ire1 a prototype of transmembrane stress signaling
báo cáo hóa học: " The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer''''s disease" ppt
... Shimohama S, Tanino H, Kawakami N, Okamura N, Kodama H, Yamaguchi T, Hayakawa T, Nunomura A, Chiba S, Perry G, Smith MA, Fujimoto S: Activation of NADPH oxidase in Alzheimer's disease brains Biochem ... isoprenylation of Rac is critical for Rac's subcellular localization, interactions with RhoGDI, anchoring to the plasma membrane and ultimately to the activation of inflammatory signaling pathways [114] ... Rho-family of small monomeric GTPases Like all Ras-superfamily members, Rac1 acts as a molecular switch cycling between an inactive guanosine diphosphate (GDP)-bound state and an active guanosine...
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Báo cáo y học: "Experimental stress in inflammatory rheumatic diseases: a review of psychophysiological stress responses" doc
... inflammation, activate both (intermediates of ) the HPA axis and the ANS Chronically elevated levels of cytokines, as occur during long-term inflammation, might lead to changes in HPA axis and ANS ... studies evaluating a battery of standard autonomic function tests, which include deep breathing, the Valsalva manoeuvre, posture changes, and sustained handgrip, unless they were part of a paradigm ... individual's appraisal of the threat of the event, perceived distress, coping behaviour and personality characteristics [4] As the appraisal of threat might partly determine the biological stress...
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Gamma glutamyltransferase is it a biomarker of oxidative stress
... untranslated region of a GGT mRNA, was initially found using HepG2 cells, and appears to serve as a tissue- specific translational enhancer82 Gamma- glutamyltransferase gene is translated into a ... that is catalytically inactive83, which undergoes an autocatalytic process into a heavy and light chain84 The heavy chain, which has the aminoterminal sequence, has a single intracellular transmembrane ... radicals to be attracted towards a magnetic field In general, free radicals are more reactive than non-radicals, even though the reactivity of radicals is widely variable6 There are free radicals...
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Tài liệu Báo cáo khoa học: Aldehydes release zinc from proteins. A pathway from oxidative stress⁄lipid peroxidation to cellular functions of zinc pptx
... [14], because evaporation of liquid during the long time period of the assay leads to a more concentrated sample, a higher absorbance reading, and hence an apparent release of more zinc than is ... E-amino groups of lysines in MT2 were carbamoylated with potassium cyanate and the modified protein was assayed for zinc release as described above Acetaldehyde releases almost the same amount of ... chemistry-generated free radicals [27] In diabetes, there are pathways for the increased formation of a- ketoaldehydes such as glyoxal and methylglyoxal from glyceraldehyde 3-phosphate Autoxidation of a- hydroxyaldehydes...
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The effects of oxidative stress on female reproduction: a review ppt
... pathways and activation of intrinsic apoptotic mechanisms Mol Endocrinol 2009, 23:1291–1305 110 Harada T, Taniguchi F, Izawa M, Ohama Y, Takenaka Y, Tagashira Y, Ikeda A, Watanabe A, Iwabe T, Terakawa ... placenta of women with preeclampsia Placenta 2009, 30:342–347 195 Sharma JB, Sharma A, Bahadur A, Vimala N, Satyam A, Mittal S: Oxidative stress markers and antioxidant levels in normal pregnancy ... Santanam N, Murphy AA, Parthasarathy S: Macrophages, oxidation, and endometriosis Ann N Y Acad Sci 2002, 955:183–198 discussion 119-200, 396-406 104 Kajihara H, Yamada Y, Kanayama S, Furukawa N,...
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Báo cáo khoa học: "USES OF C-GP.APHSlil A PROTOTYPE FOR TRANSLATION" docx
... OF THE PROTOTYPE The prototype consists of a model and a data structure The model is essentially a generalization of a Transformational System (TS) analogous to ROBRA [2] and whose grammars are ... (l) a "vertical" order or linear order of the arcs having the same initial node and (2) a "horizontal" order or partial order between two arcs on the same path A road is a path from I to Vertical ... have an operational version of the prototype, i t is intended as a f i r s t approach to proceed to the t r a n s l a t i o n of assemblers of the microprocessors a v a i l a b l e in our laboratory...
