implications for the pathogenesis of systemic autoimmune disease
Báo cáo y học: "Most nuclear systemic autoantigens are extremely disordered proteins: implications for the etiology of systemic autoimmunity" pps
... spreading to other epitopes in the Sm particle This view of the battle between the virus and the immune system is further amplified by the results of the analysis of MHC II T cell epitopes using the ProPred ... nature of the T and B cells that participate in autoimmune disease Some of these predictions are characteristic of a wide range of models of autoimmunity and are, therefore, not terribly informative ... sequences in the B/B' polypeptide followed by spreading to the rest of the Sm particle To further explore the relevance of disorder to the idea of spreading we carried out a PONDR® analysis of the EBNA1...
- 15
- 413
- 0
Báo cáo y học: "Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration" ppt
... studied These studies investigated the protein expression of these receptors rather than gene expression and separated the groups according to age rather than Page of 10 (page number not for citation ... that the lack of TNF-R1 does not affect the incidence or severity of collagen-induced arthritis in the joints [27] Repeated injections of TNF-α into the joints of TNF-R1 knockout mice enhanced the ... the changes identified in the degeneration of the IVD, which include an upregulation in type I collagen protein in the NP region [20] The results of this study show that TNF-α downregulates the...
- 10
- 678
- 0
Báo cáo y học: " Bronchoalveoloar lavage fluid cytokines and chemokines as markers and predictors for the outcome of interstitial lung disease in systemic sclerosis patients" pps
... Further studies are needed to address this question Major limitations of the study are the fact that the majority of patients received immunosuppressive therapies at the time of BAL Therefore, ... [38] In another study, anti-CD3 therapy also diminished bleomycininduced fibrosis [39] Therefore, T-cell therapy could provide a useful target for further therapies Because most of the fibroblast ... & Therapy Vol 11 No Schmidt et al cytokines could play a role in the pathogenesis of SSc-ILD and as targets of future therapies [10] Introduction Systemic sclerosis (SSc) is an autoimmune disease...
- 11
- 584
- 0
Tài liệu Guidelines for the Management of Inflammatory Bowel Disease (IBD) in Children in the United Kingdom pdf
... controversy, the evidence based evaluation by the authors of the BSG guidelines for adults with IBD has been used together with the ECCO consensus document [4] Guidelines for the Management of Inflammatory ... at minimising the impact of disease At least 30% of patients require surgery in the first 10 years of disease and approximately 70–80% will have surgery in their lifetime 3.3 Other disease sites ... Guidelines for the Management of Inflammatory Bowel Disease (IBD) in Children in the United Kingdom Index Introduction Inflammatory Bowel Disease Management of Crohn’s Disease Management of Ulcerative...
- 36
- 664
- 0
Hydroxyurea for the Treatment of Sickle Cell Disease docx
... cell disease, there is clearly a need for further research on the barriers to the use of this drug These studies should aim to identify barriers at the level of the patient, at the level of the ... reviewer reconciled the results of the first two reviewers in the case of the randomized trials 29 For the other study designs, the results of the two reviewers were averaged The quality assessment ... Most of the therapies offered to patients with sickle cell disease are supportive and little to change the underlying pathophysiology of the disease These supportive measures include the use of...
- 298
- 1,113
- 0
Báo cáo khoa học: The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer’s disease pptx
... (COX) In these enzymes, the redox potential of the metals is harnessed to provide the enzymes with their electron transfer capabilities Paradoxically, it is the same redox potential of the metals ... Ab forms amyloid plaques As amyloid plaques are prominent in the postmortem AD brain, early research theories placed the accumulation of extracellular, insoluble forms of Ab as central to the disease ... that the interaction between Ab and these metals can promote the formation of Ab oligomers, aggregates and fibrils [48,52–55] Metal mediated oligomerization of Ab may therefore contribute to the...
- 9
- 634
- 0
Báo cáo hóa học: " ICP0 antagonizes Stat 1-dependent repression of herpes simplex virus: implications for the regulation of viral latency" potx
... 105 pfu per eye of HSV-1 strain KOS-GFP or GFP relationship of the genotype and phenotype of these mice is defined in Table c The mean ± standard error of the mean of the logarithm of infectious ... compromised the integrity of the tissue Thus, consistent with other results, the Stat signaling pathway was essential to restrict the spread of wild-type HSV-1 from the site of inoculation to the TG ... [41-43] Given the dearth of evidence that the LAT or L/ST genes actually antagonize the synthesis of ICP0 and ICP34.5, further work will be required to address these hypotheses Clinical implications...
