influence of leukemia inhibitory factor
Báo cáo y học: "Expression of leukemia inhibitory factor (LIF) and its receptor gp190 in human liver and in cultured human liver myofibroblasts. Cloning of new isoforms of LIF mRNA" pdf
... expression of LIF in human liver myofibroblasts, as well as of two new isoforms of mRNA Hepatic stellate cells and activated myofibroblasts have already been shown to synthesize a number of mediators ... consistent with that of activated myofibroblasts The slightly diffuse staining is suggestive of extracellular matrix deposition consistent with the expression of the Mtype isoform of LIF Experiments ... Percent of maximal proliferation Comparative Hepatology 2004, 3:10 120 100 80 60 40 20 10 100 1000 1/dilution Figure Biological activity of myofibroblast-derived LIF Biological activity of myofibroblast-derived...
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Tài liệu Báo cáo Y học: Differential response of neuronal cells to a fusion protein of ciliary neurotrophic factor/soluble CNTF-receptor and leukemia inhibitory factor pot
... Heath, J.K (1997) An antagonist for the leukemia inhibitory factor receptor inhibits leukemia inhibitory factor, cardiotrophin-1, ciliary neurotrophic factor, and oncostatin M J Biol Chem 272, ... K.R., Vernallis, A.B & Heath, J.K (1996) Characterization of the receptor binding sites of human leukemia inhibitory factor and creation of antagonists J Biol Chem 271, 11971– 11978 Vernalis, A.B., ... consequences such as stimulation of proliferation, stimulation of differentiation, prevention of differentiation, prevention of apoptosis and activation of a family of genes coding for the acute...
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Báo cáo Y học: A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor pot
... unchanged Replacement of D6 of gp130 by the corresponding domain of the GCSFR leads to the abrogation of signal transduction of all tested cytokines As coprecipitation of this gp130 mutant and ... distance or a twist of the cytoplasmic parts of the receptors responsible for signal transduction Replacement of single membrane-proximal FNIII-domains of gp130 by corresponding domains of GCSFR leads ... domain of gp130 can be replaced by a similar domain of a different receptor without abrogation of signal transduction, this points to a spacer role of the domain Intriguingly, signal transduction of...
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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain pdf
... investigation of the increased neurotrophic activity of the AD brain revealed that it correlated with the loss of a specific neuroinhibitory factor, rather than the presence of a neurotrophic factor This factor ... survival of cultured cortical neurons [31] The neuroinhibitory action of GIF is very specific to this MT isoform and can be attributed to the small differences in the protein sequence of this isoform ... Potential role of metal-binding/exchange properties of GIF in AD One of the primary pathological hallmarks of AD is the formation of b-amyloid (Ab) plaques, composed primarily of Ab(1–40) and...
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Báo cáo Y học: N-myc oncogene overexpression down-regulates leukemia inhibitory factor in neuroblastoma ppt
... proliferation of BBCE cells (data not shown and Fig 5) The inhibitory effect of LIF on endothelial cell proliferation did not, however, exclude a direct autocrine inhibitory effect of LIF on neuroblastoma ... distribution (40–60 kDa) as a result of heterogeneity and glycosylation (Fig 1D) Sequence analysis of five different segments of the main band revealed that one of the candidate proteins was LIF, ... rate of mLÆmin)1 was used and fractions of mL were collected, lyophilized and resuspended into 100 lL culture-tested water for activity evaluation Ten microliters of 100-fold dilutions of the...
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the speed of visual processing of complex objects in the human brain. sensitivity to image properties, the influence of aging, optical factors and individual differences.
... in fulfilment of the requirements for the degree of PhD 28 February 2014 Institute of Neuroscience and Psychology School of Psychology College of Science and Engineering University of Glasgow A ... THE SPEED OF VISUAL PROCESSING OF COMPLEX OBJECTS IN THE HUMAN BRAIN Sensitivity to image properties, the influence of aging, optical factors and individual differences ... reported that out of 185 scrutinized studies, 43% used filters with cut-offs higher than 0.1 Hz and half of those used cut-offs higher than Hz Rousselet (2012) reported that out of 158 studies,...
