introduction to drug drug interactions
An Introduction To Tissue- Biomaterial Interactions pot
Ngày tải lên :
27/06/2014, 10:20
... Atherosclerosis, 185 Atomic force microscopy (AFM), 160–161, 205 See also AFM images 219 220 Index Atomic level structure, Atrophy, 128, 206 Autocrine, 206 Autocrine manner, 129 Autografts, 83, 206 Autoimmune ... Questions 13 Proteins 2.1 xv 15 Introduction 15 vii viii An Introduction To Tissue-Biomaterial Interactions 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 2.10 2.11 Protein-Surface Interactions 3.1 3.2 3.3 3.4 ... 0-471-25394-4 (Hardback); 0-471-27059-8 (Electronic) An Introduction To TissueBiomaterial Interactions An Introduction To TissueBiomaterial Interactions Kay C Dee, Ph.D Tulane University Department of...
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Báo cáo y học: "Dangerous drug interactions leading to hemolytic uremic syndrome following lung transplantation" docx
Ngày tải lên :
10/08/2014, 09:22
... developed a colonic perforation due to diverticular disease and had a colostomy Two years and seven months following her transplantation she was admitted to her local hospital with right side ... patient was transferred to our service days later with unresolving pneumonia and worsening renal indices (urea from 14 mmol/L to 29 mmol/L and creatinine from 171 mmol/L to 235 mmol/L) The Hemoglobin ... were not elevated The patient was allergic to dye therefore a CT pulmonary angiogram was not performed The clinical picture was considered to be due to an underlying rejection and she was augmented...
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Managing Drug Interactions in the Treatment of HIV-Related Tuberculosis docx
Ngày tải lên :
06/03/2014, 04:20
... overlapping side effect profiles of antituberculosis drugs and antiretroviral drugs, immune reconstitution inflammatory syndrome, and drug- drug interactions The key interactions, and the focus of this document, ... response to antiretroviral therapy then stops taking the interacting drug (e.g., ritonavir), the resulting rifabutin concentrations are likely to be sub-therapeutic These factors, in addition to the ... modern laboratory techniques to determine pathways of drug metabolism Furthermore, there are no published studies of possible drug- drug interactions between second-line antituberculosis drugs and...
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RNA Interference Technology FROM BASIC SCIENCE TO DRUG DEVELOPMENT ppt
Ngày tải lên :
06/03/2014, 09:21
... Contributors Yerramilli V B K Subrahmanyam, PhD QIAGEN, Inc 19300 Germantown Rd Germantown, MD 20874 USA E-mail: subu.yerramilli@qiagen.com Asako Sugimoto, Ph.D Laboratory Head Laboratory for ... growth factor–treated tumors This chapter also highlights Introduction the target validation of genes for several growth factors and their counter receptors To identify host cell factors potentially ... retroviral vectors for efficient delivery of siRNAs into the mammalian cells Lentiviral-based siRNA vectors will have the ability to generate transgenic animals carrying an siRNA cassette in order to achieve...
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Promoting Student Health and Wellbeing: A guide to drug education in schools ppt
Ngày tải lên :
22/03/2014, 15:20
... divided into four categories: tobacco, alcohol, illegal drugs, and other drugs Tobacco and alcohol are self-explanatory ‘Illegal drugs’ are those that are classified as controlled drugs under ... and harm to those continuing to use drugs and to the wider community, but that not condone or encourage drug use * see Alan & Clarke Policy and Regulatory Specialists (2003) Effective Drug Education ... whole-school approach to drug education and provide for other pastoral care and support • know how to recognise drug- related symptoms, including the range of reasons for young people using drugs • recognise...
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Chapter 113. Introduction to Infectious Diseases: Host–Pathogen Interactions (Part 1) docx
Ngày tải lên :
07/07/2014, 04:20
... ability to elude our best weapons and to counterattack with new survival strategies Antibiotic resistance occurs at an alarming rate among all classes of mammalian pathogens Pneumococci resistant to ... agents appear to have been brought into contact with humans by changes in the environment and by movements of human and animal populations An example of the propensity for pathogens to escape from ... have an infectious component In contrast, there are data to suggest that decreased exposures to pathogens in childhood may be contributing to an increase in the observed rates of allergic diseases...
