ifn titrations and pharmacokinetics
advances in cancer research
... the effects of human natural IFN- /3 on the synthesis of prostaglandins in IFN- sensitive and IFN- resistant cells They found that IFN stimulated prostaglandin synthesis and that this enhanced synthesis ... of breast cancer (Rolland et al., 1980).Hydrocortisone and dexamethasone, inhibitors of prostaglandin E synthesis, decreased the induction of both prostaglandin and IFN in IFN- pretreated cells, ... IFN- y receptors are different from the receptors of the other IFNs (Branca and Baglioni, 1981; Aguet et aZ., 1982) Consequently, the designations “Type I” for the IFN- a and IFN- /3 receptors and...
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Báo cáo khoa học: Arthropod nuclear receptors and their role in molting pptx
... a-helices (H1 and H3–H12) and two short b-strands, which make a three-layered helical sandwich This crystal structure contains three binding pockets with significantly lower ligand occupancy, ... Two helices (H1 and H3) comprise an outer layer and are less coplanar in USP than in RXRa Three helices (H7, H10 and H11) form part of the outer layer, and four helices (H4, H5, H8 and H9) form ... BtEcR and TmEcR were similar, as anticipated by their sequence similarity In the PonA-bound HvEcR-LBD complex, the LBD is composed of 12 helices and three small b-strands, and possesses a long and...
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Báo cáo khoa học: Cloning of a rat gene encoding the histo-blood group A enzyme Tissue expression of the gene and of the A and B antigens potx
... tongue, the oesophagus, the parotid gland, the uterus, the seminal vesicle, the thyroid and parathyroid glands and the Fig Immunohistochemical analysis of the A and B antigens expression in BDIX ... urinary bladder, the uterus and the thymus A weaker signal was obtained from the pancreas and very weak, barely detectable, signals were visible from a salivary gland, muscle and spleen The presence ... Large intestine Pancreas Parotid gland Submaxillary gland Liver Trachea Lung Kidney Urinary bladder Ovary Uterus Testis Seminal vesicle Thyroid gland Parathyroid gland Brain Muscle Skin Spleen Thymus...
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nuclear envelope dynamics in embryos and somatic cells
... editors and publishers believe that drug selection and dosage and the specifications and usage of equipment and devices, as set forth in this book, are in accord with current recommendations and ... www.landesbioscience.com Landes tracking number: 1-58706-150-3 Nuclear Envelope Dynamics in Embryos and Somatic Cells edited by Philippe Collas/CRC, 184 pp x 9/ Landes/Kluwer dual imprint/ Landes series: ... DYNAMICS IN EMBRYOS AND SOMATIC CELLS Molecular Biology Intelligence Unit 23 Landes Bioscience / Eurekah.com and Kluwer Academic / Plenum Publishers Copyright ©2002 Eurekah.com and Kluwer Academic/Plenum...
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báo cáo hóa học: " All-trans retinoic acid induces COX-2 and prostaglandin E2 synthesis in SH-SY5Y human neuroblastoma cells: involvement of retinoic acid receptors and extracellular-regulated kinase 1/2" potx
... development of several tissues and organs [4], including the brain and the spinal cord [3,5] Retinoids are also present in the brain and spinal cord of adult rats and mice [6,7] and are involved in functions ... the study and performed the statistical analysis FJLC conceived of the study, and participated in its design and coordination and helped to draft the manuscript All authors have read and approved ... (SAF200506242-C03-01 and 03) Alique is a fellow of the Spanish Ministry of Education and Science We thank Dr H Kagechika (Tokyo Medical and Dental University, Tokyo, Japan) for LE540 and HX531 and Dr H Inoue...
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Báo cáo hóa học: " Trichloroethylene exposure and somatic mutations of the VHL gene in patients with Renal Cell Carcinoma" potx
... no competing interests Authors' contributions BC and CB studied published data and conceived the study SG, DC, SF and SR performed the pathology and DNA analysis JF performed the exposure assessment ... previously published and contributed to the conception of the present study BC performed the statistical analyses and wrote the final version of the paper with SG and SR All authors read and approved ... to TCE and among those who had not, respectively 13% and 18% In summary we conclude that this study has not confirmed the association between the number and type of VHL gene mutations and exposure...
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Báo cáo hóa học: " Expression of HIV receptors, alternate receptors and co-receptors on tonsillar epithelium: implications for HIV binding and primary oral infection" doc
... damage and repair in ex vivo tonsil organ culture and HIV infection of tonsil cells Epithelial damage and repair in ex vivo tonsil organ culture and HIV infection of tonsil cells Small randomly ... HIV virions and exposed mucosal surfaces and that both the properties of the inoculum (cell free HIV virions and/ or cell associated infectivity in the form of HIV-infected cells) and the characteristics ... surface macromolecules and migrating cells implicated in HIV binding and uptake Schematic representation of cell surface macromolecules and migrating cells implicated in HIV binding and uptake The inset...
