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Báo cáo y học: "Involvement of nitric oxide (NO) in cough reflex sensitivity between non-sensitized and OVA-sensitized guinea pigs" pptx
... shown in Figure and Non-sensitized and OVA-sensitized guinea pigs were divided into three groups: control (normal saline) group and groups receiving the selective iNOS inhibitor ONO1 714 at doses of ... causes bronchoconstriction and airway remodeling, and selective iNOS inhibition attenuates these effects [29] These findings indicate that cNOS inhibition seems to be detrimental, and iNOS inhibition ... selective iNOS inhibitor ONO1 714 Figure shows the effect of ONO1 714 on the coughs induced by the 10 -4 M aerosolized capsaicin solution in non-sensitized and OVA-sensitized guinea pigs In non sensitized...
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Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"
... ornithine Co-induction of AS, cationic amino acid transporter-2, and NOS in activated murine microglial cells (19 ) and co-induction of inducible NOS and arginine recycling enzymes in cytokine-stimulated ... that the citrulline -NO cycle plays a significant role in ensuring adequate supply of arginine for the increased production of NO observed in anoxia A similar increase of NOS, AS and AL activities ... However the observed increase of arginase in reperfusion group may favor decreased production of NO in this condition Both NOS and arginase use arginine as a common substrate, and arginase may down-regulate...
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Báo cáo khoa học: In vivo degradation of nitric oxide synthase (NOS) and heat shock protein 90 (HSP90) by calpain is modulated by the formation of a NOS–HSP90 heterocomplex pot
... brain and aorta The level of HSP90 and the type of NOS isoform present in rat brain and aorta were determined by immunoblotting (Fig 1) In brain, nNOS was the most preferentially expressed isoform, ... l- [14 C]arginine (925 Bq; specific activity, 1 14 · 10 11 BqÆmol )1) , Sephacryl S-300, Sephadex G200 resins, SuperoseÒ 12 10 ⁄ 300 GL column and protein G-Sepharose were obtained from GE Healthcare, Milan, ... (immunoprecipitation buffer), containing 1% Triton X -10 0, 10 lgÆmL )1 aprotinin, 20 lgÆmL )1 leupeptin, 10 lgÆmL )1 AEBSF and phosphatase inhibitor cocktail I and II (10 lgÆmL )1) , followed by brief sonication...
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Báo cáo khoa học: Improvement of a monopartite ecdysone receptor gene switch and demonstration of its utility in regulation of transgene expression in plants pdf
... tobacco plants (Figs and 8) Moreover, in tobacco seedlings, AtZFP 11 transcript levels declined upon withdrawal of ligand, and plants began to revert to the normal phenotype (Figs and 8) In summary, ... (35S:AtZFP 11) and wild-type control plants (KY160) and increased sensitivity and higher magnitude of induction as compared to the monopartite EcR gene switch [14 ,40] In our earlier studies [14 ,15 ], ... in ltrated plants on a medium containing 50 mgÆL )1 kanamycin Resistant T1 plants surviving on kanamycin-containing medium were transferred to soil and then moved to a greenhouse for further analysis...
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Báo cáo khoa học: Subcellular localization of yeast Sec14 homologues and their involvement in regulation of phospholipid turnover pptx
... trp1, lys2, ura3, his3, sec14–1ts, [YEp1 81] leu2, trp1, lys2, ura3, his3, sec14–1ts, [YEp1 81- SEC14] leu2, trp1, lys2, ura3, his3, sec14–1ts, [YEp1 81- SFH1] leu2, trp1, lys2, ura3, his3, sec14–1ts, ... CTY392 PGY188 PGY206 PGY207 JAGwt S3 S7 PGY160 PGY159 PGY126 PGY145 PGY143 PGY137 PGY138 PGY140 PGY139 PGY1 41 PGY142 FY 16 79–28c PGY1 51 PGY152 PGY123 PGY154 PGY125 PGY156 PGY128 PGY129 PGY130 PGY95 ... 16 17 18 19 20 21 22 tidylinositol/phosphatidylcholine transfer protein (Sec14p) in phosphatidylcholine turnover and INO1 regulation J Biol Chem 272, 20873–20883 Kent, C & Carman, G.M (19 99) Interactions...
