insights from the centrosome abnormalities
Insights from the Chronic Kidney Disease in Children (CKiD) Study potx
... the Schwartz formula and dramatically improved the precision, bias, and sensitivity by reducing the constant from 0.55 to 0.47 At enrollment into CkiD, and using a measured GFR derived from the ... published by the investigators at the data coordinating center (10) The putative exposures of interest in the CKiD cohort have included glomerular diagnosis (estimated at 20% of the cohort), ... ventricular hypertension the within-individual correlation of GFRs year apart, loss to follow-up rates, and the rates of reaching renal replacement therapy in the first few years of the cohort study...
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Accounting for Changes in Social Support Among Married Older Adults: Insights From the MacArthur Studies of Successful Aging pptx
... that whereas men received the most emotional support from their wives, the women in the sample said they received the most emotional support from their children and from their friends and relatives, ... relatives to get the emotional support they need if it is not forthcoming from the spouse Even though the women in this sample reported fewer ties than men did, the support received from their broader ... 439.1 Table summarizes the sociodemographic and psychological characteristics of the sample at the time of the first interview The majority of the sample was White (83%; the remainder was African...
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beyond e learning practical insights from the usa
... developing the technology? 6.7 Is the USA the place where it is happening? 6.8 What can we learn from the US market? 6.9 What are the market opportunities? 35 35 35 LOOKING TO THE HORIZON: THE CHALLENGES ... PRACTICAL INSIGHTS FROM THE USA orient them to the company and their role within it Productivity and ROI were the watchwords at this level, and as offers and customers changed continuously, there ... if they want their eLearning programmes to succeed, and recognise that the community that learners interact with helps them define not the physical or mental skills but rather the meanings of the...
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báo cáo hóa học:" Protective versus pathogenic anti-CD4 immunity: insights from the study of natural resistance to HIV infection" potx
... hydrophobic pocket, a discontinuous region at the interface between the inner and the outer domain of gp120 [52] On the other hand, the lateral face of the D1 CD4 domain is implicated in MHC-class ... then extracted from the PDB files of the compared structures (accession numbers 3CD4 and 2NXY for CD4 and CD4-gp120 complex, respectively) as on the x-axis,a according of the 203)(gray) and the ... arthritis the developmental pattern of arthritis differed substantially between three distinct monoclonals, two of them preventing, the third one accelerating the development of the disease [40] The...
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Insights from the rat genome sequence docx
... still active, and the extinct B4 element The Alu-like B1 element is still active in the mouse but probably became extinct in the rat soon after the mouse-rat split On the other hand, the ID element, ... minor in the mouse, is present in over 160,000 copies in the rat The remainder of the euchromatic rat genome includes rat-specific repeats or rodent-specific repeats that have been lost from the mouse ... neutral DNA Interestingly, the rate of base substitution is 5-10% higher in the rat than the mouse branch, leading to a relative increase in GC content in the rat; and the rat has also accumulated...
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báo cáo khoa học: "Updates in Gastrointestinal Oncology – insights from the annual meeting of the American Society of Clinical Oncology" potx
... indicated for the first time that adjuvant systemic chemotherapy led to a superior survival as compared with the either the no-chemotherapy or the chemoradiotherapy groups Although the study methodology ... chemotherapy alone, without the addition of radiation Therefore, adjuvant chemotherapy is regarded as the standard adjuvant treatment after surgical resection of the pancreas in Europe The recent ... months in the OFF arm Both regimens were tolerable, with the exception of higher neuropathy in the OFF arm The median OS in the OFF arm was 28 weeks, and that of the FF arm was 13 weeks, thereby...
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báo cáo khoa học: "Recent advances in gastrointestinal oncology updates and insights from the 2009 annual meeting of the American Society of Clinical Oncology" doc
... in the control arm There were no differences in the rates of congestive heart failure between the two groups although there was a higher rate of asymptomatic decrease in cardiac function in the ... intervention rate Their findings support the use of upfront chemotherapy as initial management for patients with synchronous stage IV CRC without obstruction or bleeding from the primary site The ongoing ... oteracil (which inhibits the phosphorylation of 5-FU in the gastrointestinal tract, thereby reducing the gastrointestinal toxic effects of 5-FU) and is widely used in Asia for the management of gastric...
