... different with celecoxib, and somewhat higher with NSAIDs (Tables and 3) In trials of 24 weeks or longer, discontinuations due to adverse events with 800 mg celecoxib, 100/150 mg diclofenac, and 2,400 ... Clinical ulcers and bleeds Clinical ulcers and bleeds in the company clinical trial reports were as reported by investigators, and were not subjected to independent, blinded adjudication in trials ... 10 All No aspirin Aspirin NSAID, withand without ulcers in patients taking celecoxib and Endoscopically identified prophylactic low-dose aspirin NSAID, withand without prophylactic low-dose aspirin...
... radiotherapy, which agreed with the finding from head and neck study that EGFR expression was correlated with Table COX-2 expression and correlation withclinical features Clinical features EGFR ... NSCLC [21] COX-2 inhibitor has been investigated in both pre -clinical andclinical study, and has shown synergistic effects with radiation and chemtoxic drugs on tumor [3,22] COX-2 catalyzes the conversion ... 21 squamous, 26 adenomatous and adenosquamous carcinomas, with 40 moderate and well differentiated (G1-G2) and 10 low differentiated (G3) 15 cases were staged I-II and 35 III-IV based on the revised...
... Table (corrected table six) COX-2 expression and correlation withclinical features EGFR Positive expression rate P value Clinical features 0.448 Clinical features Ages negative positive < 60 ... Shen Yali, Xu Feng, Wang Jin: EGFR and COX-2 protein expression in non-small cell lung cancer and the correlation withclinical features Journal of Experimental & Clinical Cancer Research 2011, 30:27 ... as: Li et al.: Correction: EGFR and COX-2 protein expression in non-small cell lung cancer and the correlation withclinical features Journal of Experimental & Clinical Cancer Research 2011 30:32...
... stage, child score and status of the disease) and different genotypes Only one patient with mixed infection with genotype 1a and 1b and two cases with genotype 3a had co-infection with hepatitis ... patient with mixed infection with genotype 1a and 1b and one case with genotype 1b had jaundice (P < 0.001) History of jaundice was seen more in cases with mixed infection with genotype 1a and 1b ... different regions of Iran consist: 1a, 1b and 3a in center and west, 1a and 3a in north and 1a in south and east (table 2) The geographic distribution of the patients with a typeable genotyping is summarized...
... elicit a weaker Th1 immunity and are clinically more virulent in human tuberculosis By clinically and immunologically comparing tuberculosis associated with Beijing and non-Beijing strains, we ... progressive disease and reactivation of latent infection are both associated with increased production of IL-4 (Hernandez-Pando et al., 1996; Howard and Zwilling, 1999), and overexpression of ... of China and Russian Federation With respect to prevalence trends, data from settings with at least two observation points showed significant increase in Botswana, New Zealand, Poland, and Tomsk...
... both b and c) 16 the phone has been ring ing for a minute Noone …………at home(must have been/ can have been/ should have been/ none of these) 17 she’s fainted Throw some water on her face and she ... I was able to help you I would rather have gone to the park than stay home I used to visit my grandparents every weekend Shall I open the door? I shall arrive at nine (will is more common) Exercises ... prefer/ ‘d rather/ ‘d better) there are a lot of mistakes in this exercises I …… go over it again with you (will have to/ am able to/ would/ could) 10 he was a good swimmer, so he ……… Swim to the...
... approval (IRB-HSR# 10598, 10524, and1 1491) and review by the FDA (BB-IND# 9847 and 12191) Patients’ blood specimens from clinicaltrials (HSR# 1524(HSR# 10524 and 11491) were monitored during ... and Bill Goodwin Additional philanthropic support was provided by Frank and Jane Batten, the James and Rebecca Craig Foundation, George S Suddock, Richard and Sherry Sharp, and the Patients and ... handling before and after cryopreservation Some studies have defined optimal time intervals between venipuncture and cryopreservation [26-29] and optimal conditions for freezing [30] Also, handling...
... Z, Yasui Y: Reliability, effect size, and responsiveness of health status measures in the design of randomized and cluster-randomized trials Contemp Clin Trials 2005, 26:45-58 Simon GE, Revicki ... Shumaker SA, Anderson RT, Czajkowski SM: Psychological aspects of health-related quality of life measurements: tests and scales In Quality of Life and Pharmacoeconomics in ClinicalTrials 2nd edition ... disability, handicap, or quality of life Most of the instruments include items about impairment and disability, but only the WHOQOL-environmental measures handicap, and only the QLDS and the WHOQOL-psychological...
... scores were 23.0, 29.1, and 4.4 for HAM-D17, MADRS, and CGI-S, respectively Pretreatment correlations were 0.52 (CGI-S and HAM-D17), 0.53 (CGI-S and MADRS), and 0.62 (HAM-D17 and MADRS) Correlations ... 22 clinical trials, confirm and expand results of earlier comparisons of these commonly used depression rating scales [4-6] Previous analyses have included data from samples that were smaller and ... similar modes of administration and rating, and are generally performed by the same clinician However, in some clinical trials, depression rating assessments and assessments of global illness...
