... centrolobular necrosis and, later, fibrous obliteration of the hepatic venules and perivenular fibrosis [2,3] Fifteen days after the onset of the disease, the clinical symptoms vanished and liver enzymes ... aggravated the clinical course Symptomatic treatment comprised of dialysis and diuretic therapy with torasemide 10 mg/hour Lung function was sustained by mechanical ventilation Furthermore, centralnervous ... Discussion There is no accepted standard of therapy for severe SOS Despite thrombolytic therapy with tissue-plasminogen activator (t-PA) or prostaglandin E1 with or without heparin, the mortality...
... lung edema on the one hand, but protecting lung epithelial cells and inducing cell recovery on the other hand Mura and colleagues [20] estimated the VEGF expression in lung tissue and its concentration ... synthetized in gonads and adrenal glands of both males and females, whereas the synthesis in the adrenal gland becomes of increasing importance in elderly men and women The conversion to sex hormones ... both the post-traumatic immune response and cardiac function [11,12] Dehydroepiandrosterone (DHEA), the precursor of androstendione, testosterone, and estrogen, is synthetized in gonads and adrenal...
... clotting factors to the point that factors V and X and fibrinogen are depleted, then the patient develops a prolonged PT/aPTT The endogenous anticoagulant system is also reduced and, paradoxically, ... monthly basis The benefits of these therapies are considerable The short-term risks associated with plasma exchange therapy include theThe present mainstay of therapy for DIC is replacement ... bleeding from these therapies, then one can consider anti-fibrinolytic therapies, including aminocaproic acid, tranexamine, and aprotinin Recently, Ono and colleagues [24] reported that the degree...
... cells, edema in the space bounded by the villus, and separation of the epithelium from the basement membrane (Figure 1F) Treatment with GW0742 markedly reduced the histological damage in the pancreatic ... the expression of endothelial adhesion molecules, such as ICAM-1 and Pselectin that play a pivotal role in the rolling and firm attachment of neutrophils to the endothelium [28], regulating the ... vessels and upregulated the surface expression of ICAM-1 and P-Selectin on endothelial cells in the pancreas, lung and gut In contrast, there was significantly less expression of Pselectin and ICAM-1...
... and was admitted to the ICU for haemofiltration Antiretroviral therapy was continued on the ICU with ritonavir-boosted lopinavir and saquinavir Abacavir and lamivudine, which the patient was already ... the ICU The basis for this improvement is likely to be multifactorial, reflecting better understanding of HIV-associated disease, the availability of new combination antiretroviral therapy, the ... similar to the cervical adenopathy present in this patient; and therefore neck biopsy may have in fact slowed the diagnostic process Antiretroviral therapy was continued, but modified on the ICU...
... SAPS II andthe 'standardized mortality ratio' by dividing the observed by the predicted hospital mortality The severity of the patient's underlying medical condition was stratified using the McCabe ... Competing interests The authors declare that they have no competing interests Authors' contributions FJ and AV-B conceived and designed the study, and drafted the manuscript FJ supervised and was responsible ... Gram-positive and Gram-negative agents were responsible in 22 and 20 patients, respectively The average SAPS II score for the whole group was 67 ± 18 During the same period, 35 patients who met the inclusion...
... Results The computerized search yielded 85 papers, 19 of which could be included in the analysis based on the analysis of the type of article and review of the abstract From the references in these ... papers in the study; Kron and colleagues [23], Platell and colleagues [26], Meldrum and colleagues [17], Chang and colleagues [28], Sugrue and colleagues [18], Ertel and colleagues [2], Biffl and colleagues ... function were reported in the other papers Some questions cannot be answered by the analysis of the outcome parameters in this review The effects of the timing of DL andthe speed of diagnosis of...
... Table of our report [1], plasma chloride concentration was in the normal range and did not differ between the two groups On the other hand, we agree that base excess reflects not only lactic acidosis ... was caused by persistent lactate production! However, on reading the latter comment by Drs Jacobs and Brivet, we wonder whether they completely understood our report, in which CVVHDF is proposed ... Critical Care Vol 10 No Jacobs and Brivet Drs Jacobs and Brivet consider base excess to be of questionable usefulness in assessing metabolic acidosis However, as they point out above, it appears...
... interests YAK is the author and director of the Muavenet Intensive Care Information System, which is an open access, online academic information systemThe other authors declare that they have no ... representation of the performance of LOD, SOFA and MODS: cardiovascular system Shown are data of another patient, illustrating differences between organ failure scores in assessing the cardiovascular system ... Artigas A, Teres D: The Logistic Organ Dysfunction System A new way to assess organ dysfunction in the intensive care unit JAMA 1996, 276:802-810 Muavenet Intensive Care Information System [http://www.icu...
