inflammatory complexities in the cns new insights into the effects of intracellular redox state and viral infection in modulating the biology of oligodendrocytes and their precursor cells

Báo cáo y học: "New insights into the pathogenesis of glucocorticoid-induced avascular necrosis: microarray analysis of gene expression in a rat model" potx

Ngày tải lên : 12/08/2014, 14:22

... than other endothelial cells in the body In keeping with the theory of endothelial cell activation having a role in ANFH, coagulation-related gene expression in particular serine (or cysteine) ... identified on the luminal surface of endothelial cells in sections of normal human arteries and veins [44] A2M has also been implicated in hemostasis as a regulator of thrombin [45] and in the development ... is suggested to identify other risk factors GCs are the mainstay of therapy in most inflammatory disorders and they are also included in most chemotherapy protocols Therefore, ANFH is thus a...

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Tài liệu Báo cáo khoa học: Solution structure of hirsutellin A – new insights into the active site and interacting interfaces of ribotoxins docx

Ngày tải lên : 18/02/2014, 08:20

... increasing its pKa value It is known that the presence of a cation–p interaction is crucial in determining the pKa of the histidine residue in the active site of RNases and consequently in determining ... Superposition of the active-site residues of the 20 conformers of the solution structure of HtA Catalytic groups E66 and H113 are shown in red, and side chains of other residues in their vicinity are ... surface area of the corresponding side chains very low Desolvation of the charged groups should affect their pKa values, increasing the pKa of carboxylates and decreasing the pKa of histidines [24]...

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Báo cáo khoa học: New insights into the functions and N-glycan structures of factor X activator from Russell’s viper venom pot

Ngày tải lên : 07/03/2014, 06:20

... match the N-terminal sequences of the corresponding proteins [8] The ORF of LC2 encodes a precursor of 158 amino acids, including a signal peptide of 23 residues and mature protein of 135 residues ... sequences of the three subunits of RVV-X (Figs and 5) suggest the possible presence of three conformational Ca2+-binding sites in the heavy chain and none in LC1 and LC2, in accordance with the results ... platelets and endothelial cells The important role of these glycans in pharmacokinetics has been demonstrated by the slower and smaller increment of FDP in vivo after the injection of desialylated...

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Báo cáo khoa học: New insights into the P-glycoprotein-mediated efﬂuxes of rhodamines doc

Ngày tải lên : 08/03/2014, 08:20

... sensitive cells in K+-buffer were incubated with rhodamine In fact, when cells are incubated with rhodamine, before reaching the steady state, rhodamine continuously enters into the cells According ... seen, the intensity of the signal decreased when the number of cells increased Data points of Fcyto vs cells number were fitted to Eqn (9) of the experimental section and the values of F, q and ... measurement of the increase of the fluorescence signal (Fcyto) of the cells when they are incubated with the dye Actually, the dye can interact with various components inside the cells yielding modifications...

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Click Here: The State of Online Advertising - New insights into the beliefs of consumers and professional marketers ppt

Ngày tải lên : 15/03/2014, 22:20

... liked on behalf of their favorite brands, but also wish there was a dislike button for social media 68% of consumers find online ads “annoying” and “distracting” and 54% say online banner ads ... popular form of online advertising Advertising/Marketing professionals considered in the bottom professions among consumers – along with actors and dancers; not highly regarded by marketing professionals ... Deconstructing Marketing Favorite Print Magazines and Favorite TV shows are the two most preferred Consumers 45% Favorite Print Magazine ONLY 31% OF CONSUMERS ENJOY READING AND VIEWING ADVERTISEMENTS...

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Báo cáo khoa học: New insights into evolution of crustacean hyperglycaemic hormone in decapods – ﬁrst characterization in Anomura pdf

Ngày tải lên : 23/03/2014, 07:20

... between the CPRP and the mature hormone sequence, the position of the six cysteyl residues in the sequence, the size of the putative mature peptide (72 amino acid residues), and presence of the amidation ... capital letters The deduced amino acid sequence is indicated below (the asterisk indicates the stop codon) Both nucleotide and amino acid numbers are indicated at the end of the lines The putative ... labelling all along the neurons of the XO ⁄ SG system (Fig 4A) Classically, the X-organ (the grouping of perikarya in which the neuropeptides are synthesized) is located inside the medulla terminalis...