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Chapter 113. Introduction to Infectious Diseases: Host–Pathogen Interactions (Part 2) docx
Ngày tải lên :
07/07/2014, 04:20
... Chronic pulmonary secretions infection with P aeruginosa INFLAMMATORY RESPONSE Neutropenia Hematologic malignancy, Gram-negative cytotoxic enteric bacilli, chemotherapy, aplastic anemia, Pseudomonas ... infections, gingivitis Phagocytosis (cellular) Systemic lupus Streptococcus erythematosus (SLE), chronic pneumoniae, myelogenous H leukemia, influenzae megaloblastic anemia Splenectomy — H influenzae, ... monocytogenes, sarcoidosis, lepromatous Mycobacterium leprosy spp., Candida spp., Aspergillus spp., Cryptococcus neoformans, herpes simplex virus, varicellazoster virus AIDS Pneumocystis, cytomegalovirus,...
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Chapter 113. Introduction to Infectious Diseases: Host–Pathogen Interactions (Part 4) docx
Ngày tải lên :
07/07/2014, 04:20
... transcriptional activator nuclear factor κB (NF-κB), to produce cytokines that lead to inflammation and enzymes that enhance the clearance of microbes These initial responses serve not only to limit infection ... host's own major histocompatibility complex antigen to the T cell receptor Activated T cells may then act in several ways to fight infection Cytotoxic T cells may directly attack and lyse host cells ... Toll-like receptors (TLRs) are instructive in illustrating how organisms are detected and send signals to the immune system There are at least 11 TLRs, each specific to different...
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Chapter 113. Introduction to Infectious Diseases: Host–Pathogen Interactions (Part 5) doc
Ngày tải lên :
07/07/2014, 04:20
... receptors, called selectins (CD62, ELAM-1), in response to inflammatory cytokines such as tumor necrosis factor α and interleukin The binding of these selectin molecules to specific receptors ... bartonellosis, Escherichia coli O157 infection, or cryptococcosis Blood transfusions have been linked to diseases ranging from viral hepatitis to malaria to prion disease A history of exposure to ... factors for exposure to certain types of pathogens may give important clues to diagnosis A sexual history may reveal risks for exposure to HIV and other sexually transmitted pathogens A history...
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Chapter 113. Introduction to Infectious Diseases: Host–Pathogen Interactions (Part 6) docx
Ngày tải lên :
07/07/2014, 04:20
... risk (and a cost) to the patient Direct toxicity may be encountered—e.g., ototoxicity due to aminoglycosides, lipodystrophy due to antiretroviral agents, and hepatotoxicity due to antituberculous ... agents that modulate the immune response include prostaglandin inhibitors, specific lymphokines, and tumor necrosis factor inhibitors Specific antibody therapy plays a role in the treatment and prevention ... well-designed clinical trials to evaluate each new interventional modality Perspective The genetic simplicity of many infectious agents allows them to undergo rapid evolution and to develop selective...
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báo cáo khoa học: " The Chinese government’s response to drug use and HIV/AIDS: A review of policies and programs" potx
Ngày tải lên :
11/08/2014, 18:20
... arrested drug users in Compulsory Detoxification Centers” According to this policy, newly-found drug users were sent directly to compulsory detoxification centers, while relapsed drug users were to ... purpose of the compulsory and voluntary detoxification is to reduce demands for drug use, drug related crimes, and injection drug use, which are designed to eventually reduce HIV transmission rates ... combination of detoxification treatment, physical exercise, and manual labor [7,19-22] At the third level, drug users who relapse after receiving compulsory detoxification are mandated to to years of...
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A study of quality and safety of herbal medicine adulteration and herb drug interactions
Ngày tải lên :
14/09/2015, 08:23
... similar to drugs Among them, herb -drug interactions, one of the important safety issues, are often overlooked and sometimes simply categorized as toxic effects of consumed drugs 13 1.2.2 Herb -drug interactions ... of the potential food -drug/ herb -drug interactions, although they are still rare when comparing with drug- drug interactions Most of the available information about herb -drug interactions is based ... classification They act as drugs following modern pharmacological principles Herb -drug interactions which are based on the same principles as drug- drug interactions should not come to be a surprise (Izzo...
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Tumor cell response to drug induced apoptosis is a function of intra cellular redox status 3
Ngày tải lên :
16/09/2015, 17:11
... mitochondrial death pathway during nonreceptor /drug induced apoptosis are not optimally understood Death signals induced by drugs engage Bcl-2 family of proteins that will ultimately lead to ... proteins like VDAC (Tsujimoto and Shimizu, 2000) or just physically ruptures the mitochondrial membranes to spill out the cytochrome C into the apoptotic system (Crompton, 2000; Zamzami and Kroemer, ... resistant to H2O2-induced apoptosis Fig-31: Sensitivity of HCT116 cells to H2O2-induced apoptosis is Bax dependent Fig-32: Downstream cytochrome C release is absent in Bax knockout cells in response to...
