intensity response function naka rushton function and photopic hill
1 adaptive mode superposition and acceleration technique with application to frequency response function and its sensitivity
... for many situations where the MSM and MAM are required [5–9] MSM and MAM Assume the eigenvalue and eigenvector matrices of the model defined in Eq (1) are K and U, and K ¼ diagðl1 ; l2 ; ; ln ... for frequency responses and their sensitivities, Part I: undamped systems, Journal of Sound and Vibration 231 (1) (2000) 175–193 [4] Z.-Q Qu, Accurate methods for frequency responses and their sensitivities ... p Á Á Á pln Þ; U ¼ ½/1 ; /2 /n , (5) where li and /i are the ith eigenvalue and eigenvector K and U satisfy the following eigenequation and orthogonalities KU ¼ MUK; UT KU ¼ K; UT MU ¼ I;...
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Báo cáo y học: "Differential expression, function and response to inflammatory stimuli of 11β-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation" pps
... fibroblasts and show that the resulting variations in glucocorticoid metabolism play an important role in defining fibroblast cell phenotype and their functional responses to inflammation Materials and ... treatment and 8-fold increase for TNF-α treatment relative to vehicle), dermal (14fold and 4-fold increase) and synovial (31-fold and 7-fold) fibroblasts (Figure 5) By contrast, classical T-helper-1 and ... citation purposes) Figure Autocrine activation of cortisol and the regulation of fibroblast function of fibroblast function Bone marrow, dermal and synovial fibroblasts were treated with vehicle (C),...
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Tài liệu Cognitive function and brain structure correlations in healthy elderly East Asians doc
... test (Delis et al., 2001), and the Trail Making Test B (Reitan and Wolfson, 1985) Speed of processing was assessed with the TrailMaking Test A (Reitan and Wolfson, 1985) and the Symbol-Digit Modalities ... were standardized (z-transformed) and combined into six theoretically motivated composite scores (attention, verbal memory, visuospatial memory, speed of processing, executive functions and language) ... regions based on prior structural and functional imaging data that related structure to cognitive functions of interest (see Greenwood, 2007; Raz, 2005; Reuter-Lorenz and Lustig, 2005 for recent reviews)...
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Tài liệu Báo cáo khoa học: Structure determination and biochemical studies on Bacillus stearothermophilus E53Q serine hydroxymethyltransferase and its complexes provide insights on function and enzyme memory doc
... group and contained one monomer in the asymmetric unit Cell dimensions and details of data collection are shown in Table Expression and purification of bsSHMT and E53QbsSHMT The expression and purification ... supported by the Department of Science and Technology and DBT We thank Babu and James for their help during data collection VR and BSB thank the Council for Scientific and Industrial Research, Government ... Gly and Ser external aldimine complexes of E75Q and E75LrcSHMT, the electron density for the ligands was not well defined [15] In contrast, excellent electron density was observed for the ligands...
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Tài liệu Global Change and the Function and Distribution of Wetlands ppt
... II Sea Level Rise and Coastal Wetlands Response of Salt Marsh and Mangrove Wetlands to Changes in Atmospheric CO2, Climate, and Sea Level Karen McKee, Kerrylee Rogers, and Neil Saintilan ... Emissions and Wetlands Key Processes in CH4 Dynamics in Wetlands and Possible Shifts with Climate Change Hojeong Kang, Inyoung Jang, and Sunghyun Kim Part IV 99 Drought and Climate ... of Earth and Environment, Franklin and Marshall College, P.O Box 3003, Lancaster, PA 17604-3003, USA e-mail: chris.williams@fandm.edu B.A Middleton (ed.), Global Change and the Function and Distribution...
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Tài liệu Báo cáo khoa học: Relationships between structure, function and stability for pyridoxal 5¢-phosphate-dependent starch phosphorylase from Corynebacterium callunaeas revealed by reversible cofactor dissociation studies doc
... Analytical enzymes and enzyme substrates were specied in previous papers [1518] All other chemicals were of reagent grade and obtained from Sigma and Fluka Preparation of apo-Cc StP and apo-Ec MalP ... citrate and 0.1 M cysteine hydrochloride, in short, the resolution buffer Various pH values between 5.0 and 8.0 were tested, and a pH of 7.0 was chosen (see below) Prior to the resolution, CcStP and ... R226A and R242A mutants (Table 1), all enzymes were stable for h in the presence of mM potassium phosphate and potassium sulphate Reconstitutions with PLP of apo-Cc StP and mutants thereof, and...
