ingram apos s network model of depression
Báo cáo khoa học: "Much ado about nothing: A social network model of Russian paradigmatic gaps" ppt
... competition is necessary? Hudson s claim arises from a confusion of two issues Discussing the English paradigmatic gap amn’t, Hudson states that “a simple application of [the usage-based learning] ... because of analogical pressure from existing gaps Albright (2003) himself is agnostic on the issue of whether form-based competition is necessary for the existence and persistence of gaps, but ... We model the persistence and spread of the Russian verbal gaps with a multi-agent model with Bayesian learning Our model has two kinds of agents, adults and children A model cycle consists of...
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báo cáo hóa học: " Origin and consequences of brain Toll-like receptor 4 pathway stimulation in an experimental model of depression" docx
... the last several years numerous studies have appeared regarding the role of TLRs in the pathophysiology of diverse CNS diseases such as multiple sclerosis, Alzheimer s disease and brain ischemia ... levels in the brain after acute and subacute stress protocols [5], after chronic exposure to a series of stressors of mild intensity (as occurs in CMS) the main isoform implicated is the constitutive, ... microflora Chronic mild stress and tissue samples The CMS protocol used was a modification of the one proposed by Willner [25] The protocol consists of a series of different stressors that were changed...
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Báo cáo y học: "Children''''s unique experience of depression: Using a developmental approach to predict variation in symptomatology" potx
... depressive symptom patterns Participants of this study were psychiatric outpatients and were between the ages of and 13 years of age Using depression diagnoses based upon the DSM-III, children 's ... knowledge of how depressive symptoms change across the course of childhood, earlier diagnoses of depression in children can be made and the best treatment options can be selected This study has several ... http://www.capmh.com/content/1/1/9 lessness/hopelessness, guilt, suicidal thoughts/attempts, irritability, aggression and changes in psychomotor patterns Symptoms were noted as either present or absent within the...
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Báo cáo y học: "Developing a realistic sexual network model of chlamydia transmission in Britain" pot
... histories as well as further analysis of the sensitivity and robustness of the model assumptions The advantages of this individual based model over other possible choices are that the history of ... natural history of pelvic inflammatory disease and estimate the cost-effectiveness of interventions designed to prevent it The model fitting was as systematic as possible given the limitations of computing ... Sampling biases and missing data in explorations of sexual partner networks for the spread of sexually transmitted diseases Stat Med 1998, 17:2079-2097 Morris M: Telling tails explain the discrepancy...
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Báo cáo y học: "GSMN-TB: a web-based genome-scale network model of Mycobacterium tuberculosis metabolism" ppsx
... web-based software that allows online access to data files and computational methods used for constraintbased simulations of the GSMN-TB model of TB metabolism This is the first GSMN model published ... Sacchettini JC: TB drug discovery: addressing issues of persistence and resistance Tuberculosis (Edinb) 2004, 84:45-55 Edwards JS, Palsson BO: Systems properties of the Haemophilus influenzae Rd metabolic ... of M tuberculosis The genome-scale metabolic network of M tuberculosis (GSMN-TB) was constructed as described in the Materials and methods The GSMN of Streptomyces coelicolor [21] was used as...
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Tài liệu Báo cáo khoa học: Proteomic analysis of dopamine and a-synuclein interplay in a cellular model of Parkinson’s disease pathogenesis docx
... a-syn, proteins that displayed increased (›) or decreased (fl) expression as a consequence of a-synuclein overexpression; complex, proteins that displayed altered levels as a result of the association ... silver-stained gel images revealed 28 spots whose intensity was significantly different in at least one of the four groups considered (Fig 2) Two groups of spots showing remarkable changes in the isoform ... networks (A) Proteins that displayed significant changes after dopamine treatment (B) Proteins that displayed significant changes as a consequence of a-synuclein overexpression or as a result of...
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Báo cáo khoa học: "What’s There to Talk About? A Multi-Modal Model of Referring Behavior in the Presence of Shared Visual Information" potx
... patterns in the presence of various forms of shared visual information Finally, we make use of a corpus gathered from laboratory studies that allow us to decompose the various features of shared visual ... Effects of head-mounted and scene-oriented video systems on re- mote collaboration on physical tasks In Proceedings of Human Factors in Computing Systems (CHI '03), pp 513520 ACM Press Fussell, S ... the task As Table demonstrates, we use a small random selection of data consisting of 10 dialogues from each of the Shared Visual Information and No Shared Visual Information conditions Each of...
