hypertrophy in the injured liver
Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain pdf
... explaining the vast neuronal loss in the AD brain Further investigation of the increased neurotrophic activity of the AD brain revealed that it correlated with the loss of a specific neuroinhibitory ... growth-inhibitory properties of GIF in AD There have been extensive studies examining the role of GIF in AD, linked to its initial discovery as a factor deficient in the AD brain There remains no ... zinc in their axon terminals [7] In addition, the synthesis of GIF within cultured cells led to a significant increase in intracellular Zn(II) stores within those cells [7] GIF, through its zinc-binding...
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Báo cáo khoa học: Glycation damage targets glutamate dehydrogenase in the rat liver mitochondrial matrix during aging pptx
... charge profile, but also in the conformation of the molecule resulting from glycation of the charged arginine ⁄ lysine side-chain residues The fact that arginine ⁄ lysine residues are targets ... significantly increased with increasing age (27-month-old rats) Among the glycated proteins, trails of isoforms appeared, in agreement with modifications targeting the basic amino acids arginine and lysine, ... enzyme at the interface between the tricarboxylic acid (TCA) and urea cycles, indicating the interference of matrix enzymes in mitochondrial impairment function with aging in Table 1, there was...
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báo cáo khoa học: "On the genetic determinism of muscular hypertrophy in the Belgian White and Blue cattle breed" pptx
... appraisal of the conformation according genetic determinism to In the experiment we report in this paper, the degree of muscling was evaluated by the total weight of the most important muscles So in this ... on the same diet (milk from the bucket) tilt the final weight of 84 kg They were then slaughtered and the halfcarcasses dissected The average final weight was in fact 83.9 kg (S = 4.0) and the ... +/+ If the segregation of a single major gene is admitted, the question is then to know whether the gene for double-muscling is completely recessive or not The gene effect and the dominance deviation...
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Báo cáo y học: "The role of ATP and adenosine in the control of hepatic blood flow in the rabbit liver in vivo" pps
... H-shaped prosthesis inserted into the portal vein and the inferior vena cava of the in vivo rabbit model Figure Diagram of silastic H-shaped prosthesis inserted into the portal vein and the inferior ... cross-clamping at point "b", distal to the point of entry of the splenic vein into the portal vein perfusate significantly inhibited the HA response to 10-8 moles 100 g liver- 1 intra-arterial adenosine ... relating the readings to the wet weight of the liver, determined at the end of each experiment The "buffering capacity" of the HA was expressed in % as: [Increase in HA flow / Decrease in PV flow]...
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Báo cáo y học: "The aryl hydrocarbon receptor-mediated disruption of vitellogenin synthesis in the fish liver: Cross-talk between AHR- and ERα-signalling pathway" ppt
... 1) The upper panel shows the expression of the VTG gene while the lower panel displays the ethidium bromide staining of the gel to demonstrate equal loading of the samples The arrows indicate the ... genes have reached their maxima The synthesis of the cellular RNA was then blocked by exposing the cells to the transcription-inhibitor actinomycin D while the cells were either left untreated ... hours The synthesis of RNA was then inhibited using actinomycin D (0.5 mg/ml medium) The cells were incubated for to 24 hours in the presence or absence of TCDD (10 nM) The total RNA was then...
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Báo cáo y học: "Effects of ischemic pre- and postconditioning on HIF-1a, VEGF and TGF-b expression after warm ischemia and reperfusion in the rat liver" ppsx
... on I/R injuries to the liver have become indisputable with an increasing number of studies supporting this fact [12-14] The IPC protocol used in this study has previously been shown to induce ... mucosal injury The expression of VEGF mRNA was regulated upwards by the ischemic episodes in the group subjected to sustained ischemia and in the IPC+IPO group A higher expression of VEGF in the ... conditioning seems to prevent HIF-1a mRNA induction in the rat liver after ischemia and reperfusion This suggests that the protective effects of ischemic conditioning not involve the HIF-1 system On the...
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Báo cáo y học: "Evaluation of the effects of a VEGFR-2 inhibitor compound on alanine aminotransferase gene expression and enzymatic activity in the rat liver" pdf
... drugs and toxins may help in understanding the potential localization of hepatic diseases and carcinomas within the liver Understanding these regional effects is critical in the interpretation ... nature The distributional effect of copper, for example is thought to reflect the site of gastrointestinal absorption and portal streamlining into the liver [14] Other studies have indicated that the ... AG28262, a VEGFR-2 inhibitor, in treated rats in the absence of morphological changes in the liver The results of this investigation suggests that the source of increased serum ALT in AG28262 treated...
