insertion deletion and substitution rates and its causes
Báo cáo y học: "The CRIT framework for identifying cross patterns in systems biology and application to chemogenomics" ppt
... drugs labeled as high and low, and the denominator is simply the difference between the standard error for high and low Welch’s t-statistic was used to compute P values, and proteins with P < ... transcription factors and their associated targets in the yeast regulatory network, relationships between gene properties such as expression and binding status and breast cancer type, and finally using ... for both AR and ABsensitive proteins and in DNA binding for AR and hydrophilicity-sensitive proteins In addition, charge-sensitive proteins showed an enrichment in transferase activity and MlogP...
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Tài liệu Báo cáo khoa học: Molecular characterization of Arabidopsis thaliana PUF proteins – binding specificity and target candidates doc
... NRE(A+B)); and in both Box A and B, NRE(A–B–) (C) Qualitative analysis of LacZ reporter activation in the interaction of APUM-2 and APUM-7 with NRE WT and NRE mutants The iron responsive element RNA and ... APUM-5 and APUM-6 with NRE WT and mutants (E) Interaction assay of APUM-2 with Asn to His substitution in the residue 13 of the repeat (APUM-2 ⁄ N fi H) and the protein APUM-7 with His fi Asn substitution ... human and mouse possess two; and Drosophila and Dyctiostelium have only one member [5] Recently, new studies have revealed the presence of ten, two and one homologs in Trypanosome, Plasmodium and...
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Báo cáo khoa học: Nuclear localization of human spermine oxidase isoforms – possible implications in drug response and disease etiology pptx
... existence of SMO5 in human normal and tumor cell lines SMO5 cDNA was subcloned and sequenced, and active protein was produced, purified and assayed for kinetic properties and substrate specificities NCI-H157 ... to inclusion bodies, and therefore was denatured and refolded prior to analysis All SMO5 protein production and purification steps were performed in parallel with SMO ⁄ PAOh1 and PAOh4 proteins ... the substrates examined Specifically, SMO ⁄ PAOh1 exhibited kcat values for spermine and N1-acetylspermine of 7.55 s)1 and 0.28 s)1, respectively, whereas those for SMO5 measured 3.11 s)1 and 0.12...
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Báo cáo khoa học: "Learning to Translate with Source and Target Syntax" pot
... tree-sequence substitution grammar and (b) its equivalent SAMT-style treesubstitution grammar complex label X1 ∗ · · · ∗ Xn immediately dominating the old roots, and replace every sequence of substitution ... bitexts, and one on two billion words of English These were smoothed using modified Kneser-Ney (Chen and Goodman, 1998) and stored using randomized data structures similar to those of Talbot and Brants ... tree pairs and substitution 2.1 Exact tree-to-tree extraction The use of STSGs for translation was proposed in the Data-Oriented Parsing literature (Poutsma, 2000; Hearne and Way, 2003) and by Eisner...
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ECONOMIC AND SOCIAL CONSEQUENCES OF DRUG ABUSE AND ILLICIT TRAFFICKING doc
... drug abuse and trafficking A Apparent "benefits" and costs of drug abuse and trafficking “Benefits” While the apparent "benefits" of consumption for drug abusers tend to be transient and are quickly ... Europe: Belgium, Denmark, Finland, France, Germany, Italy, Netherlands, Norway, Portugal, Spain, Sweden, Switzerland and the United Kingdom of Great Britain and Northern Ireland Sources: UNDCP country ... iron and steel and motor vehicles (2.8 per cent and 5.3 per cent respectively) and approximately the same size as the international trade in textiles (7.5 per cent), oil and gas (8.6 per cent) and...
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Báo cáo khoa học: "Bridging Morpho-Syntactic Gap between Source and Target Sentences for English-Korean Statistical Machine Translation" pot
... particle and an objective particle , and insert them after the corresponding dependents Eugene and guitar respectively on content-words, which can deteriorate the performance of candidate ... 2005; Xia and McCord, 2004; Zwarts and Dras, 2007) Some reordering approaches have given significant improvements in performance for translation from French to English (Xia and McCord, 2004) and from ... the translation quality Pseudo Word Insertion Lee et al (2006) find that function words in Korean sentences are not aligned to any English words, and can simply and easily be removed by referring...
