idiopathic parkinson s disease and the monkey mptp model
PARKINSON''''S DISEASE AND MOVEMENT DISORDERS: DIAGNOSIS AND TREATMENT GUIDELINES FOR THE PRACTICING PHYSICIAN potx
Ngày tải lên :
05/03/2014, 23:20
... PARKINSON' S DISEASE AND MOVEMENT DISORDERS: DIAGNOSIS AND TREATMENT GUIDELINES FOR THE PRACTICING PHYSICIAN CURRENT CLINICAL PRACTICE Parkinson s Disease and Movement Disorders: Diagnosis and ... disorders On the island of Guam, amyotrophic lateral sclerosis, parkinsonism, and dementia occur in various combinations, perhaps as manifestations of the same disease process Outside Guam, the ... movements and assessment of speech are discussed below and in Chapter 2, respectively PRAXIS Assessment of praxis usually occurs in the course of the routine motor examination Praxis implies the...
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Tài liệu THERAPEUTICS of PARKINSON’S DISEASE and OTHER MOVEMENT DISORDERS docx
Ngày tải lên :
14/02/2014, 17:20
... grasp of the pathophysiology of 28 PARKINSON S DISEASE AND PARKINSONISM PD depends on understanding the anatomy and physiology of the basal ganglia and dopamine networks The motor system has been ... and in vivo studies have demonstrated that mutant a-synuclein, which misfolds, oligomerizes and aggregates, is resistant to UPS-mediated degradation and PARKINSON S DISEASE AND PARKINSONISM PARKINSON S ... THERAPEUTICS of PARKINSON S DISEASE and OTHER MOVEMENT DISORDERS Therapeutics of Parkinson s Disease and Other Movement Disorders Edited by Mark Hallett and Werner Poewe © 2008 John Wiley & Sons,...
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Tài liệu Parkinson’s Disease and Related Disorders docx
Ngày tải lên :
14/02/2014, 17:20
... patients diagnosed with paralysis agitans, Parkinson s Disease and Parkinsonism seen at the Columbia-Presbyterian Medical Center from 1949 to 1964 Nearly 85% had classic Parkinson s Disease and ... L.: Sleep disturbances and excessive daytime sleepiness in Parkinson disease: an overview Arnulf, I.: Sleep and wakefulness disturbances in Parkinson s disease ... about disturbances of the dopamine system in Parkinson s disease ’ (Bertler and Rosengren, 1966), still others compressed all their doubts in the terse phrase that L-dopa ‘‘was the right therapy...
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Surgical Treatment of Parkinson’s Disease and Other Movement Disorders pot
Ngày tải lên :
05/03/2014, 23:20
... interpretations of the different movement disorders, because of the existence of movement disorders such as Huntington s disease (HD) or dystonia, which seem to cross the boundary between these diseases ... of basal ganglia neurons Reports of movement disorders secondary to extrastriatal pathology should therefore come as no surprise 3.1 Parkinson s Disease Early idiopathic Parkinson s disease (PD) ... animals and humans with such disorders The most serious shortcoming of the aforementioned scheme of parkinsonian pathophysiology is, perhaps, that changes in the spontaneous discharge patterns, and...
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Báo cáo khoa học: Endogenous tetrahydroisoquinolines associated with Parkinson’s disease mimic the feedback inhibition of tyrosine hydroxylase by catecholamines doc
Ngày tải lên :
07/03/2014, 05:20
... DA in the absence of neuronal degeneration [6] The CSF levels of TIQs increase in early PD and decrease as the disease progresses [12] TH inhibition by endogenous TIQs may therefore be most prominent ... of N-methyl-norsalsolinol in the CSF: correlations with dopamine metabolites of patients with Parkinson s disease J Neurol Sci 131, 183–189 13 Lee CS, Samii A, Sossi V, Ruth TJ, Schulzer M, Holden ... compensatory processes underlie the preclinical phase of neurodegenerative disease? Insights from an animal model of Parkinsonism Neurobiol Dis 4, 247–253 16 Dauer W & Przedborski S (2003) Parkinson s...
