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Interactions of Bioactive Plant Metabolites - Synergism, Antagonism, and Additivity
... amplification and overproduction of the target protein, production of proteins that pump the drug out of the cell, underproduction of proteins that allow the drug to enter the cell, improved repair of drug-induced ... responses are averaged across in-tray replicates and divided by average responses of in-tray control wells – and (2) taking the log of a function of the scaled data Each of these steps can have detrimental ... portions of this chapter to refer to both approved drugs and bioactive plant compounds The binding of a drug to a protein may affect the function of that protein through a number of 10 Interactions of...
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Functional interactions of protein tyrosine phosphatase alpha (PTPa) and src in mouse development and integrin singaling investigation of double PTPa src deficient mice and cells
... PTPα-/-, Src-/-, and α/s DKO fibroblasts…………………………… ………………100 6.1 Summary of phenotypes of PTPα-/-, Src-/-, and PTPα-/-Src-/- mice ………….142 6.2 Summary of phenotypes of PTPα-/-, Src-/-, and α/s DKO ... or all of its functions are effected through dephosphorylation and activation of Src and/ or Fyn 1.5.3 Combinatorial regulation of PTPα catalytic activity and specificity Although the ligands for ... the regulation of the ligand binding activity of the extracellular domain of the integrins (so-called “inside-out signaling”), and for mediating interactions with the cytoskeleton and transducing...
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Báo cáo y học: "Application of Small Angle X-ray Scattering (SAXS) for Differentiation between Normal and Cancerous Breast Tissue"
... diffraction profiles for the tissue types listed in table Each of the curves is the average value of corrected intensity of samples within its classification The number of samples of each type ... optimum, in terms of peak width and peak intensity was found to be at an angle of 6.5° Therefore, all other tissue sample measurements were performed at 6.5° and at a temperature of 18°C ± 1°C Samples ... (adipose plus fibroglandular) normal tissues, 41 carcinoma and 21 fibrocystic changes Effects of storage – In order to study the effects of tissue storage upon the diffraction profiles measurements...
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Tài liệu Báo cáo khoa học: X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate docx
... Protein–ligand and water-mediated protein–ligand hydrogen bond interactions (broken lines) that stablize the pantoate molecules in site I and site II of nPS Oxygen atoms of pantoate and water ... A-chain and B-chain of nPS, and in the case of His37, the v1 torsion angle changes from 63.34° to )67.80° and )52.11° for the A-chain and B-chain of nPS, respectively The imidazole ring of His34 ... cases, and this stretch of residues was therefore not rebuilt X -ray crystallographic structure of nPS bound to pantoate Fig The absolute value of deviation in chemical shift (p.p.m.) of residues of...
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Tài liệu Báo cáo khoa học: Molecular determinants of ligand specificity in family 11 carbohydrate binding modules – an NMR, X-ray crystallography and computational chemistry approach doc
... the ligands are equal among themselves, this change in orientation is of no great importance for the establishment of the binding interactions between the ligand and CtCBM11, and this kind of behaviour ... about the binding pocket of CtCBM11 and identify which atoms of the ligand and of CtCBM11 interact preferentially Calculations were performed with cellobiose, cellotetraose and cellohexaose carbohydrates ... of the molecular interactions that define the ligand specificity in cellulosomal CBMs and the mechanism by which they recognize and select their substrates, we used X -ray crystallography, NMR and...
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Tài liệu Báo cáo khoa học: Mutational analysis of plasminogen activator inhibitor-1 Interactions of a-helix F and its neighbouring structural elements regulates the activity and the rate of latency transition pdf
... behaviour and a low unstable inhibitory activity, and for I137A a biphasic loss of activity (Fig and Table 3) The phenotype of these substitutions is therefore different from that of N139A, T146A and ... assay and expressed as percentage of the theoretical maximum The activity was monitored over time and the rate of latency transition expressed as the functional half-life, t½ The averages and standard ... assay and expressed as percentage of the theoretical maximum The activity was monitored over time and the rate of latency transition expressed as the functional half-life, t½ The averages and standard...
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Báo cáo khoa học: C-terminal, endoplasmic reticulum-lumenal domain of prosurfactant protein C – structural features and membrane interactions ppt
... using a bandwidth of nm and a response time of s, and 10 data points per nanometer were collected Each spectrum is the average of three scans Far-UV CD spectra of CTC in the presence of phospholipid ... Urea-induced and temperature-induced unfolding CD spectra of nonreduced and reduced CTC in the presence of increasing amounts of urea are shown in Fig 4A,B Nonreduced CTC showed small and continuous ... dependence of energy transfer efficiency on distance between donor and acceptor, FRET experiments indicate molecular proximity of Tyr residues in CTC and the bound bis-ANS percentages of a-helix and...
