i theoretical principles and concepts
TYPE 1 DIABETES – COMPLICATIONS, PATHOGENESIS, AND ALTERNATIVE TREATMENTS docx
... oxidants, mainly hypochlorous acid and chloramines In diabetes the formation of AOPP is induced by intensified glycoxidation processes, oxidant-antioxidant imbalance, and coexisting inflammation ... statistically significant All statistical analyses were carried out using Excel 2003, Origin and BioSTAT 2009 Results Clinical and biochemical characteristics of the patients with T1DM without and ... 16 26 significant difference in comparison with CTRL significant difference in comparison with +DC group T1DM Table Clinical and biochemical characteristics of the patients with T1DM and controls...
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báo cáo hóa học:" The cross-sectional associations between sense of coherence and diabetic microvascular complications, glycaemic control, and patients’ conceptions of type 1 diabetes" pot
... Helsinki, Finland 3Division of Nutrition, Department of Food and Environmental Sciences, University of Helsinki, Finland Authors’ contributions PHG, MS and CF designed the diabetes questionnaire ... Salminen and T Vänttinen; Mänttä Regional Hospital: I Pirttiniemi and A-M Hänninen; North Karelian Hospital: U-M Henttula, P Kekäläinen, M Pietarinen, A Rissanen and M Voutilainen; Nurmijärvi Health ... Tuomivaara and R Vainionpää; Rauma Hospital: K Laine, K Saarinen and T Salminen; Riihimäki Hospital: P Aalto, E Immonen and L Juurinen; Salo Hospital: A Alanko, J Lapinleimu, P Rautio and M Virtanen;...
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báo cáo hóa học: " Anandamide inhibits Theiler’s virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors" pdf
... of staining intensity (Figure 3D) The increased anandamide tone limits microglial activation in mice infected with Theiler’s virus The intracranial injection of Theiler’s virus induced an increase ... manuscript PMI participated in the adhesion experiments and revising manuscript draft MM helped to immunohistochemistry studies and participated in the interpretation of data and revising manuscript ... transmigration in a model of BBB; and 3) in vivo brain VCAM-1 expression and microglial reactivity in TMEV-infected mice Methods Animal and Theiler’s virus inoculation We used female Biozzi ABH and ABH mice...
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Báo cáo khoa học: "Ultrasound-guided central venous catheterization in cancer patients improves the success rate of cannulation and reduces mechanical complications: A prospective observational study of 1,978 consecutive catheterizations" pps
... L, Civardi G, Fornari F, Di Stasi M, Sbolli G, Buscarini E, Vallisa D, Rossi S, Tansini P, Buscarini L: Ultrasonically guided percutaneous splenic tissue core biopsy in patients with malignant ... procedure did not negatively impact on infective and thrombotic complications We believe this technique can be applied easily to most practitioners in clinical oncology with relevant patient benefits ... hematologic malignancies and solid tumors and we have shown that this technique may be efficacious and safe both in patients with acute leukemia and with solid tumors In addition, we emphasize that...
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VASCULAR COMPLICATIONS OF DIABETES - PART 1 ppt
... distribution of fat deposition is genetically determined and there is evidence that there are ethnic differences in body composition This may explain insulin sensitivity studies which, despite ... year It is tempting to think that this is due mainly to genetic differences but there are different incidences in genetically similar countries such as Norway and Iceland, suggesting that environmental ... Whilst the bulk of this will be type diabetes (90%) the incidence has been rising in both types The direct and indirect costs of diabetes and its complications, plus the associated reduction in...
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Báo cáo y học: "Relationship between inflammatory markers, metabolic and anthropometric variables in the Caribbean type 2 diabetic patients with and without microvascular complications" pptx
... diabetics, diabetics with nephropathy (healthy individuSerum sialic acid concentration in controlsand diabetics with Serum sialic acid concentration in controls (healthy individuals), diabetics, ... relationship between sialic acid and metabolic variables We also wished to investigate the relationship between sialic acid and lipid profiles and to determine whether sialic acid concentrations were increased ... the residents of Caribbean Island, Trinidad aged 15–60 (ii) serum sialic acid and microalobumin were positively correlated with hypertension and increased waist to hip ratio and therefore this suggests...
