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Báo cáo y học: "Spleen tyrosine kinase inhibition in the treatment of autoimmune, allergic and autoinflammatory diseases'''' pps
Ngày tải lên :
12/08/2014, 15:22
... protein Syk includes two tandem SH2 domains and a tyrosine kinase domain Interdomain A is between the two SH2 domains, and interdomain B is between the tyrosine kinase domain and C-terminal SH2 ... to determine clinical efficacy 3.5 Syk inhibitors in intestinal ischemia reperfusion injury Because hematopoietic cells are involved in the expression of intestinal ischemia-reperfusion injury (IRI), ... patients (n = 12) suffering from ITP with an R406 led to therapeutic success Specifically, in patients, the clinical response was sustained, whereas in the remaining 4, the response was of limited...
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Báo cáo y học: "otspots of homologous recombination in the human genome: not all homologous sequences are equal" ppsx
Ngày tải lên :
14/08/2014, 14:21
... a hotspot initially inferred from the observed nonuniform distribution of recombination within the human -globin gene cluster [15,16] These and other AHR hotspots cluster within small regions ... enable further insights into the most basic properties of homologous recombination refereed research What is the signal for recombination hotspots in the human genome? Does it reflect only the positional ... breaks by the recombination machinery? If so, is this dictated by access to the DNA because of a unique chromatin structure or is the signal contained within the DNA itself? We know that the signal...
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Báo cáo sinh học: " Identification of a major gene in F and F data when alleles 1 2 assumed fixed in the parental lines" pps
Ngày tải lên :
14/08/2014, 20:20
... concerning the power of this method when only F data are available, which is often the case when developing a synthetic line Furthermore, homozygosity at all loci in parental lines is not tenable in ... considering a the type I error rate as irrelevant When the variance in F increased when in fact no major gene was present, a major gene was found in 100% of the cases For smaller increases of the ... dramatically for smaller data sets Power increased when F data was included in the analysis, and additive effects I of 2a could be detected In that case the increase in variance in F caused by , the...
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Tài liệu Ideas to help you when implementing Best Practices in the Cisco Network Academy Program pdf
Ngày tải lên :
18/01/2014, 04:20
... This inte rnalization of the learning assists the student in making sense of the learning process and linking prior learning to the present as well as future learning in the way of goal setting ... and the scope of CNAP to assist the trainees and students in including all the items they might need, e.g., elements of the Threaded Case Study Note: A list of the elements will be included in the ... and the complexity of the task Begin using the less complex and shorter challenges with the students Have them work in pairs until they are familiar with the process and gain confidence in their...
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Tài liệu Limit the Data Displayed in a Bound List Box doc
Ngày tải lên :
21/01/2014, 12:20
... created called btnLoadList Enter the code in Listing 1.2 in the Click event of the btnLoadList button This code loads the data entered from txtCustLimit into the parameter of the OleDBDataAdapter1, ... created by using the ? in the Select statement of the data adapter Then Dataset1 is cleared of its data with the Clear method Finally, DataSet1 is refilled with data based off the value in txtCustLimit, ... change the line of code automatically for you It thinks you have a duplicate Class definition Now you can see that the icon of the form is correct You can continue with the steps of the How-To Select...
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Tài liệu Báo cáo khoa học: Accessibility changes within diphtheria toxin T domain when in the functional molten globule state, as determined using hydrogen⁄deuterium exchange measurements pdf
Ngày tải lên :
16/02/2014, 09:20
... diphtheria toxin is cleaved by furin into two fragments: the A chain corresponding to the catalytic domain (C domain); and the B chain corresponding to the translocation domain (T domain) and the ... receptor-binding domain The C and T domains remain covalently linked by a disulfide bond Following binding to its cell-surface receptor, diphtheria toxin is internalized through the clathrin-coated ... pathway The acidic pH in the endosome triggers a conformational change, leading to insertion of the toxin in the membrane The C domain is then translocated across the endosomal membrane into the...
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Summary Report of Issues Identified in the Commission Staff’s Examinations of Select Credit Rating Agencies potx
Ngày tải lên :
06/03/2014, 08:20
... pays the rating agency for the rating The conflict of interest inherent in this model is that rating agencies have an interest in generating business from the firms that seek the rating, which ... intended to maintain the integrity of the NRSRO’s judgment, and to prevent an NRSRO from being influenced to issue or maintain a more favorable credit rating in order to obtain or retain business ... to them by the sponsor of the RMBS They did not verify the integrity and accuracy of such information as, in their view, due diligence duties belonged to the other parties in the process They...
