... and Jenkins, 2004) We are interested to examine the role of financial analysts in producing and disseminating information about these earnings restatement firms In particular, FAF contain any ... incentives of financial analysts, i.e., they benefit from issuing optimistic earnings forecasts The benefits include promoting brokerage commissions, maintaining sound relations with investment banking ... serious conflicts of interest Notwithstanding, this study finds that financial analysts in aggregate have greater disagreement in their opinions of the restatement firms’ earnings Restatement...
... role in indicating and realizing topic continuity in a dialogue Since new topics are introduced at the beginning of new subdialogues and developed in the following sentences, one can predict that ... distinguishes three structures in a discourse structure: 1) the structure of the sequence of utterances, 2) the structure of the intentions conveyed, and 3) the attentional state Distinguishing ... antecedents of pronominal and nonpronominal definite noun phrases on the basis of the type of dialogue structure exemplified in this paper The analysis of boundary markers reveals reliable and distinctive...
... clinical outcomes in the majority of late-stage cancerpatients Data is emerging from many human and animal studies that support this premise It is therefore likely that better timing of administration ... the detection of the presence of colorectal cancer and independently associated with the increased risk of colorectal cancerin men [14], and overall cancer risk [15] Interleukin-6 (IL-6) has ... Identifying Immune Oscillatory Cycles in Advanced Cancer using L-CRP Single measurements of CRP or L-CRP have previously been used to correlate with the risk of certain cancers, prognosis or cancer...
... patients (including 82 lung cancer) SDS The single measure of symptom distress was a significant predictor of survival in lung cancer Ringdal et al [16] 1996 253 heterogeneous sample ofcancerpatients ... and recurrence incancerpatients [135] The review concluded thatthereis little consistent evidencethat psychological coping style is important in survival from or recurrence ofcancer Similarly, ... advantage of this line of research isthatof potentially providing clinicians with a more accurate picture of the patient's prognostic profile, hence possibly further improving accuracy of prognosis...
... prevalence of pain in advanced canceris about 70% with ample variations according to the cancer type and disease stage [2] Despite the existence of published and well-known guidelines for cancer pain ... 19 20 21 Cherny N: The management ofcancer pain Cancer J Clin 2000, 50:70-116 Hearn J, Higginson IJ: Cancer pain epidemiology: a systematic review InCancer Pain, Assessment and Management Edited ... file 2]) Data analysis and statistics According to the first main objective of the study (i.e., to describe the characteristics ofcancerpatientsin terms ofpatients characteristics, pharmacological...
... for CVC insertion inpatients with cancer Background Central venous access is essential inpatients with cancer, and the need for intravenous access devices for the administration ofcancer therapy ... that endothelium damage is a main risk factor in initiating thrombosis However the lack of venographic assessment of catheter-related thrombosis in our study is a limit to the determination of ... were: symptomatic vein thrombosis of upper limbs (early or late), infections, malfunctioning and lifespan of the CVC Page ofIn cases of clinical suspicion of venous thrombosis evidenced by progressive...
... Details of the procedures Disease Gastric cancer Colon cancer Hepatobiliary cancer HCC Liver metastasis Ca of biliary tract Cholelithiasis Case Male:female Surgical procedure Operating time (min) Intraoperative ... Casciani CU: Distribution in Th1 and Th2 subsets of CD4+T cells in peripheral blood of colorectal cancerpatients and involvement incancer establishment and progression Cancer Immunol Immunother ... cytokine production Therefore, in gastrointestinal cancer patients, the initial tumor establishment may arise from, or be accompanied by, a reduced Th1/Th2 Hensler et al [16]reported that during...
... PI3K domain, substrate binding domains and ATPbinding domains, is illustrated in Figure Single marker associations Risk for developing breast cancer The association between any variant in the ATM ... variation in the ATM gene where combined into one group The level of adverse side effects in the Norwegian breast cancerpatients or risk of IBTR in the American breast cancer cases were then Page of ... associated with risk of development of breast cancer (P = 0.055), with a lower frequency of the minor allele in breast cancer patients, suggesting a protective effect for of this variant (Table...
... that extended-duration prophylaxis reduces VTE in this high-risk population Prophylaxis in medical cancer inpatients Thereis a growing awareness of the risks of VTE in hospitalized medical patients ... prophylaxis, and long-term anticoagulation incancerpatients [1,16-19] However, despite the existence of these guidelines and the high-risk of VTE incancer patients, up to 75% ofcancerpatients ... demonstrated that extending the duration of prophylaxis from 1-4 weeks significantly reduced the incidence of VTE without increasing bleeding [49] In a sub-analysis ofcancerpatients from this study,...
... H: Is Phytalgic® a goldmine for osteoarthritis patients or isthere something fishy about this nutraceutical? A summary of findings and risk -of- bias assessment Arthritis Research & Therapy 2010, ... reporting in terms of risk of bias, the use of random assignment, and subsequent concealment of allocation would qualify as adequate (that is, low risk of selection bias); it seems reasonable that ... and that it claimed that they were identical and indistinguishable We argue, however, that it might be difficult to hide the taste of fish oil during a 3-month trial, probably as difficult as it is...