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Báo cáo khoa học: "Resolving Translation Ambiguity and Target Polysemy in Cross-Language Information Retrieval" potx
... and Polysemy Resolution Models In the recent works, Ballesteros and Croft (1998), and Bian and Chen (1998) employ dictionaries and co-occurrence statistics trained from target language documents ... these words be CW~, CW2, , and C W m Assume the corresponding English translations of C, CW~, CW2, , and CWm are E, EW,, E W , , and EWm, respectively EWe, EW2, , and EWm form an augmented translation ... disambiguate its meaning at first If we can find that its correct translation is "-~g-#5"" (yin2hang2), the subsequent operation is very simple That is, "~'~5-" (yin2hang2) is sent into an IR system, and...
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the effect of the hydrothermal treatment with aqueous naoh solution on the photocatalytic and photoelectrochemical propertiesof visible light-responsive TiO2thin films
... patterns of Vis-TiO2/Ti and NaOH(X)-Vis-TiO2/Ti and (b) the expanded XRD patterns of (a) (2u = 5–158) Fig XPS spectra of the Ti 2p (right) and Na 1s (left) peaks of the Vis-TiO2/Ti and NaOH(X)-Vis-TiO2/Ti ... (Laforet Engineering, XD50D) and the evolved H2 and O2 were analyzed by a gas chromatograph (GC, G2800-T, Yanaco) with a thermal conductivity detector (TCD) Results and discussion Photoelectrochemical ... titanates such as A2Ti3O7 or A2Ti2O5 H2O, where A represents Na and/ or H [17] Fig shows the Ti 2p and Na 1s XPS spectra of the VisTiO2/Ti before and after hydrothermal treatment The intensity of the Ti...
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financial statement analysis Abbott Laboratories and Target
... 23.83% Property and equipment Land Buildings and improvements Fixtures and equipment Computer hardware and software Construction-inprogress Accumulated depreciation Property and equipment, net ... and Management and Related Stockholder Matters 56 Item 13 Certain Relationships and Related Transactions, and Director Independence 56 Item 14 Principal Accountant Fees and Services 56 Exhibits ... business are retail and credit card Target is well known for their operations in general merchandise and food items They owe their success to positive perceptions of the Target brand and they have...
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MASS SPECTROMETRY IN DRUG METABOLISM AND DISPOSITION docx
... hydroxylamines and oximes and secondary amines to N-hydroxy and nitrone products Aromatic amines and amides are not substrates Thioethers can be oxidized to sulfoxides; and thiols, thioamides, and thiocarbamates ... be used as a teaching and/ or reference tool to delineate and understand the “why” and “how” with regard to the many creative uses of mass spectrometry in drug metabolism and disposition studies ... exercise at its core, and the backbone technology remains mass spectrometry (MS) However, if we consider the more complete picture, DM has expanded enormously in scope and level of understanding in...
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Báo cáo khoa học: Role of the plasma membrane leaflets in drug uptake and multidrug resistance ppt
... well as anionic drugs and dyes, but also neutral ⁄ basic amphipathic drugs and even oxyanions Previously, it has been assumed that the oxyanions arsenite and antimonite and the neutral ⁄ basic ... should help determine whether Pgp removes its substrates from the cytoplasmic leaflet, as predicted by the vacuum cleaner model, whereas MRP1 extracts its substrates from the cytoplasm Tetramethylrhodamine ... membrane is unstirred and dense with proteins Moreover, TMRM and anticancer drugs, such as anthracyclines, are positively charged and therefore bind to acidic groups in proteins and membranes Thus,...
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For Medicare Advantage Plans, Medicare Advantage Prescription Drug Plans, Prescription Drug Plans, and 1876 Cost Plans ppt
... name(s) or brand(s) of the co-branding entity or entities on its marketing materials to signify a business arrangement Co-branding arrangements allow a plan sponsor and its co-branding partner(s) ... Drug Program’s (NCPDP’s) “Pharmacy and/ or Combination ID Card” standard This standard is based on the American National Standards Institute ANSI INCITS 284-1997 standard titled Identification Card ... Formulary and Utilization Management (UM) Requirements 81 110 - Reserved 83 120 - Marketing and Sales Oversight and Responsibilities 83 120.1 - Compliance with State Licensure and...
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Báo cáo khoa học: "Combining Source and Target Language Information for Name Tagging of Machine Translation Output" ppt
... previous token F4 and F5 are used to help resolve the type conflicts, and F6 and F7 to resolve boundary conflicts When there is a conflict, we need the confidence information from both ET and English ... and William J 2005 HMM Word and Phrase Alignment for Statistical Machine Translation Proc Human Language Technology Conference and Empirical Methods in Natural Language Processing Fei Huang and ... translations, is then passed to a statistical, phrase-based MT system (Zens and Ney, 2004) Depending on its phrase table and language model, this name-aware MT system would decide whether to accept...
