inflammatory responses in the lung
Báo cáo y học: "The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis" pps
... type in the OA synovium is responsible for maintaining synovial inflammation In RA, in which the macrophage is the main promoter of disease activity, macrophage-produced TNF-α is a major therapeutic ... TNF, rather than a 'cytokine cascade' with either of these cytokines controlling the production of the other (Figure 4a) Both Enbrel and the neutralising anti-IL-1β antibody decreased the spontaneous ... of cleaving collagen type II, whereas MMP-3 is active against other components of the extracellular matrix, such as fibronectin and laminin Although there has been some interest in MMP inhibitors...
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Tài liệu BEYOND THE LAW The Bush Administration’s Unlawful Responses in the “War” on Terror pptx
... enemy combatant detainees and their supporters captured during the U.S war in Afghanistan emerged within the Bush administration in 2002 The plan was developed within months after the United States ... message by the Secretary of Defense in the face of war crime abuse can abet criminal activity Writing in a prominent newspaper in May 2004, and with the then publicized criminal treatment and interrogation ... Cruel, Inhuman, or Degrading Treatment or Punishment has condemned the use of the following interrogation tactics as either torture or cruel, inhuman, or degrading treatment: (1) restraining in very...
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Báo cáo hóa học: " Transcriptional responses in the adaptation to ischaemia-reperfusion injury: a study of the effect of ischaemic preconditioning in total knee arthroplasty patients" docx
... whether they were in the control or study group Excluded from the study were (1) patients with abnormal ankle brachial indexes indicating poor vascular supply to the limb (2) patients with inflammatory ... from the antecubital fossa of the upper limb at the initiation of surgery and at hour of ischaemia to coincide with the muscle sampling Blood was then obtained 30 min, hour and 24 hours following ... [31], and to suppress pro -inflammatory gene expression in circulating leukocytes [32] In this study, we investigated the effect of ischaemic preconditioning on the systemic inflammatory response...
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báo cáo hóa học: " A refined in vitro model to study inflammatory responses in organotypic membrane culture of postnatal rat hippocampal slices" potx
... anti -inflammatory stimuli during the culture Next, we wanted to see if either proinflammatory histone deacetylase inhibitor TSA or anti -inflammatory NF-κB inhibitor helenalin could influence the ... mediates the LPS induced intracellular NF-κB signaling pathway and evokes the release of cytokines To investigate whether the concentration of LPS had any effect on the slices during the 24 h ... illustrate the efficacy of in vitro hippocampal slice culture as an intermediate model between single cell lines and in vivo models Furthermore, we wanted to examine the possibility of refining the...
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Báo cáo y học: " Effect of Ankaferd Blood Stopper on air leakage in the lung and prevention of bleeding: an experimental study" ppsx
... the specimens were obtained from the lung The remaining rats (n = 10) were sacrificed after monitorization for five days and the lung was analyzed patologically on the fifth day The sampled lung ... In the standard surgery group (Group II), after having created an equal injury, the injury was sutured using 6-0 polyglactin (vicryl) Then the air leakage and bleeding were controlled and the ... Technique All the rats underwent left anterior thoracotomy An injury mm in length and 2mm in depth was created in the left lung parenchyma using a scalpel In the control group (Group I), no interventions...
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Báo cáo y học: "Waist circumference as the predominant contributor to the micro-inflammatory response in the metabolic syndrome: a cross sectional study" pptx
... established inflammatory markers The relative influence of the components of the MetS on these inflammatory markers may be of clinical significance aiding in the establishment of clinical guidelines ... circumference as the primary contributor of the inflammatory state in the MetS, could by itself in the future be a possible indication for statin therapy [39] In conclusion, a clarification of the relationship ... sub-clinical inflammatory response has not been previously evaluated Thus, our findings contribute original information to the literature being the largest analysis to date evaluating the association...