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Báo cáo khoa học: ""DONNELLAN''''S DISTINCTION AND A COMPUTATIONAL MODEL OF REFERENCE" pptx
... individuating set is the result of the speaker 's beliefs, not a mirror of what is actually the case A speaker may possess two distinct individuating sets that, unbeknownst to him, determine the same object ... Barwise and John Perry Situations and Attitudes The Massachsetts Institute of Technology Press, Cambridge, Massachusetts, 1983 [4] Philip R Cohen Referring as requesting In Proceedings of the ... is utterly insane! ~ To compensate for these weaknesses, BERTRAND uses a strategy based on Grosz 's notion of ffocus stack" [8,10] In conceptual terms (and without going into details), it works...
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báo cáo hóa học: " Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson''''s disease" potx
... actions of NSAIDs whereas inhibition of the constitutively expressed form (COX-1) is responsible for the gastrointestinal side effects [25] In this study we used the intrastriatal administration of ... section series was performed using an optical fractionator probe The precision of the serial section analyses was assessed by the coefficient of error (p < 0.05) TH positive cell bodies were counted ... These results show that celecoxib produced a selective reduction of local microglial reaction in response to the neurotoxin Discussion Regular intake of nonaspirin NSAIDs (and high dose of aspirin)...
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báo cáo hóa học: " Novel Aβ peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer''''s disease" potx
... traditional image analysis approach Thus, this method is shown to accurately assess amyloid burden in transgenic mouse models of AD In addition, the use of object-based analysis provides data not obtainable ... of the numbers of Aβ-positive objects (or the sum of the areas of the Aβ positive objects) for the entire section and dividing by the sum of the areas of all ROIs This analysis was performed blinded ... performed on sections processed at the same time Single ANOVA statistical analysis was used to assess the significance of the differences in plaque area, glial and C3 activation products reactivity...
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báo cáo hóa học: " Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson''''s disease" pptx
... loss instead of a loss of TH expression To determine whether valdecoxib could prevent not only MPTP-induced loss of SNpc dopaminergic neurons but also the loss of striatal dopaminergic fibers, ... ANOVA showed significant differences, pairwise comparisons between means were tested by Bonferroni post hoc testing Statistical significance was set at p < 0.05 for all analyses Results Valdecoxib ... counts were performed by using a computer-assisted image analysis system consisting of a Zeiss Axioskop2Plus photomicroscope equipped with a MS-2000 (Applied Scientific Instrumentation, Eugene,...
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báo cáo hóa học: " Anandamide inhibits Theiler’s virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors" pdf
... NAPE-PLD expression is elevated on blood vessels and in reactive astrocytes distributed closely around them suggests the synthesis of AEA by brain endothelium in MS [43] In other models of brain injury ... was measured by solid phase sandwich ELISA, using a monoclonal antibody specific for mouse sVCAM-1 (R & D Systems Inc., MN, USA), according to the manufacturer s instructions The assay sensitivity ... not shown) Discussion The ECS has been suggested to contribute to the maintenance of homeostasis between the immune and the nervous systems [34,35] Besides, the pharmacological activation of ECS...
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báo cáo hóa học: " CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson’s disease" pot
... Diseases & key Laboratory of Stem Cell Biology, Institute of Health Science, Shanghai Institutes of Biological Sciences (SIBS), Chinese Academy of Science (CAS) & Shanghai Jiao Tong University ... have shorter glial processes, as well as a disordered arrangement and increased expression of CD11b and CD45 Moreover, this increased microglial response is substantiated by enhanced expression of ... hippocampus and inferior temporal gyrus of patients suffering from Alzheimer s disease [36] Down-regulation of CD200 has also been detected in brain of multiple sclerosis (MS) patients [37] These results...
