immunologic mechanisms and tumor control
Báo cáo khoa học: "Quality of life and tumor control after short split-course chemoradiation for anal canal carcinoma" ppsx
... radiotherapy and concurrent chemotherapy with fluorouracil (5-FU) and Mitomycin C (MMC) Secondary endpoints were acute toxicity, local and regional tumor control, colostomy-free survival and overall ... local and the regional control according to the node-status was N0-75% and 88% and N(1-3)-85% and 93% respectively Among the eleven patients who had a local relapse, had isolated local relapse and ... with a T4 tumor received a boost of external beam radiation of Gy and 10 Gy directed to the primary tumor with another concurrent cycle of 5-FU and MMC for persistent disease Ninety-five and 89%...
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hemotherapy induces intra tumoral expression of chemokines in cutaneous melanoma, favoring t cell infiltration and tumor control
... Chemokines and T cell trafficking in mouse and human cutaneous melanoma 160 4.2.1 Intra-tumoral T cell trafficking and tumor control in vivo 162 VI 4.2.2 4.2.3 4.3 Chemokines and T cell ... 1.2.1 1.2.2 T cells and tumor immunosurveillance 14 1.2.3 Pathways of T cell-mediated killing of tumors 16 1.2.4 1.3 Natural killer cells and tumor immunosurveillance Mechanisms of T cell ... the local tumor microenvironment We found that CXCR3 ligands (CXCL9 and CXCL10) and CCL5 synergize to attract T cells to cutaneous melanoma, and expression of these chemokines inhibits tumor growth...
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Progress in Controlled Radical Polymerization: Mechanisms and Techniques pot
... sacrificing the polymerization rate Controlled tacticity, sequence control and preparation of materials with complex macromolecular architecture Mechanistic understanding and comprehensive structure-reactivity ... enhance control of polymer tacticity and sequence distribution (33–35) One could also prepare dimeric or trimeric species and incorporate In Progress in Controlled Radical Polymerization: Mechanisms ... variety of (co)polymers with controlled MW, MWD, topology, composition and functionality However, a In Progress in Controlled Radical Polymerization: Mechanisms and Techniques; Matyjaszewski,...
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cell cycle control mechanisms and protocols methods in molecular biology - tim humphrey, gavin brooks
... and Fission Yeasts Cell Cycle Molecules and Mechanisms of the Budding and Fission Yeasts Tim Humphrey and Amanda Pearce Summary The cell cycles of the budding yeast Saccharomyces cerevisiae and ... Tetzlaff, M., and Elledge, S J (1999) 155 Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms Science 286, 1166–1171 156 Cohen-Fix, O and Koshland, D (1997) ... fission and budding yeasts, the cell cycle is controlled both at the G1/S transition and the G2/M transition by a single highly conserved CDK, encoded by the CDC28 and cdc2+ genes of S cerevisiae and...
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Báo cáo khoa học: " Ipsilateral irradiation for well lateralized carcinomas of the oral cavity and oropharynx: results on tumor control and xerostomia" pot
... clinical examination, by both the head and neck surgeon and the radiation oncologist, endoscopy and CT scan of the head and neck region A chest X-ray or chest CT and blood test were performed to rule ... years, and once yearly until 10 years Radiation oncologists and head and neck surgeons performed a clinical examination A head and neck CT or MRI, examination under general anesthesia and/ or ... contralateral parotid and part of the contralateral submandibular gland Certainly, the salivary function can be further preserved using ipsilateral IMRT because the major salivary glands and some part...
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Báo cáo khoa học: " Local tumor control and toxicity in HIV-associated anal carcinoma treated with radiotherapy in the era of antiretroviral therapy" pps
... colostomy-free rate was 87 % and above 90 %, respectively [6] Since our study included 80 % T1/2 and 90 % nodal negative tumors in HIV-seropositive patients, local tumor control rate and colostomy-free ... prevalence of HIV-infection and HPV-infection [1-4] Standard therapy for invasive anal cancer is radiotherapy (RT) or chemo-radiation resulting in local tumor control (LC) rates and disease-free survival ... (Figure and 2) The 1-year OS in the matched HIV-seropositive and -seronegative cohort was 90 % and 100 %, and the 5year OS was 70 % and 69 %, respectively The cause of death in young non-HIV individuals...