- 23
- 413
- 0
báo cáo hóa học:" Association of measured physical performance and demographic and health characteristics with self-reported physical function: implications for the interpretation of self-reported limitations" pdf
... physical performance test batteries, which averaged measures of performance over several domains of functioning [14,15,18-20] One explanation for the weak correlations in these studies may be the problem ... physical functioning, before they had the physical examination and performance testing Analytic framework To maximize the specificity of the association between physical performance tests and self-reported ... meters and then dividing by the time in seconds needed to complete the test We categorized performance on both tests into quartiles, with the bestperforming quartile as the reference group The lock...
- 13
- 374
- 0
Báo cáo khoa học : Tissue Doppler imaging for the diagnosis of coronary artery disease ppt
... different there is deformation of the tissue in between In the case that the two locations are getting closer there is myocardial shortening, and when they move apart there is lengthening Strain ... and the velocities within a myocardial segment is the net result of motion caused by contractions in that segment, motion due to tethering to other segments, and overall motion of the heart The ... function Ultimately, for the clinician it is critical that the advantages of the new quantitative methodologies outweigh their disadvantages in terms of complexity and cost At the present time tissue...
- 9
- 467
- 0
Báo cáo y học: "Duration of bed occupancy as calculated at a random chosen day in an acute care ward. Implications for the use of scarce resources in psychiatric care" pps
... illness, whereas of 12 not waiting had a psychotic illness Duration of stay was composed of the days preceding the chosen day and the number of days of further treatment in the acute ward Twenty-three ... difference between cost of residency in the acute ward and the chosen secondary facility This cost was withdrawn from the cost of the acute ward stay for each patient The costs used in the calculations ... in training at the time of the study, was aware of the registration of time from the senior psychiatrists decision to the actual day of referral to the next step in the treatment chain, called...
- 6
- 505
- 0
Báo cáo y học: "Hypoxia in the pathogenesis of systemic sclerosis" ppt
... [74] These findings suggest that inhibition of TGF-β-dependent pathways may prevent the profibrotic effects of hypoxia Consistent with the results on TGF-β signalling, the expression of the fibrogenic ... be driven by HIF-1α-independent pathways, for instance HIF-2α and HIF-3α However, the role played by other members of the HIF family in the pathogenesis of SSc has not yet been investigated in ... However, what is the exact role played by hypoxia in the pathogenesis of SSc? Is it just the consequence of microangiopathy and fibrosis or does it contribute to the progression of SSc? DNA microarray...
- 9
- 439
- 0
Báo cáo y học: " Induction of multiple matrix metalloproteinases in human dermal and synovial fibroblasts by Staphylococcus aureus: implications in the pathogenesis of septic arthritis and other soft tissue infections" pdf
... Inhibition of its activity could therefore be anticipated to augment the risk of infection in patients with RA The reasons for the predominance of S aureus in SA and the mechanisms of pathogenecity ... involved in the induction of MMPs through activation protein (AP-1) transcription factors We therefore analyzed the mRNA expression levels of 12 members of the MAPK family using the MultiGene-12 ... down the possible candidates to molecular-weight groups of the range of >30 to 50 based on our experiments using Centricon filtration of the culture supernatants Because the molecular weight of the...
- 14
- 426
- 0
báo cáo khoa học: " Systems medicine and the integration of bioinformatic tools for the diagnosis of Alzheimer’s disease" doc
... encompass only informatics and statistics; for example, it includes the development of tools not only for storing and mining the data, but also modeling of the data in the context of disease pathophysiology ... beyond the pathways The genetics of late-onset AD is complex, although several of the common risk alleles other than APOE are involved in production, aggregation and removal of Aβ [33] Several of the ... for this disease A similar strategy could also be useful in the studies involving transgenic mouse models of AD [56] Conclusions The pathogenesis of AD is complex and there is a strong case for...
