in vivo drug metabolism drug interaction studies—study design data analysis and recommendations for dosing and labeling guidance 1999
Báo cáo y học: " Mixed states vs. pure mania in the french sample of the EMBLEM study: results at baseline and 24 months – European mania in bipolar longitudinal evaluation of medication" ppsx
... partner (live -in or not live -in) Relapse was defined for patients not achieving simple remission and patients meeting one of the following relapse criteria: increase in CGI-BP overall since the last ... treatment During the maintenance phase, the patients were assessed at 6, 12, 18 and 24 months Patients gave their informed consent for taking part in the study and confidentiality was kept in compliance ... law on information and liberty Population To be included, patients had to be aged 18 years or over, presenting as in- or out-patients for the treatment of acute or mixed mania, and initiating or...
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The development of an in vivo humanized mouse model to investigate epstein barr virus infection and tumorigenesis
... model and the high level of viremia in the germinal centers in infectious mononucleosis causes the infection of bystander germinal center cells, pushing them into the latency III growth program and ... disease in renal and liver transplant is – 5%, in heart and heart-lung transplant is – 15%, and in intestinal transplant is 10 – 15% 125 The incidence of PTLD in bone marrow transplant is 0.5% in ... MHC class I molecules for immune recognition 44 Therefore, by maintaining the latent 18 Humanized mouse model of EBV infection Introduction form of the viral genome and avoiding immune recognition,...
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data analysis and visualization in genomics and proteomics - francisco azuaje
... Text Mining and NLP Databases and Resources for Biomedical Text Mining Text Mining and Protein–Protein Interactions Other Text-Mining Applications in Genomics The Future of NLP in Biomedicine Acknowledgements ... 3.4 Integrative Data Analysis and Visualization: Motivation and Approaches Integrating Informational Views and Complexity for Understanding Function Integrating Data Analysis Techniques for Supporting ... and many other compounds, storing information on how molecules and systems interrelate IntAct is an open source protein interaction database and analysis system It holds interaction data, maintains...
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In vitro metabolic drug interaction study of warfarin with sildenafil citrate
... higher binding affinity for the primary binding sites [50, 51] while R-warfarin has greater binding affinity for the secondary binding sites [52] The serum protein binding affinity of (R)-warfarin ... potential interactions and between warfarin and sildenafil citrate Our present study was mainly designed to investigate the in vitro drug interaction between these two agents The in vitro drug interaction ... 4.4 Results 84 4.3.1 Interaction of Warfarin and Sildenafil in Rat Serum Protein Binding 84 4.3.2 Interaction of Warfarin and Sildenafil in Rat Liver Microsomal Protein Binding 90 Discussion Chapter...
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Stability and in vivo evaluation of pullulan acetate as a drug nanocarrier
... lung, and kidney were fixed in 10% phosphate buffered formalin, embedded in paraffin, sectioned, and stained with hematoxylin and eosin (H&E) In vivo pharmacokinetics and bioavailability In vivo ... stability and toxicity of PANs, and further investigated the sustained release behavior in vivo of drug loading in PANs PA was firstly synthesized and characterized by FT-IR and 1H NMR, and then ... novel hydrophobized polysaccharide/oncoprotein complex vaccine induces in vitro and in vivo cellular and humoral immune responses against HER2-expressing murine sarcomas Cancer Res 58:3385–90 Gustafson,...
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FDA Needs to Ensure More Study of Gender Differences~ in Prescription Drug Testing potx
... Iiealth and knnan Services Food and Drug Administration, Center for Drug Evaluation and Research Guideline for the Format and Content of the Clinical and Statistical Sections of New Drug Applications,fuly ... actively involved in reviewing issues relating to the participation of women in drug trials In June 1992, FI‘ )A participated in an Institute of Medicine symposium on women and drug development and in ... regarding research on s women in prescription drug testing We reviewed FDA'S policy guidance for drug manufacturers and interviewed FDA, National Institutes of Health (NIH), and Institute of Medicine...
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Báo cáo hóa học: " Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug " pot
... with Earle's salts containing 10% fetal bovine serum and standard concentrations of Lglutamine, penicillin and gentamicin The drugs tested included CDV, IDU, N-MCT, 5-(2amino-3-cyano-5-oxo-5,6,7,8-tetrahydro-4H-chromen-4yl)-1-(2-deoxypento-furanosyl)-pyrimidine-2,4(1H,3H)dione ... repeatable increase in the efficacy of N-methanocarbathymidine (N-MCT) (Table 2) This compound is a carbocyclic thymidine analog that inhibits the replication of VV both in vitro and in vivo [12,13], and ... evaluated in cell culture and in intranasally infected mice The deletion of F2L had a minimal impact on viral replication in vitro and did not appear to significantly reduce the virulence in vivo...