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Tài liệu Báo cáo khoa học: Second messenger function and the structure–activity relationship of cyclic adenosine diphosphoribose (cADPR) doc
... hypoxanthine) and the diphospho-bridge, as they can be replaced by much simpler ether strands These ether strands mimic the distance between the nucleobase and the diphospho-bridge, but on the other hand ... permeabilized T-cells and induced both local and global Ca2+ signalling in intact T-cells [46] 8-Azido- and 8-NH2-cIDPRE performed similarly (Fig 4) whereas the halogenated compounds 8-Br- and 8-Cl-cIDPRE ... when [Ca2+]i is elevated above normal basal levels [25] On the other hand, ectoenzymes producing cADPR (such as CD38 and CD157) and transport systems for cADPR in the plasma membrane open the possibility...
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Tài liệu Báo cáo khoa học: Role of cleavage and shedding in human thyrotropin receptor function and trafficking pdf
... conformation between the receptor activated by cleavage and shedding on the one hand, and the receptor activated by the ligand on the other hand This may be due to different post-translational maturation ... ELISA ([28] and see Methods) on permeabilized cells Figure 2B shows a similar total expression of the wild-type and the truncated b1, b2 and TM409 receptors As shown in Fig 2A, the b1 and b2 mutant ... localized between amino acids 357 and 369 [15], in the E3 specific region of the receptor It does not interfere with receptor function and trafficking ([30], and data not shown) Measurement of...
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Báo cáo khoa học: Protein transport in organelles: The composition, function and regulation of the Tic complex in chloroplast protein import pptx
... position and function of the long C-terminal tail on the other hand remains a matter of controversy [10,11,13–15] According to one hypothesis, the hydrophilic Tic110-Ct faces the stroma, where it functions ... binding site [10] These structures have been implicated with channel function (e.g in ligand-gated and voltage-gated K+ channels) [16], and thus could provide an explanation for the observed channel ... ATPase with a different function [24] Chaperones subsequently have been the main candidates for this ATPase activity and, indeed, members of the Hsp60 [chaperonin (Cpn)60] and Hsp100 (Hsp93) families...
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LUNG SURFACTANT FUNCTION AND DISORDER ppt
... of SP-A and SP-D 91 IV Potential Functions of SP-A and SP-D 91 V Structure of SP-A and SP-D 91 VI Ligands for SP-A and SP-D 93 VII Cells and Receptors 99 VIII Summary and Future ... Pinsky, and S Magder 158 Ventilator Management Strategies for Critical Care, edited by N S Hill and M M Levy 159 Severe Asthma: Pathogenesis and Clinical Management, Second Edition, Revised and Expanded, ... Pediatric Nasal and Sinus Disorders, edited by Tania Sih and Peter A R Clement 200 Functional Lung Imaging, edited by David Lipson and Edwin van Beek 201 Lung Surfactant Function and Disorder,...
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Báo cáo khoa học: The impact of G-protein-coupled receptor hetero-oligomerization on function and pharmacology pptx
... (2005) 2939–2946 ª 2005 FEBS Function and pharmacology of hetero-oligomers and a1b receptors [21], neurokinin NK1 and l opioid receptors [22], and the b2-adrenergic and d-opioid receptors [4] In ... dimeric ligands capable of acting as bivalent ligands The first publication showing the feasibility of constructing a bivalent ligand directed to heterodimeric receptors has come 2943 Function and pharmacology ... specificity, and consequently in determining the receptor fate and b-arrestin-mediated MAPK activation As discussed above for G-proteins, the mechanism and the stoichiometry by which GPCR and b-arrestin...
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Báo cáo khoa học: Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1 pot
... also transforms kinase and phosphatase function and regulation through serving as an anchoring scaffold, an adaptor protein directly abetting efficient phosphorylation and dephosphorylation, a ... interactions to the catalytic components (E1 and E3), kinase isoforms (PDK1, PDK2, PDK3, PDK4) and Ca2+-binding of PDP1 in translating and transmitting effector signals, and in modifying the sensitivity ... regulatory enzyme function (below) Ó FEBS 2003 1052 T E Roche et al (Eur J Biochem 270) Activated PDK2 and PDK3 function PDK2 exhibits the full set of the prototypical regulatory responses of mammalian...
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Báo cáo khoa học: Function and regulation of ABCA1 – membrane meso-domain organization and reorganization pptx
... Tall AR (2010) Role of HDL, ABCA1, and ABCG1 transporters in cholesterol Function and regulation of ABCA1 100 101 102 103 104 105 106 107 108 109 efflux and immune responses Arterioscler Thromb Vasc ... of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function J Neurosci 29, 3579–3589 Sakai H, Tanaka Y, Tanaka M, Ban N, Yamada K, Matsumura Y, Watanabe D, ... events Functional deficiencies of ABCA1 and ABCG1 cause enhanced inflammatory responses of macrophages, especially after treatment with lipopolysaccharide or other toll-like receptor ligands [84,101–103]...
