interaction of hereditary and epigenetic mechanisms in the regulation of gene expression
Báo cáo khoa học: Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions pptx
... application of SH2 domain binding peptides, which results in blocking of the binding of the SH2 domain to the substrate and thereby preventing interaction of the substrate with the kinase domain For ... C-terminus Kinase domain and C-terminus SH3 domain and C-terminus SH2 domain and C-terminus SH3, SH2 domain and C-terminus N-terminal, SH3, SH2 domain and C-terminus N-terminal, SH3, SH2, kinase ... to bind to the NR2A C-tail is independent of its kinase activity, and that dysfunction of the SH3 and ⁄ or SH2 domains does not affect this interaction The regulation of NMDARs by Src and other...
- 11
- 597
- 0
Báo cáo y học: " Full genome comparison and characterization of avian H10 viruses with different pathogenicity in Mink (Mustela vison) reveals genetic and functional differences in the non-structural gene" pot
... activation of protein kinase R and the activation of transcription factors NF-κB and IRF-3 [53-57] On the other hand, others claim the primary function of NS1 RNA binding to be inhibition of the 2'-5'- ... factor other than the presence of multiple basic amino acids in the cleavage site contributed to the severity of H10 viruses in mink Neuraminidase Haemagglutinin Phylogenetic analysis of the HA gene ... reading frame of the PB1 gene, induces apoptosis in infected cells [39] The Page of 11 substitution N66S resulted in a more severe infection with higher virus titres and increased production of inflammatory...
- 11
- 392
- 0
NOVEL MECHANISMS IN THE REGULATION OF PERINUCLEAR ACTIN ASSEMBLY 2
... participating in the assembly of perinuclear actin network This thesis has provided new findings and hypotheses on the regulation of perinuclear actin It shows that the dynamics of perinuclear actin ... by the LIM kinases 1.1.2.2.3 G1actin)binding)proteins) Actin monomer binding proteins contribute to maintaining the physiological F-/G-actin homeostasis Thymosin-β4 and profilin are two main ... cellular behaviors and signaling via the regulation of actin dynamics 1.3 The perinuclear actin and nuclear transport The nucleus contains most of the genetic materials of the cell and plays important...
- 141
- 266
- 0
Báo cáo khóa học: Disruption of the interaction between the Rieske iron–sulfur protein and cytochrome b in the yeast bc1 complex owing to a human disease-associated mutation within cytochrome b potx
... that interfacial protein–protein interactions between the hinge region of ISP and the extramembranous cd2 helix of cytochrome b are important for maintaining the structure of the hinge region and, ... 100 kHz; and modulation amplitude, 1.6 mT ISP–cytochrome b interaction at the hinge region Movement of the extrinsic domain of the ISP is facilitated by the unwinding of a single turn of the 310 ... shown in light green, the compensatory mutations are shown in pink, and the hinge region of the ISP is shown in white the integration or stability of the ISP within the bc1 complex In order to investigate...
- 7
- 498
- 0
Báo cáo Y học: Inhibition of the SERCA Ca21 pumps by curcumin Curcumin putatively stabilizes the interaction between the nucleotide-binding and phosphorylation domains in the absence of ATP pot
... ATP into contact in the absence of ATP, curcumin is then able to bind to the ATPase (possibly at the hinge region) locking the two domains together and therefore precluding ATP binding (i.e inhibiting ... concentrations of curcumin (25 mM ) the Km for the catalytic site is also possibly increased In order to further assess the possibility of curcumin affecting the interaction of ATP binding to the ATPase, ... about mM Reversing the order of addition to the ATPase (i.e curcumin then ATP) had a similar effect on the extent of ATP binding, i.e in both cases, the amount of ATP binding to the ATPase was...
- 10
- 594
- 0
báo cáo khoa học: "The use of some nanoemulsions based on aqueous propolis and lycopene extract in the skin’s protective mechanisms against UVA radiation" pps
... process of obtaining the nanoemulsion In the case of the bands group in the range of 1150-1250 cm-1, characteristic of ester groups (-C-O stretching), an increase in the intensity of the bands is observed, ... content of 35% has the effect of increased intensity of certain bands at 1450 cm-1 (-CH3 and CH2 = strain) reflected in the decrease of the transmittance Butnariu and Giuchici Journal of Nanobiotechnology ... participated in the design of the study and performed the statistical analysis MB conceived of the study, and participated in its design and coordination All authors read and approved the final manuscript...