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báo cáo khoa học: "Updates in non-small cell lung cancer - insights from the 2009 45th annual meeting of the American Society of Clinical Oncology" potx
... chemotherapy group received the planned cycles of chemotherapy The exploratory analysis of these results showed the patients with clinical stage II and T3N1 disease derived the greatest benefit from ... Lastly, there is hope for improving outcomes in the Page of 11 second-line setting given the positive data from the ZODIAC trial The important finding in this trial has demonstrated the improvement ... status In the updated results, the survival analysis continues to show the benefits from chemotherapy beyond 12 years and suggestive of cure (hazard ratio [HR} 0.78, p = 0.04) In comparison, the updated...
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Báo cáo y học: "Patient safety and acute care medicine: lessons for the future, insights from the past" ppsx
... dominance, but the search for synergies in order to achieve excellence Maximizing the best of the human and the technology is the real victory Hopefully the patient will be the ultimate victor Other lessons ... ‘reinvent the wheel’ However, the question, yet to be answered, is whether as a profession we have the insight, the will, or the humility So far, no other high-risk industry has waited, or expected the ... offer insights from the profession of engineering, the field of cognitive psychology, and even from games such as chess The conclusion should be obvious – diverse ideas already exist and, therefore,...
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Báo cáo y học: "Virus-host interactions: new insights from the small RNA world" pot
... reduce the susceptibility of the virus to the host immune system http://genomebiology.com/2005/6/11/238 the coding sequence of the env gene, and then determine the effect of these mutations on the ... loaded while the other is degraded The miRNA or siRNA in the RISC finds and silences its target mRNAs through sequence-specific recognition The viral products that interfere with the pathway are ... balance the employment (in the case of SV40) and suppression (in the case of PFV and HIV) of the host RNA-silencing pathway Do other viruses that produce dsRNA molecules avoid triggering the antiviral...
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![knechel et al - 2013 - audit quality - insights from the academic literature [aq]](https://media.store123doc.com/images/document/2015_01/06/small_EyxIW4sg8J.jpg)
knechel et al - 2013 - audit quality - insights from the academic literature [aq]
... regulators in other countries such as the FRC in the U.K., the CPAB in Canada, and the ASIC in Australia, although there are differences across countries in the manner in which the inspection ... within the structure of the basic audit methodology, as applied by the auditor, using his/her best judgment The ability to make sound judgments directly influences the quality of the audit, so the ... Pressures The quality of an auditor’s judgment is also influenced by pressures emanating from the firm itself These pressures can arise from immediate supervisors on the audit team or the overall...
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Dynamic role of plasma ferritin during pseudomonas infection insights from the limulus
... a dimer to the Fur-box in the promoter regions of iron-regulated genes (Hennecke, 1990) In the presence of low iron, Fe2+ dissociates from the Fur protein, which then releases from the Fur-box, ... INFECTION: INSIGHTS FROM THE LIMULUS ONG SEK TONG DERRICK (Bachelor of Science (Hon)) A THESIS SUBMITTED TO THE FOR THE DEGREE OF MASTER OF SCIENCES DEPARTMENT OF BIOLOGICAL SCIENCES THE NATIONAL ... pool, they would be obvious targets for bacteria to pirate iron from the host Since the cytosolic counterpart may serve as a DNA protector, the plasma ferritin should be the first to ‘sense’ the...
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Tài liệu Báo cáo khoa học: Crystal structure of the cambialistic superoxide dismutase from Aeropyrum pernix K1 – insights into the enzyme mechanism and stability pdf
... on the coordination of the metal cofactor in the active site as well as the changes it experiences in response to different metal cofactors Finally, by comparing ApeSOD with the SOD from the thermophilic ... His31, bound to the metal, in the company of a water oxygen, from the apical positions The manga˚ nese was only 0.06 A out of the equatorial plane (Table 3) The angles around the metal cofactor ... ApeSODs (A–C) The orange map represents the rA-weighted Fo)Fc electron density map at the r level, where the indicated residues are excluded from the calculation of the structure factor The blue map...
