... physical performance tests, particularly for participants in the worst-performing quartiles Despite the importance of physical performance tests, other factors were independently associated with self- reported ... the study, designed the study, performed the statistical analysis, interpreted the results, and drafted the manuscript All authors read and approved the final manuscript Competing interests The ... literature on the use of self- reports to measure physical functioning, few studies to date have examined whether factors other than measured performance on the same task influence self- reports...
... locations in the text where, for reasons of classification, the authors have been forced to sidestep the historical record, and we beg the reader's indulgence for these instances While they produce ... voiced these complaints for decades These complaints not only resonate at the operational level, but they also have fundamental implicationsfor grand strategy Finally, the flip side of the argument ... feel they could afford to match the Warsaw Pact’s conventional forces (and they did not relish the prospect of another major conventional war in Europe in any case), so they depended on the threat...
... and Implicationsforthe U.S and reportedly forced the government to shut down some factories and reduce the level of official cars on the road.71 The Chinese government has sharply criticized foreign ... incentives for farmers, which enabled them to sell a portion of their crops on the free market In addition, the government established four special economic zones along the coast forthe purpose ... Challenges, and Implicationsforthe U.S China’s 12th Five-Year Plan80 China’s Five-Year Plans (FYPs) have been issued by the government since 1953 The FYP is the major vehicle forthe government...
... examines the importance to the U.S economy of China’s investment in U.S securities, as well as the policy implications of its holdings for both the United States and China.5 Forthe United States, the ... mattress The influence is mutual.” Who needs the other more varies with American and international financial conditions The more money the U.S borrows, the more the American economy needs the PRC The ... Securities: Implicationsforthe U.S Economy holdings of U.S assets The initial effect could be a sudden and large depreciation in the value of the dollar, as the supply of dollars on the foreign...
... suffering they represent in the aggregate before they can arouse the compassion necessary forthe public to demand governmental action The industrialized world bears a major responsibility for having ... the lack of information is simply the lack of any services in a large number of countries There are other reasons forthe difficulties encountered in collecting information forthe present Atlas: ... according to the functions of the workers and the priority conditions they are required to handle Under the Information/Data collection system An organized information gathering system for service...
... suffering they represent in the aggregate before they can arouse the compassion necessary forthe public to demand governmental action The industrialized world bears a major responsibility for having ... the lack of information is simply the lack of any services in a large number of countries There are other reasons forthe difficulties encountered in collecting information forthe present Atlas: ... according to the functions of the workers and the priority conditions they are required to handle Under the Information/Data collection system An organized information gathering system for service...
... standards for research quality and objectivity Alternative Futures and Army Force Planning Implicationsforthe Future Force Era Brian Nichiporuk Prepared forthe United States Army Approved for public ... that the Army will be able to meet the 2010 deadline Concepts forthe FCS, the centerpiece of the proposed Future Force, are still in an early stage Further discussion of signposts and their ... much of the research for this study was done during the Army After Next (AAN) period that preceded the current Transformation initiative, the methodology presented herein for assessing the future...
... the force based on the long war should weigh the effects they will have on longer-term planning horizons, and the enduring missions of the force In these terms, maintaining flexibility in the force ... strategy Implicationsforthe U.S Army We now describe some implicationsforthe Army arising from the trajectories Steady State In the “Steady State” trajectory, the role of the Army would be dominated ... In this trajectory, the United States faces a conventional foe, or other threat, that forces it to reduce its focus on the long war Theimplicationsforthe Army of this other threat are not...
... and therefore the FRET assay was used to study the effect of pH on the enzyme The stability of the synthetic SceD peptide substrate was determined by incubating it in different buffers in the ... classes [3] and, therefore, the chances that the bacterium would develop cross-resistance to these drugs are quite high However, in the search for novel classes of antibiotics for combating this ... observed for LepB of E coli [32] and pH units lower than the pKa of lysine in solution The reason forthe decreased pKa of the active-site lysine in the SPases is not known It is also unclear whether...
... b-sheet A to form a latent conformer [16] However, this is unlikely as the latent conformer of the serpins is unable to form polymers [17,18] Other characteristics of the latent conformer are a ... CD because the signal at 216 nm did not change during the course of the experiment, i.e after incubation of Ser52Arg neuroserpin at either 37 °C or 45 °C for 24 h Assessment of the conformation ... neuroserpin The most likely cause forthe inactivity of Ser52Arg neuroserpin and inaccessibility of the reactive loop is that the mutant had adopted an aberrant conformation One possibility is that the...
... demonstrates the importance of the P1 anchor for MHC II (I-Au, I-Ad, I-Ak) We speculate therefore that an extension of the MBP(74–85) epitope in the N-terminus could increase the binding and affinity for ... among the peptide antigens are indicated in red) The alignment of MBP(74–85) was performed based on the highest aligned score with the three antigens, on the basis of the amino-acid preference for ... conformations, with a predetermined geometry forthe critical residues, i.e the formation of an Arg78-Asp81 salt bridge in the case of the agonist, which makes it more solvent accessible than the...