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Báo cáo y học: " Eph Receptors and Ephrin Signaling" pps
... which can bind to ephrinA and ephrinB ligands, and ephrinA5 which can 264 also bind to EphB2 [2, 3] Figure Domain structure of Eph receptors and ephrinA and ephrinB ligands Eph receptors have ... EphB and Eph A receptors and ligands have been implicated in synaptic plasticity, and play a role in repair of the nervous system following injury [30-32] Cancer Eph receptor and ephrin ligand ... EphA receptors and ephrinA ligands can regulate glucose homeostasis and insulin secretion [54, 55] EphA recep- 266 tors and ephrin ligands are expressed by β cells in the pancreas, and forward signaling...
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Báo cáo y học: "Phobic memory and somatic vulnerabilities in anorexia nervosa: a necessary unity" ppsx
... cognitive and somatic manifestations of AN "Laparophobia" and K+ channels Young women with AN are recognized for commonly manifesting greater levels of general inhibition, loneliness, and social ... learning and the strength of associations will be determined by the intrinsic morphology and kinetics as http://www.annals-general-psychiatry.com/content/4/1/15 well as the density and distribution ... age-dependent decline in learning and memory and synaptic plasticity In the hippocampus, SK3 was found predominantly in the terminal field of the mossy fibers and in fine varicose fibers, thereby...
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Báo cáo y học: "The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus" potx
... germinal centre (GC) A and GC B, and B-cell clusters C and D were derived Groups of sequences were deemed to be clonally related when they used the same V, D, J and CDR3, and differed only by base ... be seen in Fig 1, and has two distinct areas of staining for FDC and one large area of B cells encompassing both FDC regions Very few T cells could be seen within GC A and B, and no plasma cells ... spleen by staining with anti-CD20 and anti-FDC, respectively Two GCs (GC A and GC B) were excised and the rearranged VH genes amplified (as described under Materials and methods) Both GCs were located...
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Báo cáo khoa học: "Probing the link between oestrogen receptors and oesophageal cancer" ppt
... growth factors, cytokines and enzymes and has been linked with hormone-independent growth, loss of cell-cell adhesion and angiogenesis Proliferation and apoptosis The mitogenic and growth-promoting ... principally via ERa and ERb first cloned from rat prostate [32] This discovery led to a reappraisal and new perspective on the significance of the ER in health and disease The ERa and ERb, isoforms ... underlying ER and E2 interactions in oesophageal cancer are based on studies of other cancers in which ERs have been implicated and are briefly discussed below: Differential ERa and ERb expression and...
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Báo cáo y học: "Toll-like receptors and innate immune responses in systemic lupus" docx
... of type I IFNs [32,33] They harbor both TLR7 and TLR9 receptors and are exquisitely sensitive to RNA and DNA stimulation Conventional DCs (cDCs) express and respond to TLR stimuli and might promote ... immunogens and adjuvants Innate immune sensors The nucleic acid binding TLRs appear to play pivotal roles in SLE TLR7 and TLR8 bind to single-stranded RNA, TLR3 to double-stranded RNA, and TLR to ... Type I IFNs stimulate monocyte maturation into DCs, plasma cell maturation and immunoglobulin class switching, cytotoxic T and natural killer cell activity, and chemokine secretion Type I IFNs...
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Báo cáo y học: "Myeloid dendritic cells display downregulation of C-type lectin receptors and aberrant lectin uptake in systemic lupus erythematosus" pdf
... contributions SUM, KR and ST performed all experiments and analyzed the data SUM drafted the manuscript MJK conceived and designed the study and helped to draft the manuscript All authors read and approved ... thank Emily Lewis B.Sc and Jennifer Johnson B.Sc for obtaining patient blood samples; Taejah Vemuri, Marc Anderson and Amanda Bradke B.Sc for help with blood processing and cell culture; Emily ... abnormal phenotype and function of this CTLR are not secondary to a drug factor or DC maturation status IFN downregulates transcription and surface expression of the MR, and elevated levels...
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Báo cáo y học: "NOD-like receptors and inflammation" pot
... and colleagues [129] reporting similar responses to TLR ligands in wildtype and NOD2-/- cells, and indeed an increase in IL-6 in wild-type NOD2 cells on stimulation with Pam3CSK4, a TLR2 ligand ... 1), and NALP1 (NACHT, leucine rich repeat and PYD [pyrin domain] containing 1) termed NLRP1 (NLR family, pyrin domain containing 1), and so on.We again refer to the historic terminology of NOD and ... domain and a carboxyl-terminal LRR, and activation of this complex induces the combined activation of the TLR and NLR pathways The extracellular portion of flagellin is detected by TLR5, and the...