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Báo cáo khoa học: New insights into Fragile X syndrome Relating genotype to phenotype at the molecular level docx

Ngày tải lên : 30/03/2014, 15:20

... studies of the effect of the I307N mutation, which occurs in the second KH domain, we have chosen to use the tandem KH1-KH2 construct rather than the isolated KH2 domain, because inter-domain interactions ... recognition They had observed such a mode of KH domain–RNA interaction in the cocrystal structure of the KH3 domain of NOVA bound to an in vitro selected RNA [17,18] Yet another hypothesis is that the ... implicates lack of FMRP function as the primary cause of the syndrome In spite of its key importance, the effect of the I304N mutation on the structure and function of FMRP is still unclear, and there...

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Báo cáo hóa học: " New Insights into the RLS Algorithm" pdf

Ngày tải lên : 23/06/2014, 01:20

... factors: the exponential window, the level of noise at the system output, and the condition number The closer the exponential window is to one, the better the misalignment is, but the tracking abilities ... to use E the interpolation formulation to better understand the link among all variables in the RLS algorithm, and especially to emphasize the role of the interpolation error energies since − tr[R−1 ... noise, it is interesting to see how the misalignment will degrade by increasing the condition number of the input signal For example, by increasing the condition number from to 10, the misalignment...

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Báo cáo sinh học: "Making the jump: new insights into the mechanism of trans-translation" pdf

Ngày tải lên : 06/08/2014, 18:21

... that precede the resume codon to the correct positioning of the MLD Identifying determinants of template switching One problem in determining the critical elements of transtranslation in vivo has ... permutations of the -1 triplet and determined their effect on survival in the kanamycin resistance assay They found that eight of the 18 codons that were prohibited according to the -1 hypothesis [12] ... structures of (a) tRNA, (b) mRNA and (c) tmRNA (a,c) The 3’ and 5’ termini, the amino acid acceptor stem (AC) and the anticodon (A), D and T arms are indicated (b,c) The Shine-Dalgarno sequence (SD), the...

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báo cáo khoa học: " Construction of a potato consensus map and QTL meta-analysis offer new insights into the genetic architecture of late blight resistance and plant maturity traits" pps

Ngày tải lên : 11/08/2014, 11:21

... confidence intervals of the individual QTLs onto the consensus map It is based on a scaling rule between the positions of the flanking markers of the QTLs on their original maps and the positions of these ... one of them is mandatory), the trait related to the QTL and the size of the QTL mapping population used for the QTL detection The statistical method implemented in the MetaQTL software hypothesizes ... is the number of hypothetic meta-QTLs of a model) “Delta” is the rescaled value of the criterion, it is the difference between the value of the given model and the value of the best model The...

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Tài liệu NEW INSIGHTS INTO TOXICITY AND DRUG TESTING pptx

Ngày tải lên : 18/02/2014, 04:20

... contribution to the knowledge of microcystins toxicokinetics in the kidney and, consequently, an important stimulus to the investigation of microcystins toxicity in the kidneys 31 32 New Insights into Toxicity ... place in a cellular setting, the highest quality of cells should be used to determine safety and efficacy This led to the use of stem cells Stem cells are 15 16 New Insights into Toxicity and Drug ... gained from global research conducted on the geno- and phenotype of the cell line in question The HepG2 cell line, was one of 20 cell lines of human origin that was used in one of the first international...

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Báo cáo khoa học: New insights into structure–function relationships of oxalyl CoA decarboxylase fromEscherichia coli pptx

Ngày tải lên : 06/03/2014, 11:20

... between the PYR domain and the PP domain of two subunits of the functional dimer The main chain oxygen of G421 and the side-chain carboxyl oxygen of E54 interact with the amino pyrimidine moiety of ... found for the S-acetyl pantetheine part of acetyl CoA, and consequently the model for the inhibitor remains incomplete The nitrogen atom of the amino group of the adenosine ring of PADP interacts ... side chain of residue D302, the d and x nitrogen atoms of the guanodino group of R158 interact with the hydroxyl groups of ribose, and the main chain nitrogens of K220 and R280 interact with the...

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Báo cáo khoa học: Cadmium – glutathione solution structures provide new insights into heavy metal detoxiﬁcation potx

Ngày tải lên : 15/03/2014, 00:20

... revealing a large diversity of cadmium–peptide interactions varying according to pH and metal concentration [7,12–14] Nevertheless, the nature of the metal binding in the case of GSH remains subject ... despite the high levels of GSH in cells, the kinetics of the formation of Cd(GS)2 complexes at physiological pH (6.5–7.0 in the cytosol and 6.0–6.5 in the vacuole) have not been studied Furthermore, ... Moura JJ (1998) NMR determination of the global structure of the 113Cd derivative of desulforedoxin: investigation of the hydrogen bonding pattern at the metal center Protein Sci 7, 928–937 19 Pan...