- 9
- 529
- 0
Molecular mechanisms underlying the regulation of the positioning and formation of the cleavage furrow in cytokinesis in mammalian cells
... action Inhibit myosin II ATPase activity by binding to myosin II-ADP-Pi Blebbistatin and inhibit the release of the ADP Inhibit actin polymerization by binding to the barb end of the FCytochalasin ... promoting factors and contain two highly conserved domains, FH1 and FH2 FH1 domain binds to the profilin-G-actin complex to facilitate the elongation of actin filaments, while FH2 domain binds and ... centraspindlin complex, and the chromosome passenger complex are involved in the stabilization of microtubules at the equatorial region In addition, the centralspindlin complex and a member of the...
- 140
- 306
- 0
Báo cáo y học: Esterified Hyaluronic Acid and Autologous Bone in the Surgical Correction of the Infra-Bone Defects"
... without the application of a membrane in the treatment of infra bone defects, our clinical results are encouraging considering that in a similar study a mean value of the increase of the bone ... suggest that integrin-mediated interaction plays a decisive role in 67 the regulation of proliferation, migration, and differentiation of the epithelial cells [2,12,18,19] Following the surgical ... of bone graft in the damaged site and on the other hand, it creates an environment with a rich content of HA, with all the advantages deriving from the phenomenon The present study’s clinic and...
- 7
- 769
- 0
Improvement of nutrient removal and phosphorus recovery in the anaerobic/oxic/anoxic process combined with sludge ozonation and phosphorus adsorption
... ozonation) and effluent of the phosphorus adsorption column are shown in Fig During the operation, about 70% of the phosphorus in the sludge was solubilized by ozonation, and a large part of the solubilized ... 2008) The reactivated adsorbent was packed into the column again, and phosphorus was effectively adsorbed Figure Concentration of each type of phosphorus in the influent and effluent of the phosphorus ... daily, was flowed into the system The characteristics of the influent wastewater were as follows: 160–200 mg/L of SS, 55–80 mg/L of TOC, 45–55 mg/L of T-N, and 4.0–5.5 mg/L of T-P In this study,...
- 8
- 916
- 1
Characteristics of Leachate from Citrus Groves and their Changes in the Collecting Reservoirs in Matsuyama, Japan
... the middle parts of the grove from points Sampling points St.1 and St.2 are in the same stream, and sampling point St.3 is in the other stream The two streams flow together to be one stream and ... and periphery of the Seto Inland Sea The location of the research area and the distribution of the citrus groves in Matsuyama region are shown in Fig Matsuyama is situated in Shikoku Island in ... kind of citrus called Iyokan is mainly cultivated There are two small streams on the upper part of the hill and the streams flow together from 47 m above sea level The water in the stream is the...
- 10
- 717
- 0
Cadmium Removal by the Hydroponic Culture of Giant Reed (Arundo donax) and Its Concentration in the Plant
... was removed within days in every run Assuming the zero-order kinetics, the average cadmium removal rates within the days calculated from the linear approximations of the plots in Fig were estimated ... like in the case of cadmium was not observed Furthermore, the particular effect of the cadmium addition on the appearance of the plant body was not observed during days in runs to Assimilation of ... cadmium, and is synthesized from glutathione (GSH) Inouhe et al (1994) reported that the cadmium binding complex containing PCs has an important role for the cadmium-tolerance of seedlings of some...
- 7
- 701
- 0
A STUDY OF THE RELATIONSHIP BETWEEN CEO COMPENSATION AND FIRM PERFORMANCE IN THE US AIRLINE INDUSTRY 2002 2006
... Aviation Administration and placed under the control of the U.S Department of Transportation (DOT) Beginning in the 1970s, the inefficiency of the government regulated airline industry became of paramount ... that the inherent instability of the airline industry can be traced to the structure of the industry and its economics, including the highly cyclical demand for air travel, high fixed costs, and ... … by diluting and distorting managers’ incentives and thereby hurting corporate performance” (p 72) The authors argue that the inability of the optimal contracting approach in explaining executive...
- 132
- 640
- 0
Expansion and its realization in the short story “the law of life” by jack london
... for choosing the topic, the aims of the study, the methodology, the scope, and the design of the study Part B, the main part of the thesis, consists of three chapters Chapter 1, entitled Theoretical ... features of the text and the intention of the writer In this thesis, the text chosen is the short story The Law of Life” by the famous American writer, Jack London Aims of the study The study ... see the two role relationships, one between the writer and the readers, and the other between the characters (the main character and his son) In this story, the writer plays the role of the narrator...