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Báo cáo y học: "Characterization of N200 and P300: Selected Studies of the Event-Related Potential Salil H. Patel 1 and Pierre N. Azzam 2"
... investigations utilizing the auditory oddball paradigm In one such study examining frequency and intensity deviation, changes in inter-stimulus interval (ISI) and intensity in auditory oddball detection tasks ... presented with visual stimuli, in a passive paradigm, exhibit a slow positive wave, which increases in amplitude in response to novel stimuli [74] Young children exhibit identifiable visual P300s ... inducted into hypnotic states: subjects were prescribed to experience positive (entity-fabricative) or negative (entityobliterative) hallucinations while participating in visual and auditory experimental...
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Agile Web Application Development with Yii 1.1 and PHP5
... functioning framework, and for his guidance in helping me learn and contribute to the framework Table of Contents Preface Chapter 1: Meet Yii Yii is easy Yii is efficient Yii is extensible MVC ... 11: Iteration 8: Making it Pretty - Design, Layout, Themes, and Internationalization (i1 8n) Iteration planning Designing with layouts Specifying a layout Applying and using a layout Deconstructing ... and localization in Yii Chapter 12—Iteration 9: Modules – Adding Administration introduces the concept of a module in Yii by using one to add administrative functionality to the application Chapter...
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listen and speaking 1 and 2
... Directions: Listen to the following questions Decide if they have a rising or falling intonation a rising b falling a rising b falling a rising b falling a rising b falling a rising b falling a rising ... Listening Activities: Listening activities will fulfill at least one of two goals First, in addition to using the target language in speaking activities, these activities provide an opportunity ... magazine, or book In addition to providing examples of good writing and generating opportunities to integrate skills, the reading will be a jumping-off point for listening and speaking activities...
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Tài liệu ADC’s HDSL Interface Panel combines HDSL termination, DSX-1 and DSX-3 into a single shelf doc
... FTTX Fiber Product Offering ADC Fiber Distribution Hub Distribution Fiber Splicing Area Feeder Fiber Splice Area Slack Storage for Splitter Fibers Splitter Module (1x32, 1x16, or 1x8) Distribution ... Lockable in-cabinet splicing for feeder and distribution cables • Splitters provided with 2mm pigtails ready to patch into distribution ports • Extensive cable management • Preterminated with OSP ... improving our products, ADC reserves the right to change specifications without prior notice At any time, you may verify product specifications by contacting our headquarters office in Minneapolis...
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Tài liệu Chapter 4: Configuring Layer 1 and Layer 2 Features docx
... [id evc-id | interface interface-id] [detail] Displays information pertaining to a specific EVC if an EVC ID is specified, or pertaining to all EVCs on an interface if an interface is specified ... Displays information pertaining to a specific EVC if an EVC ID is specified, or pertaining to all EVCs on an interface if an interface is specified The detail option provides additional information ... service evc [id evc-id | interface interface-id] [detail] Displays information pertaining to a specific EVC if an EVC ID is specified, or pertaining to all EVCs on an interface if an interface is...
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Tài liệu Báo cáo khoa học: The Arabidopsis protein kinase Pto-interacting 1-4 is a common target of the oxidative signal-inducible 1 and mitogen-activated protein kinases docx
... HIS-OXI > < HIS-OXI < HIS-PTI HIS-PTI > < HIS-OXI < HIS-PTI < MBP Fig OXI1 phosphorylation of PTI1-4 (A) In vitro kinase assay using recombinant proteins: HIS-OXI1 (OXI), kinase-deficient HISOXI1K45R ... Escherichia coli After mixing together HIS-OXI1 and GST-PTI1-4 proteins or HIS-PTI1-4 and GST-OXI1 proteins, the 1128 Because various PTIs interact with AGCs VIII in vitro, the interaction between ... OXIK/R β-Gal OXI OXI OXIK/R OXIK/R GST PTI GST PTI Input C -TLA Input -TL 7255- < HIS-OXI GST-OXI > < GST-PTI α-HIS < HIS-PTI 55α-GST GST > Fig In vitro interactions between OXI1 and PTI1-4 (A) Yeast...
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Tài liệu Báo cáo khoa học: TMPRSS13, a type II transmembrane serine protease, is inhibited by hepatocyte growth factor activator inhibitor type 1 and activates pro-hepatocyte growth factor pdf
... activator inhibitor type (HAI-1), a Kunitz-type serine protease inhibitor, is implicated in the inhibition of two members of the TTSP family, matriptase and hepsin HAI-1 was originally identified as ... enzymatic activity without inhibitors was used as an uninhibited control The IC50 was defined as the concentration of inhibitor that inhibited the enzymatic activity by 50% compared with the uninhibited ... two-chain form exclusively in the injured tissue This conversion is mediated by serine protease activity, which is induced in the injured tissue [28] The two-chain form is required for the biological...