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Báo cáo khoa học: Interactions of HIPPI, a molecular partner of Huntingtin interacting protein HIP1, with the specific motif present at the putative promoter sequence of the caspase-1, caspase-8 and caspase-10 genes pdf
... N-terminus of HIPPI containing Myosin-like domain (HiN), and that expressing GFP-tagged pDED of HIPPI (HiD) The upper bands of the upper panel correspond to procaspase-8 (57 kDa), and the lower bands ... concentrations of NaCl, the fluor3888 escence intensities of GST–HIPPI increased, indicating a lesser extent of interactions of GST–HIPPI with AA AGACATG This result indicated that the interaction of GST–HIPPI ... 1/[DNA]µM III Fig In vitro binding assay of putative HIPPI-binding motif AAAGACATG and its mutant (A) EMSA of binding of the end-labeled bp motif AAAGACATG and two of its mutants with purified GST–HIPPI...
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Báo cáo khoa học: Identification, subcellular localization and functional interactions of PilMNOWQ and PilA4 involved in transformation competency and pilus biogenesis in the thermophilic bacterium Thermus thermophilus HB27 ppt
... to the C-termini of other members of the secretion family, such as PilQ of Myxococcus xanthus [28], ExeD of Aeromonas salmonicida [29], PilQ of P aeruginosa [25,30], and PilQ of N gonorrhoeae ... Analyses of novel Thermus competence proteins J Rumszauer et al N-terminal domain of PilQ, and the colocalization of PilQ with PilW in inner and outer membranes and the results from the pilW and pilQ ... PilA4 and PilQ are individually essential for transformation and piliation [7,8] In contrast to PilQ and PilA4, an individual role of PilM, PilN, PilO and PilW in natural transformation and piliation...
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Báo cáo khoa học: Differential interactions of decorin and decorin mutants with type I and type VI collagens pptx
... the addition of complexes were performed For the analysis of interactions between proteoglycans and collagens, the sensograms were corrected by a modification of the method of Roden and Myszka [20] ... interaction of wild-type decorin and decorin mutants with type I and type VI collagen and, for the first time, we analysed the formation of triple complexes consisting of type VI collagen, decorin and ... involving dimerization of decorin and binding of both collagens to the inner surface of decorin (B) Interaction of type I collagen with the inner surface of the decorin core protein and type VI collagen...
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Báo cáo khoa học: Production and utilization of hydrogen peroxide associated with melanogenesis and tyrosinase-mediated oxidations of DOPA and dopamine docx
... from H2O2 production during the autoxidation of dopamine following the addition of varying amounts of the diphenol into solutions of NaCl ⁄ Pi (pH 7.4) that lacked catalase (A and B) and those ... tetrahydrobiopterin; GSH, reduced glutathione compounds, and reducing agents, the activities of melanogenic enzymes and competitive oxidases, and the availability of enzyme cofactors The two-step reaction sequence ... given to understanding the role of peroxidase in the early stages of melanogenesis, despite reports of the involvement of peroxidase–H2O2 systems in later stages during the oxidation of indolequinone...
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Báo cáo khoa học: The effect of replacing the axial methionine ligand with a lysine residue in cytochrome c-550 from Paracoccus versutus assessed by X-ray crystallography and unfolding ppt
... R Worrall et al X -ray and unfolding studies of cyt c-550 Fig Close up of the heme binding pocket of (A) wt and (B) the M100K(rt) variant of ferricyt c-550, with the positions of the buried water ... structure and unfolding upon replacing the axial Met ligand with a Lys in the M100K variant of cyt c-550 from P versutus We describe three X -ray structures, one of the ferric wild type (wt) and two of ... indicated for the M100K structure (w12:backbone amides of T101 and F102, w29:Nf of K99) (D) Overlay of part of the K100 ligand binding loop for M100K(rt) and (cc) structures showing the double conformation...
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Báo cáo Y học: Determinants of the inhibition of a Taiwan habu venom metalloproteinase by its endogenous inhibitors revealed by X-ray crystallography and synthetic inhibitor analogues pdf
... pockets (A) and (B), the S)1 pockets of TM-3 (gray) and its pENW-bound form (red), respectively (C) and (D), the S)1 pockets of adamalysin II (cyan) and atrolysin C (blue) after the binding of a phosphonate ... potencies of pEWN and pEWK (Table 3) Structural comparison of pENW-(TM-3) with the peptidic inhibitor-complexes of atrolysin C, TACE and HNC Fig Diagram of the active-site structure of TM-3 complexed ... structures of TM-3 in the absence and presence of pENW, respectively, are shown Positions of the Metturn (magenta) and disulfide-linkages (blue) of TM-3 are also indicated (C), superimposition of the...
