introduction to evidence based pathology and laboratory medicine
Pathology and Laboratory Medicine - part 1 pot
... field of laboratory medicine As with the first edition, Cardiac Markers is intended for clinicians and laboratorians working in the fields of cardiology, pathology and laboratory medicine, and emergency ... clinicians and laboratory medicine specialists who require a thorough understanding of this exciting and important diagnostic area, and is must reading for all healthcare professionals who want to keep ... 00/Wu(036-0)/FM/F04.23.03 4/23/03, 12:41 PM Pathology and Laboratory Medicine Series Editors: Stewart Sell and Alan H B Wu Cardiac Markers, Second Edition, edited by Alan H B Wu, 2003 Clinical and Forensic Applications...
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Pathology and Laboratory Medicine - part 2 pps
... myocardial oxygen demand, and minimizing autolytic damage to myocytes (2,3) The thrombus became the primary therapeutic target for reperfusion therapy and monitoring because it is a keystone pathophysiological ... proteins such as collagen and von Willebrand factor (vWF) to From: Cardiac Markers, Second Edition Edited by: Alan H B Wu @ Humana Press Inc., Totowa, NJ 59 60 Christenson and Azzazy Fig Pathophysiological ... for the cutoff to diagnose ACS In addition, cTnI results (Bayer Diagnostics, Tarrytown, NY) based on a cutoff of 0.1 ng/mL (lower limit of detection 0.03 ng/mL) provided efficacy similar to that...
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Pathology and Laboratory Medicine - part 4 docx
... appears to be evidence based However, larger trial studies would be useful to increase the evidence base to determine the overall incidences and differences between cTnT and cTnI monitoring in ... of candidate mediators that may act as “myocardial depressant factors” in SIRS, including lipopolysaccharide, inflammatory cytokines, prostanoids, and nitric oxide (86) The inflammatory cytokines, ... for total CK (Beckman CX7), CK-MB, and cTnI (both Bayer Immuno1) indicated underneath and the relative molecular mass to the left ND, Not determined Lane 1: Patient with history of CHF and symptoms...
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Pathology and Laboratory Medicine - part 6 pptx
... “gold standard” cardiac marker) Lack of assay standardization and differences in the performance of commercial troponin assays Lack of assay standardization between central laboratory based and point-of-care ... This has led to continued confusion among laboratory and clinical practitioners alike as to the proper cutoff and interpretation of results This debate will likely continue well into the next ... clinical use and interpretation of clinical laboratory tests Once a laboratory test has been developed, it is necessary to determine the normal range of the analyte, that is, the Cutoff Concentrations...
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Pathology and Laboratory Medicine - part 7 pps
... of the ratio of total cholesterol to HDL-C (21) Laboratory Methodology Various commercial methods have been developed to measure CRP in serum and plasma Historically, many laboratories have relied ... lecithin, and nucleic acids, and demonstrates a non-calciumdependent binding to cationic molecules such as protamine, heparin, and histones (5) More recently, CRP has been shown to bind to various ... are based on serum and cardiovascular risk assessment strategies are to be used Time and Temperature of Storage CRP has been shown to be stable at 4ºC for 60 d (57) In a study of long-term storage,...
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Pathology and Laboratory Medicine - part 8 potx
... namely, systolic and diastolic dysfunction Both can lead to HF and ultimately death Inability to fill and relax the left ventricle is diastolic dysfunction, defined as an elevated end-diastolic pressure ... systolic and diastolic dysfunction Frequently both systolic and diastolic dysfunction are found in HF patients These functional abnormalities of the left ventricle are important contributors to ... dilation and hypertrophy, and the activation of vasoconstrictor and vasodilator forces, a delicate hemodynamic and neurohormonal balance is achieved, which restores cardiac function toward that...