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Gastric Carcinoma- New Insights into Current Management pdf

Ngày tải lên : 29/03/2014, 21:20

... the lamina propria, and respectively with the invasion of the lamina prop‐ ria, the last term being named intramucous carcinoma at the level of the esophagus and of the stomach At the level of ... old age of patients Intestinal metaplasia represents the replacement of the gastric lining and glandular epitheli‐ um by one composed of cells of the intestinal type (small or large intestine) Multiple ... programs, introducing innovating endoscopic techniques and espe‐ cially including some borderline lesions in the group of carcinomas, while other pathologists include them in the category of dysplasia...

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NEW INSIGHTS INTO ANXIETY DISORDERS pptx

Ngày tải lên : 30/03/2014, 09:20

... member of the family firm; they are denied the principle of retributive justice, as was Job in the Book of Job of the Old Testament The idea of separating the negative emotions into escalatory and ... panic and most of the patients thought they were dying Their condition was rapidly cured by getting them to breathe into a paper bag, so that they were rebreathing their own carbon dioxide Talking ... use of the work must explicitly identify the original source Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the...

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Thyroid and Parathyroid Diseases – New Insights into Some Old and Some New Issues Edited by Laura Sterian Ward pdf

Ngày tải lên : 30/03/2014, 23:20

... c - Effects occurring within minutes; Binding of iodine, T3 and T4 hormone synthesis Secretion of thyroglobulin into colloid Taking colloid back into the cell with endocytos, Effects occurring ... erythropoiesis With the protein synthesis they caused to occur in these precursor cells, they provide the synthesis of enzymes at the beginning and at the end of hemoglobin synthesis (Dillmann, ... with the increase in sensitivity, follicular cells in the gland reach hypertrophy and hyperplasia, and increase the weight of the gland and create goiter The effects of TSH decrease as the response...

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NEW INSIGHTS INTO ANXIETY DISORDERS ppt

Ngày tải lên : 30/03/2014, 23:20

... member of the family firm; they are denied the principle of retributive justice, as was Job in the Book of Job of the Old Testament The idea of separating the negative emotions into escalatory and ... panic and most of the patients thought they were dying Their condition was rapidly cured by getting them to breathe into a paper bag, so that they were rebreathing their own carbon dioxide Talking ... use of the work must explicitly identify the original source Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the...

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báo cáo hóa học:" New insights into HIV-1-primary skin disorders" pot

Ngày tải lên : 20/06/2014, 08:20

... suggested to include changes in the microcirculation, the nutrient supply of the skin, and in the production of sweat and oil in the skin [43] Xerosis has also been related to certain effects on the mast ... decrease in the number and function of Langerhans cells, CD4 + , NK cells, macrophages and monocytes [17-20] (Figure 1) While the final outcome of HIV-1 infection is the decrease in these cell ... with insect bites [26] In several other countries, mucocutaneous candidiasis and herpes zoster infections are the leading cause of skin disorders in these patients [27,28] Nevertheless, a decline...

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THYROID AND PARATHYROID DISEASES – NEW INSIGHTS INTO SOME OLD AND SOME NEW ISSUES ppt

Ngày tải lên : 27/06/2014, 10:20

... c - Effects occurring within minutes; Binding of iodine, T3 and T4 hormone synthesis Secretion of thyroglobulin into colloid Taking colloid back into the cell with endocytos, Effects occurring ... erythropoiesis With the protein synthesis they caused to occur in these precursor cells, they provide the synthesis of enzymes at the beginning and at the end of hemoglobin synthesis (Dillmann, ... with the increase in sensitivity, follicular cells in the gland reach hypertrophy and hyperplasia, and increase the weight of the gland and create goiter The effects of TSH decrease as the response...

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NEW INSIGHTS INTO FIBROMYALGIA pot

Ngày tải lên : 27/06/2014, 16:20

... pathological pain, especially deep tissue pain often persists and develops into chronic pain states Patients suffering chronic pain often complain of pain and tenderness in various parts of the body, and ... Robinson M.E (2011) Intraindividual Variability in Daily Sleep and Pain Ratings Among Chronic Pain Patients: Bidirectional Association and the Role of Negative Mood The Clinical Journal of Pain, ... Clinics of North America, Vol.28, No.2, (May 2002), ISSN 0889-857X Moldofsky H (2008) The Significance of the Sleeping-Waking Brain for the Understanding of Widespread Musculoskeletal Pain and...

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