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Báo cáo hóa học: " Molecular and macromolecular alterations of recombinant adenoviral vectors do not resolve changes in hepatic drug metabolism during infection" potx
... Dawley, Inc (Indianapolis, IN) were housed in individual cages and allowed unrestrained access to standard rodent chow (Harlan Teklad, Indianapolis, IN) and tap water A single intra-muscular injection ... after the innate immune response against the virus resolves [9] In an effort to prevent corresponding increases in drug- drug interactions, potential therapeutic failures of vital medications and secondary ... BH, Carman CV, Springer TA: Structural basis of integrin regulation and signaling Annu Rev Immunol 2007, 25:619-647 Ding X, Staudinger JL: Induction of drug metabolism by forskolin: the role of...
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Báo cáo y học: "Open Access Substance abuse and psychiatric co-morbidity as predictors of premature mortality in Swedish drug abusers a prospective longitudinal study 1970 - 2006" docx
... diagnoses were collected in a standardized manner Standardized clinical interviews (SWEDATE) and hospital records contained background data and mandatory information on length and intensity of Nyhlén ... admission and at follow up Substance type and other drugs including alcohol were identified with interviews and validated by mandatory urine samples Demographic data, types of substances used and psychiatric ... with representing no use and representing regular use for each drug on a daily basis, or a minimum of three days a week, for at least 12 months Coding and identifying causes of death In the follow-up...
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báo cáo khoa học: " Expressive writing for high-risk drug dependent patients in a primary care clinic: A pilot study" pot
... participated in its design and coordination, and helped to draft the manuscript BJ contributed to study coordination and statistical analysis MB, LW and AF participated in study planning, coordination and ... that they have no competing interests 16 Authors' contributions KB contributed to study design, coordination and supervision, performed data analysis and interpretation, and drafted the manuscript ... obtained, participants completed demographic information, baseline measures of physical and psychological health and their first 15minute expressive writing task The following instructions for...
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Predicting in vivo anti hepatofibrotic drug efficacy based on in vitro high content analysis
... determine the relative importance of each of the parameter before combining all data into a single index for ranking We proposed an innovative method for determining the optimized weights for each ... Ch1: channel for nuclear staining (blue) Ch2: channel for protein staining (red or green for two-channel images; green for three-channel images) Ch3: channel for protein staining (red for three-channel ... in a living cell [79] In addition, since multiple complex pathways are involved in fibrogenesis, drugs targeting a single protein are likely to fail at the systemic level in clinical trials For...
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Computational study of therapeutic targets and ADME associated proteins and application in drug design
... bioinformatics databases Bioinformatics is the science of using information to understand biology [17] The core of bioinformatics is the organization of information into databases Bioinformatics database ... bioinformatics and its role in facilitating drug discovery 13 1.2.1 Brief introduction to bioinformatics 14 1.2.2 Brief introduction to bioinformatics databases 18 1.3 The need for ... things are called machine learning, whose common tasks include concept learning for prediction, data clustering, and association rule mining In the information age, particularly in biological research...
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In vivo aspects of potential stereospecific drug interactions of oral warfarin and rutin in rats
... rutin treated rats in single dose study using WinNonlin 49 3.3 R- warfarin (mean) curve fitting for (a) control and (b) rutin treated rats in single dose study using WinNonlin 50 3.4 Changes in ... warfarin curve fitting for (a) control and (b) rutin treated rats using WinNonlin 71 4.3 Mean R- warfarin curve fitting for (a) control and (b) rutin treated rats using WinNonlin 72 4.4 Changes in ... warfarin elimination in different animal species 15 1.5 Warfarin drug interactions 23 1.6 Warfarin interactions with herbs and herbal products 26 1.7 Drug information: Rutin 30 1.8 Pharmacokinetic...
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Tài liệu Women Sufficiently Represented in New Drug Testing, but FDA Oversight Needs Improvement doc
... assists drug manufacturers in designing clinical drug trials, reviews proposals for conducting clinical drug trials, and approves drugs for sale in the United States based on its determination ... by those in the clinical drug trials, and effectiveness Evidence is also required to support the dosing section of the labeling, including the recommended dose and modifications in dose for specific ... participants in clinical drug trials are women than we found in our 1992 analysis of trials performed between 1988 and 1992 Adjusting for differences in the classes of drugs included in the studies,...