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fragment based drug discovery and x-ray crystallography
... Davies and Ian J Tickle Hsp90 Inhibitors and Drugs from Fragment and Virtual Screening 61 Stephen Roughley, Lisa Wright, Paul Brough, Andrew Massey, and Roderick E Hubbard Combining NMR and ... binding to a protein of a molecule, A–B, and of its component parts, A and B, in terms of the “intrinsic binding energies” of A and B, DGAi and DGBi, and a “connection Gibbs energy,” DGs that ... Marsh, Sandra Greive, and Marko Hyvonen Fragment Screening and HIV Therapeutics 181 Joseph D Bauman, Disha Patel, and Eddy Arnold Fragment-Based Approaches and Computer-Aided...
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báo cáo hóa học: " Simultaneous buried object detection and imaging technique utilizing fuzzy weighted background calculation and target energy moments on ground penetrating radar data" potx
... Defense and Security Symposium, Detection and Remediation Technologies for Mines and Mine like Targets, Orlando, USA (13-17 April 2009) DJ Daniels, P Curtis, O Lockwood, Classification of landmines ... Development of dual sensor hand-held detector, in SPIE Defense and Security Symposium, Detection and Remediation Technologies for Mines and Mine like Targets, Orlando, ABD, (5-9 April 2010) M ... 25 26 using GPR B-scan data, in SPIE Defense and Security Symposium, Detection and Remediation Technologies for Mines and Mine like Targets IX Orlando (2004), 905–912 TG Savelyev, LV Kampen,...
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Báo cáo hóa học: " Target estimation algorithm design using quantity data and target feature" pptx
... errors of positions and velocities are shown in Table From Table 3, it can be seen that the proposed algorithm demonstrates better performance, with smaller averaged position errors and velocity errors, ... multiple-model estimator and neural algorithm for radar system Int J Innov Comput Inform Control 31(2):4809–4817 (2009) B Sugandi, H Kim, JK Tan, S Ishikawa, Real time tracking and identification of ... main works for conducting image processing is shown in Figure 1, and the descriptions are given as follows (1) Gray transformation and spatial filtering: In order to effectively determine the attribute...
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DRUG DISCOVERY AND DEVELOPMENT – PRESENT AND FUTURE pptx
... Drug Discovery and Development – Present and Future Benefits for Ayurveda Benefits in Chemistry domain - Benefits in Process domain - - - Benefits in Life science domain - - - Benefits for drug ... particularly in vertebrates and plants as organism complexity evolved As discussed in sections and 4, an understanding of the evolutionary rates and relationships between homologues in model and target ... Understanding the ayurvedic basis of any 12 Drug Discovery and Development – Present and Future combination of herbs and its use in different condition requires knowledge of ayurvedic fundamentals and...
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Báo cáo khoa học: "SemiFDG-PET/CT imaging for staging and target volume delineation in conformal radiotherapy of anal carcinoma" potx
... (66.7%) cases and disease-free and overall survival (DFS and OS) rates were 66.7% and 77.8% respectively Acute and late toxicity higher than grade (RTOG/EORTC) was observed in 7/27 (25.9%) and 1/27 ... study and drafted the manuscript MEM, LT, CB and LD were involved in data collection and review EM, BC and MC worked on analysis of data EI and MB participated in the design of the study and contributed ... was given by cisplatin and 5-fluorouracil in 15 cases and mytomicin and 5-fluorouracil in cases Statistical analysis PET-GTV and PET-CTV were respectively compared to CT-GTV and CT-CTV by Wilcoxon...
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Báo cáo y học: " Injection drug use and patterns of highly active antiretroviral therapy use: an analysis of ALIVE, WIHS, and MACS cohort" ppt
... one NRTI and at least one PI and at least one NNRTI, 3) an abacavir- or tenofovir-containing regimen with at least NRTIs, 4) a regimen containing ritonavir and saquinavir and one NRTI, and no NNRTIs ... MACS, and 93% in WIHS in July 1997 to 51%, 56%, and 56% respectively in January 2004 Figure displays trends in HAART switching, downshifting and discontinuation between consecutive visits among ... conception and design, acquisition of data, and analysis and interpretation of data; 2) have been involved in drafting the manuscript; and 3) have read and given approval of the final version of...
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