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Báo cáo y học: "Toll-like receptors and NOD-like receptors in rheumatic diseases" pdf
... transformed the understanding and management of these disorders and has implications for future therapies in rheumatic diseases Important links and synergies are evident between TLRs and NLRs TLRs are ... John Wiley and Sons cells) as well as TLR ligands of microbial origin Similar to the microbial TLR ligands, endogenous TLR ligands have been found in the joints or serum of RA patients and their ... of TLR2, and culture in the presence of TLR1/2 or TLR2/6 ligands but not TLR3 ligands results in elevated levels of matrix metalloproteinases and significantly increased collagenolysis and aggrecanolysis...
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Báo cáo y học: "Type I interferon receptor controls B-cell expression of nucleic acid-sensing Toll-like receptors and autoantibody production in a murine model of lupus" doc
... including RNPs and nucleosomes All subtypes of IFN- I bind to the IFN- I receptor (IFNAR), which is composed of two chains: IFNAR1 and IFNAR2 The IFNAR2 chain exists in both transmembrane and soluble ... with IFN- α and this upregulation was also completely dependent on IFNAR2 (Figure 4b) IFNAR2 is therefore required for the induction of TLR7 and TLR9 expression in B cells in response to IFN- α and ... receptors TLR7 and TLR9 in IFNAR2-/- mice Activationof Toll-like receptors TLR7 and TLR9 in IFNAR2-/- mice (a) B cells were purified from pristane-treated wild-type (WT) or IFNAR2-/- mice, and proliferation...
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Báo cáo y học: " Bench-to-bedside review: Toll-like receptors and their role in septic shock" pps
... (18W), Mst and STSDm2245 Toll and 18W share the greatest similarity to each other and also to the cytoplasmic tail of the mammalian IL-1R1 The Drosophila 18W is required for morphogenesis and has ... these human TLRs, the microbial ligands for TLR2, TLR4, TLR9 and, most recently, for TLR5, and perhaps TLR3, have been identified (see following sections) Understanding the regulation of TLR expression ... TLR2 and TLR4 have so far been the most intensively studied members of mammalian homologs to Drosophila Toll Currently recognized ligands for TLR4 are presented in Table 2, and the known ligands...
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Báo cáo y học: "A3 adenosine receptors and mitogen-activated protein kinases in lung injury following in vivo reperfusion" pps
... Assessment of injury and apoptosis For light microscopy, samples of lung tissue were embedded in paraffin, cut into µm slices, and stained with hematoxylin and eosin The slides were coded and examined ... ischemia/reperfusion; iii, iv and v = IB-MECA 50 µg/kg, 100 µg/kg and 300 µg/kg, respectively, administered hour before reperfusion; vi and vii = MRS3558 50 µg/kg and 100 µg/kg, respectively, ... reperfusion; and viii = MRS1191 pretreatment before MRS3558 (100 µg/kg) and beginning of reperfusion *P < 0.05 versus the other groups (i, ii, iii, and viii) Western blotting for JNK, p38, and ERK...
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Báo cáo khoa học: " Expression of cell surface receptors and oxidative metabolism modulation in the clinical continuum of sepsis" ppt
... authors read and approved the manuscript Acknowledgements The authors thank Leandro Martins and Camila Valentin for their help in the recruitment of patients, and Maria da Luz Fernandes and Maria ... Neutrophil and monocyte ROS generation in septic patients (n = 41) and controls (n = 17) constitutively and after PMA, fMLP, LPS and S aureus stimulation Values are expressed in median and ranges ... constitutively and after PMA, fMLP, LPS and S aureus stimulation (p < 0.001 in all tested conditions) The median GMFI and range values in the patient group and control group at baseline and after...
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Báo cáo sinh học: " Developmental temperature and somatic excision rate of mariner transposable element in three natural populations of Drosophila simulans" pps
... bands may occur In this analysis 30, 22 and 21 isofemale lines were tested for Bordeaux, Loua and Agadir, respectively, and the ANC per line are 7.9 ±1.2 for Agadir, 5.2 t 0.5 for Bordeaux and ... modify the transcription and/ or the transposition rate of transposable elements (Strand and McDonald, 1985; Junakovic et al, 1986; lVIcDonald et al, 1987) On the other hand, populational factors, ... genes MATERIALS AND METHODS Natural populations and breeding temperature The populations used in this work came from Loua (Congo), Agadir (Morocco) and Bordeaux (France) Season and average temperature...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ rôto dây quấn đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25