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Báo cáo khoa học: Insertion of the plant photosystem I subunit G into the thylakoid membrane In vitro and in vivo studies of wild-type and tagged versions of the protein doc
... disrupting protein–protein interactions within PSI, or by altering the conformation of the loop His-tags were employed in a topological study of the major light harvesting chlorophyll a ⁄ b binding ... shown) In conclusion, we have shown using both in vitro and in vivo methods, that PSI-G adopts a topology in the thylakoid membrane with the loop facing the stroma and its N- and C-termini facing ... after 0, 30 and 60 digestion with trypsin, probed with antibodies directed against PSI-G, PSI-K (intrinsic membrane protein, stromal loop), PSI-O (intrinsic membrane protein, luminal loop) and PSI-D...
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Báo cáo khoa học: In vivo studies of altered expression patterns of p53 and proliferative control genes in chronic vitamin A deficiency and hypervitaminosis pot
... cared and handled in conformence with the Guiding Principles for Research Involving Animals and Humans, approved by the Council of the American Physiological Soceity The School of Medicine Research ... [27] In rats Fig Western blot analysis of p53 and c-Jun in liver and lung Total protein extracts were obtained as described in experimental procedures A single band of about 53 kDa was detected in ... liver and lung indicating that the amount of p53 protein was significantly increased in the liver and lung from vitamin A-deficient rats that in controls c-Jun protein was significantly decreased in...
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Báo cáo khoa học: A study of microRNAs in silico and in vivo: diagnostic and therapeutic applications in cancer pot
... of essential proteins responsible for accelerating the cell cycle, including cyclin D and retinoblastoma [56,57] Moreover, alterations in the machinery responsible for processing miRNA contributes ... lymphomagenesis in mice [44] The miRNA miR-21 is overexpressed in many solid tumors, including breast, colon, lung, prostate and stomach, and in endocrine pancreas tumors, glioblastomas and uterine leiomyomas ... examined to date [8,52], a feature that could be particularly useful in diagnosing incident cancers in otherwise normal tissues Indeed, this approach discriminates normal and neoplastic tissues in...
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Báo cáo khoa học: A study of microRNAs in silico and in vivo: bioimaging of microRNA biogenesis and regulation doc
... vector containing three tandem repeat regions of miRNA23 binding sequence (reprinted with permission [11]) information for understanding the miRNA biogenesis related to human diseases Imaging miRNA ... Several reporter-based imaging probes, including luciferase for optical imaging and sodium iodide symporter and herpes simplex virus 1-thymidine kinase for radionuclide imaging, have been widely used ... used for the in vitro and in vivo investigations of miRNA production patterns Second, noninvasive monitoring of miRNAs provides useful information of the possible role of miRNAs involving cellular...
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Báo cáo khoa học: Structural studies of the capsular polysaccharide and lipopolysaccharide O-antigen of Aeromonas salmonicida strain 80204-1 produced under in vitro and in vivo growth conditions docx
... CPS and O-chain LPS are composed of linear trisaccharide repeating units containing 3-linked 2-acetamido-2-deoxy-D-quinovose, 4-linked 3-[(N-acetyl-L-alanyl) amido]-3-deoxy-D-quinovose and 3-linked ... 3-amino-3-deoxy-D-quinovose and L-rhamnose, 10% of the newly formed CPS and LPS O-chain polysaccharide was present in the in vivo cultured cells Methylation analysis performed on in vivo cultured ... and O-chain polysaccharide of A salmonicida strain 80204-1 the previously identified O-chain containing L-rhamnose, 2-amino-2-deoxy-D-mannose and D-glucose [11], confirming that the novel CPS and...
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Pulmonary rehabilitation in multi-drug resistant tuberculosis (TB MDR): a case report potx
... strength and resistance training for upper and lower limbs, education, and techniques of energy conservation In this case, the physical training was performed on a stationary bicycle, a treadmill and ... patient continues being a center of infection in the community and can lead to the dissemination of resistant forms The risk factors for the development of resistance include inhabiting endemic ... 10/100% In activities involving instruments (preparing meals, housekeeping, and caring for others) the patient was totally dependent on his care-taker He was not involved in any productive or...
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