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... TA isoforms act similarly to p53, inducing apoptosis In comparison, ΔN isoforms have little transactivation activity and play a role blocking target genes of p53 and their respective TAp73 isoforms ... cetuximab [24,25] Wild type K-Ras statusis currently required to administer cetuximab in monotherapy, or combined with other agents, as it has been demonstrated that this is necessary but not sufficient ... curve analysis Western Blot Analysis For protein analysis, 7.5 × 105 cells were seeded, and after treatment, harvested, washed in ml of cold PBS and lysed in EBC lysis buffer (50 mM Tris pH8, 120...
... significantly (p = 0.01) lower in comparison to EAC without BE Normal tissue is considered as one-fold (b) Statistically significant value is indicated with an asterisk Grimm et al Journal of Translational ... [9-11] Evidence is accumulating, that matrix metalloproteinases (MMPs) may drive carcinogenesis according to a model of multistep carcinogenesis or a cancer stem cell hypothesis mediated by the ... adenocarcinoma is a tumor entity on its own and must be discussed differently Follow-up data were obtained from our local tumor registry of Lower Franconia/Germany This tumor registry documents...
... unpublished data) and were classified into three successional groups with regard to growth and dynamic characteristics according to Favrichon [22, 23] This grouping is based on a statistical analysis ... non-linear distribution (modal distribution) of this trait along the successional gradient Carbon isotope discrimination (∆) – roughly the difference in carbon isotope composition (∆13 C) between ... Heckel Myristicaceae FE 129.1 ± 5.5 0.45 ± 0.01 49.8 ± 0.3 18.5 ± 0.6 Virola surinamensis Warburg Myristicaceae FE 142.9 ± 5.5 0.33 ± 0.02 51.6 ± 0.3 23.1 ± 0.5 * Dicorynia guianensis G.J Amshoff...
... attempting to explain this disparity have shown that both Aboriginal men and women are at an increased risk of antecedent risk factors for HIV infection including sexual abuse, a history of IDU, poverty, ... studies dealt with missing information via assumptions about the missing data or via imputation techniques for missing data In this study, we decided to not include participants with missing information ... Romanowski B, Preiksaitis J, Campbell P, Fenton J: Hepatitis C seroprevalence and risk behaviors in patients attending sexually transmitted disease clinics Sex Transm Dis 2003, 30(1):33-38 Daniel...
... It is well known that over expression of anti-apoptotic Bcl-2 proteins leads to apoptosis-resistance and is believed to be a major reason for treatment failure in lymphoid tumors [15-19] In this ... phenotypic analysis for comparison with the established tumor cell line to insure the human origin and its stability After formation of SC tumors, serial propagation was accomplished by excising the ... heterogeneity of this group of diseases despite their common Bcell lineage It is important, therefore, that any new therapeutic strategy be evaluated across the spectrum of these tumors This is especially...
... QC-RT-PCR (A) CD4, and (B) CD8 The HIV status of each sample is depicted represents HIV positive status, ■ represents HIV negative status, and ▲ ! reepresents unknown status Page of (page number not ... Martha Pavlakis, Harvard Medical School, Boston, MA The primer sequences are: Sense 5'GGTGAAGGTCGGAGTCAACG3', Antisense 5'CAAGTTGTCATGGATGACC3' Discussion Our results indicate that there is no correlation ... means of assessing immune status without requiring repetitive and large blood draws, and could be exquisitely sensitive This method may also be useful in assessing the immune status of patients retrospectively...
... "hygiene hypothesis." However, given the fact that this is a secondary finding, and the controversies surrounding the "hygiene hypothesis," further investigation is clearly needed Surprisingly, we ... Childhood Asthma by Socioeconomic Status Int J Epidemiol 1996, 25:388-393 Almqvist C, Pershagen G, Wickman M: Low socioeconomic status as a risk factor for asthma, rhinitis and sensitization at years ... Thom T: Trends and Disparities in Coronary Heart Disease, Stroke, and Other Cardiovascular Diseases in the United States: Findings of the National Conference on Cardiovascular Disease Prevention...
... has shown that the altered redox status in liver disease is not confined to the diseased liver, but that it is a systemic phenomenon involving extrahepatic tissues [5] So, the determination of ... redox activation of NF-κB [39-41] This compensatory response has already been described in order to re-establish homeostasis in the liver and extrahepatic tissues exhibiting oxidative stress [38] ... portacaval shunting is not excessive, and indeed a plasmatic increase of lipid peroxidation is not produced, therefore it can be suspected that the novo antioxidant synthesis is reduced If so,...
... relationship as a supervisor and friend Regardless of his commitments he found time to supervise my work It has been a wonderful experience to conduct research under his supervision I wish to thank Dr ... Apoptosis is an essential mode of cell death in normal development and is responsible for maintenance of homeostasis of normal cells (Vaux and Korsmeyer, 1999) Typical characteristics of apoptosis ... to Ismail M.Hanif and M Ali Shazib for their utmost help during my candidature Zhang Lei in his help to format this thesis They have also helped me with the retrieval of references for my thesis...
... compound, first isolated and purified on photo-oxidation of merocyanine 540 The chemical structure of this imidazole compound is N,NЈ-Dibutyl-thio-4,5-imidazolindion, and its apoptosis-inducing activity ... Bax:Bcl-2 ratio is not significantly altered on 4- to 24-hour exposure to H2O2 Interestingly, analysis of subcellular distribution of Bax (in HCT116, HL60, and CEM cells) revealed that Bax redistributed ... fibrosis transmembrane conductance regulator (47) Drug-Induced Bax Translocation Is Dependent on H2O2-Mediated Cytosolic Acidification Cytosolic acidification is an early event in apoptosis and...
... presence of RSV to vincristine-induced apoptosis (Fig 6, C and D) The inhibitory effect of low concentrations of RSV on druginduced apoptosis was not exclusive to C2 or vincristine Preincubation ... (25, 40, 41) This divergent signaling by RSV is intriguing and could be explained by our earlier observations that at concentrations of Ն32 M, apoptosis induced in HL60 cells is mediated by ... ability of C2, vincristine, and daunorubicin to trigger intracellular H2O2 production even in the presence of RSV (Fig 7C) DISCUSSION Fig Resveratrol (RSV) inhibits apoptosis triggered by a novel...