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Báo cáo khoa học: "Demonstration of a prototype for a Conversational Companion for reminiscing about images" doc
... ability of the system to handle more than one kind of application at a time, and news has, of course, an unconstrained vocabulary The following is a fairly typical example of its current capacity, ... Morgan Kaufmann, CA David Traum, Susan Robinson, and Jens Stephan 2004 Evaluation of multi-party virtual reality dialogue interaction, In: Proceedings of Fourth International Conference on Language ... structure of the data in the database is an RDF triple, and the KB is more commonly referred to as a triple store In mathematical terms, a triple store is nothing more than a large database of interconnected...
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Evolution of a Prototype Financial Privacy Notice: A Report on the Form Development Project pptx
... the advantages of analyzing data at certain times and with different research analysts Field analysis recorded immediate observations of the moderator, notetaker, and observer Content analysis of ... coded and entered into a database using Atlas.ti, a qualitative research software package In our analysis, we examined and used the data collected from each round of testing to revise and refine ... privacy laws and financial institutions’ sharing practices in a factual and neutral way The language could and should not direct a consumer to make any particular decision Through the course of...
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Stress and Performance - A Review of the Literature and Its Applicability to the Military pdf
... find that battle fatigue and other stress reactions may account for as many as 50 percent of the casualties in a given war As a result of the effect that stress can have on service members and their ... can act as a moderator between stress and performance by helping reduce uncertainty associated with stress and improving the accuracy of individual expectations and performance of certain tasks ... reduce the negative effects of separation stress on attitudes toward the military While family separation may be a significant source of stress or dissatisfaction, it may not have a large effect...
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assessment of the stress and strain levels at geometrical discontinuities under elastoplastic conditions a case study
... Glinka were used to verify the validity of the local strain approach and evaluate the strain levels and its relation with the nominal stress applied to a geometrical discontinuity section of a plate ... Several levels of loading were uniaxially applied The material fringe value was determined by a calibration process (Durelli et al, 1965, Dally et al, 1978) and the isochromatic fringe values at ... applied stress from zero to the threshold of yielding, it was possible to evaluate the elastoplastic behaviour of stress and strain as well as to evaluate the parameters involved for situations near...
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Báo cáo hóa học: " Predictors of quality of life: A quantitative investigation of the stress-coping model in children with asthma" pptx
... 9:625-636 Garcia-Marcos L, Carvajal Uruena I, Escribano Montaner A, fernadez Benitez M, de la Garcia Rubia S, Tauler Toro E, Perez Fernandez V, Barcina Sancez C: Seasons and other factors affecting ... decides what can be done to deal with the situation (secondary appraisal) An event is appraised as stressful when primary appraisals exceed secondary appraisals, and by using coping processes a person ... support was found for the axis of the stress- coping model Disease characteristics, appraisal of the disease, coping, and quality of life are all significantly related to each other This part of the...
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Báo cáo sinh học: "The immunological potency and therapeutic potential of a prototype dual vaccine against influenza and Alzheimer’s disease" pdf
... in analyses and interpretation of data He drafted the manuscript AG has been involved in analyses and interpretation of data and statistical analysis She helped to draft the manuscript RC participated ... Cell viability was calculated by dividing the absorbance of wells containing samples by the absorbance of wells containing medium alone Statistical Analysis Statistical parameters (mean, standard ... 28 Nistal-Villan E, Gack MU, Martinez-Delgado G, Maharaj NP, Inn KS, Yang H, Wang R, Aggarwal AK, Jung JU, Garcia-Sastre A: Negative role of RIG-I serine phosphorylation in the regulation of interferon-beta...
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báo cáo hóa học: " Toll-like receptor 2 signaling is a mediator of apoptosis in herpes simplex virus-infected microglia" pdf
... caspase-3: 5'gggcctgaaataccaagtca-3' and 5'-aaatgaccccttcatcacca-3'; Dsip1: 5'-ggtggccctagacaacaaga-3' and 5'-tcaagcagctcacgaatctg-3'; CIDE-B: 5' ctggaactcagctcctccac-3' and 5'- cctccaggaccagtgttagc-3'; ... on arrays were scanned using a Kodak Image Station 2000R (Molecular Imaging Systems, Rochester, NY) and were quantified using GEA analysis suite software (SuperArray) Data were analyzed as relative ... cctccaggaccagtgttagc-3'; caspase-2: 5'- cagctccaagaggtttttcg-3' and 5'- acatccaggggattgtgtgt-3'; Tnfrsf1 2a: 5'-gattcggcttggtgttgatg-3' and 5'-cagtccatgcacttgtcgag-3'; RipK2: 5' cagctgggatggtatcgttt-3' and...