- 43
- 921
- 0
Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
... diseases [47] Most analyses of the regulation of AP-2 and the interactions of the transcription factor with binding partners, as well as of the regulation of target gene expression, have been performed ... role of AP-2a and AP-2e in chondrogenesis Overview of the differentiation stages during chondrogenesis and the involvement of transcription factors (henatoxylin and eosin-stained section of an ... apoptosis [73] The authors of this study ascribe the regulation of outgrowth of limb buds and patterning of the digits to the chicken AP-2 The role of AP-2a was further studied in zebrafish It...
- 9
- 642
- 0
Tài liệu Báo cáo khoa học: Osmosensing and signaling in the regulation of mammalian cell function docx
... Thus, integrin-dependent cell volume sensing and signaling integrates into the overall context of insulin signaling Similarly, sensing of glutamine-induced hepatocyte swelling by integrins feeds into ... Osmosensing and signaling in mammalian cell function F Schliess et al [7] On the other hand, hyperosmotic shrinkage prevents insulin-induced hepatocyte swelling and proteolysis inhibition, indicating ... swelling [12,13], insulin-induced hepatocyte swelling is registrated by the integrin system, leading to a Src-dependent activation of the p38-type MAPK and thereby inhibition of 5800 autophagic...
- 5
- 792
- 0
Tài liệu Báo cáo khoa học: Enzymes for the NADPH-dependent reduction of dihydroxyacetone and D-glyceraldehyde and L-glyceraldehyde in the mould Hypocrea jecorina doc
... activity in crude yeast extract as the untagged protein, indicating that the tag was not interfering with the protein activity The tagged protein was purified and then used for further analysis In the ... nkatÆmg)1 The GLD1 protein was tagged with a histidine tag at the N-terminal end by adding the coding sequence for six histidines to the end of the open reading frame, and then expressed in S cerevisiae ... cerevisiae The tagged protein had a similar activity in the crude extract as the nontagged protein, indicating that the tag did not affect the protein activity The tagged protein was then purified and...
- 7
- 510
- 0
Tài liệu Báo cáo khoa học: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation docx
... partitioning of the protein into an aggregated state The effect of copper binding on the secondary structure was determined using CD in the far UV To prepare proteins without Cu2+, part of each protein ... understanding what causes the loss of appropriate metal binding might be crucial for the understanding of the role of amyloidogenic proteins in a number of neurodegenerative disorders Copper binds ... copper binding could still allow domain swapping to occur It is of interest that a N-terminally truncated prion protein, lacking the copper binding domain is capable of domain swapping and forms...
- 14
- 586
- 0
Tài liệu Báo cáo khoa học: Altered expression of CD1d molecules and lipid accumulation in the human hepatoma cell line HepG2 after iron loading pptx
... localizes in the cytoplasm of human epithelial cells of the gastrointestinal tract and liver, two central organs in the regulation of iron metabolism [20,21] After their synthesis in the endoplasmic ... ferritin expression in nonpermeabilized (thin lines, – saponin) and permeabilized cells (thick lines, + saponin) cells cultured without and with iron as indicated (D) Perls’ staining of cytospins of ... the increase in phosphatidylserine expression was of the same order of magnitude as the upregulation of CD1d expression In other words, the same HepG2 cells expressed CD1d and phosphatidylserine...
- 14
- 682
- 0
Tài liệu Báo cáo khoa học: Inorganic pyrophosphatase in the roundworm Ascaris and its role in the development and molting process of the larval stage parasites doc
... concerning the kinetics and properties of the enzyme More strikingly, we show a novel role of the PPase enzyme in the development and molting process of A suum larvae in vitro constructed in UniZap ... immunohistochemical staining), and that the inhibition of PPasecatalyzed PPi hydrolysis by these inhibitors, is likely to prevent the synthesis of the new cuticle from the hypodermis and/ or ecdysis of the old ... of individual components were varied as indicated for the determination of Mg2+ and pH dependent rAsPPase activity The amount of Pi liberated from the hydrolysis of PPi during the course of the...
- 13
- 691
- 0
Tài liệu ‘Unheard voices’: listening to Refugees and Asylum seekers in the planning and delivery of mental health service provision in London. pptx
... ONE is the INTRODUCTION This includes an outline of the CONTEXT and main themes, the motivation and purpose of the study - the why and how PART TWO is THE REASEARCH - METHODOLOGY and FINDINGS PART ... component in the integration process: The first step towards the integration of refugees must be to identify and help with their most pressing needs Finding and settling them into safe and appropriate ... GUIDE is the last section This provides a discussion of the main themes as they emerged in the service user interviews (as listed above in the ‘Findings’ section) It breaks the themes down into manageable...
- 92
- 1,134
- 0
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25