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An Atlas of PARKINSON’S DISEASE AND RELATED DISORDERS pdf
Ngày tải lên :
14/03/2014, 22:20
... index ISBN 1-85070-943-2 Extrapyramidal disorders Atlases Parkinsonism Atlases Movement disorders Atlases I Title II Series [DNLM: Parkinson Disease atlases Basal Ganglia Diseases atlases Movement ... Parkinson s disease ©2004 CRC Press LLC Figure 11 Posture in later-stage Parkinson s disease Figure 12 Parkinson s disease: Impaired fist clenching Figure 13 Parkinson s disease: Tremor illustrated ... Parkinson s disease Any discussion of the clinical characteristics of Parkinson' s disease must take into account the inaccuracies of clinical diagnosis In a successive series of 100 patients...
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An Illustrated Pocketbook of Parkinson''''s Disease and Related Disorders pot
Ngày tải lên :
14/03/2014, 22:20
... PARKINSON S DISEASE Figure 16 Parkinson s disease: dystonic posturing of the big toe secondary to dopa therapy 15 16 AN ILLUSTRATED POCKETBOOK OF PARKINSON S DISEASE Figure 17 Parkinson s disease: ... PARKINSON S DISEASE Figure Parkinson s disease: substantia nigra showing depletion of tyrosine hydroxylase (immunostained for tyrosine hydroxylase) Courtesy of S. E.Daniel, The Parkinson s Disease Society ... Parkinson s disease AN ILLUSTRATED POCKETBOOK OF PARKINSON S DISEASE Figure 12 Parkinson s disease: impaired fist clenching 11 12 AN ILLUSTRATED POCKETBOOK OF PARKINSON S DISEASE Figure 13 Parkinson s...
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báo cáo hóa học: " Gait dynamics in mouse models of Parkinson''''s disease and Huntington''''s disease" doc
Ngày tải lên :
19/06/2014, 10:20
... used for image analyses The treadmill belt was wiped clean between studies if necessary Statistics Data are presented as means ± SE ANOVA was used to test for statistical differences among saline-treated, ... characteristic of Parkinson' s disease, Huntington 's disease, and amyotrophic lateral sclerosis Gait reflects several variables, including balance, proprioception, and coordination There are several ... in Parkinson' s disease and Huntington 's disease Mov Disord 1998, 13:428-437 Blin O, Ferrandez AM, Serratrice G: Quantitative analysis of gait in Parkinson patients: increased variability of stride...
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PARKINSON’S DISEASE AND RELATED DISORDERS - PART 5 pot
Ngày tải lên :
09/08/2014, 16:21
... Figure 14 Positive glabellar tap Persistent blinking is a feature of Parkinson s disease, but is also seen in Alzheimer s disease Figure 15 6-[18F]-fluorodopa–PET scan appearance in a normal subject ... Lysuride Pergolide Ropinirole Cabergoline Terminal expressing either D1 or D2 receptor Postsynaptic neuron Figure 16 Synthesis and metabolism of dopamine within the central nervous system The ... cells (astrocytes and macrophages) Debris and a few vascular channels can be seen (Luxol fast blue–H & E) Figure 24 CT of a patient with a Parkinsonian syndrome shows multiple lacunar infarcts...
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PARKINSON’S DISEASE AND RELATED DISORDERS - PART 6 ppt
Ngày tải lên :
09/08/2014, 16:21
... normal subject (left) compared with that in Parkinson' s disease (middle) and in progressive supranuclear palsy (right) (11C-raclopride is a selective reversible antagonist of D2 receptors) Figure ... degeneration shows atrophy of the putamen with rarefaction and gliosis (H & E) Figure 35 Transverse section of midbrain in striatonigral degeneration shows pallor of the substantia nigra ©2004 CRC Press ... (H & Es) ©2004 CRC Press LLC Figure 40 Histological sections showing examples of oligodendroglial cytoplasmic inclusions in multiple system atrophy (H & Es) ©2004 CRC Press LLC Figure 41 Sagittal...