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Tương quan giữa đa hình di truyền gen Myogenin và gen mã hóa yếu tố ức chế ung thư máu (Leukemia inhibitory factor) với các đặc tính sinh lý-hóa máu lợn
... H Lapillonne, L.A van Grunsven, B.B Rudkin, J Samarut, Withdrawal of differentiation inhibitory activity /leukemia inhibitory factor up-regulates D-type cyclins and cyclin dependent kinase inhibitors ... Regulation of conceptus development and attachment in pigs J Reprod Fertil Suppl 52 (1997) 133 [10] A.Spötter, C Drögemüller, H Hamann and O Distl, Evidence of a new leukemia inhibitory factor- associated ... Công nghệ Sinh học 3(3) (2005) 311 [7] C.L Stewart, Leukaemia inhibitory factor and the regulation of pre-implantation development of the mammalian embryo Mol Reprod Dev 39 (1994) 233 [8] [9]...
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The influence of socio cultural factors on body image satisfaction among singaporean college women
... understandings of ideal female body image, perceived importance of having a good body image in today’s society, perceived influence of media on participants’ body image satisfaction, impact of participants’ ... changed views of body image and the reasons for the change will also be presented to discuss the trend of this issue over the time in the life of the participants Lastly, the influence of the three ... is a potential indicator of the adoption of disordered eating behaviors: women demonstrating higher degree of dissatisfaction with their bodies are at a higher risk of adopting disordered eating...
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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): reactivity and structure of metal–thiolate clusters* doc
... relationship of human neuronal growth inhibitory factor (hGIF) J Inorg Biochem 102, 1965–1972 10 Howells C, West AK & Chung RS (2010) Neuronal growth inhibitory factor (metallothionein-3): evaluation of ... exposure of Cu(I)4Zn4MT3 to air resulted in the slow formation of a disulfide linkage by cysteine oxidation of the a-domain and a concominant release of one Zn ion, but the spectroscopic features of ... Binding of more Zn(II) ⁄ Cd(II) is very likely to be non-specific Whether the binding of seven equivalents of Zn(II) ⁄ Cd(II) in MT3 is more heterogeneous than the binding of seven equivalents of Zn(II)...
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báo cáo hóa học:" The influence of oral health conditions, socioeconomic status and home environment factors on schoolchildren''''s self-perception of quality of life" pot
... The influence of oral health conditions, socioeconomic status and home environment factors on schoolchildrens selfperception of quality of life Janice S Paula 1, Isabel ... environment factors that could influence the OHRQoL of children, which have not yet been studied in a statistical regression model Purpose The objective this study was to investigate the influence of ... differing from zero This fact highlights the importance of further studies to investigate other factors that may influence the quality of life of children, which are not related to clinical conditions...
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Báo cáo lâm nghiệp: "The influence of selected factors on energy requirements for plain milling of beech wood" ppsx
... (°) Error F P SS – sum of squares, PC – disspersion, F – F-test, P – p-level of signifikance The results of the influence of observed parameters from the common values of both these materials ... from the statistical evaluation by multifactor analysis of variance that the influence of all observed factors on cutting input is significant, and the order of their significance was vc – cutting ... 15 20 25 the size of taken off layer was e = mm (thickness of remote layer) For each combination of parameters, the experimental material was investigated with double motion of the machine, i.e...
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Báo cáo lâm nghiệp: "Influence of cross section dimensions on Timoshenko’s shear factor – Application to wooden beams in free-free flexural vibration" ppsx
... using the shear factor The aim of our study was to gain further insight into the effect of the cross section size on the shear factor value We propose a new theoretical shear factor formulation ... formula of equation (9) was used with the shear factor K* expression (8) to evaluate the size effect of the cross section on the first five vibration frequencies with a length-to-depth ratio of 10 ... maximum of 1.2% when the height to width ratio reached 0.1 • The influence of cross section ratio variations on the first five vibration frequencies was negligible, with a maximum bias of –0.45%...
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Báo cáo y học: "Macrophage migration inhibitory factor: a mediator of matrix metalloproteinase-2 production in rheumatoid arthritis" pdf
... and activation of JNK and PKCδ by MIF required the interaction of Src JNK and Src are upstream activators of PKCδ and phosphorylation of JNK leads to the activation of cjun A number of molecules ... migration inhibitory factor Consistent with these results, in rat osteoblasts MIF stimulates phosphorylation of tyrosine, autophosphorylation of Src, activation of Ras, activation of extracellular ... number of animals in each group) EC, endothelial cell; MIF -/-, macrophage migration inhibitory factor gene-deficient; MMP, matrix metalloproteinase; WT, wild-type of 25 nM) Phosphorylation of JNK...
