in patients with cancer
Báo cáo khoa học: The in vitro effects of CRE-decoy oligonucleotides in combination with conventional chemotherapy in colorectal cancer cell lines potx
... chemotherapy Indeed, it has been shown that a palindromic trioctamer of this sequence can interfere with CREB binding, and specifically inhibit PKA subunit expression, interfering with the CRE-PKA ... containing 10 lM BrdU for 30 mins before fixing with ice-cold 70% (v/v) ethanol and permeabilization in M HCl with 0.5% (v/v) Triton X-100 Samples were washed and incubated with fluorescein isothiocyanate-conjugated ... combining CDO with cytotoxic agents in HCT116 and GEO cells Cells were cultured with CDO (C) alone or in combination with 5-FU, SN38 or VP16 There were significant reductions in cell number in...
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RESPIRATORY HEALTH EFFECTS OF PASSIVE SMOKING: LUNG CANCER AND OTHER DISORDERS ppt
... lung cancer in nonsmoking adults and noncancer respiratory illnesses in children, with emphasis on the epidemiologic data Further, because two thorough reviews on passive smoking were completed in ... (OHEA) within the Office of Research and Development, with major contract funding provided by the Indoor Air Division within the Office of Air and Radiation's Office of Atmospheric and Indoor ... distribution and arithmetic means of vapor-phase nicotine levels over a 1-week period in the main living area in residences in Onondaga and Suffolk Counties in New York State between January and April...
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báo cáo hóa học:" Pain in cancer. An outcome research project to evaluate the epidemiology, the quality and the effects of pain treatment in cancer patients" pptx
... aimed at making available to treating physicians, patients and families valid information about pain management in cancer Two main lines of activities were identified as necessary: information ... history including past cancer history, b) physical examination, c) recording of medications and recent therapies, including analgesic consumption, d) pain assessment using the Brief Pian Inventory ... available in medical literature any large parallel randomized controlled trial conducted in advanced cancer patients suffering from severe pain (step in the WHO's pain ladder), comparing any alternative...
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Báo cáo y học: "Anti-tumorigenic and Pro-apoptotic effects of CKBM on gastric cancer growth in n" potx
... for 90 min, and then incubated with Link reagent (LSAB kit, DAKO) for 60 at room temperature Sections were incubated with Streptavadin (LSAB kit, DAKO) for 60 min, and further incubated with hydrogen-peroxidasediaminobenzidine ... 30 and stained with diaminobenzidine-H2O2 for 10 Finally, the sections were counterstained with Mayer’s hematoxylin For positive control, sections were treated with 0.5 U/ml DNase I in Dnase buffer ... contain various anti-carcinogenic compounds including lunasin and lectins that were shown to induce apoptosis in malignant cells [13] As CKBM contains these compounds, this would partially explain...
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Báo cáo khoa học: "A paraneoplastic manifestation of metastatic breast cancer responding to endocrine therapy: a case report" ppsx
... illustrating the need for physicians to maintain a high index of suspicion for paraneoplastic syndromes in women presenting with unusual neurological symptoms with no obvious cause In breast cancer patients ... during monitoring of patients Conclusion Our case has shown that ER positive breast cancer may present with paraneoplastic manifestations including papillitis, neuropathy and myositis Endocrine ... responding to an aromatase inhibitor This suggests that endocrine therapy may be an appropriate treatment for the paraneoplastic manifestations of breast cancer in patients with hormone responsive...
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Báo cáo khoa học: " Effects of osteopontin inhibition on radiosensitivityof MDA-MB-231 breast cancer cells" doc
... expression with OPN-induced invasion and migration in human breast cancer cells These findings are consistent with our data analyzing the protein expression levels of the migration marker uPA with ... inhibition are in agreement with previous findings that the knockdown of OPN reduces the clonogenic survival, migration and invasion rate, and proliferation in different breast cancer cell lines ... treatment with recombinant OPN confers an increased resistance to UV-induced apoptosis in HT29 cells [41] However, OPN siRNA transfection alone and in combination with irradiation showed only minor...
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Báo cáo khoa học: "Effects of propranolol in combination with radiation on apoptosis and survival of gastric cancer cells in vitro" ppsx
... Apoptosis induction by isoproterenol or propranolol in combination with irradiation in BGC-823 and SGC-7901 cells There was an increasing rate of apoptosis in gastric cancer cell lines in response ... treatment for gastric cancer patients Taken together, radiotherapy in combination with propranolol can be more useful for patients with a high risk of recurrence in gastric cancer Investigation of ... cancer cells Int J Cancer 2004, 108:181-188 16 Liao Z, Komaki R, Mason KA, Milas L: Role of cyclooxygenase inhibitors in combination with radiation therapy in lung cancer Clin Lung Cancer 2003,...