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Báo cáo y học: "Mechanisms of quadriceps muscle weakness in knee joint osteoarthritis: the effects of prolonged vibration on torque and muscle activation in osteoarthritic and healthy control subjects" pps
... in the conception and design of the study, collection, analysis and interpretation of the data and the drafting and revision of the manuscript PM was involved in the conception and design of the ... study, analysis and interpretation of the data and in the revision of the manuscript GL was involved in the conception and design of the study, collection and interpretation of the data and in the ... (p = 0.005) Data are means and standard deviations Figure Percentage change in quadriceps and hamstrings peak torque (Nm) following vibration in the osteoarthritis and control groups * = significant...
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Mechanisms and Mechanical Devices Sourcebook - Chapter 3
... APPLICATIONS Viscous liquid adhesives are used to glue fabrics and paper, apply paper labels, make cardboard and wooden boxes and shoes, and bind books Specially designed machines are required if ... 56 CUTTING MECHANISMS By pressing down on the foot pedal of this mechanism, the top knife and the clamp will be moved downward However, when the clamp presses on the material, both it and link ... would bend and jam Avoid these designs, if possible—Especially if automatic assembly methods will be employed A rotary screw-feed handles screws, headed pings, shouldered shafts, and similar...
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Mechanisms and Mechanical Devices Sourcebook - Chapter 4
... 4, and T3/T4 = L3/L4 = 2/3, where T3 and T4 are the numbers of teeth on gears and T1 and T2 will denote the numbers of teeth on gears and 98 and S = ∆θ 3/θ30 Hence θ30(1 + S)L3 = 360º For S = and ... = r4 and r2 = r3, there is no “differential motion” and the output remains stationary Thus if one gear pair, say and 4, is made partly circular and partly noncircular, then where r2 = r3 and r1 ... intermittent mechanisms based on timing belts, pulleys, and linkages (see drawing) instead of the usual genevas or cams is capable of cyclic start -and- stop motions with smooth acceleration and deceleration...
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Mechanisms and Mechanical Devices Sourcebook - Chapter 5
... Dynamic and static balancing is simplified when an expanding wheel is attached to a nonexpanding main wheel As a pulley, an expanding wheel can have a steel band fastened to only one section and ... 11:45 AM Page 134 TWELVE EXPANDING AND CONTRACTING DEVICES Parallel bars, telescoping slides, and other devices that can spark answers to many design problems Figs and Expanding grilles are often ... steel band, or rope around the drum is fastened to the driving and driven members; sprocket-wheels and chain can replace the drum and belt GEARS Fig Matching gear-segments Fig 10 Racks and coupled...
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Mechanisms and Mechanical Devices Sourcebook - Chapter 6
... and longer life 178 Sclater Chapter 5/3/01 12:24 PM Page 179 OVERRIDING SPRING MECHANISMS FOR LOW-TORQUE DRIVES Overriding spring mechanisms are widely used in the design of instruments and controls ... radial and axial stiffness with a relatively low and controlled angular stiffness Considerable attention was given to solving the practical problems of mounting the pivot in a precise and controlled ... Bearing adjustment This screw arrangement is a handy way for providing bearing adjustment and overload protection Rapid and slow feed With left- and right-hand threads, slide motion with the nut locked...
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Mechanisms and Mechanical Devices Sourcebook - Chapter 7
... 204 Fig Mechanisms for generating (A) modified cycloidal curves, and (B) basic cycloidal curves true cycloidal This is done by a second steel-band arrangement As carriage I moves, bands and cause ... equations of motion Fig A standard differential winch consists of two drums, D1 and D , and a cable or chain which is anchored on both ends and wound clockwise around one drum and counterclockwise around ... power amplifier controls pump displacement, while its input is controlled by hand In a more recent development requiring remote manual control, a servomotor replaces this local handwheel Approximately...
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Mechanisms and Mechanical Devices Sourcebook - Chapter 8
... power losses in the gears and bearings and from windage and churning of lubricant gear power: A gear’s load and speed capacity, determined by gear dimensions and type Helical and helical-type gears ... motor comparable in size and power to those used in standard reel-to-reel recorders, and a large bi-peripheral flywheel and sturdy capstan that reduces wow and flutter and drives the tape A patent ... rollers, and are in contact with driving and driven disks Belleville springs provide the loading force between the balls and the disks The position of the balls controls the ratio of contact radii, and...