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Tumor cell response to drug induced apoptosis is a function of intra cellular redox status 2
Ngày tải lên :
16/09/2015, 17:11
... and leakage of pro-apoptotic proteins to the cytosol However, most of these studies seem to imply that the mitochondrial burst of H2O2 is likely to be a downstream effector mechanism for the execution ... results point to a direct effect of an acidic intracellular milieu in trafficking Bax from the cytosol to the mitochondria It is interesting to note that one of the first studies to report a relationship ... from the mitochondria This could lead to peroxidative damage of mitochondrial lipids, such as cardiolipin, and facilitate the egress of cytochrome c, Smac/Diablo, or apoptosis inducing factor (AIF)...
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Tumor cell response to drug induced apoptosis is a function of intra cellular redox status 1
Ngày tải lên :
16/09/2015, 17:11
... indirectly to the apoptosis-inhibitory activity of RSV In addition, data presented here not only implicate mitochondrial H2O2 production as a critical effector mechanism during druginduced apoptosis ... that the inhibitory activity of RSV on drug- induced apoptosis was linked to its ability to increase NADPH oxidase-dependent intracellular O2Ϫ production Interestingly, all of the drugs used in ... cells to apoptotic stimuli that require mitochondrial amplification factors Taken together, these results indicate that the increase in intracellular O2Ϫ on exposure of leukemia cells to RSV...
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In vivo aspects of potential stereospecific drug interactions of oral warfarin and rutin in rats
Ngày tải lên :
09/10/2015, 11:24
... mechanisms for such interactions are yet to be established (1) New drug products are routinely examined in vitro and in vivo for the potential to cause drug interactions via inhibition of drug- metabolizing ... assay method is able to successfully separate the enantiomers and detect fluorimetrically It was found to be highly sensitive and specific 1.1.7 WARFARIN DRUG INTERACTIONS Drug interactions involving ... substances that inhibit cytochrome P450 isoforms have higher potential for drug interactions (73) But experimental data on herb -drug interactions are limited and scarce (74) Potential interactions of alternative...
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RESEARCH POLYAMIDOAMINE DENDRIMERS MODIFIED BY BIOCOMPATIBLE POLYMERS (PEG AND PLURONIC) APPLICATION TO DRUG
Ngày tải lên :
28/04/2016, 17:48
... Particularly anti-cancer drugs are not only toxic to cancer cells but also toxic to the healthy cells Many scientific reports indicate that the encapsulation of drugs to treat cancer or nano polymer ... encapsulated drug 5-FU ( PAMAM G4.0-PEG6K/5-FU, PAMAM G4.0-P123/5-FU and PAMAM G4.0-F127/5-FU ) is capable of powerful cytotoxic concentrations cytotoxic IC50 2-3 times compared to 5-FU control ... TEM to examine the morphology of the PAMAM - PEG and PAMAM - Pluronic Use the SRB staining method , dyed fluorescent dye MTT and FDA / EB to assess cytotoxicity in vitro Using UV-Vis and HPLC to...
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food drug interactions
Ngày tải lên :
06/12/2016, 01:03
... the drug Decreased transit time: cathartic agents, laxatives, drugs containing sorbitol, drugs that increase peristalsis Drug Effects on Nutrition; Absorption Change GI environment – Proton ... degree to which a drug or other substance reaches the circulation and becomes available to the target organ or tissue Half-life: amount of time it takes for the blood concentration of a drug to decrease ... especially if the drug is taken orally Distribution When the drug leaves the systemic circulation and moves to various parts of the body Drugs in the bloodstream are often bound to plasma proteins;...
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An introduction to disk drive modeling
Ngày tải lên :
12/09/2012, 14:16
... cylinder skewing and sector-based sparing with one spare sector per track This needs to be accounted for in mapping logical blocks to the physical sectors Adding all these factors results in the ... 97560 sector size 256 bytes 512 bytes cylinders 1449 1962 tracks per cylinder 19 data sectors per track 113 72 number of zones 1 track skew 34 sectors sectors cylinder skew 43 sectors 18 sectors ... specifications, since the only alternative is to determine them experimentally The information required to determine how much power to apply to the pivot motor and for how long on a particular seek...
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