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Báo cáo khoa học: "The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiation" pot
... lost or inactivated in a variety of solid human tumors, including prostate cancer Increased levels of PIP3 trigger the recruitment of phosphatidylinositide-dependent serine/threonine kinase (PDK1) ... apoptosis in PC3 and LNCaP prostate cancer cell lines, although with different potency In contrast, the anti-neoplastic effects of ionizing radiation in LNCaP cells did not involve apoptosis induction ... distinct potential of the drugs to interfere with Akt signaling We therefore next examined treatment-induced changes in the levels of phospho-serine 473 Akt (p-Akt) Phosphorylation at serine...
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Báo cáo khoa học: "Effects of radiation therapy on tissue and serum concentrations of tumour associated trypsin inhibitor and their prognostic significance in rectal cancer patients" doc
... s-creatinine, this could in part be explained by an impaired renal function in elderly patients, which is in line with previous findings demonstrating an association between increased s-TATI concentrations ... trypsin inhibitor (TATI) using the streptavidin-biotin system J Immunol Methods 1993, 161:97-106 Goldstein NS, Bosler D: An approach to interpreting immunohistochemical stains of adenocarcinoma in ... Tumourassociated trypsin inhibitor, carcinoembryonic antigen and acute-phase reactant proteins CRP and alpha1-antitrypsin in patients with gastrointestinal malignancies Clin Biochem 2004, 37:56-60...
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Báo cáo khoa học: " Distinct effects of rectum delineation methods in 3D-confromal vs. IMRT treatment planning of prostate cancer" pdf
... of the filling a precise delineation of the inner contour of the rectal wall was difficult for some patients resulting in asymmetric rectal wall thicknesses between anterior (within high-dose ... radiation doses in patients with localized prostate cancer: The combined experience of nine institutions in patients treated in 1994 and 1995 Int J Radiat Oncol Biol Phys 2005, 61(2):415-419 Schultheiss ... endpoints and different classifications of rectal toxicity in the literature Within this retrospective planning study it was demonstrated that the method of contouring the rectum significantly influenced...
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Báo cáo y học: " mRNA expression profiles show differential regulatory effects of microRNAs between estrogen receptor-positive and estrogen receptor-negative breast cancer" pdf
... higher RE-scores in ER- than in ER+ samples (c) Proportion of RE-changing miRNAs with higher inhibitory effect in ER- samples (red) and RE-changing miRNAs with lower inhibitory effect in ER- samples ... to be located in the fragile sites (regions with high frequencies of copy number alterations in cancers) of human chromosomes, indicating that many miRNAs may be linked to carcinogenesis [10] ... The numbers of miRNAs with ARR < and ARR > are listed in Table As shown, more miRNAs have ARR < in all datasets, indicating their stronger inhibitory effect in ER- breast cancer Although the ARR...
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báo cáo khoa học: " XAF1 expression and regulatory effects of somatostatin on XAF1 in prostate cancer cells" docx
... were maintained in RPMI-1640 medium supplemented with 10% foetal bovine serum (FBS) RWPE-1 cells were maintained in complete keratinocyte serum-free medium (K-SFM) containing 50 μg/ml bovine pituitary ... cell lines We found that somatostatin and Octreotide up-regulated XAF1 mRNA and protein expression in prostate cancer cell lines The enhanced XAF1 expression by somatostatin indicates a promising ... [23] In the current study, we examined XAF1 mRNA and protein expression in four cell lines, and determined regulatory effects of somatostatin and Octreotide on XAF1 expression in prostate cancer...
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báo cáo khoa học: "Enhancive effects of Lewis y antigen on CD44-mediated adhesion and spreading of human ovarian cancer cell line RMG-I" pps
... by 0.25% trypsin and cultured in DMEM medium containing 10% FBS to prepare singlecell suspension Cells were washed twice with cold PBS when growing in a single layer, and fixed with 4% paraformaldehyde ... competitively inhibit the binding of HA to CD44, and found that the invasion of colorectal cancer cells to basement membranes was decreased by 95% The above findings indicate that CD44 is involved in several ... ovarian carcinoma cells with high dissemination potential by repeated passage of the cells in vivo into nude mice, and involvement of Le(x)determinant in the dissemination potential Jpn J Cancer Res...
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báo cáo khoa học: " Potent cytotoxic effects of Calomeria amaranthoides on ovarian cancers" pps
... “naphthofuranone” by the National Cancer Institute (NCI) in their in vivo“ anti-tumor screening data, testing the drug against P388 Leukemia in CD2F1 mice, however, no final conclusive results were ... with Cisplatin were in poor condition and became wasted compared with the EPD treated mice Ovarian cancer has a poor prognosis With more than 60% of the patients presenting the disease in stage ... (Charles River Laboratories, France) In order to mimic advanced ovarian cancer the mice were injected intraperitoneally (i.p.) with 107 OVCAR3 cells (ATCC) into the abdominal cavity to form ascites Three...
