... the binding affinity ofthe kinase or its catalytic activity at another site, so that the phosphorylation kinetics of one residue can depend on the phosphorylation state of other residues in the ... Because the physical properties ofthe target protein will generally change with the number of phosphorylated residues, the kinetic parameters can depend on the target’s phosphorylation state The ... the shape ofthe response curve is strongly affected by the two groups ofparameters that determine the protein–protein interactions: the concentrations ofthe enzymes relative to the target protein,...
... problem of finding theorder best supported by the evidence can be stated as a general shortest path problem: to find the preferred order for {a, b}, find the sum ofthe weights ofthe pairs in the ... either ofthe methods gives the right answer for about 89% ofthe test data, one ofthe two is right 95.00% ofthe time This indicates that a method which combined the information used by the ... 1% ofthe pairs in the corpus are in the ‘wrong’ order For an even larger percentage of pairs either order is acceptable, so an evaluation procedure which assumes that the observed order is the...
... reservations: the topos ofthe basic incomprehensibility ofthe camps and the notion of singularity, the incomparability of that welter of ENTRY crimes subsumed under the name of Auschwitz Both theses ... symmetry of absolute violence: the ability of each to kill the other In the state of nature, the power of one person to kill ends where the power ofthe next begins Even slaves can reverse the violence ... all the prisoners perished within the course of a year, new transports assured the preservation ofthe power system ofthe camp Their ranks were replenished The leading figure in the cast of mass...
... graph of girth at least g having the least number of vertices Then the girth of G is g and the diameter of G is at most g A proof of this theorem can be found in [14, pp 66, 384, 385], see also the ... roughly the 3/2 power ofthe indicated lower bounds the electronic journal of combinatorics (no 2) (1997) , #R13 Preliminary Results and Proof of Theorem A The possibility of improving the upper ... and the proof of this fact is not simple The upper bound on the girth of graphs CD(n, q), together with the statement in Theorem 2.1 regarding diameter of cages, implies that for every k ≥ there...
... colored i The degree of all the vertices of Aj ∪ Bj in this subgraph is d − 1, the degrees of all the vertices of Ai are at least (k − (r + 1)(d − 1))/(r − 1) and the degrees of all vertices of Ai ... large, the electronic journal of combinatorics 10 (2003), #R32 Kn contains two edge disjoint copies of H where in the second copy, the vertex playing the role of vjd+1 plays the role ofthe vertex ... any d-subgraph of H may only contain the vertices {v1 , , vd2 −d+1 } Thus, theorderof any d-subgraph of H is at most d2 − d + The crucial point to observe is that the vertices of excess degree,...
... tried to spare her the worst of it For the rest ofthe week, Hermione went running with them in the mornings and worked with Harry in the garden the rest ofthe day After the second day, Dudley ... to be the source for all ofthe weeds in the garden Then he looked up and goggled at the sight of Hermione She was wearing the bikini She spread a towel on a patch of grass and sat on it, then ... tore the paper off their packages Inside were brand new, shining Nimbus 2001 brooms Ginny exclaimed over hers The top ofthe line is the Nimbus 3000 now And the Firebolt, of course But these...
... were taken at the desired sampling times The pH ofthe samples and the temperature ofthe solution inside the photoreactor were continuously monitored The adjustment ofthe pH ofthe solution ... Effect of pH The results ofthe degradation of PCBs at different pH values are shown in Figs and Even when the initial pH ofthe solution was adjusted to 10, a drastic decrease in the pH ofthe ... important in the economics ofthe process and may influence the amount of hydrogen peroxide to be used in the process Based from the results of this phase ofthe experiment, the optimum H2O2 is 24.71...
... validation ofthe sequence numbers of reset packets Validating the TTL value in the reset packet to ensure that it is similar to the TTL value seen for the rest ofthe connection would improve the chances ... equally loaded at the moment they issued the resets Unfortunately, we found that the experiment engendered so much packet loss (not all ofthe resets were returned for all ofthe connections) ... when the resets beat the GET packet to the destination and so they were ignored by the careful validation that was applied Nevertheless, the connection was successfully torn down as soon as the...
... advantage of p53 mutation analysis, and a unique feature of this database, is the availability ofthe residual activity ofthe majority of p53 missense mutants The biological activity of mutant ... the cross indicates the cut-off value used in PREDMUT The limit between the classes was set to the activity value of 25%, because this value was observed to be a natural divider ofthe data The ... favour of a severe mutant At the other end ofthe spectrum, where we have low energy, there is 75% probability for the mutation to be nonsevere if the energy is 0.125 or lower Thus, on the basis of...