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Báo cáo y học: "Increased serum levels of macrophage migration inhibitory factor in patients with primary Sjögren''''s syndrome" potx
... et al.: Mutation screening of the macrophage migration inhibitory factor gene: positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile idiopathic ... Macrophage migration inhibitory factor: controller of systemic inflammation Crit Care 2006, 10:138 Bucala R, Lolis E: Macrophage migration inhibitory factor: a critical component of autoimmune inflammatory ... Hayashi Y, Sato M: Suppression of tumor necrosis factor αinduced matrix metalloproteinase production by the introduction of a super-repressor form of inhibitor of nuclear factor κBα complementary DNA...
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Báo cáo khoa học: " The influence of smoking and other risk factors on the outcome after radiochemotherapy for anal cancer" ppt
... total dose of radiotherapy In this case radiochemotherapy was stopped after first cycle of chemotherapy at a dose of 43 Gy because of toxicity and old age of the patient The intensity of chemotherapy ... risk factor for the development of anal cancer is well known, no data about the influence of smoking during combined radiotherapy on the outcome after therapy exist as of now The exact role of ... combination of one of these risk factors with smoking [7-11] Combined radiochemotherapy is the gold-standard in treatment of anal cancer since Nigro et al reported their data [12] Local control rates of...
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Báo cáo y học: "An exploration of how clinician attitudes and beliefs influence the implementation of lifestyle risk factor management in primary healthcare: a grounded theory study" pot
... risk factors • Views about continuation of risk factor management as part of professional role1/team or service3 • Support required for continuation of risk factor management practices in professional ... factor management practices, and the impact of structural or contextual factors on this A better conceptual understanding of how clinician beliefs and attitudes influence the implementation of ... view of the benefits of intervening beyond the individual, and for the purposes of primary through to tertiary prevention and maintenance of quality of life; viewed their role as facilitators of...
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Báo cáo y học: "Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor" ppsx
... dose-dependent effect of SE-encoding HLA-DRB1 alleles: 29.8% of RA cases and 24.9% of controls had one allele (OR 1.89, 95% CI 1.13 to 3.13), whereas 14% of RA cases and 5.6% of controls were homozygous ... presence of HLA-DR3, ACPA had a median value of (0 to 594), whereas in the absence of HLA-DR3, ACPA had a median value of 360 (0 to 1,000) (P = 0.002) ACPA was (0 to 653) in the presence of DERAA-encoding ... described, with 68% of SE-negative patients having ACPAs compared with 32% in our cohort [29] One reason for the lack of association may be the influence of external risk factors Tobacco exposure...
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Báo cáo y học: "Macrophage migration inhibitory factor enhances osteoclastogenesis through upregulation of RANKL expression from fibroblast-like synoviocytes in patients with rheumatoid arthriti" doc
... standard deviation of three separate experiments *P < 0.05 and **P < 0.005 MIF, macrophage migration inhibitory factor; RA, rheumatoid arthritis; RANKL, receptor activator of nuclear factor kappa-B ... sites of synovial bone destruction [33] RANKL is the key molecule in OC differentiation and the augmentation of activity and survival of these cells, and is often called OC differentiation factor ... The effect of macrophage-colony stimulating factor and other humoral factors (interleukin-1, -3, -6, and -11, tumor necrosis factor- alpha, and granulocyte macrophage-colony stimulating factor) on...
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Báo cáo y học: " Risk factors for hospitalization among adults with asthma: the influence of sociodemographic factors and asthma severity" pps
... Skobeloff EM, Spivey WH, St Clair SS, Schoffstall JM: The influence of age and sex on asthma admissions JAMA 1992, 268: 3437–3440 Osborne ML, Vollmer WM, Linton KL, Buist AS: Characteristics of ... history of ever smoking (43% of participants in both interviews versus 37% of non-participants at followup), female gender (73% versus 66%), atopic history (82% versus 83%), or severity -of- asthma ... 13-item diseasespecific severity -of- asthma score with four subscales: frequency of current asthma symptoms (daytime or nocturnal), use of systemic corticosteroids, use of other asthma medications...
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