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Tài liệu Báo cáo khoa học: Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells pdf
... TAG synthesis was initially hindered following stearate administration and was completely interrupted at longer incubation periods Interestingly, the interruption of TAG synthesis preceded the appearance ... also indicated by in vivo experiments using genetically modified mice bearing an inactivating mutation in the gene encoding the enzyme stearoyl-CoA desaturase This enzyme is responsible for the introduction ... supporting the notion that it constitutes the initiating event in the process of lipotoxicity Stearate has to be activated in order to be toxic The first enzyme involved in metabolism of FFAs after their...
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Tài liệu Báo cáo khoa học: Treatment of neutral glycosphingolipid lysosomal storage diseases via inhibition of the ABC drug transporter, MDR1 Cyclosporin A can lower serum and liver globotriaosyl ceramide levels in the Fabry mouse model doc
... also evident in the Fabry mice (Fig 7A) The VT1 binding in the Fabry mouse lung (Fig 7C) was increased in the bronchiolar epithelium Staining of bronchiolar epithelial cells in the lung was significantly ... background in the wildtype mouse liver (Fig 6A), but within the Fabry liver VT1 binding detected Gb3 in the stellate Kupffer cells, distributed throughout the section, and in cells lining the portal ... staining increased in Fabry mouse; (E, F) brain microvascular endothelial staining in Fabry mouse Magnification ·16 no VT1 staining of normal brain (Fig 7F) In Fabry brain, extensive staining of the...
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Tài liệu Báo cáo khoa học: Changes in rat liver mitochondria with aging Lon protease-like activity and N e-carboxymethyllysine accumulation in the matrix doc
... impairment in the inner membrane The decrease in enzymatic Lon protease activity may be the result of either a loss of efficiency in relation to damaged protein and/or a decrease in the amount ... this protein in the matrix We have not detected any significant modification in the amount of this protein in the matrix We can conclude that the decrease in this enzymatic activity is the result ... that there is intracellular lipid glycoxidation that affects the phosphatidylethanolamine from membranes of these organelles [11] In the present investigation, we detected CML proteins using the...
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Báo cáo Y học: Functional expression of human liver cytosolic b-glucosidase in Pichia pastoris Insights into its role in the metabolism of dietary glucosides ppt
... mLámin)1 The following gradients were used: incubations containing arbutin or salicin as substrate; 100% C initial, increasing D to 20% (10 min), 50% (15 min), 100% (5 min), held at 100% (5 min); ... human liver Furthermore, we investigated the speci®city of the human CBG with respect to the glycone and aglycone moieties, and in particular characterized the ef®ciency of the enzyme in hydrolysing ... 17% A/83% B initial (1 min), increasing B to 90% (10 min), held at 90% (4 min) The column was re-equilibrated (5 min) in the appropriate starting solvent conditions following gradient development...
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Báo cáo khoa học: Transcriptome profiling analysis reveals multiple modulatory effects of Ginkgo biloba extract in the liver of rats on a high-fat diet pdf
... protein that blocks the processing of sterol regulatory element-binding proteins (SREBPs) by binding to SREBP cleavage-activating protein, thus preventing the latter from escorting SREBPs to the ... Genes involved in fatty acid biosynthesis, such as Acacb, Acbd6 (acyl-CoA-binding domain containing 6), Scd2 (stearoyl-CoA desaturase 2) or associated genes, Sorbs3 (sorbin and SH3 domain containing ... prevented the harm caused by an HFD In addition, we found no significant alterations in the levels of alanine aminotransferase, aspartate aminotransferase or creatinine kinase in either group...
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Báo cáo khoa học: Interaction of an 40 kDa protein from regenerating rat liver with the )148 to )124 region of c-jun complexed with RLjunRP coincides with enhanced c-jun expression in proliferating rat liver pdf
... some other inducible factor interacts with RLjunRP bound to the )148 to )124 region, and further enhances c-jun transcription in proliferating liver Most of the studies to gain an insight into the ... proliferating tissue to mimic in vivo conditions Surgical removal of twothirds of the liver results in regeneration of the remaining liver lobes until the original liver mass is regained [22–24] ... guanidine/HCl in the denaturing buffer to M, 1.5 M, 0.75 M, 0.38 M and 0.185 M with incubation after each addition The membrane was then incubated in blocking buffer [5% (w/v) BSA in 1· binding...
