infection malignancies in pediatric heart transplant recipients
Báo cáo y học: "Does left atrial volume affect exercise capacity of heart transplant recipients" docx
... and clinically insignificant finding during any post -transplant echocardiography This fact often leads to an under-appreciation of how left atrial enlargement may play a role in transplanted heart ... critical reading of the manuscript Author details Division of Cardiovascular Diseases, Department of Internal Medicine University of Cincinnati, Cincinnati, Ohio, USA 2UC Health, Cincinnati Ohio, ... Cincinnati, Cincinnati, Ohio, USA 6Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio, USA Page of Authors’ contributions MAW carried out collection of data, data analysis, and editing...
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Cytomegalovirus infections in solid organ transplant recipients
... Cytomegalovirus infections in solid organ transplant recipients 1.3 Clinical findings associated with human cytomegalovirus infections 1.3.1 Infections in immunocompetent hosts CMV infection in normal ... Cytomegalovirus infections in solid organ transplant recipients Recurrent infections may consist of either reactivation of the virus strain causing primary infection or reinfection by a new virus strain Recurrent ... perinatal infections 1.2.3 Immunosuppressed hosts 1.3 12 14 Clinical findings associated with human cytomegalovirus infections 16 1.3.1 Infections in immunocompetent hosts 16 1.3.2 Infections in...
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Tuberculosis in Liver Transplant Recipients: A Systematic Review and Meta-Analysis of Individual Patient Data doc
... pulmonary MTB infection was defined as including lung or mediastinal lymph node involvement We defined multiorgan (ie, miliary) MTB infection as involvement of or more organs (lymph nodes draining infected ... result in the absence of symptoms or clinical findings suggestive of active infection In analyzing LTBI treatment, we included studies reporting 10 or more patients with a known pretransplant MTB infection ... failure requiring liver transplantation (1.2%) Posttransplant Active MTB Infection Clinical Characteristics In of the 139 included cases, MTB infection was suspected to have arisen from the transplanted...
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Chapter 126. Infections in Transplant Recipients (Part 1) pdf
... transplants T gondii usually causes disease in the brain In hematopoietic stem cell transplant recipients, acute pulmonary disease may also occur Heart transplant recipients develop disease in ... columns and monoclonal-antibody depletion procedures results in a higher incidence of contamination In one series of patients receiving contaminated products, 14% had fever or bacteremia, but none ... thawing were helpful in guiding therapy for the recipient Table 126-1 Organisms Transmitted by Organ Transplantation and Their Primary Sites of Reactivation Disease a Bl ood L ungs H eart B rain...
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Chapter 126. Infections in Transplant Recipients (Part 2) potx
... mature in an old host who has several latent infections already Nevertheless, most infections occur in a predictable time frame after transplantation (Table 126-2) Table 126-2 Common Sources of Infections ... to infection The reconstitution that follows transplantation has been likened to maturation of the immune system in neonates The analogy does not entirely predict infections seen in HSCT recipients, ... aspects of infection unique to various transplantation settings Infections in Hematopoietic Stem Cell Transplant (HSCT) Recipients Transplantation of hematopoietic stem cells from bone marrow...
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Chapter 126. Infections in Transplant Recipients (Part 4) ppsx
... ulcerations occur in both the lower and the upper gastrointestinal tract, and it may be difficult to distinguish diarrhea due to GVHD from that due to CMV infection The finding of CMV in the liver ... abnormalities It is interesting that the ocular and neurologic manifestations of CMV infections are uncommon in these patients Management of CMV disease in HSCT recipients includes strategies ... strain from the donor is also common in CMVpositive recipients, and most seropositive patients who undergo hematopoietic stem cell transplantation excrete CMV, with or without clinical findings...
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Chapter 126. Infections in Transplant Recipients (Part 5) potx
... infection of B cells leads to several interesting phenomena in HSCT recipients The marrow ablation that occurs as part of the HSCT procedure may sometimes eliminate latent EBV from the host Infection ... combat disease Treatment of CMV pneumonia in HSCT recipients (unlike that in other clinical settings) involves both IV immune globulin (IVIg) and ganciclovir In patients who cannot tolerate ganciclovir, ... Although encephalitis developing after transplantation has been associated with HHV-6 in cerebrospinal fluid (CSF), the causality of the association is not well defined In several cases, plasma viremia...
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Chapter 126. Infections in Transplant Recipients (Part 6) ppsx
... Aerosolized ribavirin is difficult to administer Antibody in particular may prove more active in immunocompromised hosts, but relevant evaluation is lacking Influenza also occurs in HSCT recipients and ... of influenza Amantadine and rimantadine have limited effects, primarily reducing symptoms and shortening the duration of illness caused by sensitive strains of influenza A virus The neuraminidase ... (accounting for
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Chapter 126. Infections in Transplant Recipients (Part 7) docx
... glomerulopathy in kidney transplant recipients, bronchiolitis obliterans in lung transplant recipients, vasculopathy in heart transplant recipients, and the vanishing bile duct syndrome in liver transplant ... acute infections in recipients of SOT are different from those that infect HSCT recipients because SOT recipients not go through a period of neutropenia As the transplantation procedure involves ... therapy (when indicated), and rapid diagnosis and treatment of infections can be lifesaving in SOT recipients, who, unlike most HSCT recipients, continue to be immunosuppressed SOT recipients are...
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Chapter 126. Infections in Transplant Recipients (Part 8) potx
... transplantation decreases the incidence of early and middle-period infections (see below, Table 126-4, and Table 126-5) Table 126-5 Prophylaxis of Infections in Transplant Recipients Risk Organism ... cephalosporins to decrease the risk of postoperative complications Urinary tract infections developing soon after transplantation are usually related to anatomic alterations resulting from surgery ... surgery Such early infections may require prolonged treatment (e.g., weeks of antibiotic administration for pyelonephritis) Urinary tract infections that occur >6 months after transplantation may...