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Tài liệu Báo cáo khoa học: The two Caenorhabditis elegans metallothioneins (CeMT-1 and CeMT-2) discriminate between essential zinc and toxic cadmium docx
... metal ions will differ, and this offers a straightforward mode of discrimination In contrast, discrimination between the essential Zn(II) and toxic Cd(II), which have relatively similar coordination ... contains a 15 amino acid insert with two additional histidines and one cysteine [23,24,29], with a further histidine at position 54 (see Fig S1A for sequence alignment) Recent in vitro characterization ... reduction in Cd(II) affinity is to a considerable extent, but not exclusively, due to weaker binding to the histidine-rich site It is therefore likely that the difference in affinities for binding to...
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Tài liệu Báo cáo khoa học: Synergistic activation of signalling to extracellular signal-regulated kinases 1 and 2 by epidermal growth factor and 4b-phorbol 12-myristate 13-acetate pptx
... stimulators showed a considerably higher signal intensity (Fig 4B), which is consistent with the results discussed in the previous section Positive feedback circuit via cPLA2 and PKC is not involved ... various concentrations of EGF (Becton Dickinson) and/ or PMA (Calbiochem) for different periods of time as indicated PKC was inhibited by preincubation with lM bisindolylmaleimide I (also referred ... oscillations and bistability [4,8,22] We have investigated the interaction between the ERK cascade and protein kinase C (PKC) PKC is also involved in processes like proliferation, differentiation and...
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Tài liệu Báo cáo khoa học: Characterization of promoter 3 of the human thromboxane A2 receptor gene A functional AP-1 and octamer motif are required for basal promoter activity docx
... desensitization of its signaling in response to the potent anti-aggregatory ⁄ vasodilatory autocoids prostaglandin (PG) I2 (prostacyclin) and nitric oxide (NO) through mechanisms involving direct ... 19p13.3 and that arise through a novel differential splicing mechanism involving retention of bifunctional intronic ⁄ exonic sequences within the TPa mRNA [15–17] TPa and TPb are identical for their ... humans is indeed unclear, there is mounting evidence that they undergo differential signaling and regulation, strengthening the viewpoint that TPa and TPb may have distinct physiologic ⁄ pathophysiologic...
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Tài liệu Báo cáo khoa học: Functional hierarchy of plasminogen kringles 1 and 4 in fibrinolysis and plasmin-induced cell detachment and apoptosis docx
... purified active siteinhibited plasmin was tested directly, similar partial and complete inhibitory effects were observed (Fig 5) thus indicating accessibility and participation of both K1 and ... Plasminogen transitions and proteolysis tion into plasmin in situ However, data linking plasminogen conformations and LBS accessibility to its functional properties such as binding to fibrin and ... manner as indicated by the complete inhibition of this activation by 6-Ahx (IC50 ¼ mm, Fig 2A, inset) By blocking the LBS of Glu-Pg K1, mAb 34D3 inhibits plasminogen binding (Fig 1) and activation...
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Tài liệu Báo cáo khoa học: Gene transcription of fgl2 in endothelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3 pdf
... PCR2.1 by digestion with HindIII and SalI and transferred into the pGL2-Basic utilizing the HindIII and XhoI sites A 3¢-deleted promoter fragment was amplified from a pM166 template using a common ... the initiating ATG by site directed mutagenesis The restriction fragment extending 3.5 kb upstream from the introduced SalI site was excised by digestion with SalI and SmaI (utilizing the SmaI ... induced fulminant hepatic failure [21,22] Administration of neutralizing antibodies against fgl2 conferred protection against MHV-3 induced fulminant hepatic failure in susceptible BALB/cJ mice...
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Tài liệu Báo cáo Y học: Binding of gelsolin domain 2 to actin An actin interface distinct from that of gelsolin domain 1 and from ADF/cofilin pptx
... DISCUSSION The actin-binding site on S2 S2 (137–247) contains gelsolin’s initial F-actin binding site prior to severing/capping microfilaments [40], but the orientation of contacting residues and ... Bazari, H., Wallek, M & Matsudaira, P (1992) An actin footprint on villin Single site substitutions in a cluster of basic residues inhibit the actin severing but not capping activity of villin ... S2 equivalents) within residues 197–226 (including the long helix of the domain) and within residues 161 – 172 (including the A strand and the AB loop in S2) in the interaction with F-actin We...
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