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Báo cáo hóa học: " An exploration of job stress and health in the Norwegian police service: a cross sectional study" docx
... and design, acquisition, analysis and interpretation of data and drafting of the manuscript EH was involved in design, interpretation of data, drafting of the manuscript and supervision ØE was ... conception and design, interpretation of data, drafting of the manuscript and supervision BL was involved in analysis and interpretation of data AMB is the guarantor for this paper Acknowledgements ... psychological distress [5] proper training to be a police officer are unquestionably very important However, this "perfect" image that starts already at the Police Academy may also constitute a disadvantage...
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Báo cáo hóa học: " Research Article A Prototype System for Selective Dissemination of Broadcast News in European Portuguese" potx
... Other approaches are forced to use a smaller language model in the first pass and rescore with a larger language model R Amaral et al Table 2: APP impact on speech recognition Segment boundary Manual ... deletion is a critical problem In fact, our TS algorithm has several pitfalls: (i) it fails when Table 3: Topic segmentation results APP Manual Manual Auto ASR Manual Auto Auto Recall % 88.8 88.8 ... notion was defined as a seminal event or activity, along with all directly related events and activities.” Reference [1] as an example, a story about the victims and the damages of a volcanic eruption,...
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Báo cáo khoa học: "A comparison of photosynthetic responses to water stress in seedlings from 3 oak species: Quercus petraea (Matt) Liebl, Q rubra L and Q cerris L" doc
... example, a ψ wp of about -3 MPa was accompanied by a D for ≈ 0.26 in Q cerris and Q petraea, but of ≈ 0.30 in Q rubra Osmotic leaf water potential potential at full turgor (π and ... oversaturation of the leaf disks Drought effects on stomatal conductance and net CO assimilation rate Stomatal conductance to water vapor (ψ ) w and net CO assimilation rates (A) dis2 played ... Oak species are distributed over a large geographic range and display great variations in their abilities to tolerate periods of restricted water supply This latter factor probably plays a major...
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Báo cáo y học: "Psychological stress and fibromyalgia: a review of the evidence suggesting a neuroendocrine link" pps
... chronic stress and fibromyalgia We have shown that activities of several endocrine axes and neurotransmitters change in parallel in both fibromyalgia and stress In particular, there are decreased basal ... LA, Alarcon GS, Triana-Alexander M, Alexander RW, Martin MY, Alberts KR: Perceived physical and emotional trauma as precipitating events in fibromyalgia Associations with health care seeking and ... McBeth J, Silman AJ, Ray D, Macfarlane GJ: A population based study of chronic widespread pain and the hypothalamic–pituitary–adrenal (HPA) axis: results from a pilot study [abstract] Rheumatology...
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Báo cáo y học: "PLCb1-SHP-2 complex, PLCb1 tyrosine dephosphorylation and SHP-2 phosphatase activity: a new part of Angiotensin II signaling?" ppt
... is necessary to allow the association of the tyrosine kinase c-Abl with p19 0A, a RhoA activating GTPase and the cAbl-mediated p19 0A phosphorylation to maintain basal p19 0A activation and consequently ... including the Ras-Raf-MAP kinase, JAK/ STAT, PI3K/Akt, NF-B, and NFAT pathways [22-24] and accumulating evidence suggests that SHP-2 also functions as an adaptor/scaffolding In fact Wang et al [25] ... suggests that SHP-2 may function as part of a complex in other pathways The concept of and the role(s) for complex formation has gained increasing attention as a means to direct signals toward a particular...
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báo cáo khoa học: "Emotional stress as a trigger of myasthenic crisis and concomitant takotsubo cardiomyopathy: a case report" pot
... was calculated as 32% on a cardiac catheterization and 40% on a transthoracic echocardiogram Shortly after cardiac catheterization, she developed bilateral ophthalmoparesis, significant bulbar ... including apical ballooning cardiomyopathy, stress- induced cardiomyopathy, ampulla cardiomyopathy, and broken heart syndrome It is a clinical diagnosis generally defined as an acute left ventricular ... microcirculation of the heart, and elevated catecholamine states [4,7] TC has been described in many different stressful and catastrophic circumstances such as car accidents, family deaths, and even major...
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