... EH4ÆNAD(P)+ species In the case of a true oxidase, it makes sense forthe enzyme to stabilize the EH4 form, since the reduced flavin is reactive with O2 Other enzymes in the family, such as the NADH peroxidase ... to the conclusion that the enzyme is likely to be purified in the sulfenic acid form (Scheme 1) This result is not surprising, given that most of the enzyme is obtained in the apo form from the ... 2) The kcat app obtained in the presence of 100 lm NADH and FAD and 115 lm O2 is 8.2 s)1, which correlates well with the catalytic constant observed forthe CoADR reaction Thermostability and thermoactivity...
... blue) Also shown are the heme ligands (histidine and methionine in each case), the cysteines that form thioether bonds to the heme, and the methyl group of the alanine of the C fasciculata AXXCH ... phases from the final model of the halfreduced form, is contoured at the 1.5r level, where r represents the ˚ rms electron density forthe unit cell Contours more than 1.5 A from any of the displayed ... structure of the trypanosomatid cytochrome.) The stereochemistry of heme attachment through the thioether bond is conserved in C fasciculata cytochrome c (Figs and 4); it therefore remains the same...
... policy The leaders convened by AAHSA and the Fund deplored the absence of a synthesis of information and analysis pertinent to developing public and institutional policy forthe future They welcomed ... not available The average age of the informal caregiver is 60 The great majority of primary informal caregivers not hold paying jobs, either because they have retired or because they belonged ... forthe poor, is the major public program covering long-term care forthe elderly and for disabled people of all ages Despite the public’s tremendous interest in, and demand for, care in the...
... one subunit The diphosphate residue is bound to the PP domain of the other subunit at the same dimer together with the octahedral coordinated Mg2+ (Fig 5) The amino acid arrangement at the active ... 4) In going from the nonactivated form of ScPDC to the activated one, one dimer has to rotate by about 30° relative to the other For comparison, the corresponding angle found for (nonactivated) ... between the R and the PP domains The dimer reorientation leads to the generation of a closed and an open side in the tetramer Consequently, new interaction areas are formed at the closed side of the...
... [41-43] Given the dearth of evidence that the LAT or L/ST genes actually antagonize the synthesis of ICP0 and ICP34.5, further work will be required to address these hypotheses Clinical implications ... role for PML in the process by which host cells repress ICP0- viruses in vivo Therefore, it remains to be determined how ICP0 antagonizes Stat 1dependent repression of HSV-1 Implicationsforthe ... antigen synthesis before CD8+ T cells can destroy the host cell Given the arrangement of genes in the RL region (Fig 4), it is possible that the LAT and/or L/ST genes may serve to ensure the timely...
... forthe different tested variables in each of the [site x year] combinations of the study, for each stage and each provenance The coefficients of variation (CV), ie the ratio of the mean to the ... using the sine curve reconstitution of daily temperatures were slightly higher than those obtained with the simpler formula Tm (Tmin + Tmax)/2 The latter formula was therefore used forthe threshold ... replaced by ) the difference with the overall mean for all provenances The mean of these deviations was then calculated for each provenance (cf table VII) The earliness of the Tamjout provenance was...
... behaviour) The patients waiting in the acute wards used the services of the department to the same extent as the other patients, they were not "idly waiting" Some established a close therapeutic ... residency in the acute ward and the chosen secondary facility This cost was withdrawn from the cost of the acute ward stay for each patient The costs used in the calculations were taken from the hospital ... were smoother The burden on the families would also be increased by the uncertainty[17] These factors are not part of the calculations of the study, but would if entered have increased the imputed...
... shown for each protein forthe HLA antigens (from the top down): DRB1_0101; DRB1_0102; DRB_0301; and DRB1_0305 The patterns forthe remaining MHC II alleles follow the same general trends The black ... predicting order Forthe 19 LDRs presented in the figures, we have also determined the degree of disorder using the two DISEMBL™ and the DISOPRED disorder predictors For all the predictors, on ... therefore, would not be predicted to be epitopes For reasons of space we only show the results for four alleles and the four autoantigens whose PONDR® plot was displayed in Fig For example, for...
... expression The basal gene expression forthe collagen type I gene was significantly higher in the degenerate cells than in the normal NP cells (P = 0.05) There was no significant difference in the basal ... studied These studies investigated the protein expression of these receptors rather than gene expression and separated the groups according to age rather than Page of 10 (page number not for citation ... and threshold values The data were then exported into Excel (Microsoft Corporation, Redmond, WA, USA) for further analysis Data were analysed using the 2-ΔΔCt method using the housekeeping gene...