... the final evaluation ofthe kinetic parameters in the presence of stearate Evaluation of kinetic parameters Fig Comparison of three models for the catalytic action of plasmin in the presence of ... decrease of plasmin activity in the course ofthe assay in the presence of stearate (Table 1) The good fit of Model III progress curves to the experimental data supports the concept that in the presence ... abbreviation ofthe respective fatty acid name indicate its concentration (in lM) The ‘0 ’ indicates the set ofparameters in the absence of fatty acids Shaded ellipses combine parameters belonging to the...
... ofthe saints ofthe Most High, is made to lie at the basis ofthe action ofthe last Synod! History and Ecclesiastical Relations ofthe Churches ofthe Presbyterial Order at Amoy, China 17 The ... Surely it is not the spirit ofthe world, neither is it the spirit ofthe devil Try the experiment, then, and see whether the wonders of God's grace will alienate the hearts of his people Your ... according to the new plan, the Missionaries form themselves into the kind of Classis now required of them; what will be the relation ofthe Classis of Amoy to the Board of Foreign Missions? Is the Classis,...
... Adoption oftheorderof business Adoption ofthe minutes ofthe meeting ofthe Standing Committee (17 November 2006, San Marino) f g Progress report ofthe Bureau ofthe Assembly and the Standing ... EPP/CD)) a b c d e Examination of credentials (Doc 11124) Election ofthe President ofthe Assembly Election ofthe Vice-Presidents ofthe Assembly Appointment of members of committees (Commissions ... Patriarch BARTHOLOMEW I p.m End ofthe sitting p.m Committees p.m Communication from Mr Terry DAVIS, Secretary General ofthe Council of Europe, on the state ofthe Council of Europe Questions Sexual...
... from the intensity ratios of internal standards in the test and reference samples The presence ofthe internal standard probes at different locations ofthe array allowed quantification ofthe ... the expression level ofthe RNAi pathway components in each cell type and ⁄ or by different transfection efficiencies These hypotheses highlight the importance ofthe cellular environment in the ... ofthe array homogeneity, which is taken into account in the normalization Furthermore, in order to consider the purity and quality ofthe mRNA, a second normalization step was performed on the...
... over 30 The excess of ATP ensured that none ofthe reactions were rate-limited by ATP concentration The levels of incorporation of 32P into the peptide were used to calculate the kinetics of phosphorylation ... structure The two groups of peaks at 6.85 and 7.15 p.p.m correspond to the aromatic resonances ofthe seven tyrosines in the protein, and the inset 2D expansion ofthe 1H-1H COSY shows that the seven ... perform the phosphorylations, in the absence of any other influencing factors To determine whether theorder observed in vivo is solely due to the differential phosphorylation kinetics of Lck for the...
... increases with the number of affected members, the closeness ofthe relationship to the patient, and earlier age of onset.10,11 Medical information that patients provide about their relatives often is ... by sharp dissection in the plane between the fascia propria ofthe rectum and the presacral fascia Radial clearance of mesorectal tissue enables the en bloc removal ofthe primary rectal cancer ... occupy
... estimate for the second -order rate constant of ka ¼ 104 m)1Æs)1 for the binding of MgATP to p38 MAPKa gives a rate constant for the dissociation of MgATP from the enzyme of k-a ¼ 3.5 s)1, if the dissociation ... to the nucleophilic addition of a water molecule to the c-phosphoryl group of MgATP (kp), and the formation of MgADP and inorganic phosphate (Pi) These products then dissociate (kdiss) from the ... MAPK isoforms, how these interactions are regulated, how they interplay with catalysis, how they may be exploited therapeutically or how they differ within the family There is currently a lot of...
... confirms the XRD results The reason ofthe small height ofthe peak seems to be that the IZO thin film was as thin as mm, whereas the thickness ofthe wafer was as large as 450 mm The change of surface ... than the change of n values The differences of n values in UV or IR range may be due to the variation of dielectric functions ofthe films depending upon the deposition parametersThe change of ... shows the change of XRD pattern in the range of 2us10–808 as the substrate temperature increased The IZO films deposited at temperatures below 350 8C were amorphous, whereas the XRD profile of the...