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Chapter 126. Infections in Transplant Recipients (Part 9) pot
... predisposing to bacterial infection VZV may cause fatal disseminated infection in nonimmune kidney transplant recipients, but in immune patients reactivation zoster usually does not disseminate ... for transplant recipients Additional oral prophylactic agents, such as maribavir, are in clinical study Infection with the other herpes-group viruses may become evident within months after transplantation ... to prevent and treat CMV infection in renal transplant recipients An immune globulin preparation enriched with antibodies to CMV was used by many centers in the past in an effort to protect the...
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Chapter 126. Infections in Transplant Recipients (Part 10) pdf
... (see "Middle-Period Infections," above) Heart Transplantation Early Infections Sternal wound infection and mediastinitis are early complications of heart transplantation An indolent course is ... blastomycosis may cause pulmonary infiltrates or disseminated disease Late Infections Late infections (>6 months after kidney transplantation) may involve the CNS and include CMV retinitis as well as other ... hominis infection is suspected M hominis mediastinitis has been cured with a combination of surgical debridement (sometimes requiring muscle-flap placement) and the administration of clindamycin...
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Chapter 126. Infections in Transplant Recipients (Part 11) pptx
... particularly in patients maintained on intense immunosuppressive therapy A subset of heart and heart- lung transplant recipients may develop early fulminant EBV-LPD (within months) Treatment includes ... scenario is increasingly common, particularly in patients with ongoing GVHD Late Infections EBV infection usually presents as a lymphoma-like proliferation of B cells late after heart transplantation, ... Aspergillus L monocytogenes meningitis should be considered in heart transplant recipients with fever and headache CMV infection is associated with poor outcomes after heart transplantation The virus...
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Chapter 126. Infections in Transplant Recipients (Part 12) pptx
... controversial Success in preventing reinfection with hepatitis B virus has increased in recent years; in contrast, reinfection of the graft with hepatitis C virus occurs in all patients, with ... Treatment includes antibiotic administration and drainage as necessary Liver transplant patients have a high incidence of fungal infections, and the occurrence of fungal (often candidal) infection ... cholangitis, including abdominal pain and jaundice Although these findings may suggest graft rejection, rejection is typically accompanied by marked elevation of liver function enzymes In contrast, in...
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Chapter 126. Infections in Transplant Recipients (Part 13) ppsx
... of CMV infection, EBV-LPD, and infections with opportunistic pathogens in patients receiving a pancreatic transplant are similar to those in other SOT recipients Miscellaneous Infections in Solid ... bacterial and yeast infections Most pancreatic transplants are drained into the bowel, whereas the remaining transplants (~20%) are drained into the bladder A cuff of duodenum is used in the anastomosis ... Organ Transplantation Indwelling IV Catheter Infections The prolonged use of indwelling IV catheters for administration of medications, blood products, and nutrition is common in diverse transplantation...
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Chapter 126. Infections in Transplant Recipients (Part 14) docx
... Munoz P et al: Mycobacterium tuberculosis infection in recipients of solid organ transplants Clin Infect Dis 40:581, 2005 [PMID: 15712081] Zerr DM et al: Clinical outcomes of human herpesvirus reactivation ... prevention of infection with several HPV serotypes most commonly implicated in cervical and anal carcinomas and in anogenital and laryngeal warts For example, the tetravalent vaccine contains HPV serotypes ... poliomyelitis, meningococcal infection, and typhoid The live typhoid vaccines are not recommended for use in most immunocompromised patients, but inactivated or purified polysaccharide typhoid vaccine can...
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Chapter 126. Infections in Transplant Recipients (Part 15) pps
... recommendations Seasonal influenza Vaccinate in the fall Vaccinate in the fall Vaccinate close Vaccinate close contacts Poliomyelitis contacts Administer Administer inactivated vaccine Measles/mumps/rubella ... recipients Among renal transplant recipients, rates of melanoma are modestly increased and rates of cancers of the kidney and bladder are increased Vaccination of Transplant Recipients In ... are being evaluated Yearly immunization of household and other contacts (including health care personnel) against influenza benefits the patient by preventing local spread Table 126-6 Vaccination...
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Chapter 126. Infections in Transplant Recipients (Part 17) doc
... drug Finally, clinical infections with MRSA strains exhibiting high-level vancomycin resistance due to VRE-derived plasmids have been reported in several patients in the United States, often in ... community-acquired "staph infections" in some U.S cities now caused by strains resistant to β-lactam antibiotics (Chap 129) The potential incursion of these strains into hospitals and the resulting impact on ... provide cohort nursing for colonized/infected patients Control device-related infections Enlist administrative support proactively Source: Adapted from: RA Weinstein, Emerg Infect Dis 7:188, 2001;...
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báo cáo khoa học: "Incidence and clinicopathologic behavior of uterine cervical carcinoma in renal transplant recipients" potx
... was performed using the BenchMark Automated Slide Staining System (Ventana Medical System) according to the manufacturer’s instructions The result of the nuclear staining was interpreted as positive, ... high-risk HPV and infiltrating cervical carcinoma punctate Page of ISH, in situ hybridization arising from the use of immunosuppressants increased the incidence of cervical intraepithelial neoplasia ... staining pattern in the nucleus indicates that integration occurred Therefore, because it was reported that the integration of the HPV DNA plays an important role in the early stage of carcinogenesis,...
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