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báo cáo hóa học:" The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization" pptx
... grants NAG-2 -12 86, NCC2 -13 61 and the Department of Veterans Affairs Medical Research Service in support of MHF and this project We thank Sandra Spurlock for the data plate reading and data analysis ... the final steps of mineralization Figure FGF-2 and BMP-2, the yin and yang of mineralization: Contrast of effect of 24 hours of treatment with FGF-2 or BMP2 on fold increase in abundance of mineralization-related ... in general, BMP-2 maintained the mineralizing RNA profile of igf -1, alp, and bmp-2 and significantly increased expression of other genes associated with mineralization like col1a1, fn, ilgf -1, ...
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báo cáo hóa học:" The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization" pdf
... grants NAG-2 -12 86, NCC2 -13 61 and the Department of Veterans Affairs Medical Research Service in support of MHF and this project We thank Sandra Spurlock for the data plate reading and data analysis ... the final steps of mineralization Figure FGF-2 and BMP-2, the yin and yang of mineralization: Contrast of effect of 24 hours of treatment with FGF-2 or BMP2 on fold increase in abundance of mineralization-related ... in general, BMP-2 maintained the mineralizing RNA profile of igf -1, alp, and bmp-2 and significantly increased expression of other genes associated with mineralization like col1a1, fn, ilgf -1, ...
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Báo cáo y học: "CD147 overexpression on synoviocytes in rheumatoid arthritis enhances matrix metalloproteinase production and invasiveness of synoviocytes" pptx
... Expression of gelatinase B and the extracellular matrix metalloproteinase inducer EMMPRIN in benign and malignant pigment cell lesions of the skin Am J Pathol 19 97, 15 1:665-670 Page 11 of 12 (page ... CD147 was expressed predominantly on the MLS and FLS in the lining and sublining layers of RA synovium, and macrophages acted as the amplifier of the pathogenetic cascade in RA via the increase ... between CD147 and RA, and of the possible mechanism and regulation of the effect of CD147 on MMP production, will help in the development of innovative therapeutic interventions for RA Competing interests...
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Báo cáo y học: "The role of codon selection in regulation of translation efficiency deduced from synthetic libraries" potx
... 0 .16 and 0.28 are plotted as red squares, and the rest of the genes are plotted as grey circles Navon and Pilpel Genome Biology 2 011 , 12 :R12 http://genomebiology.com/2 011 /12 /2/R12 Page of 10 sequences ... protein abundance protein abundance 2.5 1. 5 0.5 1. 2 relative location ~0.5 relative location ~0.8 other 1. 5 0.5 1. 25 1. 3 1. 35 1. 4 1. 45 1. 5 Bottleneck relative strength 1. 55 1. 6 1. 2 1. 25 1. 3 1. 35 1. 4 ... Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation Nat Biotechnol 2007, 25 :11 7 -12 4 doi :10 .11 86/gb-2 011 -12 -2-r12 Cite this...
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Báo cáo y học: "A poxvirus Bcl-2-like gene family involved in regulation of host immune response: sequence similarity and evolutionary history" pptx
... ligand binding site [11 ] Arg 81 at the C-terminal end of alpha-helix in N1 is exposed and charged residues at equivalent positions are conserved in A46 and N2 families Conservation of these exposed ... part of the dimerization surface in N1, B15 and A52 proteins [11 ,12 ,14 ] In the N1 homodimer residues Arg7 and Asp14 of alpha-helix of different monomers form a potential salt bridge, contributing ... membranes, and valosin containing protein p97/p47 complex interacting protein (VCPIP1), a deubiquitinating enzyme required for Golgi and ER assembly These interaction data can help González and Esteban...
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Báo cáo y học: " The role of IFN-γ in regulation of IFN-γ-inducible protein 10 (IP-10) expression in lung epithelial cell and peripheral blood mononuclear cell co-cultures" potx
... is an increased IP -10 secretion in the presence of IFN-γ in co-cultures and a slight increase after IL -12 treatment (See Figure 5.) However, the basal, IFN-γ and IL -12 induced secretion of IP -10 ... ¤¤¤ IP -10 ng/ml ¤¤¤ ¤¤¤ *** ¤¤¤ Table 1: Secretion of IFN-γ in lung epithelial cell lines and PBMCs + IL -12 ¤ * *** IFN-g ng/ml 0 .1 10 Only Media - 0 .1 10 - 0 .1 10 - 0 .1 10 - 0 .1 10 - 0 .1 10 PBMCs ... from monocytes in response to IL -12 (C) Addition of recombinant IL -12 induces IP -10 secretion both by inducing IFN-γ secretion from lymphocytes and by an IFN-γ independent pathway, which cannot...