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Báo cáo toán học: " A phenomenological model of seizure initiation suggests network structure may explain seizure frequency in idiopathic generalised epilepsy" potx
... This means that the class of graphs describing the networks considered here is the class of directed, unweighted, unlabelled graphs For networks of N nodes, this class is nite, which permits us ... dynamics) to occur 3.2 Three-node networks The next simplest case is that of networks consisting of three nodes Figure shows the set of 13 topologically distinct networks consisting of three nodes ... much is known about the physiological processes occurring at short timescales (e.g., ms or s) This is also the timescale characterised by features that are most reproducible across subjects; such...
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báo cáo hóa học:" A phenomenological model of seizure initiation suggests network structure may explain seizure frequency in idiopathic generalised epilepsy" pptx
... This means that the class of graphs describing the networks considered here is the class of directed, unweighted, unlabelled graphs For networks of N nodes, this class is nite, which permits us ... dynamics) to occur 3.2 Three-node networks The next simplest case is that of networks consisting of three nodes Figure shows the set of 13 topologically distinct networks consisting of three nodes ... much is known about the physiological processes occurring at short timescales (e.g., ms or s) This is also the timescale characterised by features that are most reproducible across subjects; such...
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A self organizing neural network model for a mechanism of pattern recognition unaffected by shift in position
... position of the stimulus pattern than that of presynaptic S- cells Since this C-plane consists of an array of such C-cells, several C-cells which are situated near the top of this C-plane respond ... As was discussed in Chap 2, one of the basic hypotheses employed in the neocognitron is the assumption that all the S- cells in the same S- plane have input synapses of the same spatial distribution, ... rest of the S- planes are to send representatives for other stimulus patterns As is seen from these discussions, if we consider that a single S- plane in the neocognitron corresponds to a single excitatory...
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Báo cáo khoa hoc:"The PX-EM algorithm for fast stable fitting of Henderson’s mixed model" ppt
... class of models First, the “sire-maternal grandsire” model (or SMGS model) as described by Bertrand and Benyshek [3], y = Xβ + Zs us + Zt ut + e, (4) where us and ut refer to (q × 1) vectors of ... gain of PX-EM The paper is organized as follows into six sections In Section 2, the general structure of the models is described and in Section a typical EM implementation for these models (called ... iteration of the EM algorithm consists of two steps, the expectation or E step and the maximization or M step In the Gaussian mixed model, this separates the computation into two simple pieces The E-step...
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Quantitative evaluation of motor function before and after engraftment of dopaminergic neurons in a rat model of Parkinson''''s disease ppt
... CatWalk system, has been used to detect footfall patterns, as well as selected time and distance measurements of persons with early-stage Parkinson 's disease [41] The GaitRite system comprises an ... each group is expressed as mean ± s. e.m for each condition All statistical tests were performed with SPSS statistical software (version 15) Statistical significance was evaluated using oneway ... exogenous cells may provide better long-term results Stem cells are viewed as a possible source of neurons for cell-based therapies of neurodegenerative disorders, such as Parkinson 's disease and Alzheimer's...
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Ceftriaxone-induced up-regulation of cortical and striatal GLT1 in the R6/2 model of Huntington’s disease pps
... analysis of variance (ANOVA) and Bonferroni post hoc tests All statistical tests required a level of significance of at least P < 0.05 Results Body weights Table shows the mean body weight of all ... Huntington s Disease W.B Saunders London, 1996 Ross CA: Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington s disease and related disorders Neuron 2002, 35(5):819-822 Behrens PF, ... http://www.jbiomedsci.com/content/17/1/62 data suggest that the mechanism for increasing GLT1 expression is still functional even in late stage HD Acknowledgements This research was supported by NINDS (R01 NS35663; F31 NS064791)...
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báo cáo khoa học: " A systems biology model of the regulatory network in Populus leaves reveals interacting regulators and conserved regulation" potx
... expression profiles in modules using the expression profiles of transcription factors In the case of two regulators, the expression of a module m is represented as a weighted sum of the expression ... Regulatory network predicts expression in unseen experiments Bootstrap analysis is often used in computational studies to evaluate the statistical significance of models such as phylogenetic trees [37] ... used a least square regression model to infer regulators of each transcriptional module Here, the expression of a module mi was modeled as the weighted sum of the expression of a set of transcription...
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