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Mechanisms and Mechanical Devices Sourcebook - Chapter 9
... the control cam To engage the clutch, the control cam is raised and the Fig Pawl and Ratchet Clutch: (External Control) The driving ratchet of this clutch is keyed to the driving shaft, and the ... requirements of MIL-E-5400, class and MILK-3926 specifications Applications were seen in counter and reset switches and controls for machines and machine tools, radar systems, and precision potentiometers ... faster Edges of the clutch bands carry the entire load, and there is also a compound action of one band upon another As the torque builds up, each band pushes down on the band beneath it, so each...
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Mechanisms and Mechanical Devices Sourcebook - Chapter 10
... combined with two separate controllers and actuators The first controls the in-feed speed and tension of the paper stock, and the second controls the wind-up The in-feed is controlled by maintaining ... 1:07 PM Page 350 Speed and Tension Control (continued ) Fig Floating rolls are direct indicators of speed and tension in the paper web Controlleractuators adjust feed and windup rolls to maintain ... exists, control action is continued in the same direction Thus, the control process is a step-by-step response to make the correction and to stop the operation of the controller The proportioning controller...
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Mechanisms and Mechanical Devices Sourcebook - Chapter 11
... completely encased and cannot expand beyond its original diameter The standard pump is made of bronze and will handle volumes to 15 gpm The Squeegee develops a vacuum of 25 in of mercury and will work ... single-gland type Automatic wear control compensates for normal wear and maintains volumetric efficiency This pump will handle to 300 gph without churning or foaming It needs no lubrication and operates ... given speed The pump is reversible and can be driven by a gasoline engine or electric motor The rubber cushions withstand the action of oil, kerosene, and gasoline, and the pump operates at any angle...
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Mechanisms and Mechanical Devices Sourcebook - Chapter 13
... opposite sense to ψ14, ψ13 and ψ12 This establishes points A′2, A′3 and A′4, but here A′3 and A′4 coincide because of symmetry of A3 and A4 about A0B0 Draw lines A1A′2 and A1A′4, and the perpendicular ... snap-action Over-centering toggle mechanisms, as shown in Fig 1, are widely used in mechanical and electrical switches, latch mechanisms and mechanical overload controls These toggles also serve ... way For example, in Fig two angular motions, φ12 and φ13, must be synchronized with two others, ψ12 and ψ13, about the given pivot points A0 and B0 and the given crank length A0A This means that...
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Mechanisms and Mechanical Devices Sourcebook - Chapter 14
... elements and icons, and 2D drafting and detailing capability, which support design collaboration and compatibility among CAD, CAM, and computer-aided engineering (CAE) applications Designers and engineers ... permit lettering, callouts, and the entry of notes and parts lists, and some even offer the capability for calculating such physical properties as volume, weight, and center of gravity if the ... datums, and section lines • Automated geometric dimensioning and tolerancing (GD&T) • Symbol creation, including those for weld and surface finish, with real-time edit or move capability and leaders...
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Mechanisms and Mechanical Devices Sourcebook - Chapter 15
... revised and edited the Second Edition of Mechanisms and Mechanical Devices Sourcebook after the death of Mr Chironis The late Nicholas P Chironis developed the concept for Mechanisms and Mechanical ... Motion Technologies Group, Radford, VA Ledex Actuation Products, TRW Control Systems, Vandalia OH Sandia National Laboratories, Sandia Corporation, Albuquerque, NM SolidWorks Corporation, Concord, ... and newspapers on various topics in engineering and industrial marketing Mr Sclater holds degrees from Brown University and Northeastern University, and he has completed graduate courses in industrial...
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Mechanisms and Mechanical Devices Sourcebook - Chapter 12
... left-handed threads, • An eye on a shank with external righthanded threads, and • A flanged collar with left-handed external threads to mate with the shank of the firstmentioned eye, and right-handed ... connectors In step 5, the handle is pushed upward an additional 15º, locking the handle cam and the slide In step 6, the handle is rotated an additional 30º, forcing the box and the mating spring-loaded ... the handle and retention cams as the box is moved rearward and downward 409 Sclater Chapter 12 5/3/01 1:24 PM Page 410 Perpendicular-Force Latch (continued ) dle has been installed on the handle...
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