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Báo cáo y học: " Cysteinyl-leukotrienes in the regulation of β2-adrenoceptor function: an in vitro model of asthma" ppsx
... contraction [15 -17 ] and proliferation [18 ,19 ], eosinophil recruitment into the airways [20], increased microvascular permeability [ 21] , enhanced mucus secretion and decreased mucus transport [12 ,22] ... References 10 11 12 13 14 15 16 17 18 19 20 21 Emala C, Black C, Curry C, Levine MA, Hirshman CA: Impaired beta-adrenergic receptor activation of adenylyl cyclase in airway smooth muscle in the basenji-greyhound ... betaadrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms Biochemistry 19 92, 31( 12): 319 3- 319 7 Boterman M, Elzinga CR, Wagemakers...
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Báo cáo y học: " Discordance between microvascular permeability and leukocyte dynamics in septic inducible nitric oxide synthase deficient mice" pot
... findings of the present study suggest that iNOS is an important initiator of increased vascular permeability in sepsis Selective iNOS inhibition with 14 00W and induction of sepsis in iNOS- deficient ... and without iNOS induction, but microvascular leakage in septic mice was not increased in the absence of iNOS This finding does not result from differences in circulating WBC counts, and is not ... higher in septic wild-type (622 ± 63 seconds -1) and septic iNOS- deficient mice (6 61 ± 87 seconds -1) than in wild-type ( 610 ± 74 seconds -1) or iNOS- deficient control mice ( 618 ± 87 seconds -1) , but...
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THE ROLE OF THE CTD PHOSPHATASE RTR1 AND POST-TRANSLATIONAL MODIFICATIONS IN REGULATION OF RNA POLYMERASE II
... obtained from erg6Δrtr1Δ in the presence of MG132 using Scaffold software 67 18 Sequence coverage of Rpb1 obtained following erg6Δ rtr1 in the presence of MG132 using Scaffold software ... Chromotek Anti-Rat IgG 1: 1000 TBS Life Technologies Anti-Mouse IgG 1: 1000 5% Milk Anti-Rpb4 Neoclone Anti-Mouse IgG 1: 1000 TBS Anti-CBP Santa Cruz Anti-Goat IgG 1: 1000 5% Milk III Transformation of ... Kinase Phosphatase Kinase S5 Phosphatase S7 Kinase Phosphatase Mammals S cerevisiae Active Transcription Phase Cdk9, Cdk12 (Cdk13?) Fcp1, Cdc14 Bur1, Ctk1 Elongation Fcp1 Late Elongation/Termination...
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Role of p73 in regulation of cell death specific role in mitotic cell death and potential regulation of caspase 2s
... caspase-2S promoter 4.5.2 DNA binding domain of p73β is required for inducing caspase-2S activity 72 74 77 77 79 81 83 87 88 89 89 93 95 99 10 2 10 5 10 9 11 4 11 5 11 9 12 2 12 4 12 7 13 0 13 1 13 1 13 1 13 2 ... xii xii xiv 1. 1 p53 tumor suppressor family 1. 1 .1 p53 1. 1.2 p63 1. 1.3 p73 1. 1.3 .1 p73 and cancers 1. 1.3.2 p73 regulation 1. 1.3.3 p73 protein modifications 1. 1.4 p53 family in apoptosis and as tumor ... Over-expression of p73 in cancers 5.4 Conclusion 15 4 15 5 Bibliography 17 3 15 5 15 6 15 8 15 9 16 0 16 1 16 2 16 3 16 6 16 6 16 8 16 8 17 0 17 1 v SUMMARY p73 is a member of the p53 family of transcription factors...