- 5
- 311
- 0
báo cáo khoa học: " Pollen development in Annona cherimola Mill. (Annonaceae). Implications for the evolution of aggregated pollen" pdf
... concomitantly with the layering of the exine [54] and the formation of the pollen aperture is related to endoplasmic reticulum blocking the deposition of primexine [3] The callose remnant at the pollen ... cherimola, the confined space that permits the delay in the dissolution of the PMC wall and the tapetal chamber and pollen rotation that allows the adhesion of the sticky proximal faces by the formation ... afternoon of the following day when the flower enters the male stage Anther dehiscence occurs concomitantly in all stamens of a flower and, as the anthers dehisce, they detach from the flower...
- 10
- 338
- 0
Báo cáo y học: "Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies" ppsx
... reactivated in 60% of the patients tested (25 out of 42 patients) [302] These results constitute a proof -of- concept for the co-administration of (at least) two different categories of therapeutically ... Nucleotide (nt1) is the start of U3 in the 5'LTR The transcription start site corresponds to the junction of U3 and R (C) Schematic representation of the nucleosomal organization of the HIV-1 genome ... elongation (B) Following the synthesis of the first molecules of Tat, this viral protein migrates to the nucleus Tat then binds to the RNA hairpin TAR, located in the 5' region of all nascent HIV-1...
- 29
- 322
- 0
Báo cáo y học: "Capacity utilization and the cost of primary care visits: Implications for the costs of scaling up health interventions" pdf
... Benjamin Nganda for their efforts in gathering cost data at the country level; and Tessa Tan Torres for her input in the development of the methods used The work represents the views of the authors ... validity of the results for extrapolation to a wider number of countries We also recognize that the mathematical specification of the model we report here, the log-log form, does not allow the identification ... atypical of the country as a whole Moreover, they will also be wrong if they not allow the cost of an outpatient visit to change as coverage increases Because most of the studies of the costs of scaling...
- 9
- 495
- 0
Báo cáo y học: " Mathematical model of blunt injury to the vascular wall via formation of rouleaux and changes in local hemodynamic and rheological factors. Implications for the mechanism of traumatic myocardial infarction" pot
... u2, the particle size a, the quantities and shapes of inclusions, and the physical properties of the phases (see equation 1) (The effects of the shape and multiplicity of particles, and of some ... on the concentration of erythrocytes The quantity of rouleaux depends on shear stress (the higher the shear stress, the lower the rouleaux content of the blood) and erythrocyte concentration (the ... of viscosity of the mixture, and an increase in shear stress results in a decrease of viscosity of the mixture The quantity of rouleaux depends on shear stress (the higher the shear stress, the...
- 10
- 345
- 0
Substance p regulates chemokine production in leukocytes implications in the pathogenesis of acute pancreatitis and associated lung injury
... locally or systemically, amplify the local as well as systemic inflammatory responses in acute pancreatitis The severity of the disease is therefore largely determined by the actions of these molecules ... 2004) For the importance of these kinases in regulation of inflammatory gene expression as demonstrated in various cellular systems, the role of MAPKs was investigated in the later part of the ... potentially life-threatening disease The severe form of the disease is associated with the development of SIRS and MODS, of which impaired lung function is frequently the earliest sign (Bhatia et...
- 209
- 302
- 0
Cultivated conjunctival epithelial transplantation for the treatment of ocular surface disease
... ocular surface diseases have limited success, as this serves to replace only the corneal epithelium The lack of the supportive function of the conjunctiva often contributes to the failure To ... subpopulation of epithelial cells of the ocular surface The limbus is a 1.5 to 2mm wide area that straddles the cornea and bulbar conjunctiva Corneal epithelial stem cells reside in the basal region of the ... Examination of these events in vivo is complicated by the multitude of epithelial and mesenchymal factors that contribute to the complex ocular environment Therefore cell culture is one of the best...
- 176
- 255
- 0
Báo cáo khoa học: NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and its antagonist Structural implications for the MHC II (I-Au)–peptide complex from docking calculations ppt
... studies of the epitope of MBP therefore we may conclude that the conformation of epitopes of the integral protein must be affected by posttranslational modifications Docking calculations of the MBP(74–85) ... was the case in water, the key characteristic of the structure of the native epitope in Me2SO is the presence of a large number of electrostatic interactions, especially in the central region of ... between the side chains of Arg78 and Glu82/Asp81 independently of the nature of the solvent (protic or nonprotic) This might come from the peptide conformation, which drives the orientation of these...
- 15
- 447
- 0
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008