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SUPPLEMENTARY LIST FOR TODAY IN CONTINUATION OF THE ADVANCE LIST ALREADY CIRCULATED docx
Ngày tải lên :
06/03/2014, 23:20
... CO.,MC DHINGRA, VINOD K SINGH,SINHA AND ASSOCIATES FEDERATION OF ALL INDIA ICMR E Vs INDIAN COUNCIL OF MEDICAL RESE M/S SIKRI AND CO.,V.K RAO, MANISH MALHOTRA,MC DHINGRA,VINOD K SINGH,SINHA AND ... | | | | | | | INDIAN INSTITUTE OF PLANNING AND MANAGEMENT SOCIETY Vs ALL INDIA COUNCIL OF TECHNICAL EDUCATION AND ANR INDIAN INSTITUTE OF PLANNING AND MANAGEMENT SOCIETY Vs ALL INDIA COUNCIL ... REQUESTED TO PAGINATE THEIR FILES IN CONFORMITY WITH THE COURT FILE IN ADVANCE NOTE II: COUNSELS ARE REQUESTED TO PROVIDE LIST OF BOOKS/ACTS ON WHICH THEY ARE RELYING IN ADVANCE NOTE III: IN REGULAR...
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Báo cáo khoa học: Relationship between functional activity and protein stability in the presence of all classes of stabilizing osmolytes ppt
Ngày tải lên :
07/03/2014, 00:20
... references therein] The binding model claims that an increase in the osmolyte-induced stability arises from the preferential hydration (or exclusion of the osmolyte) leading to a shift in the denaturation ... glycine, l-alanine, l-proline, l-lysine, l-serine, b-alanine, taurine, sarcosine, dimethylglycine, glycine betaine, trimethylamine N-oxide, and cytidine 2¢-3¢ cyclic monophosphate were also obtained ... and DGD° values in the presence of these osmolytes are given in Table However, DGD° values of RNase-A in the presence of alanine, serine, lysine, b-alanine, taurine and dimethylglycine have not...
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Báo cáo khoa học: A mouse model for in vivo tracking of the major dust mite allergen Der p 2 after inhalation docx
Ngày tải lên :
07/03/2014, 21:20
... In vivo tracking of 75 Se-labelled Der p intrinsic biological properties of the allergens may all contribute to their allergenicity [1–4] The intrinsic properties required for evoking an allergic ... contribute to the allergenicity of HDM by favouring a pro -in ammatory environment in the airways In the case of most allergens though, including other dust mite allergens such as Der p 2, detailed investigations ... labelling of recombinant proteins by means of incorporating a radioactive selenocysteine residue in a C-terminal Sel-tag [18] Der p carrying the Sel-tag had an intact core sequence and maintained allergen-specific...
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Báo cáo khoa học: Molecular dynamics structures of peptide nucleic acidÆDNA hybrid in the wild-type and mutated alleles of Ki-ras proto-oncogene ppt
Ngày tải lên :
07/03/2014, 21:20
... interrupted stacking, fluctuating nature of the hydrogen bond and water organization in the vicinity of the mismatch might be the contributing factors for the increase in free energy and diminished stability ... duplexes, their comparison, especially in the vicinity of the mismatch in PDwt compared with DDwt duplex may give clues towards deciphering the origin of the destabilization and hence, diminution of the ... significant variableness in the water interactions surrounding the mismatch Water interaction in the vicinity of A C mismatch Figure 7A–L depicts the nature of water interaction in the neighbourhood...
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No Safer Place in the World for Your Money - How to Make Sure All Your Deposits Are Protected by FDIC Insurance docx
Ngày tải lên :
15/03/2014, 10:20
... healthy institution to assume the insured deposits The account owners can then decide whether to remain as customers of the other bank or move their money elsewhere If the FDIC cannot find another institution ... to the insurance limit, including principal and any accrued interest through the date of the closing In most cases, the FDIC provides access to accounts on the next business day by arranging with ... on the link to the online order form The video also can be downloaded for use on a portable audio (MP3) player by clicking on the link to the video and then going to the “resources” tab Read the...