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Báo cáo khoa học: A1–Protein Function and Ageing pptx
... 150 and 47 lm, for BChE w.t 320 and 23 lm for 2-PAM and HI-6, respectively Introduced mutations lowered oxime binding affinities for both oximes, and Ki were 590 and 87 lm for Y337A, 650 and 110 ... and have isoelectric point of 6.6, 6.1, 5.2 and 4.7 respectively Disulphide linked toxin and lectin subunits of HmRIP and isoforms have molecular weight of 28 and 34 kDa while that of HmRIP and ... substrate specificities of JBG I and II implied that JBG I and II seem to correspond to HBG I and II We have isolated two candidates of cDNAs (1932 and 1862 bp) encoding JBG I and II, which contained...
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Báo cáo khoa học: "CLASSIFICATION OF MODALITY FUNCTION AND ITS APPLICATION ANALYSIS TO JAPANESE LANGUAGE" doc
... Natural Language, "Formal Semantics and Pragrnatics for Natural Languages", ed by F Guenthner and S J Schmidt, 1979 [6] Nakau, M : Tense, Aspect, and Modality, "Syntax and Semantics" 5, ed by M Shibatani, ... "rareru"), 3) hope Ctehoshii'" and "temoraitai"), 4~ request ,~"temorau"), 5) benefit ("tekureru teageru", and "teyaru") This is the most fundamental function and it simply adds the modality ... "rareru", %eiru", %a', where "dake", "rarern', "teiru", and "ta" are modality exp~'essions "Hiroko" and "yasai" have semantic categories, [human] and [food] respectively in each word frame [ or iterative...
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WETLANDS ECOSYSTEMS IN ASIA: FUNCTION AND MANAGEMENT pptx
... Conservation and Uses of Mangroves in Hong Kong and Mainland China N.F.Y Tam 11.1 Introduction 11.2 Mangrove Distribution and Characteristics in Hong Kong and Mainland China 11.3 Uses and Functions ... Natural Wetland Systems and Their Functions; II Wetland Biogeochemisty; III Wetland Management Strategies in Asia and IV Constructed Wetlands The basic information of natural wetland systems ... Carruthers, J.E Thomas, P.M Glibert Wetland Utilization and Protection in China Q.G Zhao, J Song 27 Ecological and Environmental Function of Wetland Landscape in the Liaohe Delta D.N Xiao, X.Z...
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Báo cáo khoa học: Mammalian transglutaminases Identification of substrates as a key to physiological function and physiopathological relevance pot
... It consists of an N-terminal b-sandwich, a core (which contains a transamidation site and a Ca2+-binding site, and has a helices and b sheets in equal amounts), and two C-terminal b-barrel domains ... substrates and to investigate alterations in their properties Nevertheless, biochemical and functional proteomic studies in both in vitro and cellular systems have furthered our understanding of ... [53], periplakin [48] and suprabasin intermediate filaments [45,54] (Table 2) In vitro, loricrin, SPR 1, -2 and -3, and trichohyalin functioned as complete substrates for TG1 and TG3 [48] In addition,...
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Báo cáo khoa học: An asymmetric ion channel derived from gramicidin A Synthesis, function and NMR structure ppt
... types: those between aHi and NHi+6 (i ¼ 1, 3, and for chain A, and 1, 3, 5, 7, and for chain B); and those between aHi and NHi-6 (i ¼ 10 and for chain A, and 14, 12, 10, and for chain B) These ... A and Trp15 of chain B are highly uncertain (with three and four unambiguous data points and R of 0.98 and 0.98, respectively) Fig NOESY spectrum (150 ms) in the region of (F2) 9.7–8.0 p.p.m and ... Compound contains the nonstandard amino acids d-valine and d-leucine Molecules of these two residues were thus created and added to the protein dictionary of sybyl and the standard library of dyana...
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Báo cáo khoa học: Role of the surface charges D72 and K8 in the function and structural stability of the cytochrome c6 from Nostoc sp. PCC 7119 potx
... Results and Discussion Functional characterization of wild-type cyt c6 and its mutants Wild-type cyt c6 and its mutant forms were successfully expressed in Escherichia coli strain GM119 and purified ... K8D (,) and D72A ⁄ K8A (e), and for (B) K8D ( ), D72K (s), D72N (n), D72A (,) and D72K ⁄ K8A (e) The lines correspond to the DHU(T) functions obtained by multiple fits for wild-type (A) and for ... charge neutralization (by mutation to alanine) and charge inversion (by mutation to lysine and aspartate, respectively) at positions D72 and K8 After functional characterization by laser-flash absorption...
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