... cartilage volume changes contrasted with the clinical, radiological, and biomarker data We felt it was necessary to confirm our previous results [13,14] and provide new and clinically relevant information ... baseline demographics, withclinicaland imaging data as predictors controlling at the same time potential confounders such as age, gender, and BMI (Table with all the variables and Table using a ... but not with tibio-femoral cartilage loss, and somewhat with Wluka and colleagues [36], who demonstrated a weak association between the worsening of OA symptoms (knee pain and stiffness) and increased...
... females with stable SLE No improvement of disease activity and patients deteriorated [18] DHEA or prasterone Androgen Review: analysis of randomized controlled trials (7) comparing DHEA with a ... hopefully some of them represent interesting candidates for future clinicaltrials Two peptides and one peptide construct have reached advanced clinicaltrials in lupus patients The efficacy of the ... phase I and phase II clinicaltrials conducted by ImmuPharma (Mulhouse, France) Peptide P140 was found to be safe and well tolerated by subjects, and significantly improved the SLEDAI score and biological...
... CD19 + cells) Results Clinical characteristics of the patients and response to rituximab therapy The clinicaland laboratory characteristics of the RA patients who were treated with rituximab are ... demographic andclinical characteristics were Available online http://arthritis-research.com/content/11/4/R131 Table Demographic andclinical characteristics of rheumatoid arthritis patients treated with ... of +clinical response to rituximab with depletion of CD19+CD27+ memory B cells Clinical response to rituximab correlates with depletion of CD19+CD27+ memory B cells in peripheral blood (PB) and...
... patients with OCD from non -clinical samples as well as from patients with anxiety disorder [9] In summary, the OCI and the OCI-R were shown to have good psychometric properties in both clinicaland ... GDM and JJ designed the study, collected and analyzed the data, and wrote the first draft of the paper WHY collected the data and assisted data analysis RCKC conceived and designed the study, and ... Inventory-Revised scale: Replication and extension to nonclinical andclinical individuals with OCD symptoms BMC Psychiatry 2011 11:129 Submit your next manuscript to BioMed Central and take full advantage...
... patients treated with ziprasidone (p = 08) risperidone and quetiapine in large, randomized clinicaltrials measuring time to discontinuation for any cause [3,28], echoing our results and suggesting ... Kollack-Walker S: Randomized, double-blind 6-month comparison of olanzapine and quetiapine in patients with schizophrenia or schizoaffective disorder with prominent negative symptoms and poor functioning ... Lilly and Company Clinical Trial Database, met inclusion criteria, including trial each comparing olanzapine to risperidone [13], quetiapine [14], and aripiprazole [15], andtrials comparing olanzapine...
... angiosarcoma and ASCC not only share identical clinical features and a similar histopathological pattern in common histological staining but also show overlaps of cytokeratin-expression and of expression ... Classification of Tumours Pathology and Genetics of Head and Neck Tumours Edited by: Barnes L, Eveson JW, Reichart P, Sidransky D IARC Press, Lyon; 2005:129 Pindborg JJ, Reichart PA, Smith CJ, van der ... detection of ASCC cells presents on the one hand a distinguishing feature between ASCC and angiosarcoma and on the other hand a tumour biological indicator of the unfavourable prognosis of ASCC An abundant...
... hemodynamic goals in clinicaltrialsand whether this variation is associated with patient outcomes To better understand the hemodynamic goals in clinicaltrials in the sepsis research, and to inform ... patients with established severe sepsis and septic shock [18], and Tuchschmidt and colleagues examined the role of goaldirected therapy in septic shock [12] The studies of both Tuchschmidt and Alia and ... Jadad and colleagues [9] score analysis Yes Yesb Peake and colleagues [10] Yes Yesc Bollaert and colleagues [11] Yes No Spapen and colleagues [19] Yes No Alia and colleagues [18] Yes No Boldt and...
... alone [11] With the subsequent use of HAART, immune restoration disease (IRD) was then defined as a very important and common clinical syndrome IRD occurs with a wide range of pathogens and the ... that have arisen from astute clinical observations and detailed study of clinical samples The initial description of the association between clinical resistance to AZT and a mutation from leucine ... double stranded (ds)RNA activated PKR system and its role in restricting HIV replication in astrocytes [23]; and critical steps in HIV RNA and reverse transcriptase dimerisation, packaging and virion...
... present review both randomized and non-randomized trials because many trials carried out in China are non-randomized which may provide supplementary evidence to randomized trials [31] Double blinding ... studies and reviews in the electronic databases http://www.cmjournal.org/content/4/1/4 Inclusion criteria We included randomized controlled trials (RCTs) and non-randomized controlled clinicaltrials ... remaining 13 in China Six trials were published in English [6,14,15,17,22,24] and three trials had more than two arms Among the included trials, ten RCTs and seven CCTs involved 2090 and 1409 pregnant...