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Báo cáo khoa học: Intrinsic local disorder and a network of charge–charge interactions are key to actinoporin membrane disruption and cytotoxicity ppt
... of the molecular interactions of StnII with the membrane at residue level, but also to better understand the cytotoxic mechanism of this family of proteins Results Global fold of StnII-R29Q and ... wild-type protein (B) and the StnII-R29Q (C) and StnII-Y111N (D) variants Blue and red correspond to positively and negatively charged areas, respectively The side chains of R29 and Y111 are shown ... composed by b-strands 145–150 and 156–161 and they are rich in hydrophobic and exposed residues In particular, the aromatic rings of Y140 and W146 have high accessible surface area (30% and 35%, respectively)...
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ECOLOGY OF COLD SEEP SEDIMENTS: INTERACTIONS OF FAUNA WITH FLOW, CHEMISTRY AND MICROBES potx
... addresses the communities of organisms that inhabit cold seep sediments, focusing on soft-bodied, mid-size organisms (e.g., macrofauna and meiofauna) and on the nature of their interaction with ... environments often support surprisingly high densities of macrofauna Estimates of density vary with the mesh size employed but values of >10,000 ind m–2 are common and local patches of >40,000 ... microbes and infauna Dattagupta (2004) suggests that release of sulphate by roots of seep vestimentiferans in the Gulf of Mexico enhances sulphate reduction locally and thus the production of sulphide...
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Báo cáo khoa học: Contributions to catalysis and potential interactions of the three catalytic domains in a contiguous trimeric creatine kinase doc
... case, and that these interactions may be representative of a suite of interactions and structural changes that are required for catalysis across this entire enzyme family Results and Discussion FlgCKs ... elements for catalysis and are at least capable of the same types of structural interactions described for oligomeric CK isoforms It is important to note that these isoforms have FEBS Journal ... its closing [5] This ‘tugof-war’ scenario, whereby the closing of one active site exerts pressure through a suite of atomic interactions to inhibit the binding and closing of any other active sites...
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INTERACTIONS OF POLYMERS WITH FIBRILLAR STRUCTURE OF CELLULOSE FIBRES: A NEW APPROACH TO BONDING AND STRENGTH IN PAPER docx
... to explain the interactions between strength additives and fibres and to understand the mechanisms of development of strength and the influence of the polymers applied This way of thinking emerged ... heterogeneity of real paper stocks and the interdependence of adsorption, retention, and formation, the interactions of polymers with different pulp components are complicated and the true effect of an ... RESULTS AND DISCUSSION 34 4.1 Interactions of polymers with cellulose fibrils 34 4.1.1 Dispersion/aggregation of fibrils and fibrillated fibre surfaces 35 4.1.2 Interactions of polymers...
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Interactions of Chemical Variations and Biocide Performance at Paper Machines potx
... errors in demanding biocide dosing 15 THE OBJECTIVE AND THE OUTLINE OF THE STUDY The objective of this work was to study the interactions of microbial activity, biocide usage and - creation and chemical ... the DLVO (Derjaguin and Landau, Verwey and Overbeek) theory (Derjaguin and Landau 1941; Verwey and Overbeek 1948) The theory explains how particles in aqueous system interact and how different ... of the system and further the flocculation and coagulation Figure illustrates how different forces attract and repulse the particles, what is the effect of salt concentration, and what kind of...
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Báo cáo " Research on organizing spatial production of economic models for agro - fisheries and processing industry in Diem Dien Town, Thai Thuy District, Thai Binh " doc
... industrial production and construction - 3.8%, on commerce and service - 10%, and on handicraft - 4.4% In 2005, the rate of labor of town made up 49.6% of the total population, but the number of labor ... 2.81% of natural land area, however, aquaculture production is still potential and its capability can be expanded further based on the potential of exploitation and utilization of tidal peak and ... accounted for 6.2% of GDP in 2004 The marine economic consists of the branches of catching and exploiting organism sources and seafood processing 3.2.1 The catching and exploiting sources of the marine...
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Báo cáo khoa học: Surface-enhanced vibrational spectroscopy for probing transient interactions of proteins with biomimetic interfaces: electric field effects on structure, dynamics and function of cytochromec doc
... demands are imposed on the sensitivity and selectivity of the methodology, which should provide molecular structure and dynamics information In this article, we present the potential of Raman and ... spectroscopy: since the electronic transitions of most of the protein cofactors (e.g haem) of proteins are at shorter wavelengths, the combination of molecular RR and the surface-enhanced Raman effect ... a unique fingerprint of the specific conformation of a molecule SERR and SEIRA spectroscopy of cytochrome c [10] Both techniques, however, are associated with low sensitivity and selectivity For...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng 9 tr 25