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PARKINSON’S DISEASE AND RELATED DISORDERS - PART 7 pot
Ngày tải lên :
09/08/2014, 16:21
... Press LLC Figure 57 Dystonic posturing of the hand consequent to perinatal hypoxia Figure 58 Dystonic posturing of the foot consequent to perinatal hypoxia There is inversion of the foot and ... deviation at the wrist and the abducted posture of the little finger ©2004 CRC Press LLC A B C Figure 49 This patient with corticobasal degeneration shows ideomotor apraxia of the left hand When asked ... 45 Histological section of cerebral cortex in corticobasal degeneration shows severe gliosis and an achromatic neuron (H & E) Figure 46 Histological sections of cerebral cortex showing swollen...
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PARKINSON’S DISEASE AND RELATED DISORDERS - PART 8 ppt
Ngày tải lên :
09/08/2014, 16:21
... Histology in Wilson 's disease shows atrophy and rarefaction of the putamen (black arrows) Loss of myelin bundles in the putamen contrasts with the more normal appearances in the globus pallidus ... Huntington 's disease is accompanied by DNA gels (lower) which indicate trinucleotide repeats of between 40 and 52 ©2004 CRC Press LLC Figure 68 Coronal section of brain in Huntington 's disease shows symmetrical ... fast blue) Figure 63 Histology of brain in Wilson 's disease shows a Bergmann type astrocyte within an atrophic putamen (H & E) ©2004 CRC Press LLC Figure 64 Histology of brain in Wilson 's disease...
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báo cáo hóa học: " Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson''''s disease" pptx
Ngày tải lên :
19/06/2014, 22:20
... drugs have shown protective effects in reducing the risk of neurodegenerative disease such as Alzheimer 's disease [8,18] and PD [19] In the present study, we tested the hypothesis that excessive ... to attenuate the progressive cell loss induced by the inflammatory response Using adjacent SNpc sections to stain and count the number of TH- and Nissl-stained neurons and Mac-1stained activated ... TH-positive neurons than the WT mice (#p < 0.05 and ##p < 0.01, respectively) Nissl staining showed similar trends and statistical results (Fig 2C &2D), which indicates a true loss of the TH-positive...
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The Use of Selected Medicinal Herbs for Chemoprevention and Treatment of Cancer, Parkinson’s Disease, Heart Disease, and Depression
Ngày tải lên :
25/10/2013, 05:20
... 11.3 Parkinson s Disease Parkinson s disease (also known as Parkinson disease or PD) is a degenerative disorder of the central nervous system that often impairs the sufferer s motor skills and speech ... Processes, Inflammation, and Tumor Angiogenesis and Metastasis Inflammatory processes mediated by COX-2 and associated growth factors have been implicated in the invasiveness of various types of ... flesh, including essential fatty acids from seeds and seed oils, and fibers, such as microcrystalline cellulose, pectins, lignins, cutin-like polymers, and condensed tannins, have been suggested...
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Báo cáo khoa học: High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract Implications for Parkinson’s disease docx
Ngày tải lên :
16/03/2014, 11:20
... human tissues, and that this has implications for how to interpret the role of the studied enzymes in health and disease Results The distribution and relative intensity of expression of the Adh1, ... nervous system neurons A recent study analyzed the enteric nervous system in PD and found that both Meissner s and Auerbach s plexuses were affected already in early stages of disease and terminal ... including the tongue and esophagus The mRNA signal was located at the base of the stratified squamous epithelium, with a gradient observed towards the superficial layers, while the submucosa showed...
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báo cáo hóa học: " The effects of high frequency subthalamic stimulation on balance performance and fear of falling in patients with Parkinson''''s disease" docx
Ngày tải lên :
19/06/2014, 08:20
... assessed the patient with clinical performance tests, and the same PT assessed all patients in all test situations The tests were out of practical reasons performed in the following order: the ... times consecutively as fast as possible is registered The subject is sitting in an armchair (seat height of 46 cm) with the back against the chair, and with arms folded across the chest The subject 's ... (60 seconds) is accomplished Best value is registered Time is registered in seconds, and gaitspeed is calculated as meters per second (m /s) A digital stopwatch is used In the study by Smithson...
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