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Tài liệu People Make the City,’’ Executive Summary - Joint Urban Operations Observations and Insights from Afghanistan and Iraq pdf
... center sponsored by the Office of the Secretary of Defense, the Joint Staff, the Unified Combatant Commands, the Department of the Navy, the Marine Corps, the defense agencies, and the defense Intelligence ... Understand—Understand the nature of the conflict, the enemy, the battlefield, and the nature of the indigenous population and culture.4 • Shape—Create favorable conditions for the engage and consolidate ... Introduction Men make the city and not walls or ships without men in them.6 —Nicias the Athenian Syracuse, Sicily, 413 BC We write a lot of the lessons we’ve learned, but we don’t learn from the lessons...
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Tài liệu Báo cáo khoa học: Structural insights into the substrate specificity and activity of ervatamins, the papain-like cysteine proteases from a tropical plant, Ervatamia coronaria ppt
... the zwitterions comes from the long central a-helix to which the catalytic Cys belongs [49] The polarizing effect originating from the helix concerned facilitates the transfer of the proton from ... maintained together in either the test set or the working set Although ˚ the data could be processed up to 2.5 A, there were some practical problems in using the full dataset in the refinement – the twin ... which occupies the active site cleft from the S1 to the S3 subsites of the enzyme Enzyme kinetic studies with chromogenic peptide substrates, along with the structural information from the enzyme–inhibitor...
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Protecting the Homeland Insights from Army Wargames Richard Brennan docx
... warfare At the time the games were conducted there was a lack of clarity concerning both the future threats to the homeland and the evolving role of the Army in homeland security Indeed, within the ... warfare At the time the games were conducted there was a lack of clarity on both the future threats to the homeland and the evolving role of the Army in homeland security Indeed, within the various ... on the outcome of the wargame Although a number of unexpected insights were generated from the 1997 Winter Wargame, no mention was made of the potential threats to the United States in any of the...
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Báo cáo khoa học: New insights into the functions and N-glycan structures of factor X activator from Russell’s viper venom pot
... but not the extra GlcNAc residue, if the latter bisects the b-Man residue at the C4 position Finally, an H ion would be formed through concerted loss of the substituents on the 6-arm and the bisecting ... was established from several complementary ion series First, the D ion formed at the bisected 3,4,6-linked b-Man residue carried the extra bisecting GlcNAc residue together with the 6-arm substituents ... proteins were sequenced Of these, 10 clones were found to encode the LC2 and LC1 subunits Others were found to encode other variants of the C-lectin-like venom proteins The amino acid sequences...
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Báo cáo khoa học: Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis pptx
... that the shift of the phosphate moiety from the aromatic purinetrione system to the periphery of the active site is restricted by the position of Arg128 from one side and the conformation of the ... if the ribityl chain in the other structures The distance between the pyrimidine ring and the phosphate atom in the phosphate moiety is 6.9 A The location of this group is the same as in the ... isotherms for the inhibitors (F) The lled circles in the binding isotherms represent the experimental values of the heat change at each injection; the continuous lines represent the results of the...
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Báo cáo khoa học: Aspartate transcarbamylase from the hyperthermophilic archaeonPyrococcus abyssi Insights into cooperative and allosteric mechanisms docx
... ordered binding of the substrates, first CP then aspartate [13] These results raised the possibility that binding of the substrates does not follow the same ordered mechanism as in the case of E coli ... the activity in the absence of nucleotide effectors Relative activity defined as A ⁄ A0*100; where A is the activity in the presence of the effector and A0 the activity in its absence E50 is the ... increase the relative activity from 70 to 100% A further increase in ATP concentration brought the activity to the same activated level as in the absence of CTP, thus ATP counteracts completely the...
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Báo cáo Y học: The role of zinc in the methylation of the coenzyme M thiol group in methanol:coenzyme M methyltransferase from Methanosarcina barkeri New insights from X-ray absorption spectroscopy doc
... presumably the oxygens of two H2O molecules Furthermore, there may be a thiol group of an amino-acid residue which moves closer to the active-site zinc due the structural rearrangement resulting from the ... shown in the following, the interpretation of the EXAFS of the mutant enzymes is conrmed by a comparative analysis of the zinc K-edge spectra (XANES spectra, see Fig 2) of the wild-type and the mutants ... ligands increases from to whereas in the case of MtbA the number increases from to suggests that it is unlikely that the His tagging is responsible for the differences between the MtaA- and MtbA-EXAFS...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng 9 tr 25