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báo cáo khoa học: "Effects of ulinastatin and docetaxel on breast cancer invasion and expression of uPA, uPAR and ERK" docx
... outcome in clinic Ulinastatin can bind to tumor cells through its N-terminal Domain I and exert its inhibitory effect on proteolytic activity of plasmin by binding to tumor cells through its C-terminal ... Plasminogen binding and activation at the breast cancer cell surface: the integral role of urokinase activity Breast Cancer Res 2007, 9(1):R14 Nguyen DH, Hussaini IM, Gonias SL: Binding of urokinase-type ... level, suggesting that ulinastatin can inhibit uPA at genetic level and subsequently reducing the expression of uPAR ERK belongs to a class of serine/threonine protein kinases found in late 80s...
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báo cáo khoa học: " Effects of metastasis-associated in colon cancer 1 inhibition by small hairpin RNA on ovarian carcinoma OVCAR-3 cells" pot
... as 3, without positive cell scored as Cells without brown staining scored as 0, with mild brown staining scored as 1, with moderate brown staining scored as 2, with intense brown staining scored ... (Hematoxylin staining, × 100) biomarker for colon cancer, gastric carcinoma, lung cancer, and hepatocellular carcinoma [5-8] In this study, we detected high levels of MACC1 in ovarian cancer tissues ... metastasis-associated in colon cancer 1; MAPK: mitogen-activated protein kinase; MEK: mitogen-activated protein kinase kinase; Met: hepatocyte growth factor receptor; PI3K: phosphoinositide 3-kinase; RNAi: RNA interference;...
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báo cáo khoa học: " Effects of RNA interference-mediated gene silencing of JMJD2A on human breast cancer cell line MDA-MB-231 in vitro" pptx
... of the insert were removed by wiping with a cotton swab The cells that migrated to the bottom surface of the insert were fixed in 100% methanol for min, stained in Giemsa for min, rinsed in PBS ... migration and invasion of MDA-MB-231 cell line, thereby indicating that JMJD2A may be involved in the estrogen signaling pathway Though JMJD2A and 2B exhibited robust interactions with ER, in contrast ... well and incubated in RPMI 1640 medium (GIBCO, Invitrogen, USA) containing 10% FBS (GIBCO, Invitrogen, USA) RPMI 1640 medium containing 10% FBS was replaced by serum-free Opti-MEM (GIBCO, Invitrogen,...
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báo cáo khoa học: " Effects of DNMT1 silencing on malignant phenotype and methylated gene expression in cervical cancer cells" pdf
... (Shanghai, China) After transfection, the inhibition efficiency was examined using quantitative polymerase chain reaction (qPCR) Transfections were performed with Lipfectamine TM2000 according to the ... the protocol (Invitrogen Co.) Cells were harvested and rinsed twice in ice-cold PBS, and kept on ice for 30 in cell lysis buffer containing mM PMSF while agitating constantly, and insoluble cell ... genes in association with overexpression of DNA methyltransferase (DNMT1) during multistage carcinogenesis of the pancreas Carcinogenesis 2006, 27(6):1160-1168 Sowinska A, Jagodzinski PP: RNA interference-mediated...
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báo cáo khoa học: "The effects of β-glucan on human immune and cancer cells" pptx
... for cancer patients Future studies should aim to obtain such information so it can assist us in applying βglucans rationally and effectively to our cancer patients in the future Competing interests ... tumors in >60% of patients when it was combined with chemotherapy in a arms control study comparing with chemotherapy alone [73] The effects were less obvious with leukemia, stomach and brain cancer ... to an invading pathogen is essential for controlling infection Dectin-1, which is a type II transmembrane protein receptor that binds β-1,3 and β-1,6 glucans, can initiate and regulate the innate...
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báo cáo khoa học: " A case of limbic encephalitis presenting as a paraneoplastic manifestation of limited stage small cell lung cancer: a case report" ppsx
... associated with PLE are small cell lung cancer, testicular tumors, thymoma, Hodgkin’s lymphoma and breast cancer In an analysis of 50 patients with PLE, Gultekin and colleagues [4] found that lung cancer ... common findings are consistent with inflammatory changes (pleocytosis, increased protein, oligoclonal bands and increased immunoglobulin content) Anti-neuronal antibodies are frequently found in the ... complex in nature Moreover, hypothalamic involvement can manifest with hyperthermia, hyperphagia or pituitary hormonal deficits [2] Patients with PLE often present with symptoms of neurological involvement...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25