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Nonalcoholic fatty liver disease in children living in the obeseogenic society doc
... hepatic insulin sensitivity On the other hand, TNF recruits inflammatory cells to injured tissues and promotes insulin resistance Adiponectin and TNF alpha are mutually antagonistic and inhibit ... seem to depend on continuing therapy as rebound increase of liver enzymes and worsening of histological features happen following cessation of therapy Other concerns include increased body weight ... clinical background and imaging studies On the other hand, performing liver biopsy will establish the diagnosis, provide prognostic information, assess severity, and motivate the patient and the...
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Báo cáo khoa học: Liver receptor homolog-1 localization in the nuclear body is regulated by sumoylation and cAMP signaling in rat granulosa cells docx
... is attenuated by the cAMP signaling pathway Our studies further indicate a novel regulatory mechanism of cAMP signaling for altering the sumoylation cycle, involving modulating the expression of ... associated with the targeting of LRH-1 into nuclear bodies that is inhibited by cAMP signaling Because the ovary expresses LRH-1, we further examined the effect of sumoylation site mutation on the nuclear ... western blotting E1 and E2 [44] In the present study, we observed that activation of the cAMP pathway caused a significant change in the sumoylation machinery The mRNA levels of the E1 activating subunit...
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Báo cáo khoa học: Proteome analysis of a rat liver nuclear insoluble protein fraction and localization of a novel protein, ISP36, to compartments in the interchromatin space pptx
... further determined the localization of this protein in the nucleus as described below The other proteins are discussed in detail in the Discussion Predicted amino acid sequences for the murine, ... no in the NCBI protein database proteins Filamentous proteins listed in Table 1, i.e lamin B1, lamin A, lamin C, vimentin, keratin types and and actin, were all included in this group Lamins ... throughout the interchromatin space, because: (a) the protein was fractionated into the nuclear insoluble fraction in the native state (Fig 5); (b) the protein was 4333 Interchromatin space protein ISP36...
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Báo cáo hóa học: "The density of macrophages in the invasive front is inversely correlated to liver metastasis in colon cancer" docx
... grading The study was conducted in accordance with the Helsinki Declaration and approved by the Ethics Committee of our institution Patients were informed of the investigational nature of the ... macrophage infiltration in the invasive front (81.0%) than in those with a lower macrophage infiltration (48.6%), which is in agreement with the previous studies [36-39] The mechanisms behind the antitumor ... conceived the study, participated in the design, and coordinated and helped draft the manuscript All authors read and approved the final manuscript Competing interests The authors declare that they...
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báo cáo hóa học: " Tumor necrosis factor-mediated inhibition of interleukin-18 in the brain: a clinical and experimental study in head-injured patients and in a murine model of closed head injury." pot
... pro-inflammatory mediators, depending on the kinetic of their expression and posttraumatic regulation in the injured brain [3,12,13] However, the TNF-dependent regulation of IL18 in the injured ... corresponds to the time-point of maximal extent of intracerebral inflammation in the model of CHI used in this study [17] For assessment of intracerebral IL-18 levels, the murine brains were immediately ... levels in brains of normal WT mice, compared to normal untreated mice, which were in a similar range as in the brain -injured groups (53.6 ± 9.6 ng/ml, Fig 1) These data imply that a minor penetrating...
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Báo cáo hóa học: "Hypertrophy of the feet and ankles presenting in primary hypertrophic osteoarthropathy or pachydermoperiostosis: a case report" docx
... All the authors of this article participated in the clinical work-up, the medical photography, the literature search and the writing of the manuscript All authors read and approved the final ... cases) [6] The combination of thickened skin and bony enlargement can result in great thickening of the extremities, which is the most striking physical finding [5] Seborrhea is noted in more than ... articular surfaces are spared, but intermittent swelling of the joints is common; they often cause moderate pain but they also can be asymptomatic, as in our case [5] The bony changes consist of symmetric,...
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Báo cáo hóa học: " The Acute Liver Injury in Mice Caused by Nano-Anatase TiO2" docx
... hepatocyte injury and apoptosis Alkaline phosphatase is mainly distributed in the liver, bone, and in bile duct, and ALT and AST exist in the liver, heart, and other organs When the organs injured, the ... might cause the damage of the liver of mice Titanium Contents in Liver and Liver DNA The contents of titanium in liver and the purified DNA from liver of mice during 14 days daily injection of ... and then induce NF-jB activation, leading to the expression of the NF-jB-controlled proinflammatory cytokines (such as IL-1b, IL-6) in liver of mice and the in ammatory response of liver, but the...
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