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Pathology and Laboratory Medicine - part 9 ppt
... receptor-mediated endocytosis The C-type receptors are recycled to the cellular membrane, and the various natriuretic peptides are degraded to building blocks Heart Failure and BNP 381 Fig Age- and ... sensitivity and specificity of BNP and echocardiographic diagnosis of ventricular dysfunction (any abnormal—systolic or diastolic), systolic dysfunction (vs normal and diastolic), diastolic dysfunction ... included the presence of symptoms, presence of normal or mildly reduced systolic function, and evidence of abnormal LV relaxation and filling, diastolic distensibility, and diastolic stiffness (62) Redfield...
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Pathology and Laboratory Medicine - part 10 pps
... binds to the von Willebrand factor receptor and is involved with the adhesion to platelets to the subendothelium, particularly under conditions of high sheer stress GP Ia–IIa receptor binds to collagen ... receptor to bind to fibrinogen where it can interact with another platelet to initiate aggregation GP IIb/IIIa activation also leads to the binding of fibronectin and von Willebrand Factor, which ... inhibitor, and a2-antiplasmin Factors V and II A single point mutation in the Factor V gene produces a factor that when activated is resistant to degradation by the activated protein C and S...
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PATHOLOGY AND LABORATORY MEDICINE - part 3 ppsx
... pathophysiology of this cardiotoxicity remains poorly understood Mitoxantrone Mitoxantrone has pharmaceutical effects similar to those of anthracyclines, and it also produces cardiotoxicity that in many ... The HER2 proto-oncogene is a transmembrane receptor tyrosine kinase that belongs to the epidermal growth factor family This receptor is overexpressed in 10–35% of patients with cancer and is associated ... related to exposure to cardiotoxic agents and for determining the efficiency of cardioprotective procedures in both preclinical and clinical situations The antibodies used in the first- and second-generation...
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PATHOLOGY AND LABORATORY MEDICINE - PART 5 pps
... Traceability in Laboratory Medicine (JCTLM) has been established with the aim to support worldwide traceability, comparability, and equivalence of measurement results in laboratory medicine (Table ... Validation and selection to be completed No homogeneity and stability To be performed informations Validation and selection to be completed Complete characterization To be performed to be performed ... material and the manufacturer’s standing procedure can be used in industry to assign values to commercial calibrators Clinical laboratories use routine procedures with validated calibrators, both...
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Báo cáo y học: "Serum urate, menopause, and postmenopausal hormone use: from eminence to evidence-based medicine" ppt
... effect of hormonal factors on gout incidence could find the increases in serum urate induced by menopause and the protection conferred by hormone replacement therapy too modest to be of very much ... by estrogen and progestin replacements [7] One might infer from these results that the increase in serum urate of 0.34 to 0.36 mg/dl seen in Hak and Choi’s study may not be enough to significantly ... and Saag menopausal women are adequate controls for a different group of postmenopausal women These interesting results obtained by Hak and Choi are concordant with those published by Simon and...
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Báo cáo y học: " Barriers and facilitators to evidence based care of type 2 diabetes patients: experiences of general practitioners participating to a quality improvement program" ppt
... provided reassurance by intonation and body language in order to disclose the very personal feelings and experiences of the interviewees The interviews took 30 to 45 minutes and were conducted individually ... to reach treatment targets and regular follow-up Attitude and motivation - laxity regarding treatment targets and timely follow-up - attitude to polypharmacy - skepticism regarding evidence- based ... nurse educator as complementary to their own and, feeling that they themselves lacked the requisite skills and time, were relieved to relinquish patient education to them 'I prefer to have the...
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báo cáo khoa học: " A cluster randomized trial to improve adherence to evidence-based guidelines on diabetes and reduce clinical inertia in primary care physicians in Belgium: study protocol [NTR 1369]" potx
... program goal is to improve adherence to evidencebased guidelines and to reduce clinical inertia in primary care physicians, and to therefore improve the management of glycemic control and cardio-vascular ... cornerstone to high-quality diabetes care [33,34] Office system and organizational factors that contribute to clinical inertia are the absence of decision support and a team approach to care ... guidelines and clinical inertia: physician factors, patient factors, and office system and organizational factors [28-30] Physician factors that contribute to clinical inertia include an overestimation...
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