Fund Interest/miscellaneous receipts Total revenues Appropriations: Regular session Special session Total ... opportunities through tourism History Established in 1903, HVCB, then known as the Hawai`i Visitors Bureau, is the oldest tourism organization in the Pacific region and began as a committee ofthe Honolulu...
... employees received individual annual bonuses in excess of $25,000 The authority did not assess the appropriateness ofthe salary levels or the incentive program bonus amounts The authority s non-involvement ... expenditures of state contract funds, such as purchasing an office Christmas tree and spending over $100 for less than a pound of coffee for office use, they not appear to be widespread Thus, based ... employees and their expenses Expenditures by HVCB s Kaua‘i Visitors Bureau and its China and Japan offices indicate varying degrees of improper management of state funds The Kaua‘i Visitor s Bureau...
... It was HVCB s understanding that its sole function was to serve as a pass-through for payments to vendors’ services procured by the special advisor Without questioning whether services it was paying ... role was to pay invoices it received fromthe governor s office for services the special advisor procured The arrangement between the university and HVCB was also suspect for other reasons First, ... that it has a responsibility to determine whether the contractor s work is faithful tothe contract terms and whether the contractor s services are satisfactory Our review ofthe authority s two...
... authority s contract procurement methods and assigns responsibility of overseeing the procurement steps to various sections It also specifies that overall responsibility for a contract rests with the section ... includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements An audit also includes assessing the accounting principles used and significant estimates ... evaluations of its contractors The State and Legislature should take appropriate steps to assess the extent to which HVCB violated generally accepted accounting standards under its contracts with the...
... estimates and assumptions relating tothe reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities at the date ofthe financial statements and the reported ... absence of donor-imposed restrictions Accordingly, net assets of HVCB and changes therein are classified and reported as follows: Unrestricted Net Assets - Net assets not subject to donor-imposed ... Statements of Activities (Exhibit 3.2) These statements present the revenues, expenses and changes in net assets of HVCB for the years ended December 31, 2002 and 2001 Statements of Cash Flows (Exhibit...
... This is trial version www.adultpdf.com Responses ofthe Affected Agencies Comments on Agency Responses We transmitted drafts of this report tothe Board of Directors ofthe Hawai‘i Tourism Authority, ... thanked us for recognizing the authority s efforts to address some ofthe concerns raised in a prior audit They also noted their support for our audit as a tool to improve its operations, respond to ... director also stated that they were surprised by many of our findings and consider some of them serious enough to warrant further investigation The response outlined additional actions that the authority...
... Special studies respond to requests from both houses ofthe Legislature The studies usually address specific problems for which the Legislature is seeking solutions Hawai‘i s laws provide the Auditor ... Office ofthe Auditor The missions ofthe Office ofthe Auditor are assigned by the Hawai‘i State Constitution (Article VII, Section 10) The primary mission is to conduct post audits ofthe ... benefits Such bills cannot be enacted unless they are referred tothe Office ofthe Auditor for an assessment ofthe social and financial impact ofthe proposed measure Analyses of proposed special...
... Hawai‘i tourism in a sustainable manner consistent with our economic goals, cultural values, preservation of natural resources, community desires and visitor industry needs The authority is responsible ... board of directors for use in the case of emergencies as determined by the governor, such as conflicts or disasters that disrupt commerce and affect tourism The emergency fund money comes from ... it enters into contracts or agreements valued at $25,000 and over The Legislature established three special funds administered by HTA to support its mission The Tourism Special Fund, the Convention...
... that maps out the long-term goals and processes to assess the accomplishments of its major contractors, the authority s board of directors is unable to demonstrate that the promotional dollars have ... activities and those of its contractors Evaluate the adequacy of HTA s measures of effectiveness in providing a basis for performance assessments and an assurance that taxpayers receive value for the ... consultants to assist with strengthening its oversight over contractor spending and compliance with contractual obligations Objectives ofthe Audit Assess HTA s planning process to guide its activities...
... comments by the stakeholders We also found that HTA s assessment ofthe contractors fail to provide sufficient details on the steps necessary to improve their marketing efforts The contractor self-assessments ... limitations when used as a tool for contractor evaluation First, the survey measures states of mind, rather than the number of visitors who visited Hawai‘i in response to a contractor s efforts, also ... doing business with the contractor and hires a vendor to prepare a satisfaction survey ofthe chosen stakeholder The surveys seek opinions on issues including: knowledge ofthe visitor industry, ability...
... controls over the HVCB and its other contractors But the fundamental issue remains: the authority s planning processes and its assessment of marketing efforts continue to be largely based on conjecture ... terms of its success in meeting planned outcomes, using benchmarks and performance measures tothe extent feasible With regard to its oversight over contractors, the Hawai‘i Tourism Authority should: ... experts familiar with trends and opportunities in the convention business Based on the examples cited, spending practices of HTA s contractors differ markedly from typical uses of public funds The...
... This is trial version www.adultpdf.com This is trial version www.adultpdf.com This is trial version www.adultpdf.com This is trial version www.adultpdf.com This is trial version www.adultpdf.com ... trial version www.adultpdf.com This is trial version www.adultpdf.com This is trial version www.adultpdf.com This is trial version www.adultpdf.com This is trial version www.adultpdf.com ...
... comparison ofthe effect of its deployment of state resources We discuss this issue in our report with reference to performance reporting standards promulgated by the Destination Marketing Association ... accountability system that most appropriately tracks the success of programs in generating the desire to travel to Hawai‘i.” Because of factors beyond its control, the HTA “selected consideration ... projects, even of staff members Our report seeks to convey that objectively measured goals and their use in assessment and reporting are hallmarks of commitment to results in a strategically oriented...
... DISCUSSION In plantations, survival rates are linked tothe ability to survive transplanting stress and to out-compete the growth of noxious grasses Storage in dark conditions slowed downthe ... were sensitive to transplanting stress as their growth rates were significantly lower than those ofthe other treatments except for the treatment 4DD Storage in dark conditions increased the sensitivity ... stress The healthy appearance ofthe plants months after transplanting showed that the seedlings were able to overcome the initial transplanting stress The distribution of surviving plants was...