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Báo cáo y học: "Inflammatory responses in epithelia: endotoxininduced IL-6 secretion and iNOS/NO production are differentially regulated in mouse mammary epithelial cells" pot
... again the differential regulation of IL-6 and NO in mammary epithelial cells It remains intriguing but unknown whether or how the cellular ratios and influence thereof on regulation of the inflammatory ... p65 and p50, increased their binding activity in response to ET compared to the basal binding activity in SCp2 cell nuclear protein extracts Figure 3A shows an abrupt increase in ET-induced p65 ... ET during intramammary infection [15] Therefore, we investigated the effect of SCp2 and SCg6 interaction on ET-induced inflammation Surprisingly, the coculture of SCp2 and SCg6 cells in the absence...
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Báo cáo y học: "Cytokine & chemokine response in the lungs, pleural fluid and serum in thoracic surgery using one-lung ventilatio" pps
... contralateral lungs The inter-individual difference was present in the BAL of the lungs but less in the pleural space and in the blood, respectively The difference in extent of response underlines the ... of chemokines in lung surgery and give a first insight in the cytokine and chemokine reaction in complex thoracic surgery Further studies to determine the impact of the loco-regional inflammatory ... performed the pleural lavages and the surgery, was involved in the statistical analysis and the drafting of the manuscript; DO was involved in the design of the study and the drafting of the manuscript...
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Báo cáo y học: "Waist circumference as the predominant contributor to the micro-inflammatory response in the metabolic syndrome: a cross sectional study" doc
... established inflammatory markers The relative influence of the components of the MetS on these inflammatory markers may be of clinical significance aiding in the establishment of clinical guidelines ... circumference as the primary contributor of the inflammatory state in the MetS, could by itself in the future be a possible indication for statin therapy [39] In conclusion, a clarification of the relationship ... sub-clinical inflammatory response has not been previously evaluated Thus, our findings contribute original information to the literature being the largest analysis to date evaluating the association...
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Báo cáo y học: "Inhibition of allogeneic inflammatory responses by the Ribonucleotide Reductase Inhibitors, Didox and Trimidox" pot
... generation of humoral responses The differential inhibition of Th1 cytokines by HU results in a net increase in Th2 type cytokines, thus further lowering the immune response and increasing the potential ... to inhibit the proliferation of T-cells in the transplant setting by both inhibiting Tcell proliferation and reducing detrimental cytokine secretion However, the question remains whether these ... type cytokines These cytokines are known to suppress many pro -inflammatory cytokines and chemokines In the transplant scenario, upregulation of these cytokines may be important in the generation...
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Báo cáo y học: "Suppression of LPS-induced inflammatory responses in macrophages infected with Leishmania" pot
... following induction with LPS Despite recent interest in IL-17, a key cytokine involved in a variety immune responses, including the induction of other cytokines, its production from macrophages in ... differently to the inflammatory macrophages found at infection sites in the skin during Leishmania inoculation Further, the metacyclicenriched promastigote population inoculated during natural infection ... counter -inflammatory response against LPS-induced proinflammatory macrophage cytokines, we also analysed the effect of Leishmania uptake upon LPS-induction of the proinflammatory cytokines IL-1a...
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Báo cáo y học: "CD73 represses pro-inflammatory responses in human endothelial cells" pptx
... endothelial cells is normally only induced by inflammatory stimuli such as LPS or interleukin 1b [33,34] In the future it would be interesting to determine whether the anti -inflammatory effects of CD73 ... functions in modulating the clustering of the integrin LFA-1 or in inhibiting apoptosis, but so far no such role of CD73 has been described in endothelial cells [1,29] However, an A2B adenosine receptor ... 1B), indicating that CD73 is the major source of extracellular adenosine in these cells CD73 regulates adhesion molecule expression in endothelial cells Pro -inflammatory cytokines up-regulate the...
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Báo cáo y học: "Inflammatory changes in the airways of mice caused by cigarette smoke exposure are only partially reversed after smoking cessation" docx
... after smoking cessation [24,25] In contrast, other studies indicate that there is an ongoing airway inflammation in COPD patients who had stopped smoking [29-32] These findings indicate that inflammatory ... exposure These results indicate that smoking cessation leads to a reduction in inflammatory cell types and a change in cell composition in the BALF, mainly caused by a decline in neutrophils Lung inflammation ... after smoking cessation, suggesting that the Th1 skewing will diminish after smoking cessation Despite of the decrease in cell numbers and the reduction in cytokine and chemokine levels in the BALF...