... as the occurrence of severe organ failure in two or more organ systems during the ICU stay, either on the same day or on different days Statistical analysis Based on the SOFA scoring system, the ... of data, and drafted the manuscript RK helped to design the study, and participated in the acquisition of data TW-L participated in the design of the study, and analysis and interpretation of ... 15 16 The authors declare that they have no competing interests Authors' contributions AU was involved in the design of the study, in the acquisition, analysis and interpretation of data, and drafted...
... this a suggestion for a standardisation of scoring MOF in trauma? This question remains unanswered and needs further investigation The Ulvik paper adds a further step to the knowledge of long-term ... not answer this question, but the point is crucial Is it the efficacy of the resuscitation, or the treatment of sepsis that affects long-term survival? If sepsis is the key, late outcome in trauma ... been validated also in trauma and in general ICU patients [7,8] Recently it has been shown that the admission SOFA score, SOFA Max, andthe changes in SOFA over the first 48 hours are correlated...
... transfusion than utilized in the early goal-directed therapy study [27] While the interpretation of these findings may be limited by the nature of the study (mail-based survey) andthe moderate response ... confirmed the main results Reported adverse events were rare, and included clotting of the device and erythema These results suggest PMX-F may be a promising therapy for severe sepsis The included ... cytokines, including TNFα, IL-6 and malondialdehyde Supporting the role of heat shock proteins, heat shock protein 70 was increased in the heart, the endothelium, the lung andthe liver of animals treated...
... coagulopathies and disorders of the autonomic and peripheral nervous systems [7] There have been few data published describing the effect of an episode of multiple-organ failure on the long-term ... for the study and comparator groups has not been performed, the similarity of the long-term survival curves suggests that the background risks of the two groups are, indeed, comparable Figure The ... Rowan K: Case mix, outcome and length of stay for admissions to adult, general critical care units in England, Wales and Northern Ireland: the Intensive Care National Audit and Research Centre Case...
... Pathophysiologic Implications of Intra- abdominalHypertensionThe effects of intra- abdominalhypertension are not limited just to the intra- abdominal organs, but rather have an impact either directly or indirectly ... that are either rigid (costal arch, spine, and pelvis) or flexible (abdominal wall and diaphragm) The compliance of these walls andthe volume of the organs contained within determine the pressure ... conference definitions and recommendations on intra- abdominalhypertension (IAH) andtheabdominal compartment syndrome (ACS) – the long road to the final publications, how did we get there? Acta Clin...
... inexpensive, and maintain theabdominal domain In addition, the preservation of the accessibility to theabdominal cavity andthe feasibility of gradual closure of theabdominal wall are important The ... on intra- abdominalhypertensionandabdominal compartment syndrome II Recommendations Intensive Care Med 2007, 33:951-962 De laet I, Malbrain MLNG: ICU management of the patient with intra- abdominal ... attempts However, the major source of morbidity is associated with the management and complications of the open abdomen Management of the open abdomen In view of the complicated and often fatal...
... cells, and platelets [46] AT-III is synthesized by the liver and endothelium, and protein C by the liver On the contrary, the tPA–PAI-1 complex is considered to be synthesized mainly by the activated ... confirmation of the capability of the AP for strict blood glucose control (by calculating the daily mean BG) and for the evaluation of the GT (M value) Whether the blood concentration of the stress-related ... from the results that there were no significant correlations between the M value andthe blood concentration of these hormones (Table 5), and that there were no significant differences in the...
... measurements and documentation WRH conceived the study protocol, and helped to interpret the data and to draft the manuscript BF helped to interpret the data and to draft the manuscript HK conceived the ... participated in the study design and its coordination, and helped to draft the manuscript HU performed the statistical analysis and helped to interpret the data WP conceived the study, and helped ... measurements and documentation, performed the statistical analysis, and helped to draft the manuscript KHS participated in the design of the study and performed the calculations for the microcirculatory...
... contributions BS, VP, and GM contributed to the conception and design of the study They were responsible for acquisition, analysis, and interpretation of data BS drafted the manuscript RMS and WH participated ... or more organ systems The APACHE II score was calculated after admission of a patient to the ICU and, in addition, the Simplified Acute Physiology Score (SAPS II) was calculated on the first day ... targeting the lower end of the therapeutic aPTT range in these very ill patients For example, one recent study investigated argatroban treatment in critically ill ICU patients with HIT II andthe necessity...