... mix ofpatients (e.g type of tumour, number of BMT patients, disease status and extent, and level of ICU support) In particular, the prognosis for cancerpatients receiving MV is very poor In ... outcome inpatients admitted to ICUs Although none of these models should be used to predict individual outcomes, they can assist physicians in discussions of prognosis and in clinical decision making ... considerable, but thereis a possible impact of missing data in the unsatisfactory performance of the models As stated above, the study did not interfere with clinical decisions, including request...
... Amphotericin during conditioning Acyclovir during conditioning Vancomycin during conditioning The main site of liver damage in this setting is the hepatic sinusoid, and the resulting clinical syndrome ... diagnosis is considered sufficient to establish a presumptive diagnosis of TMA In this setting, disseminated intravascular coagulopathy must be ruled out The incidence of TMA associated with cancer ... reported with many anti -cancer agents, including gemcitabine, bleomycin, cisplatin, CCNU, cytosine arabinoside, daunorubicin, deoxycoformycin, 5-FU, azathioprine and interferon α [25] Lastly,...
... predictive of mortality inpatients with septic shock [10] Moreover, inpatients with cancer, a persistent increase of NT-proBNP early after administration of high-dose chemotherapy is strongly ... the use of epinephrine, norepinephrine, and/or dobutamine was decided by the physician in charge of the patient Stress-dose steroids were routinely administered in our patients presenting septic ... marker that allows risk stratification of septic shock inpatients with cancer, early detection of high-risk patients could permit us to evaluate new therapeutic options, including human recombinant-activated...
... purpose of the present study, individual organ failures were diagnosed in case of a SOFA score ≥ points in each domain [14] In addition, patients receiving dialysis in the context of acute kidney injury ... similar in neutropenic and non-neutropenic septic critically ill cancerpatients Since inadequately treated infections can be rapidly fatal in neutropenic cancer patients, a great deal of clinical ... information PP is coordinator of the Polyvalent Intensive Care Unit and president of the Antibiotic Commission of São Francisco Xavier Hospital PP is Professor of Medicine of the Faculty of Medical...
... trials showing a statistically significant increase in PFS, resulting in a reduced risk of progression of about 30% In the meta-analysis conducted by Valachis et al, improved PFS was statistically ... lack of significant benefit in OS, and the toxicity profile Moreover, the regulatory panel withheld the indication for breast cancer, and the final decision is still pending The main question raised ... molecular characteristics ofcancer [5,6] Angiogenesis represents an important step in the pathogenesis, invasion, progression and development of metastatic phenotype of breast cancer and is regulated...
... Martin, 2007) which include components of the cell cytoskeleton, like components of actin microfilaments, actin associated proteins, myosin, gelsolin, filamin, spectrins, microtubular proteins including ... the aminoterminal DNA-binding domain of the enzyme from the carboxy-terminal catalytic domain resulting in the loss of normal PARP1 function Although the role of PARP in apoptosis remains to be ... technology can benefit cancer therapy by allowing the unraveling of the molecular events following drug treatment that may be of consequence in therapy Microarray data is increasingly being used...
... expression of an E2F variant containing the DNA binding motif but not the pRb-binding or transactivation domain or introduction of a competitor plasmid containing multiple E2F binding sites, preventing ... for binding to proteins containing LXCXE motifs while the pocket-domain and the C-domain are involved in binding E2F proteins Mdm2 (as well as c-Abl) binds to the C-domain All pocket proteins ... suppressing function independently of p53 p19ARF may act as an antagonist of the MDM2-mediated inactivation of pRb, since it can bind and inactivate MDM2 Therefore, it would be interesting to...
... 26(7):1086-92 Knox JJ, Wong R, Visbal AL, Horgan AM, Guindi M, Hornby J, Xu W, Ringash J, Keshavjee S, Chen E, Haider M, Darling G: Phase trial of preoperative irinotecan plus cisplatin and conformal radiotherapy, ... alone in esophageal cancer patients: is it time for additional evidence? World Journal of Surgical Oncology 2011 9:41 Submit your next manuscript to BioMed Central and take full advantage of: • ... Oncology Group; Australasian Gastro-Intestinal Trials Group: Surgery alone versus chemoradiotherapy followed by surgery for resectable cancerof the oesophagus: a randomised controlled phase III trial...
... carcinoma, dInvasive Paget’s disease, eDistance metastasispatients had lung metastasis and two had liver metastasis One patient had mediastinal involvement On the other hand, patients had DM in ... survival in breast cancer? A meta-analysis J Clin Oncol 2000, 18:1220-1229 24 Sotiriou C, Wirapati P, Loi S, et al: Gene expression profiling in breast cancer: understanding the molecular basis of histologic ... therapy inpatients with high-risk breast cancer receiving adjuvant chemotherapy: 20-year results of the British Columbia randomized trial J Natl Cancer Inst 2005, 97:116-126 Harris JR, Halpin-Murphy...
... http://www.translational-medicine.com/content/7/1/1 Figure Western blotting analysis of survivin protein in oral cancer cell lines Western blotting analysis of survivin protein in oral cancer cell lines Lysates ... Survivin expression in oral cancer cells We previously showed that the survivin mRNA level was elevated in various cancer cell lines, including gastric cancer cells, colon cancer cells, breast cancer ... various cancerpatients including breast cancer, colorectal cancer, and gastric cancerpatients [23] On the basis of these findings in vitro, clinical trials of survivin-2B80-88 peptide immunotherapy...