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Báo cáo y học: " Allergic inflammation does not impact chemical-induced carcinogenesis in the lungs of mice" pdf
... value in streamlining future research [45,46] Our negative findings may aid in focusing future basic investigations into the relationship of lung carcinogenesis with inflammation in pertinent ... on lung carcinogenesis In the present studies, we aimed at determining the impact of experimental-induced allergic airway inflammation on chemical-induced lung carcinogenesis in mice We hypothesized ... (to TSB) The study sponsors had no involvement in the study design, in the collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript...
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Báo cáo y học: "Pre- and post-bronchodilator lung function as predictors of mortality in the Lung Health Study" pot
... ASB assisted in acquiring the data, drafting the manuscript, and interpreting the results All authors have read and approved the final manuscript 12 Acknowledgements The authors thank the staff ... post-bronchodilator lung function measurements at these visits The rationale for using these visits was that the inclusion criteria limited the range of lung disease severity at baseline to mild and ... body mass index and randomization cohort were included in the adjusted models Results There were a total of 5,887 participants in the Lung Health Study, of whom 721 died by the end of the follow-up...
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Báo cáo y học: " Glutathione S-transferase omega in the lung and sputum supernatants of COPD patients" potx
... Grx1, in being able to be excreted into the airways where it can participate in the maintenance of GSH homeostasis GSH levels are increased in the BAL fluid representing epithelial lining fluid ... incubating the sections in 3% hydrogen peroxide in absolute methanol for 15 minutes The sections were incubated with the primary antibody for GSTO1-1 using a dilution of 1:200 The immunostaining ... laboratory and others [17,26,27] β-actin has shown high individual variability, especially in tissue samples from the diseased lung Instead of using β-actin as a loading control, the protein concentration...
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Báo cáo y học: "Sequestration and homing of bone marrow-derived lineage negative progenitor cells in the lung during pneumococcal pneumonia" ppsx
... lungs Few of these Lin- PCs migrated into the airspaces (approximately 3.1% of all the cells remaining in the lung) , therefore approximately 14.6% of the initially infused Lin- PCs homed to lung ... important role in inflammatory responses against lung infection as well as contributing in tissue repair processes following the infection Further studies will be required to elucidate the mechanism ... sequestered (2 hours) in the lung while the Lin- PCs were preferentially retained (24 hours) there during pneumococcal pneumonia Furthermore, these progenitor cells also remained in the lung tissues and...
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Báo cáo y học: "Phenotypical and functional characterization of alveolar macrophage subpopulations in the lungs of NO2-exposed rats" pot
... conclusion, our findings clearly suggest that the newly recruited ED7+ AM are involved in the regulation of the ongoing inflammatory process Whether the antiinflammatory effects of IL10 or the proinflammatory ... expression in separated AM subpopulations In the context of an oxidant-induced inflammatory reaction in the lung AM are not only involved in the regulation of the inflammatory reaction by release of ... < 0.01 the proinflammatory cytokine TNF-α However, significantly increased mRNA levels were found in the ED7+ population for IL-12 p40 and iNOS Interestingly, the expression of the antiinflammatory...
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Báo cáo y học: " Clinical implications for Vascular Endothelial Growth Factor in the lung: friend or foe?" ppt
... may be the dilution caused from the alveolar flooding rather than the degree of lung injury [29] In the early stage of lung injury different insults and proinflamatory cytokines stimulate the production ... VEGF, suggesting a possible role for VEGF in the vascular heterogeneity of IPF [63] The question according to these findings is whether the increase in vascular density observed in the least fibrotic ... play a role in lung epithelial cell proliferation According to that, regulation of VEGF synthesis in the lung may affect lung injury repair [22] These observations indicate that the expression...
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Tìm thêm: xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25