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Báo cáo khoa học: Choline increases serum insulin in rat when injected intraperitoneally and augments basal and stimulated aceylcholine release from the rat minced pancreas in vitro pptx
Ngày tải lên :
17/03/2014, 09:20
... receptors inhibits the effect of choline on serum insulin levels; (c) determine whether oral glucose administration in uences the response of serum insulin to choline; and (d) determine whether the increase ... relatively selective antagonists of muscarinic receptors on choline-induced increases in serum insulin To determine the involvement of muscarinic acetylcholine receptor subtypes in the increase in serum ... peripherally acting selective antagonist of the ganglionic nicotinic receptor, entirely blocked the choline-induced increase in serum Insulin (ngÆmL)1) Saline + saline Saline + choline Pirenzepine...
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CONSOLIDATED LIST OF FINANCIAL SANCTIONS TARGETS IN THE UK pdf
Ngày tải lên :
23/03/2014, 02:20
... moving recruits to Al-Qaida training camps in South Asia In Jan 2008, convicted in absentia by the Bahraini High Criminal Court for financing terrorism, undergoing terrorist training, facilitating ... Abdallah (2) AWDH, Bin Laden, Osama, Mohamed (3) BIN LADEN, Usama (4) BIN LADIN, Osama (5) BIN LADIN, Osama, bin Muhammad, bin Awad (6) BIN LADIN, Shaykh, Usama (7) BIN LADIN, Usama (8) BIN LADIN, ... Qods Other Information: Both UK listing and EU listing under Terrorism and Terrorist Financing EU listing under Syria UN listing under Iran (nuc prol) Male UN Ref I.47.D.6 Involved in providing...
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Báo cáo khoa học: Identification of domains involved in the allosteric regulation of cytosolic Arabidopsis thaliana NADP-malic enzymes ppt
Ngày tải lên :
23/03/2014, 04:20
... smaller decrease in the catalytic activity when the allosteric site is occupied by the inhibitor, in comparison with the parental enzyme NADP-ME3 (Table 1) In the case of ME3.2¢, the inhibition by ... indicate that, despite the differences detected, the binding sites for the substrates were integral in the chimeric proteins Regulatory properties of the chimeric NADP-MEs in the oxidative decarboxylation ... are involved in fumarate activation (in yellow), CoA activation (underlined) and malate inhibition (in green) of the forward reaction are highlighted In addition, the regions involved in succinate...
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Allergic Diseases – Highlights in the Clinic, Mechanisms and Treatment Edited by Celso Pereira docx
Ngày tải lên :
23/03/2014, 17:20
... leader in the field Clinicians will all benefit from these reviews The effort and dedication of the authors in the time expended in the writing of the different chapters is fully demonstrated by the ... of the genes identified by hypothesis-independent genome-wide approaches and is a group of genes involved in maintaining the integrity of the epithelial barrier at the mucosal surface and signalling ... with very promising therapy approaches So the aim and the project was at the final the scope of the title Allergic diseases - highlights in the clinic, mechanisms and treatment, since it would...
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Alice’s Adventures in WonderlandBy Lewis Caroll (1865)Download free eBooks of classic literature, books and novels at Planet eBook. Subscribe to our free eBooks blog and email newsletter..All in the Golden AfternoonAll in the golden afternoon Full ppt
Ngày tải lên :
24/03/2014, 00:20
... found herself in a long, low hall, which was lit up by a row of lamps hanging from the roof There were doors all round the hall, but they were all locked; and when Alice had been all the way down ... with their heads downward! The Antipathies, I think—’ (she was rather glad there WAS no one listening, this time, as it didn’t sound at all the right word) ‘—but I shall have to ask them what the ... the seaside once in her life, and had come to the general conclusion, that wherever you go to on the English coast you find a number of bathing machines in the sea, some children digging in the...
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Andersen’s Fairy TalesBy Hans Christian Andersen.THE EMPEROR’S NEW CLOTHESMany years ago, there was an Emperor, who was so excessively fond of new clothes, that he spent all his money in dress. He did not trouble himself in the least about his sold pdf
Ngày tải lên :
24/03/2014, 00:20
... violent knocking at the door, and the old King, the Prince’s father, went out himself to open it It was a Princess who was standing outside the door What with the rain and the wind, she was in a sad ... is.’ So the faithful old minister went into the hall, where the knaves were working with all their might, at their empty looms ‘What can be the meaning of this?’ thought the old man, opening his ... placed themselves in front of her, and spread out their dresses the swineherd got ten kisses, and the Princess the kitchen-pot That was delightful! The pot was boiling the whole evening, and the...
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