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báo cáo hóa học:" Physical activity and change in quality of life during menopause- an 8-year follow-up study" docx
... (95%) 10 97 1. 01 0.99 to 1. 30 225 513 359 (ref.) 0.93 0.88 0.77 o 1. 14 0.70 to 1. 11 284 358 455 (ref.) 1. 01 1.28** 0.85 to 1. 21 1.08 to 1. 51 19 2 71 383 424 14 .18 5.94 1. 95 (ref.) 232 590 275 1. 46*** ... 1. 46*** 1. 49*** 1. 24 to 1. 73 1. 23 to 1. 80 208 765 12 4 1. 26** 1. 20 1. 07 to 1. 50 0.94 to 1. 53 403 17 7 517 0.73 1. 26* 8.38 to 24.00 4. 91 to 7 .19 1. 67 to 2.28 0.73 to 1. 18 1. 02 to 1. 56 0.340 Interpretation ... N, Plantiga PL Weight gain at the time of menopause Arch Intern Med 19 91; 1 51: 97 -10 2 [15 ] Wang Q, Hassanger C, Ravn P, Wang S, Christiansen C Total and regional body composition changes in early...
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Báo cáo lâm nghiệp: "Variability in Populus leaf anatomy and morphology in relation to canopy position, biomass production, and varietal taxon" docx
... Lower 15 .1 13.0 ±0.5 ±0.3 14 .1 11. 6 ±0.6 ±0.3 14 .6 11 .6 ±0.5 ±0.4 14 .5 11 .4 ±0.2 ±0.5 14 .4 12 .3 ±0.8 ±0 .1 14.4 11 .6 ±0.4 ±0.7 13 .3 10 .2 ±0.5 ±0.4 13 .1 11. 1 ±0.6 ±0.3 12 .4 10 .9 ±0.2 ±0.4 12 .9 11 .2 ... Lower 17 .6 17 .0 0.8 ±0.6 15 .7 13 .4 ±0.2 ±0.6 15 .1 12.4 ±0.4 ±0.6 17 .7 13 .1 ±0.9 ±0.3 18 .0 13 .5 ±0.7 ±0.2 16 .4 12 .8 ±0.9 ±0.3 16 .0 12 .6 ±0.7 ±0.6 18 .1 12.8 ±0.9 ±0.3 14 .0 12 .4 ±0.3 ±0.6 14 .7 13 .1 ... observed for the N and D×N taxa Genotypes with thin leaves had a significantly higher PpT/SpT ratio than genotypes with SpT (µm) Upper Lower 15 5.4 13 3.8 ±2.8 1. 6 18 3.8 11 6.9 1. 4 ±3 .1 1 51. 3 11 3.9...
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Control of Robot Manipulators in Joint Space - R. Kelly, V. Santibanez and A. Loria Part 1 ppt
... Algorithms K.F Man, K.S Tang and S Kwong Neural Networks for Modelling and Control of Dynamic Systems M Nørgaard, O Ravn, L.K Hansen and N.K Poulsen Modelling and Control of Robot Manipulators (2nd ... science, mechanical engineering and applied mathematics As a result, courses on robotics continue to gain interest and, following the demands of modern industry, every year more and more program ... Systems P Albertos and A Sala Control Systems with Input and Output Constraints A.H Glattfelder and W Schaufelberger Analysis and Control of Non-linear Process Systems K Hangos, J Bokor and G Szederkényi...
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Báo cáo y học: "Pre-clinical development as microbicide of zinc tetra-ascorbo-camphorate, a novel terpenoid derivative: Potent in vitro inhibitory activity against both R5- and X4-tropic HIV-1 strains without significant in vivo mucosal toxicity" docx
... http://www.aidsrestherapy.com/content/5 /1/ 10 10 11 Effects of low and mucosa in the New Zealand20 μM) of C14 Figure model on cervicovaginal high concentrations (1 and White rabbit Effects of low and high concentrations (1 and 20 ... HIV-1NDK and R5-tropic HIV-1Ba-L CC50a Antiviral molecules IC50b MΦ DC T cells MΦ* DC* T cells* C14 >10 >10 >10 HIV-1Ba-L 1. 3 ± 01 HIV-1NDK 0.02 ± 0.0 HIV-1Ba-L 1. 3 ± 0 .1 HIV-1NDK 1. 8 ± 0 .1 HIV-1Ba-L ... inhibit the entry of HIV -1 into T cells and may limit the reverse transcription step into macrophages and DC These findings indicate that C14 harbours potent HIV -1 entry inhibition activity and/ ...
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